Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson’s Disease Patients by Seyed-Mohammad Fereshtehnejad, Hasti Hadizadeh, Farzaneh Farhadi, Gholam Ali Shahidi, Ahmad Delbari, Johan Lökk

“…A total number of 140 PD patients with the mean current age of 61.3 (SD=10.4) yr were recruited in this study. PD patients with the onset age of ≤50 yr were defined as “early-onset” (EOPD) group (n=45), while the ones with >50 yr at the time of diagnosis were categorized as the “typical-onset” (TOPD) patients (n=95). …”
Get full text

Evaluation of the efficacy of a novel lumbar exoskeleton with multiple interventions for patients with lumbar disc herniation: a multicenter randomized controlled trial of non-infe... by Xiaonan Huang, Xiaonan Huang, Lele Huang, Lele Huang, Lei Shi, Lifan Xu, Lifan Xu, Chengbing Cao, Heng Wu, Min Cao, Can Lv, Ping Shi, Guohui Zhang, Fanfu Fang

“…Outcomes included efficacy rate after 10 treatments, Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and lumbar ROM—were assessed at 3, 6, and 10 treatments.ResultsA total of 118 eligible participants were recruited. After 10 treatments, both groups showed significant improvements in VAS scores, ODI, and lumbar ROM compared to baseline (P < 0.001). …”
Get full text

Comparative Evaluation of Bandage Contact Lenses and Eye Patching after Bilateral Cataract Surgery by Dalan Jing, Aihua Deng, Hongmei Wang, Yilin Chou, Xiaodan Jiang, Zhenxiang Chen, Xuemin Li, Tingyi Wen

“…Sixteen (32 eyes) patients who planned to undergo bilateral cataract surgery were recruited. The two eyes of each patient were randomly divided into 2 groups. …”
Get full text

Outcomes of anterior cruciate ligament reconstruction surgery from private and public healthcare services in AustraliaKey points by Thomas J. West, Andrea M. Bruder, Kay M. Crossley, Michael A. Girdwood, Laura K. To, Jamon L. Couch, Mark J. Scholes, Sebastian C.S. Evans, Melissa J. Haberfield, Christian J. Barton, Ewa M. Roos, Alysha De Livera, Adam G. Culvenor

“…Future research should consider potential disparities in outcomes between participants using differing healthcare services both clinically and when recruiting participants into research studies evaluating outcomes post-ACLR.…”
Get full text

Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…To overcome this challenge and take advantage of PD-L1 upregulation upon gemcitabine treatment, we generated recombinant PD-L1xCD3 bispecific T cell engagers (BiTEs) to simultaneously block PD-1/PD-L1 signaling and recruit T lymphocytes to eliminate CCA cells. Two recombinant PD-L1xCD3 BiTEs (mBiTE and sBiTE contain anti-PD-L1 scFv region from atezolizumab and from a published sequence, respectively) were able to specifically bind to both CD3 on T lymphocytes, and to PD-L1 overexpressed after gemcitabine treatment on CCA (KKU213A, KKU055, and KKU100) cells. mBiTE and sBiTE significantly enhanced T lymphocyte cytotoxicity against CCA cells, especially after gemcitabine treatment, and their magnitudes of cytotoxicity were positively associated with the levels of PD-L1 expression. …”
Get full text

CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…The Community Health and Intergenerational study aims to holistically examine ageing in place by investigating the resilience and vulnerability factors of the ageing process in the biological, psychological and social domains within the environment.Methods and analysis Using a cohort multiple randomised controlled trial design, comprehensive health profiles of community-dwelling older adults will be collected. The objective is to recruit 1000 participants (aged 60–99 years) living in the western region of Singapore within a period of 3 years (2018–2020). …”
Get full text

Using nasal sprays to prevent respiratory tract infections: a qualitative study of online consumer reviews and primary care patient interviews by Paul Little, Katherine Bradbury, Lucy Yardley, Adam W A Geraghty, Ben Ainsworth, Kate Greenwell, Deb Smith, Laura Dennison, Sian Williamson, James Denison-Day, Fiona Mowbray, Samantha Richards-Hall

“…Interview transcripts were analysed using thematic analysis.Setting Primary care, UK.Participants 407 online customer reviews. 13 purposively recruited primary care patients who had experienced recurrent infections and/or had risk factors for severe infections.Results Both studies identified various factors that might influence nasal spray use including: high motivation to avoid RTIs, particularly during the COVID-19 pandemic; fatalistic views about RTIs; beliefs about alternative prevention methods; the importance of personal recommendation; perceived complexity and familiarity of nasal sprays; personal experiences of spray success or failure; tolerable and off-putting side effects; concerns about medicines; and the nose as unpleasant and unhygienic.Conclusions People who suffer disruptive, frequent or severe RTIs or who are vulnerable to RTIs are interested in using a nasal spray for prevention. …”
Get full text

After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia by Mario Delia, Paola Carluccio, Anna Mestice, Roberta Frappampina, Francesco Albano, Giorgina Specchia, Pellegrino Musto

“…In particular, immune suppressive regulatory T cells (Tregs) may contribute to this defective antileukemic immune response, being recruited by bone marrow leukemic cells to evade immune surveillance. …”
Get full text

Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices by Asmaa M. Zahran, Helal F. Hetta, Zeinab Albadry M. Zahran, Alaa Rashad, Amal Rayan, Dalia O. Mohamed, Zeinab Ahmed Abd Elhameed, Salah M. Khallaf, Gaber El-Saber Batiha, Yasir Waheed, Khalid Muhammad, Hanaa Nafady-Hego

“…The current study is aimed at providing the predictive and prognostic role of Mo-MDSCs in advanced non-small-cell lung cancer (NSCLC) in relation to different hematologic indices. Methods. We recruited 40 cases of advanced NSCLC, stages III and IV, aged>18–<70 years old, and eligible to receive chemotherapy with or without radiotherapy, along with 20 healthy controls of comparable age and sex; after diagnosis and staging of patients, blood samples were collected for flow cytometric detection of Mo-MDSCs. …”
Get full text

Talking with pregnant women exposed to cannabis use after cannabis legalization: Experiences of professionals working in Québec's social and healthcare system by Karen A. Dominguez-Cancino, Rose Chabot, Yolaine Frossard de Saugy, Kristelle Alunni-Menichini, Lysiane Robidoux-Léonard, Genève Guilbert-Gauthier, Karine Bertrand, Christophe Huỳnh, Pablo Martínez, Helen-Maria Vasiliadis, Nadia L'Espérance, Victoria Massamba, Julie Loslier, José Ignacio Nazif-Munoz

“…Purposeful sampling was employed to recruit 19 professionals, including physicians, nurses, psychologists, and social workers. …”
Get full text

Genetic variants on chromosome 19 (rs439401 and rs4420638) are associated with obesity and high blood pressure in the Algerian population by H. Boulenouar, S. Mediene Benchekor, H. Ouhaibi Djellouli, S. Larjam Hetraf, L. Houti, I. Hammani-Medjaoui

“…We performed this work using a population-based, cross-sectional study of a representative sample of 787 individuals (378 men and 409 women, aged between 30 and 64 years) recruited in the city of Oran, Algeria (the ISOR Study); the subjects were genotyped for four polymorphisms, rs7412, rs429358, rs4420638 and rs439401, located in the APOE gene, using the KASPar technology. rs439401 showed a significant association with hypertension (HBP). …”
Get full text

A HEALTH RELATED QUALITY OF LIFE AND PSYCHOPATHOLOGICAL SYMPTOMS IN PEOPLE WITH HEMOPHILIA, BLOODBORNE CO-INFECTIONS AND COMORBIDITIES: AN ITALIAN MULTICENTER OBSERVATIONAL STUDY by Mario Schiavoni, CARLO PRUNETI, SARA GUIDOTTI, ALESSANDRA MOSCATELLO, FRANCESCA GIORDANO, ANTONELLA COLUCCIA, RITA CARLOTTA SANTORO, MARIA FRANCESCA MANSUETO, EZIO ZANON, RENATO MARINO, ISABELLA CANTORI, RAIMONDO DE CRISTOFARO

“…Methods: Seventy patients (mean age 46.77±11.3), 64 with severe hemophilia A (Factor VIII: C < 1 IU/dL) and 6 with severe hemophilia B (Factor IX <1 IU/dL), were consecutively recruited from seven Hemophilia Centers in Italy of Italian Association of Hemophilia Centers (AICE). …”
Get full text

Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study by Jichen Zhang, Jiancan Lu, Hongling Zhu, Xinglu Zhou, Xijuan Wei, Mingjun Gu

“…A total of 247 T2DM patients were recruited in this retrospective study and divided into 75 subjects with MCI and 172 with normal cognition. …”
Get full text

Fusion Model Using Resting Neurophysiological Data to Help Mass Screening of Methamphetamine Use Disorder by Chun-Chuan Chen, Meng-Chang Tsai, Eric Hsiao-Kuang Wu, Shao-Rong Sheng, Jia-Jeng Lee, Yung-En Lu, Shih-Ching Yeh

“…Forty-six patients with MUD and 26 healthy controls were recruited and machine learning methods were employed to systematically compare the classification results of different fusion models. …”
Get full text

Relationship between subjective masticatory performance assessed by food acceptance questionnaire and comprehensively assessed oral function in older outpatients at a dental hospit... by Ryota Futatsuya, Yohei Hama, Mitsuzumi Okada, Mayuko Matsuzaki, Linjing Xiong, Kohei Yamaguchi, Kanako Noritake, Yoshiyuki Sasaki, Manabu Kanazawa

“…Methods Patients aged ≥ 65 years were recruited from an outpatient dental clinic at Tokyo Medical and Dental University. …”
Get full text

Metabolic Modulation and Potential Biomarkers of the Prognosis Identification for Severe Aortic Stenosis after TAVR by a Metabolomics Study by Yanbiao Liao, Chang Liu, Tianyuan Xiong, Mingyue Zhao, Wen Zheng, Yuan Feng, Yijian Li, Yuanweixiang Ou, Zhengang Zhao, Yong Peng, Jiafu Wei, Qiao Li, Wei Meng, Xiaojing Liu, Mao Chen

“…Fifty-nine consecutive AS patients were prospectively recruited. Blood samples from the ascending aorta, coronary sinus, and peripheral vein at before and after TAVR were collected, respectively. …”
Get full text

MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…In this mechanism, MYH9 was shown to bind to β-catenin and to increase its protein level by recruiting the deubiquitinase USP2 to form a complex. …”
Get full text

Patient perspectives and utilization of telemedicine for chronic conditions in Pakistan barriers and facilitators towards its access by Muhammad Muzzamil, Mahek Karim, Sara Saeed Khurram, Iffat Zafar Aga, Shahkamal Hashmi, Hina Gul Hassan, Yasha Younus

“…The investigation was conducted at the Sehat Kahani head office, where 460 persons with chronic diseases were recruited. These participants were initially identified by Electronic Health Records (EHR) of Sehat Kahani and subsequently registered following randomization through systematic random sampling. …”
Get full text

A comprehensive overview of acupuncture therapy over the past 20 years: Machine learning-based bibliometric analysis by Chen Liu, Shuqing Liu, Yu Wang, Xinyi Xia, Yu Zhang, Huili Jiang, Tuya Bao, Xuehong Ma

“…Results: A total of 17,584 publications were finally recruited in this article. The publications were derived from 57 countries, with China, The United States and England being the top three countries. …”
Get full text

Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest by Pan Pan, Shubao Wei, Huabing Li, Yangpan Ou, Feng Liu, Wenyan Jiang, Wenmei Li, Yiwu Lei, Yanqing Tang, Wenbin Guo, Shuguang Luo

“…A total of 48 subjects, including 24 untreated patients with BSP and 24 healthy controls, were recruited to undergo functional magnetic resonance imaging (fMRI). …”
Get full text