Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Yet, 49 % of respondents emphasized the need for more real world evidence on CDK4/6i switch safety and efficacy. 96 % of respondents reported discontinuation rates between 0% and 25 % of patients, with constipation and hematological toxicity being the most frequent treatment discontinuation reasons. The oncologists prescribing CDK4/6i switch reported that most of these patients were in first line treatment (85 %) and the most common second CDK4/6i most frequently initiated was palbociclib (69 %), then abemaciclib (17 %) and ribociclib (14 %). …”
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Five-year Variations in Air Pollutant Emissions with Ultra-low Emission Retrofits in a 660 MW Coal-fired Power Unit by Zhiyong Li, Zhuangzhuang Ren, Chengjing Cao, Chen Liu, Zhen Zhai, Jixiang Liu, Ziyi Zhan, Changtao Huang, Lan Chen, Hongdan Yuan

“…Unlike EFs expressed in mg m−3, the most decreases of EFs in kg h−1 and g MWh−1 in 2015 by more than 97.0% compared to 2014 for three air pollutants arisen from reasonable air supply or enhancement in thoroughness of coal combustion.…”
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Structural performance of lightweight fibre-reinforced oil palm shell concrete subjected to impact loadings under varying boundary conditions by Idris Ahmed Ja'e, Zakaria Che Muda, Agusril Syamsir, Chiemela Victor Amaechi, Hamad Almujibah, Ali.E.A. Elshekh, Maaz Osman Bashir, Abdulrazak H. Almaliki

“…However, these only had a minimal influence on controlling crack length and width, and did not result in reasonable improvement of the residual strength. These findings highlight the limitations as well as the potential of utilising OPS in fibre-reinforced lightweight suspended concrete slabs and other impact-resistant constructions.…”
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Understanding the Broad-line Region of Active Galactic Nuclei with Photoionization. I. The Moderate-accretion Regime by Qiaoya Wu, Yue Shen, Hengxiao Guo, Scott F. Anderson, W. N. Brandt, Catherine J. Grier, Patrick B. Hall, Luis C. Ho, Yasaman Homayouni, Keith Horne, Jennifer I-Hsiu Li, Donald P. Schneider

“…The UV/optical line strengths and their dependences on accretion parameters are reasonably well reproduced by the locally optimally emitting cloud photoionization models. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…Given the highly complex and non-linear interactions between the genetic determinants of longevity, we reasoned that a composite polygenic score would approximate a substantial portion of the variance in lifespan and developed the integrated longevity genetic scores (iLGSs) for distinguishing exceptional survival. …”
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Acceptability patterns of hypothetic taxes on different types of foods in France by Florian Manneville, Barthélemy Sarda, Emmanuelle Kesse-Guyot, Sandrine Péneau, Bernard Srour, Julia Baudry, Benjamin Allès, Yann Le Bodo, Serge Hercberg, Mathilde Touvier, Chantal Julia

“…Participants completed an ad hoc web-based questionnaire to test patterns of hypothetical food taxes acceptability (i.e. overall perception combined with reasons for supporting or not) on eight food types: fatty foods, salty foods, sugary foods, fatty and salty foods, fatty and sugary products, meat products, foods/beverages with unfavourable front-of-pack nutrition label and ‘ultra-processed foods’. …”
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VANDAL BEHAVIOUR OF ADOLESCENTS AS A LEGAL AND PSYCHOLOGICAL PROBLEM by O. V. Gurova

“…The contradictions in the psychological theory, educational practice and consciousness of society were revealed: between the widespread occurrence of acts of vandal behaviour and the limited methods and means to prevent it; between the mass involvement of adolescents in vandalism and the lack of specialised age-based programmes to correct vandal behaviour; between the prevalence of unauthorized graphic activity of schoolchildren and other forms of vandal behaviour in the educational environment and the reluctance of teachers and administration of educational institutions to recognise this as a noteworthy problem; between the social significance of determination of lawful and effective punishment (in terms of prevention) and insufficient attention to personal reasons that encourage a person to commit or not to commit vandal acts; between common scientific interest in the individual psychological and socio-typological features of adolescents committing vandalism and inadequate attention to the socio-psychological motivational determinants, initiating and forming the readiness to commit vandal actions. …”
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Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study by Ana María Cintora-Sanz, Cristina Horrillo-García, Víctor Quesada-Cubo, Ana María Pérez-Alonso, Alicia Gutiérrez-Misis

“…These respiratory diseases that cause acute respiratory failure (ARF) are one of the main reasons for hospitalization and death, generating high health care costs. …”
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Exploring Web-Based Support for Suicidal Ideation in the Scottish Population: Usability Study by Heather McClelland, Rory C O'Connor, Laura Gibson, Donald J MacIntyre

“…Based on participant responses to the evaluation survey (n=101), the website was associated with a significant reduction in suicidal thoughts (P=.03). Reasons for visiting the website varied. Marketing data implied that people were more likely to engage with advertisements, which they felt were more personal, and visitors to the website were more likely to engage with videos, which corresponded to their age. …”
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Validation of the Acute Physiology and Chronic Health Evaluation (APACHE) II and IV Score in COVID-19 Patients by Jeroen Vandenbrande, Laurens Verbrugge, Liesbeth Bruckers, Laurien Geebelen, Ester Geerts, Ina Callebaut, Ine Gruyters, Liesbeth Heremans, Jasperina Dubois, Bjorn Stessel

“…Results. 116 patients were admitted to our ICU during the study period. 13 were excluded for various reasons, leaving 103 patients in the statistical analysis of the overall population. 57 patients were treated with anti-Xa adjusted prophylactic dosages of LMWH and were supplementary analyzed in a subgroup analysis. …”
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Conversion from clinically isolated syndrome to multiple sclerosis: what paraclinical tests findings are the most characteristic? by M. Malciūtė, I. Čelpačenko, R. Stankevičiūtė, R. Balnytė

“…Unspecified brain MRI lesions are also distinctive for MS patients; however, this result should be interpreted with consideration due to methodological reasons …”
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Alleviating symptoms of paediatric acute rhinosinusitis and acute otitis media with otorrhea using nasal-spraying Bacillus probiotics: a randomized controlled trial by Thanh Huu Khieu, Dung Phuong Le, Binh Thanh Nguyen, Binh Thanh Ngo, Hong Thi Chu, Duc Minh Truong, Hung Minh Nguyen, Anh Hoa Nguyen, Tung Dinh Pham, Anh Thi Van Nguyen

“…These conditions are among the primary reasons that children visit hospitals and require antibiotic treatment. …”
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Impact of geochemical reactivity on desulphation requirements in a sandstone reservoir containing carbonate and sulphate minerals by Ali M. Al-Behadili, Eric J. Mackay

“…On the other hand, the carbonate scales may form due to a variety of reasons: changes in temperature, pressure, pH and CO2 concentration in the aqueous or hydrocarbon phases. …”
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The Potential Clinical Utility of the Customized Large Language Model in Gastroenterology: A Pilot Study by Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee, Jonghyung Park, Eunsil Kim, Subeen Kim, Minjae Kimm, Seoung-Ho Choi

“…Even with the implementation of ‘Chain of Thought’ prompt engineering, the customized GPT did not achieve improved reasoning. Conventional GPT-4o achieved the highest score among the AI models (14/15). …”
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From the Banks of the Orkhon to the Banks of the Neva: the History of Mining and Transit of Mongolian Gold to the Russian Empire at the beginning of the 20th century. by Aldar A. Shirapov, Anna M. Plekhanova

“…The main method used is historical-genetic, the use of which helped to identify the reasons according to which the Mongolor joint-stock company was created, as well as to reconstruct the mechanism of both gold production by this company and its further transit to Russia. …”
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Comparison of Essential Oils of Houttuynia cordata Thunb. from Different Processing Methods and Harvest Seasons Based on GC-MS and Chemometric Analysis by Xue Pan, Haiying Li, Dingfang Chen, Jinjin Zheng, Longhua Yin, Juan Zou, Yalun Zhang, Kaiwen Deng, Meifeng Xiao, Lei Meng, Fuyuan He

“…Moreover, the contents of β-myrcene and β-phellandrene were higher in FHC1 oils, while the contents of 2,6-octadien-1-ol, 3,7-dimethyl-, acetate, and (z)-phytol were higher in FHC2 oils. For these reasons, this study provides a scientific basis for quality control and clinical medication.…”
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Characterising melanoma diagnostic pathways for patients in routine practice using administrative health data in Ontario, Canada: a population-based study by Frances C Wright, Timothy P Hanna, Patti A Groome, Nicole J Look Hong, Meaghan E Mavor, Yuka Asai, Hugh Langley

“…Future research should address reasons for these differences, including whether they are associated with inefficient or inappropriate care.…”
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Exploring the Social Media Discussion of Breast Cancer Treatment Choices: Quantitative Natural Language Processing Study by Daphna Y Spiegel, Isabel D Friesner, William Zhang, Travis Zack, Gianna Yan, Julia Willcox, Nicolas Prionas, Lisa Singer, Catherine Park, Julian C Hong

“…Paragraphs were analyzed with a VADER (Valence Aware Dictionary for Sentiment Reasoning) compound sentiment score (ranging from −1 to 1, corresponding to negativity or positivity) and GoEmotions scores (0‐1) corresponding to the intensity of 27 different emotions and neutrality. …”
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The Fake History: Soviet Totalitarianism and the Memory of the Guerrilla War by Bernardas Gailius

“…They could more fruitfully trigger discussions and help to find some reasonable common points. This way, the traditional interpretation of the guerrilla war could be slowly built, and the historical culture would regain its normal dynamics. …”
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Typical Forms of Plans for Certain Investigative (Search) Actions by O. O. Khan

“…The written detailed plan of simultaneous interrogation of two or more already interrogated persons (face-to-face interrogation) may include the following elements: a) the situation of simultaneous interrogation of two or more already interrogated persons; b) versions of the reasons for the contradictions in the testimony; c) tasks to clarify them; d) questions to the interrogated person; e) the procedure for presenting evidence and other tactics; e) materials (evidence) available to the investigation. …”
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