Triglyceride lowering in patients with different severities of hypertriglyceridaemia-associated acute pancreatitis: secondary analysis of a multicentre, prospective cohort study by Xiaoling Li, Lin Gao, Xiang Luo, Wenjian Mao, Lu Ke, Xiaoyan Lai, Lingyan Fu, Yaolu Liu

“…In this study, we aimed to explore the association between rapid decline in serum TG levels and organ failure in patients with different severities of HTG-AP.Methods This is a secondary analysis of data from a multicentre, prospective registry recruiting HTG-AP patients admitted within 72 hours from the onset of symptoms. …”
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Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus by Leticia Elizondo-Montemayor, Adrian M. Gonzalez-Gil, Oscar Tamez-Rivera, Carla Toledo-Salinas, Mariana Peschard-Franco, Nora A. Rodríguez-Gutiérrez, Christian Silva-Platas, Gerardo Garcia-Rivas

“…A cross-sample of 40 Mexican children and adolescents aged 7-17 were recruited, 20 diagnosed with T2DM and 20 healthy controls. …”
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Oral health improvement for nursing home residents through delegated remotivation and reinstruction (MundZaRR Study): study protocol of a cluster-randomised controlled trial by Falk Schwendicke, Peter Schlattmann, Gabriele Meyer, Katrin Hertrampf, Georg Gassmann, Jens Abraham, Volker Hammen

“…Based on a feasibility study, considering clustering and possible attrition, we aim at recruiting 618 residents in 18 clusters. In the intervention group, dentists will assign one or more intervention component from the box (phase 1). …”
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The efficacy and safety of half-dose glucocorticoids combined with rituximab versus high-dose glucocorticoids for initial treatment of minimal change disease: a single-center exper... by Xueting Li, Peng Yan, Lu Zhang, Wei Qiao, Zhengbiao Xue, Xiangdong Fang, Ben Ke, Shuying Zhu

“…The aim of this study was to investigate the clinical efficacy and safety of half-dose glucocorticoids combined with rituximab (RTX) for the initial treatment of MCD.MethodsWe recruited 74 patients with MCD confirmed by renal biopsy. …”
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The novel manualized RELIEVE-group treatment for burdened relatives of cancer patients: a feasibility study by Jessica Neumann, Jessica Neumann, Jil Beckord, Jil Beckord, Helen Samira Hesse, Helen Samira Hesse, Carl Martin, Carl Martin, Carlotta Mons, Carlotta Mons, Diana Chur, Diana Chur, Jörg Hense, Jörg Hense, Mitra Tewes, Martin Teufel, Martin Teufel, Eva-Maria Skoda, Eva-Maria Skoda

“…A total of 33 relatives of cancer patients were recruited from the West German Tumor Center and participated in the five modules of the RELIEVE treatment which included an introduction, communication skills, stress and anxiety management and self-care. …”
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Inexperienced Evaluator Identification of Hand Ischemia Via Video Processed with Pigment-Enhancing Technology by Max Horowitz, BS, Aygul Iskandarova, MD, Gabriel Yohe, MS, Shihab Rahman, BS, Nicholas Durr, PhD, Aviram M. Giladi, MD, MS

“…Methods: Healthy volunteers were recruited for us to record videos of their hands both perfused and under tourniquet-induced ischemia. …”
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Perspectives of nurses and patient representatives on the morally competent nurse: An international focus group study by Chris Gastmans, Evelyne Mertens, Alvisa Palese, Brian Keogh, Francesca Apolloni, Johanna Wiisak, Catherine Mc Cabe, Maria Dimitriadou, Alessandro Galazzi, Michael Igoumenidis, Nikos Stefanopoulos, Paraskevi Charitou, Evridiki Papastavrou, Riitta Suhonen, Stefania Chiappinotto

“…Participants: A purposive sample of 38 nurses and 35 patient representatives was recruited. They were geographically spread across six European countries. …”
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Associations between fear of COVID-19 and mental health in Ghana: A sequential mediation model by Jiajia Ye, Po-Ching Huang, Emma Sethina Adjaottor, Frimpong-Manso Addo, Mark D. Griffiths, Daniel Kwasi Ahorsu, Chung-Ying Lin

“…Methods: A total of 635 participants aged between 18 and 29 years (mean age = 20.2 years [SD = 2.04]) were recruited to complete measures of COVID-19 fear, stress, perceived stigma, preventive behaviors, and mental health status from June to August 2022. …”
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Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject by Winnie Yeo, Lok-Wa Yuen, Kelvin Kam-Fai Tsoi, Emily Ying-Yang Chan, Carol C Kwok, Inda Soong, Ting-Ying Ng, Joanne Chiu, Miranda Chan, Sharon Wing-Wai Chan, Ting-Ting Wong, Yolanda Ho-Yan Chan, Lawrence Pui-Ki Li, Chun-Chung Yau, Wai-Ka Hung, Polly Suk-Yee Cheung

“…Results: In total, 5186 breast cancer patients and 5571 controls were recruited. Several modifiable risk factors were identified. …”
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Teaching communication skills to OTL-HNS residents: multisource feedback and simulated scenarios by Pier-Luc Beaudoin, Mathilde Labbé, Amanda Fanous, Meredith Young, Jamie Rappaport, Yoon Soo Park, John Manoukian, Lily H. P. Nguyen

“…Methods For three consecutive years, OTL-HNS residents were recruited to participate in a total of nine simulation-based clinical scenarios in which communication skills could be honed. …”
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Burnout and its relationship with depressive symptoms in primary school teachers under the “Double Reduction” policy in China by Yunhui Zhong, Shuixiu Lai, Yibo Li, Kan Yang, Hong Tang, Xiang-yang Zhang, Xiang-yang Zhang, Xiang-yang Zhang

“…This study examined self-reported burnout levels of primary school teachers and investigated the relationship between burnout and depressive symptoms in the context of the “Double Reduction” policy in China.MethodsA cross-sectional survey recruited 3,199 primary school teachers from 15 cities across China. …”
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Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention by Runzhen Chen, Chen Liu, Peng Zhou, Yu Tan, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Yi Chen, Li Song, Hanjun Zhao, Hongbing Yan

“…A total of 3940 consecutive ACS patients treated by PCI with postprocedural hsCRP measurements were retrospectively recruited. Patients were stratified into 5 groups according to quintiles of hsCRP. …”
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Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy (PPOIT) in inducing desensitisation or toleran... by Michael O’Sullivan, Michael S Gold, Francesca Orsini, Adriana Chebar Lozinsky, Paxton Loke, Susan L. Prescott, Patrick Quinn, Audrey DunnGalvin, Mimi LK Tang, Anne-Louise Ponsoby, Ee Lyn Su, Marnie Robinson, Dean Tey, Kuang-Chih Hsiao, Molly O’Sullivan, Christine Axelrad, Sigrid Pitkin, Jessica Metcalfe, Susan Fahy-Scheer, Thalayasingam Meera, Jovanka King, Fuad Abass, Abigail Cheung, Rachel Wallace, Samara Baldwin

“…Here we describe the protocol for a Phase IIb multicentre, double-blind, randomised, controlled trial (PPOIT-003) with dual primary objectives to evaluate the effectiveness of PPOIT at inducing SU (assessed at 8 weeks after treatment cessation) compared with placebo treatment and peanut OIT alone, in children with peanut allergy.Methods and analysis 200 children 1 to 10 years of age with current peanut allergy confirmed by failed double-blind placebo-controlled food challenge (DBPCFC) at study screening will be recruited from three tertiary paediatric hospitals in Australia. …”
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Work–health–personal life conflicts in naive patients with chronic hepatitis B receiving initial treatment in China: a qualitative study by Li Zhang, Ying Chen, Ying Li, Hongmei Wang, Lin Zhu, Xiaoyang Lu, Yingjing Zheng, Donald Patrick, Fengjiao Xu, Mengna Song, Xiao Cheng, Boyan Chen

“…Then, researchers chose one tertiary hospital from each city as the study site, so a total of six tertiary hospitals were involved.Participants We recruited 32 patients with CHB (59.38% male) who had just started antiviral therapy for no more than three months. …”
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Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis by Mengqi Liu, Mengqi Liu, Jie Tang, Jie Tang, Gaoyang Xu, Gaoyang Xu, Xu Chen, Xu Chen, Kun Fang, Fan He, Fan He, Yi Zheng, Yi Zheng

“…Previous studies have indicated that adolescents with MDD exhibit immune activation.ObjectiveThis study aimed to compare cytokine levels in adolescents with MDD to healthy controls and assess their diagnostic value.MethodsThis cross-sectional study included 58 adolescent patients with depression from Beijing Anding Hospital (outpatients and inpatients) and 40 healthy adolescents recruited from the community. Multiplex cytokine analysis (Luminex xMAP) was used to measure serum levels of several cytokines. …”
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Fatigue, pain and faecal incontinence in adult inflammatory bowel disease patients and the unmet need: a national cross-sectional survey by Ailsa Hart, Laura Miller, Fionn Cléirigh Büttner, Thomas Hamborg, Sonia Saxena, Richard C. G. Pollok, Imogen Stagg, Vari Wileman, Qasim Aziz, Wladyslawa Czuber-Dochan, Lesley Dibley, Borislava Mihaylova, Rona Moss-Morris, Chris Roukas, Christine Norton

“…Methods Adults with IBD in the UK, recruited from clinics, the national IBD-BioResource, a patient charity and social media sources, completed PROMIS validated patient-reported questionnaires to identify fatigue, pain and faecal incontinence, in addition to symptom severity and impact, disease activity, anxiety and depression questionnaires and questions about their desire for help with these symptoms. …”
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Prediction of long-term drug-free outcomes in ACPA-positive and ACPA-negative rheumatoid arthritis by combined clinical and ultrasound assessment of residual disease: a 5-year pros... by Carlomaurizio Montecucco, Garifallia Sakellariou, Claudia Alpini, Catherine Klersy, Serena Bugatti, Ludovico De Stefano, Emanuele Bozzalla Cassione, Antonio Manzo, Blerina Xoxi, Terenzj Luvaro, Ylenia Sammali

“…Objective To delineate, within the framework of current clinical practice and criteria, the sustainability of first-line immuno-suppressive treatment discontinuation in rheumatoid arthritis (RA) and the impact of residual disease in remission on long-term drug-free (DF) outcomes.Methods RA patients, referring to the Pavia early arthritis clinic (EAC) between 2009 and 2021 and achieving remission after Disease Activity Score-driven methotrexate (MTX) monotherapy, were recruited. Eligible patients underwent DF follow-up at 3-month intervals over 5 years after MTX discontinuation. …”
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Utilizing Technology-Enabled Intervention to Improve Blood Glucose Self-Management Outcome in Type 2 Diabetic Patients Initiated on Insulin Therapy: A Retrospective Real-World Stud... by Jian Lin, Xia Li, Shan Jiang, Xiao Ma, Yuxin Yang, Zhiguang Zhou

“…In total, 14,085 T2DM patients were recruited. Compared with baseline, significant reductions in FBG and PPG were evident at week 12 (FBG: -0.39 mmol/L; PPG: −0.79 mmol/L; both P<0.001). …”
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Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients by Zhouping Wang, Yufen Xu, Huazhong Zhou, Yanfei Wang, Wei Li, Zhaoliang Lu, Zhiyong Jiang, Xueping Gu, Hao Zheng, Lanlan Zeng, Ping Huang, Li Zhang, Xiaoqiong Gu

“…Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies have assessed the relationship between P2RY12 polymorphisms and IVIG resistance in patients with KD. We recruited 148 KD patients with IVIG resistance and 611 with IVIG sensitivity and selected five P2RY12 polymorphisms: rs9859538, rs1491974, rs7637803, rs6809699, and rs2046934. …”
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COVID-19 vaccination and cerebral small vessel disease progression—A prospective cohort study by Yiu Ming Bonaventure Ip, Sangqi Pang, Alan Yao, Lucas Lau, Anki Miu, Katarina Chiu, Ho Ko, Andrew Kwok, Helen Y Chan, Sharon Lee, Howard Chan, Trista Hung, Bonnie Lam, Vincent Hui, Haipeng Li, Lin Shi, Jill Abrigo, Xinyi Leng, Yannie Soo, Sze Ho Ma, Vincent CT Mok, Hugh S Markus, Chris Mok, David SC Hui, Thomas W Leung

“…Results: Of the 415 subjects recruited, 190 received BNT162b2, 152 received CoronaVac, and 73 remained unvaccinated. …”
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