Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair by Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo

“…Taken together, we rationally explained a novel and important mechanism of the miR-124-mediated high sensitivity to TMZ-induced cell death in GBM and provided evidence to support that miR-124-RAD51 regulatory axis could be a promising candidate in the comprehensive treatment with TMZ in GBM.…”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…These effects were directly linked to their inhibition of PKM2 enzymatic activity, validating the proposed mechanism of action in their rational design. ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Isolation, purification, structural characteristic and antioxidative property of polysaccharides from A. cepa L. var. agrogatum Don by Hongcheng Liu, Hongxiu Fan, Jing Zhang, Shanshan Zhang, Wenting Zhao, Tingting Liu, Dawei Wang

“…These results provide a reference for further research and rational development of ALAP polysaccharides. Keywords: Polysaccharides, Allium cepa L. var. agrogatum Don, Structural characterization, Antioxidative property…”
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Dynamically Cyclic Fe2+/Fe3+ Active Sites as Electron and Proton-Feeding Centers Boosting CO2 Photoreduction Powered by Benzyl Alcohol Oxidation by Ben Lei, Gaofeng Zhou, Zhongyou Gong, Chao Liu, Ying Zhou, Vitaliy P. Guro, Yanjuan Sun, Jianping Sheng, Fan Dong

“…Solar-driven CO2 photoreduction holds promise for sustainable fuel and chemical productions, but the complex proton-coupled multi-electron transfer processes and sluggish oxidation half-reaction kinetics substantially hinder its efficiency. Here, we devised a rational catalyst design to address these challenges by fabricating ferrocene carboxylic acid-functionalized Cs3Sb2Br9 nanocrystals (CSB-Fc NCs), which facilitate simultaneous benzyl alcohol oxidation and CO2 reduction reactions under visible-light irradiation. …”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…Conclusions: TG can treat hypertension by affecting differential strains and differential metabolites, providing a scientific basis for guiding the rational use of TG.…”
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Evaluating the Accessibility of Urban Public Open Spaces Based on an Improved 2SFCA Model: A Case Study Within Chengdu’s Second Ring Road by Ling Jian, Xiaojiang Xia, Yinbing Zhao, Yang Zhang, Yuanqiao Wang, Yi Tang, Jie Chang, Changliu Wang

“…The rational allocation of urban public open spaces (UPOS) is critical for creating a livable urban environment. …”
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Integrating biodiversity assessments into local conservation planning: the importance of assessing suitable data sources by Ferraille, Thibaut, Kerbiriou, Christian, Bigard, Charlotte, Claireau, Fabien, Thompson, John D.

“…Finally, we propose a workflow to guide SEA stakeholders through the process of data rationalization and use in conservation planning. …”
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Understanding spatiotemporal changes and influencing factors in the habitat quality of coastal waters: A case study of Jiangsu Province, China (2006–2020) by Zhou Chen, Yanjing Chen, Haifeng Zhang, Hong Zhang, Min Xu

“…However, there were few effective and rational explorations of spatiotemporal changes and influencing factors in coastal waters habitat quality. …”
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As-cast microstructure characteristics of K439B nickel-based superalloy thin- walled castings of different thickness by ZHOU Depeng, SUI Dashan, MA Jinyuan, GUI Daxing, DONG Anping, SUN Baode

“…These results of the experimental and simulation analysis could provide a reference to rationally design the casting process for the K439B nickel-based superalloy thin-walled casting crafts.…”
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Diagnostics and treatment of exocrine pancreatic insufficiency: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…Patient should intake at least normal daily amount of fat and divide daily ration to at least six meals. Patients should be motivated to restrain from alcohol consumption and smoking as they can lead to further progression of pancreatic exocrine insufficiency and symptoms of pancreatitis.…”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…Patient should be consulted by nutritionist, no significant limitation of fat intake is recommended. Daily ration should be divided into six or more meals. Patients should be motivated to stop both alcohol intake and smoking as they can cause progression of PEI alone and/or persistence of symptoms, like pancreatic pain.…”
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The global energy challenge: second-generation feedstocks on marginal lands for a sustainable biofuel production by Claudio Russo, Valerio Cirillo, Nausicaa Pollaro, Fabio Terribile, Andrea Chiodini, Albino Maggio

“…To fully exploit this option, it will be critical to calibrate plant growth models to estimate the potential biofuel production on marginal land from second-generation feedstock and to create tools for a more rational management of this land. Graphical abstract…”
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Polymorphism of renin — angiotensin system genes in progression of liver fibrosis in patients with chronic hepatitis C by O. V. Taratina, T. N. Krasnova, L. M. Samokhodskaya, T. N. Lopatkina, V. A. Tkachuk, N. A. Mukhin

“…As chronic hepatitis C is multifactorial disease, it is rational to use testing of allelic variants of angiotensinogen gene in patient-specific approach at CHC management.…”
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The structural characteristics of dietary fibers from Tremella fuciformis and their hypolipidemic effects in mice by Shanshan Zhang, Xinle Xu, Xu Cao, Tingting Liu

“…These results provide a reference for further research and rational development of T. fuciformis.…”
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mtlA, a novel typing gene offering enhanced resolution for pandemic Vibrio species by Lei Zhou, Danlei Liu, Zilong Zhang, Yongqiang Zhu, Huajun Zheng

“…Therefore, based on the prevalent characteristics of pathogenic Vibrio, it is imperative for us to classify and trace various Vibrio species that cause human illness and prescribe medication rationally to control the spread of diseases. In our investigation, we explored the prevalence and typing accuracy of the mtlA gene in Vibrio. …”
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Preoperative CT-based radiomics nomogram to predict the micropapillary pattern in lung adenocarcinoma of size 2 cm or less by Xiaoyu Pan, Liang Fu, Jiecai Lv, Lijuan Feng, Kai Li, Siqi Chen, Xi Deng, Liling Long

“…DCA confirmed that the nomogram model had the better clinical benefit.ConclusionsThe nomogram model achieved promising prediction efficiency for identifying the presence of the MPP in LUAD tumors ≤2 cm, allowing clinicians to develop more rational and efficacious personalized treatment strategies.…”
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Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer by Yanliang Chen, Chan Zhou, Xiaoqiao Zhang, Min Chen, Meifang Wang, Lisha Zhang, Yanhui Chen, Litao Huang, Junjun Sun, Dandan Wang, Yong Chen

“…Its clinical routine use may assist clinicians in selecting more rational practices for individuals, which is important for improving the prognosis of NSCLC patients. …”
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Efficacy of Fat Supplements with Different Unsaturated/Saturated FA Ratios Undergoing First Postpartum Ovulation in Lactating Anovulatory Goats by Caroline P. Silva, César C. L. Fernandes, Juliana P. M. Alves, Camila M. Cavalcanti, Felipe B. B. Oliveira, Alfredo J. H. Conde, Diana Celia S. N. Pinheiro, Darcio I. A. Teixeira, Anibal C. Rego, Davide Rondina

“…Thirty-eight An-glo-Nubian-crossbred adult goats were allocated into three groups, one with a control diet (<i>n</i> = 12), fed a total mixed ration (TMR) comprising chopped elephant grass and concentrate; an algal diet (<i>n</i> = 13), fed TMR + green microalgae (1% dry matter); and a linseed diet (<i>n</i> = 13), TMR + linseed (12% dry matter). …”
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Development of indicators and analysis of barriers for assessment and prevention of cutaneous graft-versus-host disease after haematopoietic stem cell transplantation in children by YANG Liling, ZHAN Sha, XUE Xiaoyan, CHEN Kai, LIU Qing, WANG Li, WANG Yiyi, WU Meng, LU Qunfeng

“…The main obstacles were the lack of relevant training and the absence of a rational management mechanism. The main facilitating factors were reliable sources of evidence and a high level of cooperation from potential stakeholders. …”
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Optimizing the Production of Polysaccharides from Cyanobacterium sp. IPPAS B-1200 by Stanislav A. Sukhikh, Ekaterina A. Budenkova, Yulia-Danae S. Boychenko, Veronika D. Anokhova, Vyacheslav F. Dolganyuk, Egor V. Kashirskih

“…For freeze drying, the rational parameters were 8 h at –15°C.…”
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