High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis by Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

“…Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. …”
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Preliminary Assessment of Methane Concentration Variation Observed by GOSAT in China by Xiuchun Qin, Liping Lei, Zhonghua He, Zhao-Cheng Zeng, Masahiro Kawasaki, Masafumi Ohashi, Yutaka Matsumi

“…To further investigate the high XCH4 concentration during this low-emission period, we use the HYSPLIT model to simulate the atmosphere dynamic transport process, and the result suggests that the typical closed topography of Sichuan Basin, which may lead to CH4 accumulation and keep it from diffusion, is one possible reason for the high XCH4 value in winter.…”
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Experimental Investigation into the Bedding Plane Slip Effect on the Overlying Strata Behavior in Longwall Top Coal Caving of Soft Coal Seam by Hengfeng Liu, Jixiong Zhang, Nan Zhou, Qiang Sun, Meng Li, Zhizhong Cui

“…The results demonstrate that the beam slip model proposed in this paper is reasonable and able to describe the behaviors of overlying strata and bedding plane slip.…”
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Intravascular Residence Time Determination for the Cyanide Antidote Dimethyl Trisulfide in Rat by Using Liquid-Liquid Extraction Coupled with High Performance Liquid Chromatography by Deepthika De Silva, Steven Lee, Anna Duke, Siva Angalakurthi, Ching-En Chou, Afshin Ebrahimpour, David E. Thompson, Ilona Petrikovics

“…The results indicated a half-life of 36 min in a rat model, suggesting that the circulation time is long enough to provide a reasonable time interval for cyanide antagonism.…”
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Impact of forced migration on the sustainable development of rural territories by V. Shcherbak, I. Brizgan, V. Chevhanova, L. Svistun, O. Hryhoryeva

“…The use of game theory to identify conflicts of interest between refugees and host communities was justified. The reasonability to use the taxonomy method to construct a map of positioning rural areas according to the size of local budgets and the degree of integration of refugees is justified. …”
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Plant growth-promoting bacteria and nanomaterials synergism to enhance Lolium perenne growth and phytoremediation in cadmium-contaminated soil by Asifa Farooqi, Ejaz ul Haq, Anders Johansen, Lea Ellegaard-Jensen, Mazhar Iqbal, Sohail Yousaf, Maximilian Lackner

“…The highest Cd uptake (92 %) by ryegrass was observed in Serratia bozhouensis and GNPs treatments. The reasons for increased plant growth and Cd-phytoremediation by the PGPB-GNPs combination are explained. …”
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Selective Flotation of a Copper-molybdenum Bulk Concentrate from Xizang by Jinming GUO, Hongying YANG, Shiqi ZHANG, Linlin TONG, Zhenan JIN, Qin ZHANG

“…Studies have shown that the copper-molybdenum bulk concentrate contains 19.00% Cu and 0.38% Mo, and the grade of molybdenum is relatively low. The main reasons for this are the low separation efficiency of copper and molybdenum and the poor quality of molybdenum concentrates. …”
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Use of systemic therapies in adults with atopic dermatitis: 12-month results from the European prospective observational study in patients eligible for systemic therapy for atopic... by Marjolein de Bruin-Weller, Andrew E. Pink, Silvia M. Ferrucci, Annalisa Patrizi, Ake Svensson, Marie L. A. Schuttelaar, Marie Tauber, Marius Ardeleanu, Shyamalie Jayawardena, Moataz Daoud

“…The median duration of treatment was 1.1 months for oral systemic corticosteroids, 3.2 months for injectable corticosteroids, 4.8 months for cyclosporine, 7.3 months for methotrexate, and 14.9 months for dupilumab. The most frequent reasons for stopping treatment included lack of efficacy, patient decision, adverse events, and disease well controlled.Conclusion The 12-month interim EUROSTAD study analysis highlights the current trends and outcomes of systemic treatments for moderate-to-severe AD. …”
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Construction Techniques and Quality Test and Evaluation of Lightweight Cellular Concrete Mixed with Fly Ash as Subgrade Material by Xin Liu, Chengwei Ni, Hong Ji, Shuyan Tan, Baoning Hong

“…Thirdly, the suitable pouring thickness of the single layer and reasonable interval time between layers are determined by the vertical delamination test and surface strength test. …”
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Determinants of Online Local Budget Transparency in Croatia and Slovenia by Katarina Ott, Mihaela Bronić, Branko Stanić, Maja Klun, Jože Benčina

“…This study demonstrates the possibility of developing a standardised measure of local budget transparency and using it to investigate the reasons for different levels of transparency in the two – and potentially other – CEE countries. …”
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The “e-Generation”: The Technological Usage and Experiences of Medical Students from a Developing Country by Priyasdarshani Galappatthy, Wasundara S. Wathurapatha, Priyanga Ranasinghe, Maheshi D. M. S. Wijayabandara, Dinuka S. Warapitiya, Krishantha Weerasuriya

“…Nonaffordability was the most common reason for having not owning a PED (46%). Nonaffordability and lack of knowledge were key determinants of the usage of PEDs and medical “apps.” …”
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Development trends and territorial organisation of the medical tourism market in Russia by Chistobaev Anatolii I., Grudtsyn Nikolai A., Semeno-Va Zoia A., Kulakovskiy Evgeniy S.

“…It is shown that medical tourism, as a component of health tourism, involves the organised travel of potential patients to medical clinics outside their country or region to receive qualified medical assistance at reasonable prices. Based on data from the global ranking of countries in medical tourism, it is established that Russia has achieved certain successes in the development of this sector of the green economy in the service industry over a relatively short period, but at the same time, there are numerous problems requiring resolution. …”
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A Collaborative Data Network for the Asia Oceania Region Enabled by Emerging Technologies to Foster Innovation in a Secure and Open Environment by Alison Specht, Kim Bryceson, Shoufeng Cao, Margaret O’Brien, S. M. Guru, Pedro Pizzigatti Correa, Michelle Waycott

“…These benefits can be for reporting (state of the environment, achievement of Sustainable Development Goals, conservation objectives), for research (exploration of international phylogenetics, development of new pharmaceuticals), or for economic reasons. Confidence in the value of data is best achieved if the information used to underpin statements and conclusions is open to scrutiny. …”
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Improving the Stability of Subsurface Structures in Deep Metal Mines by Stress and Energy Adjustment: A Case Study by Huanxin Liu, Xingquan Liu, Zhuoying Tan, Yang Liu, Guilin Li

“…By increasing the bench height and the reasonable timing of support by calculating, the elastic strain energy of rock in the shaft is prereleased, which benefits the long-term stability of the shaft.…”
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Engaging older adults in diagnostic safety: implementing a diagnostic communication note sheet in a primary care setting by Alberta Tran, Leah Blackall, Mary A. Hill, Mary A. Hill, William Gallagher

“…IntroductionAdults over the age of 65 are at a higher risk for diagnostic errors due to a myriad of reasons. In primary care settings, a large contributor of diagnostic errors are breakdowns in information gathering and synthesis throughout the patient-provider encounter. …”
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Multiobjective Core Reloading Pattern Optimization of PARR-1 Using Modified Genetic Algorithm Coupled with Monte Carlo Methods by Nadeem Shaukat, Ammar Ahmad, Bukhtiar Mohsin, Rustam Khan, Salah Ud-Din Khan, Shahab Ud-Din Khan

“…It has been observed that the developed intelligent strategy performs these tasks with a reasonable computational cost.…”
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Multiple outbreaks for the same pandemic: Local transportation and social distancing explain the different 'waves' of A-H1N1pdm cases observed in México during 2009 by Marco Arieli Herrera-Valdez, Maytee Cruz-Aponte, Carlos Castillo-Chavez

“…A year later, México's data show an epidemic pattern characterized by three 'waves''. The reasons this three-wave patterns are theoretically investigated via models that incorporate México's general trends of land transportation, public health measures, and the regular opening and closing of schools during 2009. …”
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Prevalence of Metabolic Syndrome in Patients with Psoriasis by Ilkin Zindancı, Ozlem Albayrak, Mukaddes Kavala, Emek Kocaturk, Burce Can, Sibel Sudogan, Melek Koç

“…Our findings suggest that psoriasis preconditions occurrence of a group of diseases such as diabetes mellitus, hypertension, and metabolic syndrome. For this reason, patients with psoriasis should be treated early and they should be followed with respect to metabolic diseases.…”
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Erodibility and sedimentation potential of marly formations at the watershed scale by F. Rostami, S. Feiznia, M. Aleali, M. Heshmati, B. Yousefi yegane

“…Furthermore, field measurement and soil samples analyzed for effective factors releaved that sediment yields for Kashkan and Gurpi were 7243.3 and 10837.5 m3/ha/y, respectively. The reasons for erosion intensity and sedimentation in the two mentioned formations are slopes, vegetation and land use in addition to the type of rocks in Kashkan and Gurpi formations which are predominantly marl and shale.…”
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Effects of a Multidisciplinary Educational Rehabilitative Intervention in Breast Cancer Survivors: The Role of Body Image on Quality of Life Outcomes by Giovanni Morone, Marco Iosa, Augusto Fusco, Antonella Scappaticci, Maria Rosaria Alcuri, Vincenzo Maria Saraceni, Stefano Paolucci, Teresa Paolucci

“…In breast cancer survivors, own body image may change due to physical and psychological reasons, worsening women’s living. The aim of the study was to investigate whether body image may affect the functional and quality of life outcomes after a multidisciplinary and educational rehabilitative intervention in sixty women with primary nonmetastatic breast cancer who have undergone conservative surgery. …”
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