Peer-based Retention Of people who Use Drugs in Rural Research (PROUD-R2): a multisite, randomised, 12-month trial to compare efficacy of standard versus peer-based approaches to r... by Morgan Brown, Miriam R Elman, Jodi Lapidus, April M Young, Kathryn E Lancaster, Sarann Bielavitz, Ryan R Cook, Gillian Leichtling, Edward Freeman, Angela T Estadt, Rhonda Alexander, Caiti Barrie, Kandi Conn, Rhody Elzaghal, Lisa Maybrier, Renee McDowell, Cathy Neal, Elizabeth N Waddell, P Todd Korthuis

“…Participants randomised to the intervention arm are asked to recruit a ‘study buddy’ in addition to receiving standard retention outreach. …”
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Patterns and predictors of mortality in a semi-urban population-based cohort in Sri Lanka: findings from the Ragama Health Study by Anuradhani Kasturiratne, Dileepa Senajith Ediriweera, Madunil Anuk Niriella, Hithanadura Janaka de Silva, Arunasalam Pathmeswaran, Shamila Thivanshi De Silva, Uthuru Beddage Thulani, Anuradha Supun Dassanayake, Arjuna Priyadarsin De Silva, Sureka Chackrewarthy, Udaya Ranawaka, Norihiro Kato, Ananda Rajitha Wickremasinghe

“…Objective To describe patterns and predictors of mortality in a semi-urban population in Sri Lanka.Design A prospective population-based cohort study.Setting Ragama Medical Officer of Health area in the Gampaha district, Sri Lanka.Participants Adults between 35 and 64 years of age were recruited using an age stratified random sampling technique in 2007.Measures At baseline, we recorded socio-demographic, lifestyle, anthropometric, biochemical and clinical data of the participants. …”
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Comprehensive analysis of vaginal microbiota in Chinese women with genital tuberculosis: implications for diagnosis and treatment by Zhan Zhang, Xiaonan Zong, Zhaohui Liu, Xiaoyu Dong, Huihui Bai, Linyuan Fan, Ting Li

“…We comprehensively analyzed the vaginal microbiota in Chinese women with genital tuberculosis. Results We recruited women with pelvic (n = 28), endometrial (n = 16), and pulmonary (n = 12) tuberculosis as the research group, and healthy women (n = 11) as the control group. …”
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Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men by Anders Juul, Niels Jørgensen, Niels E Skakkebæk, Shanna H Swan, Tina Kold Jensen, Mads Gottschau, Jens Otto Broby Madsen, Anne-Maria Andersson, Tina Harmer Lassen, Lærke Priskorn

“…Objective Study associations between three measures of alcohol consumption (recent, typical/habitual, binging), semen quality and serum reproductive hormones.Design Cross-sectional population based study.Setting and participants 1221 young Danish men, aged 18–28 years were recruited when they attended a compulsory medical examination to determine their fitness for military service from 2008 to 2012. …”
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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

“…Our study provides evidence that the complex formed by the hERG1 potassium channel and the β1 subunit of integrin receptors preferentially localizes in Lipid Rafts (LRs) in Pancreatic Ductal Adenocarcinoma (PDAC) cell lines and primary samples. The complex recruits the p85 subunit of phosphatidyl-inositol-3-kinase (PI3K), activating phosphoinositide metabolism and triggering an intracellular signaling pathway centered on Akt. …”
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Depression screening using patient-targeted feedback in general practices: study protocol of the German multicentre GET.FEEDBACK.GP randomised controlled trial by Joachim Szecsenyi, Hans-Helmut König, Karl Wegscheider, Martin Härter, Bernd Löwe, Antonius Schneider, Martin Scherer, Jürgen Gallinat, Antonia Zapf, Sebastian Kohlmann, Marco Lehmann, Marion Eisele, Lea-Elena Braunschneider, Gabriella Marx, Stefanie Joos, Gaby Resmark, Christine Allwang, Christoph Nikendei, Sven Schulz, Katja Brenk-Franz

“…The GET.FEEDBACK.GP RCT will test the efficacy of this patient-targeted feedback intervention in primary care.Methods and analysis The multicentre three-arm GET.FEEDBACK.GP RCT aims to recruit a total of 1074 primary care patients from North, East and South Germany. …”
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Real-world effectiveness of sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir/voxilaprevir against genotype 3 hepatitis C virus infection: a systematic r... by Liwei Zhuang, Liwei Zhuang, Junnan Li, Yu Zhang, Shibo Ji, Huichun Xing, Huichun Xing

“…The sustained virologic response (SVR) rates were analyzed using the Freeman–Tukey double arcsine transformation in a random-effects model in R4.1.0 software.ResultsWe recruited 3,177 patients with HCV GT3 in 19 studies from 9 countries. …”
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Effects of different microfracture drilling parameters on bone quality: a finite element analysis by Jiayi Luo, Jiayi Luo, Zihao Zou, Qiang Zou, Qiang Zou, Siwei Luo, Jialin He, Chuan Ye, Chuan Ye

“…BackgroundMicrofracture drilling is a surgical technique that involves creating multiple perforations in areas of cartilage defects to recruit stem cells from the bone marrow, thereby promoting cartilage regeneration in the knee joint. …”
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Efficacy of wearable transcutaneous electrical acupoint stimulation bracelet on moderate-to-severe postoperative nausea and vomiting in patients after general anesthesia: a study p... by Peng Ding, Dong-yu Zheng, Hong-wei Zhu, Ming Gong, Yong-qiang Wang, Ling-yan Jin, Guang-li Ren, Hui-jing Shi, Yong-hua Li

“…Methods This trial will be conducted in Shanghai and Tianjin, China, with a total of 232 participants recruited from four academic hospitals. Participants will be randomly allocated into the TEAS group or the control group in a 1:1 ratio. …”
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Office BP measurement using conical cuffs in children and adolescents with obesity by Kleo Evripidou, Julio Alvarez-Pitti, Ana De Blas-Zapata, Athanasia Chainoglou, Ioannis Goulas, Karel Herberigs, Gilad Hamdani, Stella Stabouli

“…The aim of the present study was to examine differences in office blood pressure (BP) levels using conical cuffs compared to standard-shaped cylindrical cuffs in children and adolescents with obesity.Design and method We performed an observational study, including 37 children and adolescents with obesity, who were consequently recruited from the outpatient clinics of the Obesity and Cardiovascular Risk Unit at General University Hospital Consortium of Valencia. …”
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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Formation of abnormal blood vessels increases area of hypoxia which recruits suppressor cells, blocks tumor infiltration by CD8+ T lymphocytes, inhibits efficacy of chemoterapeutic drug and leads to cancer relapse. …”
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Dietary insulin load and index in relation to incident gestational diabetes mellitus: a prospective cohort study by Azadeh Aminianfar, Hamid Zolfaghari, Sanaz Soltani, Hossein Hajianfar, Leila Azadbakht, Zahra Shahshahan, Ahmad Esmaillzadeh

“…In this prospective cohort study, 812 pregnant in their first trimester were recruited and followed. Usual dietary intakes were measured using a validated 117-item semi-quantitative food frequency questionnaire at weeks 8–16 of gestations. …”
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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial protocol by Danielle Mazza, Angela Taft, Kevin McGeechan, Kirsten Black, Heather McKay, Marion Haas, Jayne Lucke, Jeffery F Peipert

“…Using randomisation stratified by whether the GP inserts LARCs or not, a total of 54 groups will be allocated to the intervention (online ‘LARC First’ training and rapid referral pathways) or control arm (usual care). We aim to recruit 729 women from each arm. The primary outcome will be the number of LARCs inserted; secondary outcomes include the women's choice of contraceptive method and quality of life (Short Form Health Survey, SF-36). …”
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Impact of the COVID-19 pandemic on type 2 diabetes care and factors associated with care disruption in Kenya and Tanzania by Richard E. Sanya, Caroline H. Karugu, Peter Binyaruka, Shukri F. Mohamed, Lyagamula Kisia, Peter Kibe, Irene Mashasi, Grace Mhalu, Christopher Bunn, Manuela Deidda, Frances S. Mair, Eleanor Grieve, Cindy M. Gray, Sally Mtenga, Gershim Asiki

“…A questionnaire captured data on blood glucose testing, changes in medication prescription and access, and healthcare provider access. Results We recruited 1000 participants (500/country). Diabetes care was disrupted in both countries, with 34.8% and 32.8% of the participants reporting change in place and frequency of testing in Kenya, respectively. …”
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High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population by Hongyang Wang, Dan Bing, Jin Li, Linyi Xie, Fen Xiong, Lan Lan, Dayong Wang, Jing Guan, Qiuju Wang

“…A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and identified by Sanger sequencing or next-generation sequencing; the participants included 30 patients from 16 reported families and 20 new cases. …”
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Asymptomatic Malaria Infection and Hidden Parasitic Burden in Gabonese Schoolchildren: Unveiling Silent Co-Infections in Rural and Urban Settings by Patrice Makouloutou-Nzassi, Lady Charlene Kouna, Chérone Nancy Mbani Mpega Ntigui, Neil Michel Longo-Pendy, Judy Armel Bourobou Bourobou, Felicien Bangueboussa, Nick Chenis Atiga, Jean Bernard Lekana-Douki, Larson Boundenga, Sandrine Lydie Oyegue-Liabagui

“…This cross-sectional study involved afebrile school children recruited at schools between May and June 2021. Blood and stool samples were collected from participants whose parents or legal guardians provided informed consent to participate in the study. …”
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Cross-cultural validation and reference norms for the DCDDaily-Q questionnaire Chinese version (DCDDaily-Q-CN): evaluating children’s motor performance in activities of daily livin... by Meihuan Huang, Yujun Zhan, Haishan Zhou, Ping Song, Yanping Fan, Yang Lu, Yijing Chen, Zhen Lv, Qing Liu, Guojun Yun, Jianguo Cao

“…Thirty children (aged 5–10 years) diagnosed with DCD were recruited through clinical referrals, and a matched control group (n = 30) was randomly selected from the reference group. …”
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Exploratory study of patients’ and carers’ preferences for postdischarge surgical wound monitoring using survey and interviews by Keith Wilson, Nigel Westwood, Catherine Wloch, Pauline Harrington, Luke J Rogers, Judith Tanner, Gavin Murphy, Colin S Brown, Jeremy Dearling, Ricky Vaja, Melissa Rochon, Lyn Brierley Jones

“…Participants were invited to share the survey link with other patients and carers. Interviewees were recruited through the survey.Participants Seventy participants completed the survey: 74% patients and 26% carers. …”
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Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial by Gordana Taleska Stupica, Maja Sostaric, Marija Bozhinovska, Lea Rupert, Zoran Bosnic, Ales Jerin, Alojz Ihan, Tomislav Klokocovnik, Matej Podbregar

“…Seventy-six patients with prolonged CPB were recruited and randomized, with 60 included in final analysis. …”
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HCV and HBV genotypes: vital in the progression of HCV/ HBV co-infection by Yasmin Badshah, Maria Shabbir, Khushbukhat Khan, Sameen Zafar, Tayyaba Afsar, Fohad Mabood Husain, Houda Amor, Suhail Razak

“…Methods In this study 2500 HCV-positive patients were recruited from Pakistan. The presence and prevalence of HCV and HBV was confirmed through ELISA and nested PCR. …”
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