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1041
Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics
Published 2025-01-01“…Tumor cells in MIBC displayed enhanced glycolytic activity and downregulation of chemokines and MHC-II molecules, reducing immune cell recruitment and facilitating immune evasion. This highlights glycolysis as a potential therapeutic target for disrupting tumor progression. …”
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1042
Multifunctional biosynthesized magnetosome for multimodal imaging and combined therapy of tumor
Published 2025-02-01“…The large recruitment of tumor-associated macrophages and low exposure of tumor-associated antigens in tumor microenvironment have severely suppress the efficacy of anti-tumor immunotherapy. …”
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1043
Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial
Published 2020-01-01“…Results. 80 patients were screened, but 33 were recruited. Sleep studies showed no statistical differences on arousal index or length of sleep. …”
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1044
House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model
Published 2023-01-01“…Mast cell responses are important in asthma as they, upon activation, release mediators inducing bronchoconstriction, inflammatory cell recruitment, and often remodelling of the airways. As guinea pigs exhibit anatomical, physiological, and pharmacological features resembling human airways, including mast cell distribution and mediator release, we evaluated the effect of extracts from two common allergens, house dust mite (HDM) and cat dander (CDE), on histopathological changes and the composition of tryptase- and chymase-positive mast cells in the guinea pig lungs. …”
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1045
Enhancing work environments and reducing turnover intention: a multicenter longitudinal cohort study on differentiated nursing practices in Dutch hospitals
Published 2025-01-01“…Abstract Background Addressing the growing challenge of nurse retention requires coordinated actions at national and global levels to improve recruitment, retention policies, and investments in the nursing work environment. …”
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1046
Implementation of a program to strengthen oral hygiene in patient with cleft deformities: a prospective randomized controlled clinical trial
Published 2025-01-01“…Trial status: 8th Version date 2023 May 05; recruitment began in June 2023 and will be completed in June 2024.…”
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1047
Electrophysiological Predictors of Clinical Outcome in Traumatic Neuropathies: A Multicenter Prospective Study
Published 2016-01-01“…No correlations were found with needle electromyography qualitative evaluations, changes in maximal voluntary recruitment, age, and gender. Conclusions. Nerve conduction studies (NCS) represent the more accurate neurophysiological markers of clinical outcome in patients with TN. …”
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1048
The Impact of Politics on Education Sector Performance in Burundi Sub-County Rubanda District.
Published 2024“…The perceived impact of politics in staff-personnel administration in secondary schools includes the fact that preferential appointment of head teachers by the government generates conflict and recruitment of unqualified teachers into secondary schools shows bias in favor of relations of politicians leading to low quality of teaching. …”
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1049
Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia
Published 2021-06-01“…It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity. …”
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1050
Gait physiotherapy with motor imagery in people with Parkinson’s disease: a protocol for randomized control GAITimagery trial
Published 2025-01-01“…This study aims to determine if gait training combined with MI has a greater effect on the gait of people with PD than just gait training.MethodsThe GAITimagery is designed as a double-blind, randomized control trial, including a convenience sample in 2 parallel groups (1:1) with two interventions of 2 sessions per week during 6-week and 8-week follow-up. The initial recruitment will be 88 participants with idiopathic PD and unimpaired cognition state, who will be randomly divided into two groups: GAITimagery (GiG) or the active control Gait group (GaG). …”
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1051
Qualitative evaluation of the implementation and national roll-out of the NHS App in England
Published 2025-01-01“…In this longitudinal study (2021–2023) we examined how the NHS App became implemented in the pandemic context and beyond. Methods We recruited 88 participants in 62 qualitative interviews and four focus groups. …”
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1052
Implementing a workplace participatory approach to support working caregivers in balancing their work, private life and informal care: results of a process evaluation
Published 2025-01-01“…The implementation frameworks of Steckler and Linnan (2002) and Carrol et al. (2007) were applied to evaluate recruitment, reach, dosage, fidelity and context, as well as stakeholders’ satisfaction, experiences and perceived intervention outcomes. …”
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1053
Structured follow-up pathway to support people after transient ischaemic attack and minor stroke (SUPPORT TIA): protocol for a feasibility study and process evaluation
Published 2022-06-01“…Sixty participants will be recruited from TIA clinics or stroke wards at three hospital sites (England). …”
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1054
Chemokine Profiles Are Affected in Serum of Patients with Acute Rejection of Kidney Allograft
Published 2021-01-01“…Our study of 138 patients focused on one-year monitoring of serum concentrations of 12 chemokines regulating the recruitment of different immune cells into transplanted allograft and on in vitro regulation of the same chemokines release by interactions of renal proximal epithelial cells with monocyte/macrophage cell line stimulated with TNF alpha. …”
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1055
Excess ventilation and chemosensitivity in patients with inefficient ventilation and chronic coronary syndrome or heart failure: a case–control study
Published 2025-01-01“…The Duffin rebreathing method was used to determine the resting end-expiratory partial pressure of carbon dioxide (PETCO2), ventilatory recruitment threshold (VRT), and slope (sensitivity) during a hyperoxic (150 mmHg O2) and hypoxic (50 mmHg O2) rebreathing test to determine the central and peripheral chemosensitivity.ResultsIn patients with CCS, HF, controls, and young healthy adults, median V̇E/V̇CO2 slopes were 40.2, 41.3, 30.5, and 28.0, respectively. …”
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1056
Prediction of reduced left ventricular ejection fraction using atrial fibrillation or flutter electrocardiograms: A machine-learning study
Published 2025-01-01“…A hold-out test dataset was constructed using a different recruitment period. Five-fold cross-validation and calibration plots were used to evaluate performance. …”
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1057
Determinants of rural practice among a cohort of dental professionals in Australia
Published 2025-01-01“…Similarly, students from rural and remote locations were highly likely to practice in rural/ remote locations. Increasing the recruitment of students with rural backgrounds may positively impact graduates’ decisions to practice in rural areas.…”
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1058
Evaluation of topical 1% posaconazole therapy in refractory fungal keratitis
Published 2025-01-01“…Results: The mean age of 35 patients recruited in the PCZ treatment group was 45 ± 17.32 years and that for the conventional treatment group was 43.22 ± 15.04 years. …”
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1059
‘That’s kind of under my work blanket’—redeployment experiences of children’s hospital staff during the covid-19 pandemic: a qualitative interview study
Published 2025-01-01“…Rapid Research Evaluation and Appraisal Lab sheets were used to share data; team-based analysis was facilitated using a framework approach. Results Recruitment and interviews took place from March-November 2021. …”
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1060
Impact of mindfulness-based tri-modal prehabilitation on functional recovery and selected surgical outcomes of patients with colorectal cancer admitted to surgical hospital wards:...
Published 2024-12-01“…Secondary outcome measures cover nutritional status, psychological status and selected biomarker status. Patient recruitment to the study started in April 2022.Ethics and dissemination This study was approved by the Ethics Review Committee of the Faculty of the Medical Sciences University of Sri Jayewardenepura (Registration No: FMC/ USJP ERC 29/19) and the Ethics Review Committee of Colombo South Teaching Hospital (Reference number 915). …”
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