Long-Term Safety and Effectiveness of Dimethyl Fumarate in Patients with Multiple Sclerosis Treated in Routine Medical Practice: Final Analysis of the ESTEEM Study by Krupa Shah Pandey, Kathryn Giles, Konstantin Balashov, Richard Macdonell, Jörg Windsheimer, Mikel Martinez, Ivan Božin, Stephanie Raynaud, Matthew Scaramozza, Oksana Mokliatchouk, Zhaonan Sun, Nicholas Belviso, Yayoi Sato, Xiaochen Lin, Annette Okai

“…Patients received DMF for a mean (SD) duration of 31.0 (22.7) months. Primary reasons for discontinuation were AEs (n = 1237; 24%); the most common were gastrointestinal AEs (n = 469; 9%), blood and lymphatic disorders (n = 218; 4%), and vascular disorders (n = 200; 4%). …”
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Implementation of multidisciplinary team decisions on the management of complex bone and joint infections: an observational study by Jaap L.J. Hanssen, Henrica M.J. van der Linden, Martha T. van der Beek, Robert J.P. van der Wal, Marco F. Termaat, Mark G.J. de Boer, Henk Scheper

“…The overall implementation rate of MDT decisions was 92%. Reasons for non-implementation were disagreement by the treating surgeon with the MDT regarding the optimal treatment (n = 24, 23%), patient preference for a different treatment (n = 19, 18%), new clinical information not yet available during the MDT meeting that made the physician change management (n = 17, 16%) or unknown (n = 45, 43%). …”
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Call for Papers: Intergenerational Justice Prize 2020 by FRFG, IF (Foundation for the Rights of Future Generations, Intergenerational Foundation)

“…For the 2020 prize, the FRFG and IF call for papers on the following topic: Intergenerational wealth transfers through inheritance and gifts Topic abstract Wealth transfers across generations combine justice between past, present and future generations (intergenerational justice) with justice within the present generation (intragenerational justice) as a major reason for the increasing inequality in a society is the accumulation of wealth within families over time. …”
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Current concepts of chronic gastritis and gastropathies: new international consensus RE.GA.IN by S.M. Tkach, N.V. Kharchenko, A.E. Dorofieiev, Yu.Z. Hurkalo, L.M. Ryzhiy

“…The RE.GA.IN consensus was concluded in Venice in November 2022 after 8 months of intensive global scientific reasonings. RE.GA.IN mission itself has been focused on critically reviewing, updating, sharing and building consensus on the current scientific knowledge of inflammatory gastric lesions. …”
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Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Bhensri Naemiratch, Natinee Kulpijit, Supanat Ruangkajorn, Nicholas P. J. Day, Jetsumon Prachumsri, Phaik Yeong Cheah

“…Results Three major themes emerged: experiences and perceptions of MIST, reasons for joining MIST, and ethical considerations. …”
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Association between Anemia and Risk of Parkinson Disease by Yao-Chin Wang, Abel Po-Hao Huang, Sheng-Po Yuan, Chu-Ya Huang, Chieh-Chen Wu, Tahmina Nasrin Poly, Suleman Atique, Woon-Man Kung

“…Three articles were further excluded for prespecified reasons including insufficient data and duplications, and 4 articles were included in our systematic review and meta-analysis. …”
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Optimum technique of carotid artery reconstruction in her atherosclerotic lesion by V. V. Akhmetov, V. I. Dunaeva, F. A. Vryganov, S. V. Ordynets, I. P. Dudano

“…When using a narrow patch geometric changes in the width of the patch are the smallest. The main reason of the frequent geometrical changes in the dis-tal part of the patch was the patch wrapping inside the artery with the formation of a duplicate. …”
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Functional Status of Pancreatic α and β Cells in Type 2 Diabetes Mellitus Patients with Different Plasma Triglyceride Levels: A Retrospective Analysis by Hang Guo, Chunlei Ma, Xiaoming Wu, Congqing Pan

“…Hypertriglyceridemia aggravated the dysfunction of pancreatic α and β cells. A reasonable control of the TG level makes it easier for blood glucose to reach the standard.…”
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Experiments and Index Construction for Disaster Caused by Low Temperature Affecting Hetao Sunflower in Inner Mongolia by Duan Xiaofeng, Liu Wei, Bao Jiajing, Liu Yanli, Li Shuqi, Tang Hongyan

“…It is proved that the harmful accumulated temperature indices can reasonably and objectively reflect the freezing condition of sunflower, which can provide a scientific basis for meteorological services such as early warning and evaluation of freezing damage in autumn for Hetao sunflower.…”
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Christian vs liberal conceptions of human rights by Piotr Mazurkiewicz

“…Religion not only reveals the ultimate meaning of human life and the reasons for which it is worthwhile to be human, but it has also been a source of public morality. …”
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A secure and energy-efficient routing using coupled ensemble selection approach and optimal type-2 fuzzy logic in WSN by S. Ambareesh, Pundalik Chavan, S. Supreeth, Rajesh Nandalike, P. Dayananda, S. Rohith

“…Additionally, our proposed technique complements secure routing by means of efficaciously counteracting the effects of compromised nodes, for this reason maintaining community integrity. Multiple test results show that RSA’s enhanced IT2FLS system consistently outperforms new standards. …”
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Marigold: a machine learning-based web app for zebrafish pose tracking by Gregory Teicher, R. Madison Riffe, Wayne Barnaby, Gabrielle Martin, Benjamin E. Clayton, Josef G. Trapani, Gerald B. Downes

“…By leveraging a highly efficient, custom-designed neural network architecture, Marigold achieves reasonable training and inference speeds even on modestly powered computers lacking a discrete graphics processing unit. …”
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Coupling mechanism of seepage and coal and rock mass destruction during coal and gas outburst by Shiling ZHANG, Junfei CUI, Shudong HE

“…Based on elasticity and plasticity mechanics, the limit equilibrium equation of coal body in working face under the action of gas pressure is constructed, and then the seepage flow is coupled with the coal body stress in the limit equilibrium area. The mechanical reasons for the generation of tensile stress and tensile failure of coal under the action of gas pressure are obtained. …”
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Kleist vs. Musschenbroek – a difficult way to truth by Jerzy Sawicki

“…In the circle of reliable researchers in the history of science, the priority of Kleist’s discovery is widely recognized, but even they have a problem with naming the electric capacitor discovered by the Cammin physicist differently than the Leiden jar. One of the reasons for the poor knowledge of Kleist and his experiment is scant scientific literature on the subject and the ignorance of the source texts written by the Cammin explorer. …”
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Prospects of Back Surface Field Effect in Ultra-Thin High-Efficiency CdS/CdTe Solar Cells from Numerical Modeling by Nowshad Amin, M. A. Matin, M. M. Aliyu, M. A. Alghoul, M. R. Karim, K. Sopian

“…The conventional baseline case structure of CdS/CdTe cell has been explored with reduced CdTe absorber and CdS window layer thickness, where 1 μm thin CdTe and 50 nm CdS layers showed reasonable efficiencies over 15%. The viability of 1 μm CdTe absorber layer together with possible back surface field (BSF) layers to reduce minority carrier recombination loss at the back contact in ultra thin CdS/CdTe cells was investigated. …”
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Optimization of fermentation conditions to increase the production of antifungal metabolites from Streptomyces sp. KN37 by Xiaoyue Yang, Lijing Yuan, Muhammad Zeeshan, Chuntian Yang, Wen Gao, Guoqiang Zhang, Chunjuan Wang

“…In this study, we used the response surface method to optimize the fermentation medium and conditions of the strain KN37, for investigating the reasons for the enhanced biological activity at both the metabolic and transcriptomic levels. …”
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Mind the G(ap): bridging prevention needs and approaches for GHB/GBL users and their social environment by Antonia Bendau, Lukas Roediger, Andrea Piest, Rüdiger Schmolke, Katharin Ahrend, Moritz Bruno Petzold, Twyla Michnevich, Felix Betzler

“…Perceptions and needs regarding prevention and harm-reduction, reasons and measures of decreasing use, and the impact of GHB/GBL/BD use were analyzed both quantitatively and qualitatively. …”
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Preparation and response surface optimization of lightweight porous structures by Kai HE, Xiangjun PEI, Xiaochao ZHANG, Qiang LI, QianRu HOU, Mengqi WANG, Shansong HUANG, Minghui MENG

“…Relevant porous structure preparation experiments were conducted to explore its physical and mechanical properties at different single factor levels, and then a reasonable range of mix designs was obtained. Response surface methodology was used to obtain the optimal mix ratio of lightweight porous structure with certain compressive strength and good planting space and permeability. …”
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Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…Two investigators will independently extract information from eligible articles and document reasons for exclusions. The primary outcomes will encompass changes in systolic and diastolic BP. …”
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Water security assessment framework for deltas of the transboundary river basins by T.H. Truong, L.T.T. Nguyen, D.D. Nguyen, T. Pham, T.M. Vu, P.H. Nguyen, Q.T. Nguyen

“…The degree of water security in flood season is higher than that in the dry season. The main reasons that lead to the medium-level water security of the region have been identified, including high dependence on external water resources (more than 90%) and transboundary water cooperation between the basin countries and rather low water productivity in economic sectors. …”
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