Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

“…The immunogenicity of Reg proteins could recruit immune cells leading to an anti-tumor effect. …”
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Maximal mouth opening in infants and toddlers with spinal muscular atrophy: a prospective controlled study by Jana Zang, Deike Weiss, Charlotte Dumitrascu, Julia Glinzer, Marie Wegner, Anna Strube, Jonas Denecke, Almut Niessen, Christina Pflug

“…Methods Children with SMA (0–24 months) who received disease-modifying therapy at a single neuropediatric center and similarly aged healthy children were prospectively recruited. MMO was measured using a cardboard scale and a custom-designed instrument. …”
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Total Antioxidant Status in Type 2 Diabetic Patients in Palestine by Akram T. Kharroubi, Hisham M. Darwish, Mutaz A. Akkawi, Abdelkareem A. Ashareef, Zaher A. Almasri, Khaldoun A. Bader, Umaiyeh M. Khammash

“…A sample of convenience composed of 212 type 2 diabetic and 208 normal subjects above the age of 40 were recruited. Only 9.8% of the subjects had normal body mass index (BMI) levels (<25), 29% were overweight (≥25 to <30), and 61.2% were obese (≥30). …”
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The negative impacts of bisphenols on thyroid function in adults with bisphenol A exposure level exceeding the tolerable daily intake by Ziwei Pei, Lei Zhang, Yan Bao, Jingguang Li, Qin Zhuo

“…We carried out a cross-sectional study in Chengdu, China, recruiting 1486 adults without special indentities and diseases (aged 18–68), and measured 6 BPs in urine. …”
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Chinese nurses’ perspectives on child-friendly healthcare practice assessment: a qualitative study by Wei Xiao Huang, Mei Chan Chong, Li Yoong Tang, Xiao Xia Liu, Mei Fang, Yun Yun Shen, Xiao Li Guo

“…Method This descriptive qualitative study employed purposive and snowball sampling methods to recruit 14 pediatric nurses from six hospitals in Zhejiang province, Southeast China. …”
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The relationship between malocclusion and speech patterns: a cross-sectional study by Nada E. Tashkandi, Razan AlDosary, Hissah Zamandar, Misk Alalwan, Mohannad Alwothainani, Hissah Aljoaid, Duaa Alghazhmri, Eman Allam, Anand Marya, Samar M. Adel

“…Materials and methods One hundred native subjects (28.92 ± 12.09 years old) were recruited for this cross-sectional study. The Peer Assessment Rating (PAR) index was used to describe malocclusion pattern. …”
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Factors Affecting Social Support Status of People Living with HIV/AIDS at Selected Hospitals of North Shewa Zone, Amhara Region, Ethiopia by Elyas Admasu Basha, Behailu Tariku Derseh, Abate Dargie Wubetu, Nigus Alemnew Engidaw, Kefyalew Dagne Gizachew

“…Systematic random sampling was used to recruit the study population after selecting study areas by lottery methods. …”
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CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…To elevate endogenous Gad1 levels, we used the CRISPR/Cas9-based epigenome editing technology to recruit histone acetyltransferase p300 to Gad1. Cells transfected with a fusion protein consisting of the nuclease-null dCas9 protein and the catalytic core of p300 (dCas9p300), as well as a guide RNA targeting Gad1 promoter (gRNAGad1), had significantly increased Gad1 mRNA expression and histone acetylation at Gad1 promoter. …”
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PRPF3-Associated Autosomal Dominant Retinitis Pigmentosa and CYP4V2-Associated Bietti’s Crystalline Corneoretinal Dystrophy Coexist in a Multigenerational Chinese Family by Xiaohong Meng, Qiyou Li, Hong Guo, Haiwei Xu, Shiying Li, Zhengqin Yin

“…A pedigree consisted of 56 individuals in 5 generations was recruited. Comprehensive ophthalmic examinations were performed in 16 family members affected. …”
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Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility by Jiaoyuan Xu, Meilan Xian, Linhui Huang, Yamei Zheng, Lei Zhang, Jie Zhao, Jie Chen, Siguang Li, Lingsang Lin, Yi Zhong, Zehua Yang, Haihong Wu, Tian Xie, Yipeng Ding

“…The aim of this study was to further explore the potential relationship between IL18R1 single nucleotide polymorphisms (SNPs) and COPD risk.Methods Nine hundred and ninety-six subjects were recruited (498 COPD cases and 498 healthy controls). …”
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Pilot Trial of the Reboot Online Program: An Internet-Delivered, Multidisciplinary Pain Management Program for Chronic Pain by Regina Schultz, Jessica Smith, Jill M. Newby, Tania Gardner, Christine T. Shiner, Gavin Andrews, Steven G. Faux

“…Twenty participants experiencing pain of at least three months duration were recruited. All participants were enrolled in the “Reboot Online” program, consisting of eight online lessons completed over 16 weeks. …”
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A mixed methods exploratory study assessing youth knowledge, self-efficacy and mental health outcomes in transition to adult healthcare by Jennifer G. Andrews, Rena Shifren, Richard Wahl, Wendy Parent-Johnson, Scott Klewer

“…There are numerous efforts to define transition elements and encourage formalized processes readying youth for adulthood, yet significant challenges remain. Methods: We recruited individuals who were age 12 years or older and not transitioned or 18 years and older who transitioned within 24 months to complete questionnaires and participate in a focus group. …”
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Do Unresectable Giant Cell Tumors of Bone Treated With Denosumab Progress After Discontinuation of Treatment? by DENO Research Group, Carolina de laCalva, Manuel Angulo, Paula González‐Rojo, Ana Peiró, Pau Machado, Juan Luis Cebrián, Roberto García‐Maroto, Antonio Valcárcel, Pablo Puertas, Gregorio Valero‐Cifuentes, Óscar Pablos, Miriam Maireles, María Luisa Fontalva, Iván Chaves, Aida Orce, Luis Coll‐Mesa, Israel Pérez, Fausto González, María delCarmen Sanz, Isidro Gracia

“…Sixteen patients diagnosed with unresectable GCTBs and treated with denosumab who had reached the end of their treatment were recruited for the study and had been followed up for a minimum of 2 years. …”
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ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα+ cancer-associated fibroblasts during hepatocarcinogenesis by Haoran Bai, Xinyu Zhu, Lu Gao, Shiyao Feng, Hegen Li, Xiaoqiang Gu, Jiahua Xu, Chen Zong, Xiaojuan Hou, Xue Yang, Jinghua Jiang, Qiudong Zhao, Lixin Wei, Li Zhang, Zhipeng Han, Wenting Liu, Jianxin Qian

“…On the one hand, they secrete the chemokines CCL3 and CXCL12, which recruit macrophages to the tumour site. On the other hand, they produce TGFβ, inducing the polarization of these macrophages towards an immunosuppressive phenotype. …”
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The effects of different carbon-fiber plate shapes in shoes on lower limb biomechanics following running-induced fatigue by Yufan Xu, Chengyuan Zhu, Yufei Fang, Zhenghui Lu, Zhenghui Lu, Zhenghui Lu, Yang Song, Chen Hu, Dong Sun, Yaodong Gu

“…The purpose of this study was to investigate the effects of different CFP shapes in running shoes on the lower limb biomechanics of runners following running-induced fatigue. 12 male runners (aged 21.8 ± 1.3 years, mass 59.1 ± 4.1 kg, height 168.9 ± 2.2 cm, weekly running distance 68.8 ± 5.5 km/week) were recruited for this study. Two-way repeated measures ANOVA was used to compare kinematic and kinetic data, while SPM (Statistical Parametric Mapping) was used to assess the activation levels of lower limb muscles. …”
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Measuring the impact of managing incontinence on people with dementia and informal caregivers: Cognitive debriefing interviews of ‘ICIQ-Cog’ (English translation) by Miriam Avery, Nikki Cotterill, Mandy Fader, Margaret Macaulay, Ruth Kirschner-Hermanns, Cathy Murphy

“…Methods:: Cognitive debriefing interviews were conducted with 13 unpaid caregivers of people with dementia and problems with incontinence or toilet use recruited via Joint Dementia Research. Interviews were conducted across 3 rounds and transcribed then thematically analysed based on the questionnaire framework. …”
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Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China by Jing Cheng, Bing Han, Qin Li, Fangzhen Xia, Hualing Zhai, Ningjian Wang, Michael Jensen, Yingli Lu

“…Methods. 4309 men were recruited from SPECT-China study in 2014-2015, which was performed in 22 sites in East China. …”
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Repeatability and Reproducibility of SMTube Measurement in Dry Eye Disease Patients by Yiran Hao, Lei Tian, Kai Cao, Ying Jie

“…To evaluate the intraobserver repeatability and interobserver reproducibility of Strip Meniscometry Tube (SMTube) and determine the correlations among the SMTube measurements and other ocular examinations in dry eye disease (DED) patients. Methods. The study recruited 73 eyes of 49 DED patients. Every subject was subjected to the following five measurements sequentially: the Ocular Surface Disease Index (OSDI) questionnaire, Tear Meniscus Height (TMH) assessment, SMTube measurements, tear film breakup time (BUT) examination, and Schirmer I test (SIT). …”
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Modifiable life style factors and male reproductive health: a cross-sectional study in IVF clinic attendees in Ghana by Brodrick Yeboah Amoah, Saliah Yao Bayamina, Cosmos Gborsong, Hubert Owusu, George Awuku Asare, Emmanuel Kwabena Yeboah, Josephine Ablakwa, Georgina Hammond

“…This study investigates the relationships between modifiable lifestyle factors, reproductive hormones, and semen quality in Ghanaian males attending an IVF clinic.MethodsA cross-sectional study was conducted with 212 male participants recruited from a fertility clinic in Ghana. Lifestyle factors were assessed using standardized questionnaires, and semen samples were analyzed following WHO guidelines. …”
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Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children by Yang Zhuo, Yalan Yang, Mingjun Zhang, Ying Xu, Zhongping Chen, Lihong Mu, Xiaojun Tang, Zhaohui Zhong, Juan Chen, Li Zhou

“…Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. SNPs in IFN-γ signaling pathway including IFNG, IFNGR1, IFNGR2, and IL12B were genotyped. …”
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