A non-randomised open-label exploratory ‘window of opportunity’ study of TG02 treatment in patients with locally advanced primary and recurrent RAS mutant colorectal cancer by Sara Roth, Kasmira Claire Wilson, Robert George Ramsay, Catherine Mitchell, Shienny Sampurno, Toan Duc Pham, Joseph Cherng Huei Kong, Stephen Q. Wong, Alexander Graham Heriot, Sanjeev Deva, Matthew Burge, Cecilie Sverdrup, Anne-Sophie Moller, Lukasz Kuryk, Jon Amund Eriksen, Magnus Jaderberg, John Raymond Zalcberg, Michael Michael

“…Results: Six patients with rectal cancer were recruited to evaluate TG02. Three patients experienced a total of 16 treatment-related adverse events; all grade 1. …”
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Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study by Zhen Guo, Zhenyu Xiong, Lixiang He, Shaozhao Zhang, Xinghao Xu, Guanzhong Chen, Mengjie Xie, Wenjing Zhang, Ziwen Hui, Jiaying Li, Xinxue Liao, Xiaodong Zhuang

“…A total of 190 patients were recruited from one-center. Patients were divided into two groups according to the cut-off value of TyG-BMI index (Ln[triglycerides (mg/dL)* glucose (mg/dL)/2]*BMI). …”
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Understanding Psychological Wellbeing Among Iranian Healthcare Workers: The Role of Resilience and Social Capital by Maryam Akbari, Mohammad Hossein Kaveh, Rosanna Cousins, Hamidreza Mokarami, Mehdi Jahangiri, Changiz Rahimi Taghanaki

“…Systematic random sampling was used to recruit 140 employees working in healthcare centers in Shiraz, Iran, in 2021. …”
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Neonatal outcomes in offspring of mothers with pregestational diabetes: a hospital-based multicentre prospective cohort study protocol by Manu Raj, Vishnu Renjith, Renjitha Bhaskaran, Anju Philip Thurkkada, Radhamany Kunjukutty, Sobha S Nair, Annie Soman, Sethulakshmi Ramachandran

“…The study targets to recruit 1260 pregnant women. All pregnant women above the age of eighteen who had confirmed pregnancy in an early pregnancy scan and in the first trimester of pregnancy visiting the three study sites for antenatal care will be included in the study. …”
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High-dose dual therapy for Helicobacter pylori eradication inducing less impact on the gut microbiota by Jia-Lun Guan, Ting-Ting Xu, Ya Lin, Yan-Shuai Mo, Bi-Yu He, Ying-Ying Han, Ji-Yan Li, Su-Hong Xia, Ya-Ni Zhou, Jia-Zhi Liao, Pei-Yuan Li

“…Pylori-infected treatment-naive patients were recruited and screened from September 2023 to April 2024 and randomly assigned to the HDDT group (esomeprazole 20 mg, amoxicillin 750 mg, qid, 14 days) or BQT group (esomeprazole 20 mg, amoxicillin 1000 mg, clarithromycin 500 mg, and bismuth potassium citrate 600 mg, bid, 14 days). …”
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Effectiveness of a comic book intervention on mental health literacy among adolescents and youth in Burkina Faso: a randomized controlled trial protocol by Irene Brandt, Sylvain Some, Ourohiré Millogo, Oumar Sourabié, Jacob Burns, Sachin Shinde, Matthias Haucke, Nathan Sivewright, Christine Neumann, Shraddha Bajaria, Katian Napon, Clarisse Dah, Marina Taonda, Jason T. Siegel, Mary Mwanyika Sando, Till Bärnighausen, Ali Sié, Shuyan Liu

“…Our study aims to fill this gap by evaluating the effectiveness of comic books in enhancing mental health literacy among adolescents and young adults aged 10–24 years. Methods We will recruit 2,007 participants aged 10–24, stratify them by age, and randomly assign them to three groups (1:1:1): a comic book intervention group (Intervention 1), a text-only flyer group (Intervention 2), and a control group with no intervention. …”
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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

“…Results indicated improvements in all measures except disability, at either T1 or T2, or both.Conclusions This study showed it was feasible to deliver the intervention, including training RHPs, and recruit and follow-up participants with high retention. …”
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Responsiveness and clinical utility of PROMIS instruments in pediatric Crohn's disease: insights from a longitudinal study by Sara Azevedo, Sara Azevedo, Maria Miguel Oliveira, Maria Miguel Oliveira, Paulo Nogueira, Paulo Nogueira, Paulo Nogueira, Ana Isabel Lopes, Ana Isabel Lopes

“…Integrating patient-reported outcomes (PROs) into clinical practice is crucial for comprehensive disease management.ObjectiveTo evaluate the responsiveness and clinical utility of Patient-Reported Outcomes Measurement Information System (PROMIS) instruments, compared with standard clinical assessment tools in pediatric CD patients.MethodsA longitudinal, prospective study with 31 pediatric Crohn's disease (CD) patients aged 8–17 years recruited from a Pediatric Gastroenterology Unit. Data were collected at baseline and every 6 months over 18 months. …”
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Will Climate Change Alter the Swimming Behavior of Larval Stone Crabs?: A Guided-Inquiry Lesson by Abigail L. Smith, Jessyca LaBadie, Aly Busse, Emilie Solomon, Casie Farrell, Daniel M. Holstein, Zuo George Xue, Philip M. Gravinese

“…The larvae of species like the Florida stone crab (Menippe mercenaria) are free swimming, allowing a population to disperse and recruit into new habitats. After release, stone crab larvae undergo vertical swimming excursions in response to abiotic stimuli (gravity, light, pressure) allowing them to control their depth. …”
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Plant-microbe interactions influence plant performance via boosting beneficial root-endophytic bacteria by Sai Guo, Rubin Pan, Yan Zhang, Quanwei Gu, Qirong Shen, Jian Yang, Luqi Huang, Zongzhuan Shen, Rong Li

“…Healthy plant roots recruited some potentially beneficial bacteria partners, particularly Pseudomonas into the endosphere. …”
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A Missense Mutation in OPA1 Causes Dominant Optic Atrophy in a Chinese Family by Shaoyi Mei, Xiaosheng Huang, Lin Cheng, Shiming Peng, Tianhui Zhu, Liang Chen, Yan Wang, Jun Zhao

“…A 5-generation pedigree of 35 family members including 12 individuals affected with DOA was recruited from Shenzhen Eye Hospital, China. Four affected family members and one unaffected family member were selected for whole exome sequencing. …”
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Novel Compound Heterozygous BBS2 and Homozygous MKKS Variants Detected in Chinese Families with Bardet–Biedl Syndrome by Li Huang, Limei Sun, Zhirong Wang, Songshan Li, Chonglin Chen, Xiaoling Luo, Xiaoyan Ding

“…Materials and Methods. Two families were recruited in this study. Family A was a four-generation family with four affected and 15 unaffected members participating in the study, and family B was a consanguineous family with one affected and three unaffected members participating. …”
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Rationale and design for the thoracic Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial: a parallel-group, double-blinded... by Jing Zhao, Hui Zhang, Ziyu Zheng, Baobao Gao, Lini Wang, Chong Lei, Hailong Dong, Taoyuan Zhang, Jiao Gao, Lihong Hou

“…The mechanism is not clear, and there is still a lack of safe and effective preventive measures.Methods and analysis The Paravertebral Adjunctive Dexamethasone Palmitate Reducing chronic pain After cardiac surgery (PANDORA) trial is a parallel-group, double-blinded, randomised controlled, single-centre study recruiting 902 participants undergoing MICS. Participants will be randomised in a 1:1 ratio to dexamethasone palmitate (D-PAL) emulsion group and dexamethasone (DSP) group. …”
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Effect of oxytocin nasal spray pretreatment on postoperative acute stress disorder in patients with accidental traumatic fracture: a single-centre prospective randomised controlled... by Ling Ren, Qingqing Huang, Hengdi Zhang, Jingzheng Zeng, Yi Wen, Haifeng Shu, Gu Gong

“…This study aims to investigate the effect of pretreatment with oxytocin nasal spray on postoperative ASD in patients with accidental trauma and fracture to provide new clinical insights for the prevention of postoperative ASD.Methods and analysis This study is a single-centre, double-blind, randomised controlled clinical trial. The trial aims to recruit 328 patients with accidental traumatic fractures who underwent surgical treatment. …”
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The Validity of a Smartphone-Based Application for Assessing Cognitive Function in the Elderly by Jin-Young Min, Duri Kim, Hana Jang, Hyunjoo Kim, Soojin Kim, Seungbo Lee, Yae-eun Seo, Ye-jin Kim, Jong-yoon Kim, Kyoung-Bok Min

“…This study examined whether a smartphone-based cognitive assessment, Brain OK, was valid for evaluating cognitive performance and identifying people at risk of cognitive impairment. <b>Methods:</b> We recruited 88 study participants aged over 60. They completed two cognitive tests with the Montreal Cognitive Assessment (MoCA), a validated paper-and-pencil cognitive screening tool, and Brain OK, a smartphone-based cognitive testing application. …”
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Adaptations to the welsh national exercise referral scheme during the COVID-19 pandemic: a qualitative study exploring the experiences of service users and providers and supplement... by Katie Newby, Neil Howlett, Adam P. Wagner, Nigel Lloyd, Imogen Freethy, Charis Bontoft, Olujoke Fakoya, Shelley Jackson, Carla Jackson, Wendy Wills, Mary-Ann McKibben, Annie Petherick, Katherine E. Brown

“…Maximum variation sampling was used to recruit participants. Interviews with service users (n = 21) and one person who declined the service, and three focus groups with service providers (n = 19), were conducted. …”
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Improved Predictability of Diagnosis and Prognosis Using Serum‐ and Tissue‐Derived Extracellular Vesicles From Bulk mRNA Sequencing in Pancreatic Ductal Adenocarcinoma by Qian Zhu, Zhang Chen, Ming Tian, Xin Yan, Xiangdong Gongye, Zhicheng Liu, Anbang Zhao, Zhiyong Yang, Yufeng Yuan

“…A large cohort was subsequently recruited to validate these findings. The diagnostic capacity of the identified miRNAs was assessed using the Brier score and area under the curve (AUC). …”
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Towards PErsonalised PRognosis for children with traumatic brain injury: the PEPR study protocol by Jaap Oosterlaan, Marsh Königs, Job B M van Woensel, Marc Engelen, Marjan E Steenweg, Petra J W Pouwels, Cece C Kooper, Hilgo Bruining, Arne Popma, Dennis R Buis, Maayke Hunfeld

“…In addition, the potential added value of advanced neuroimaging data and the use of machine learning algorithms in the development of prognostic models will be assessed.Methods and analysis 210 children aged 4–18 years diagnosed with mild-to-severe TBI will be prospectively recruited from a research network of Dutch hospitals. …”
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Adherence to stand-by emergency treatment and mosquito protection measures in short-term travellers to moderate malaria risk areas by Daniel Julien Franken, Vita Willemijn Jongen, Anna Rooyakkers, Martin Peter Grobusch, Jelte Elsinga, Margarita Boering, Maria Prins, Brigitte Antonia Geertruida Lucía van Cleef

“…We used Poisson regression to assess determinants for adherence to mosquito protection measures. Results: Of 686 recruited travellers, 405 (59 %) completed the diary. …”
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Nurses' Sleep Quality and Its Influencing Factors During the First Explosive COVID‐19 Outbreak in Zhejiang, China, After the Relaxation of Epidemic Prevention and Control Measures:... by Lifen Lu, Di Sheng, Yaling Zhu, Xiaowei Xia, Guanghui Chen, Jiali Liang, Xiulan Shen, Gui Zheng

“…The participants were recruited using convenience sampling, and the survey was distributed via the WeChat platform. …”
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