In situ detection of piRNA‐651 in exosomes and cells for cancer diagnosis by a new gold nanoparticle nucleic acid probe by Qin‐Xin Gao, Qian‐Qian Wu, Zhi‐Ying Dong, Xiao‐Yuan Qin, Lin‐Yan Zhai, Bao‐Ping Xie, Wen‐Jun Duan

“…To avoid low sensitivity and kinetics in detecting large‐sized PIWI‐interacting RNA complexes, we rationally designed the structure and detection scheme of piR‐651 probe, which was synthesized by modifying 13‐nm gold particles with high‐density Anchor‐Report DNA duplexes through the butanol dehydration method. …”
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An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode by Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu

“…Overall, HNC-1664 achieves broad-spectrum characteristics by favoring an alternative base pairing strategy to non-catalytically block RNA synthesis, providing a novel concept for the rational development of NA drugs.…”
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A Review of Agricultural Film Mapping: Current Status, Challenges, and Future Directions by Mengmeng Zhang, Jinwei Dong, Quansheng Ge, Hasituya, Pengyu Hao

“…The accurate and timely agricultural film maps are expected to support effective land management, rationalize human land use behavior, and inform policy formulation for environmental sustainability.…”
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…To fully utilize the potential of bpAbs for anti-HER2 drug development, it is crucial to consider formats that offer stability and high-yield production, along with a functional balance between the two epitopes. In this study, we rationally designed a bpAb, KJ015, that shares a common light chain with two Fab arms and exhibits functionally balanced high affinity for two HER2 non-overlapping epitopes. …”
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Data-driven exploration of weak coordination microenvironment in solid-state electrolyte for safe and energy-dense batteries by Zhoujie Lao, Kehao Tao, Xiao Xiao, Haotian Qu, Xinru Wu, Zhiyuan Han, Runhua Gao, Jian Wang, Xian Wu, An Chen, Lei Shi, Chengshuai Chang, Yanze Song, Xiangyu Wang, Jinjin Li, Yanfei Zhu, Guangmin Zhou

“…Although various plasticizers have been introduced to improve lithium-ion conduction kinetics, the lack of microenvironment understanding impedes the rational design of high-performance polymer electrolytes. …”
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An overview of RE-Mg-based alloys for hydrogen storage: Structure, properties, progresses and perspectives by Dongsheng Zhou, Chunling Zheng, Yanghuan Zhang, Hanfeng Sun, Peng Sheng, Xin Zhang, Jun Li, Shihai Guo, Dongliang Zhao

“…By comparing the differences and characteristics between the organizational structures and hydrogen storage properties of different RE-Mg systems, a feasible idea and solution for the rational design and development of RE-Mg-based alloys with high hydrogen storage capacity, low cost, and fast hydrogen absorption and desorption kinetics was proposed.…”
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Ecological and toxicological condition of militarily degraded chernozems: A case study of the Chkalovsk territorial community by Kateryna Smirnova, Sviatoslav Baliuk, Anatolii Kucher, Ludmila Vorotyntseva, Anna Honcharova

“…The findings can be used when developing a post-war soil restoration programme and the rational use of land in agricultural production…”
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Constructing individualized follow-up strategies for locally advanced esophageal squamous cell carcinoma patients based on dynamic recurrence risk changes by Yibin Cai, Jianming Ding, XiaoJun Cai, Weikun Su, Guibin Weng, Xinlong Zheng, Shijie Chen, Lin Chen, YiJin Lin, Qiwei Yao, Chunkang Yang

“…Individualized follow-up strategies developed on the basis of CS can better monitor the changes in patients’ conditions and contribute to timely salvage treatment and rational allocation of healthcare resources.…”
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Impact of stream-groundwater interaction on stream water source composition: A case study of the Dosit River by Lanfang DING, Zhiyuan ZHANG, Xiaowei JIANG, Xusheng WANG, Li WAN

“…These findings can provide guidance for the rational management of water resources and effective prevention of river pollution in arid and semi-arid regions.…”
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A New Method for Research on Unsteady Pressure Dynamics and Productivity of Ultralow-Permeability Reservoirs by Kun Wang, Li Li, Xiao Chen, Wei Liang, Yong Yang, Zhenghe Yan, Jianwen Dai, Wei Li, Yahui Wang, Weifang Wang, Min Li, Danling Wang

“…The interpretation results turn out to be reasonable and can truly reflect the situation of low-permeability reservoirs, which can give guidance to the rational development of low-permeability reservoirs.…”
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Effects of Tremella fuciformis -Derived Polysaccharides with Different Molecular Weight on D-Galactose-Induced Aging of Mice by Donghui Luo, Xiaofei Liu, Jingjing Guan, Guili Jang, Yanglin Hua, Xinfei Zhang, Xiaofei Xu

“…These findings would provide rational guidance for a better application of TFPs in anti-aging foods and expand our understanding of the structure-function relationship of mushroom polysaccharides.…”
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Boron isotopes fractionation and its application progress in groundwater research by Chenbo LEI, Huaming GUO, Shiping XING

“…The composition and variation of B isotope in groundwater are of great significance to understanding hydrogeochemical processes and the rational development of groundwater resources. Based on the introduction of the principle of B isotope fractionation, this review summarizes the effects of hydrogeochemical processes such as adsorption/coprecipitation, desorption, weathering, and evaporation on groundwater δ11B values. …”
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Updating Labor Legislation in the Context of Introducing Independent Forms of Work: Telecommuting and Work from Home by A. L. Klymenko

“…The author has substantiated the rational approaches based on the current state of affairs at the labor market and in the economy of Ukraine regarding the most correct interpretation of these norms by both parties – employees and the employer to minimize any misunderstandings and risks. …”
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The a criminal’s identity as an element of forensic characteristics of causing negligent serious or moderate bodily harm by K. M. Penzieva

“…The following criminologically significant features inherent in the person of the criminal have been analyzed, such as demographic data, moral qualities, psychological features; a set of psychophysical properties and qualities, motivational attitudes, emotional and rational spheres of human consciousness; social and legal data, natural and biological information about a person; socio-demographic properties, psychological qualities, biological features; social, biological, psychological and other characteristics. …”
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Effectiveness of Self-Differentiation Training on Sensation Seeking and Impulsivity in Divorced Students with Tendency toward High Risk Behaviors by Mohaddeseh Darvishi, Noushin Taghinejad, Azita Amirfakhraei

“…From the research results, it can be inferred that self-differentiation training, which employs techniques such as the differentiation between rational and irrational beliefs, the provision of participants with specific communication skills, and the acceptance of responsibility, can be an effective approach to reducing sensation-seeking and impulsivity in students from divorced families who are inclined to engage in risky behaviors.…”
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Fodder qualities of heterotic hybrids from intergeneric crosses between maize and eastern gamagrass by P. A. Panikhin, V. A. Sokolov

“…Its grain and green biomass possess good fodder qualities and are actively used in feed rations for cattle, smaller ruminants, and poultry. …”
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Energy-and-Technology Installation Based on a Rolling Mill Heating Furnace with the Option of Hydrogen Production by V. A. Sednin, E. O. Ivanchikov, V. A. Kaliy, A. Y. Martinchuk

“…The conditions for the implementation of the copper-chlorine Cu–Cl thermochemical cycle were investigated, and a rational variant of its implementation has been determined, taking into account the use of thermal waste (secondary energy resources) of the heating furnaces of the rolling mill. …”
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Crop wild relatives inventory and conservation in the Primorsky Region of the Russian Federation by G. V. Talovina, E. V. Aistova

“…A complete CWR inventory is the fundamental basis for the development of in situ conservation as an integral part of a system of science-based rational use of the genetic diversity. A taxonomic analysis of the list has revealed the native/adventive species ratio. …”
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Fodder productivity and digestible energy value of oat (<i>Avena sativa</i> L.) cultivars and breeding lines under the conditions of the Northern Trans-Urals by M. N. Fomina, Yu. S. Ivanova, N. A. Bragin, M. V. Bragina

“…Adequate animal feeding is possible when high-quality fodders are available and the rations are well balanced in basic nutrients.   Materials and methods. …”
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Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…However, the detailed mechanisms of how adjuvants enhance immune responses remain poorly understood and may be a barrier that reduces the rational selection of vaccine components. Previous studies on mechanisms of action of adjuvants have focused on how they activate innate immune responses, including the regulation of cell recruitment and activation, cytokine/chemokine production, and the regulation of some “immune” genes. …”
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