Medication use and potential drug-drug interactions in a general surgery clinic: A descriptive studyMain points by Sevgi Teker Yıldırım, Şevket Cumhur Yeğen, Songül Tezcan

“…We suspect that the elevated number of medications administered postoperatively could have led to pDDIs Consequently, we expect that clinical pharmacy services will help ensure the safe and rational use of medications in surgical clinics.…”
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Assessment of the Logical Prescription of Albumin Drug According to Guideline and Patient Safety for Inpatients in Intensive Care Units of Iranian Hospital: A Cross-Sectional Study by Naghme Dashti, Hesamoddin Hosseinjani, Saeid Eslami, Seyed Mohammad Tabatabaei, Hasan Vakili Arki

“…Conclusion: The research highlights the importance of continuous guideline-base DUE on rational drug utilization, patient safety and hospitals costs. …”
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Construction and high-throughput screening of gradient nanowire coatings on titanium surface towards ameliorated osseointegration by Ruiyue Hang, Yuyu Zhao, Huanming Chen, Xiaomei Li, Runhua Yao, Yonghua Sun, Xiaohong Yao, Long Bai, Huaiyu Wang, Yong Han, Ruiqiang Hang

“…Despite its promise, rational optimization of surface nanomorphology for ameliorated osseointegration remains a significant challenge. …”
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Hot corrosion resistance of AlCoCrFeNi2.1 coatings at 900 °C by Li Zhang, Qilu Ye, Yan Ji, Yunxin Wang, Bin Yang

“…Therefore, in high-temperature corrosion environments, the rational design and control of residual compressive stress provide an effective approach to improving the hot corrosion resistance of AlCoCrFeNi2.1 EHEA coatings.…”
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Complex congenital heart and lung defects as a cause of hydrops fetalis in French bulldogs –micro-CT with contrast study by Olga Szaluś-Jordanow, Karolina Barszcz, Wojciech Mądry, Michał Buczyński, Michał Czopowicz, Adam Gierulski, Agata Moroz-Fik, Zofia Nowek, Marcin Mickiewicz, Michał Grzegorczyk, Jakub Jaroszewicz, Sylwia Tarka, Tomasz Stępień, Wojciech Święszkowski

“…Examination of the heart in conjunction with the lungs appears to be a rational approach in animals with hydrops fetalis.…”
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Aggregation‐induced circularly polarized luminescence and delayed fluorescence enabled by activating high‐level reverse intersystem crossing by Ke Wang, Xinwen Ou, Xiaofei Niu, Zhenghao Wang, Fengyan Song, Xiaobin Dong, Wu‐jie Guo, Hui‐Qing Peng, Zujin Zhao, Jacky W. Y. Lam, Jianwei Sun, Hongkai Wu, Shu‐Yan Yu, Fei Li, Ben Zhong Tang

“…However, much effort has been normally focused on the utilization of T1 excitons but seldom on the utilization of higher excited triplet state Tn (n > 1) excitons. Rational manipulation of higher excited triplet state Tn (n > 1) excitons and suppression of Kasha's rule of CPL materials remains a major challenge. …”
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Dioxin Control in the Co-processing of Waste Printed Circuit Board and Copper Concentrate with an Ausmelt Furnace by Wei Li, Jia Sun, Deng-Feng Ma, Xian-Long Liu, Sheng Li, Jian-Ye Bei, Ming-Xiu Zhan, Xiao-Qing Lin, Tong Chen

“…These findings will facilitate the rational control of dioxin emissions with the co-processing of WPCB in an Ausmelt furnace.…”
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Generic residue numbering of the GAIN domain of adhesion GPCRs by Florian Seufert, Guillermo Pérez-Hernández, Gáspár Pándy-Szekeres, Ramon Guixà-González, Tobias Langenhan, David E. Gloriam, Peter W. Hildebrand

“…In summary, our work enables researchers to generate hypothesis and rationalize experiments related to GAIN domain function and pathology.…”
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An extended discontinuous deformation analysis for simulation of grouting reinforcement in a water-rich fractured rock tunnel by Jingyao Gao, Siyu Peng, Guangqi Chen, Hongyun Fan

“…Additionally, a set of compression tests is conducted on the fresh and grouted rock specimens to verify the reinforcement method and calibrate the rational properties of reinforced joints. An engineering-scale model based on a real water inrush case of the Yonglian tunnel in a water-rich fractured zone has been established. …”
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Changes in crop mix and the effects on agricultural carbon emissions in China by Fei Meng, Hang Chen, Yongzhong Tan, Wenying Xiong

“…To optimize crop cultivation and mitigate carbon emissions, possible strategies including rational crop production layout, land transfer, and clean production technologies were proposed.…”
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MiRNA target enrichment analysis of co-expression network modules reveals important miRNAs and their roles in breast cancer progression by Bazyari Mohammad Javad, Aghaee-Bakhtiari Seyed Hamid

“…Because the genes in one module have similar expression, it is rational to think the same regulatory elements such as miRNAs control their expression. …”
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Structural and electronic features enabling delocalized charge-carriers in CuSbSe 2 by Yuchen Fu, Hugh Lohan, Marcello Righetto, Yi-Teng Huang, Seán R. Kavanagh, Chang-Woo Cho, Szymon J. Zelewski, Young Won Woo, Harry Demetriou, Martyn A. McLachlan, Sandrine Heutz, Benjamin A. Piot, David O. Scanlon, Akshay Rao, Laura M. Herz, Aron Walsh, Robert L. Z. Hoye

“…These insights can drive forward the rational discovery of perovskite-inspired materials that can avoid carrier localization.…”
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Degradation dynamics of Trifluralin in Qinghai-Tibet Plateau and screening of its degrading strains by Dong Zhao, Lei Wang, Shuo Shen, Enyu Lu, Junlong Feng, Nima Bai, Hongyu Chen, Wei Li

“…The findings of this study provide important data for the environmental risk assessment of FLL and suggest potential biological resources for the rational use and environmental remediation of this herbicide. …”
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Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Wanjoo Chun

“…This study contributes valuable insights into the structural basis for targeting the Plasmodium proteasome and paves the way for the rational design of compounds with enhanced specificity and efficacy against malaria.…”
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Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease by Vincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

“…This structural analysis combined with enzymatic assays provides insights for the rational design of inhibitors that are robust against resistance toward developing antiviral treatments for EV68 infections.…”
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Impact of corticosteroids on the efficacy of CD19/22 CAR-T cell therapy in pediatric patients with B-ALL: a single-center study by Jing Yang, Jing Zhang, Xinyu Wan, Jiaoyang Cai, Jiaoyang Cai, Tianyi Wang, Xiaomin Yang, Wenjie Li, Lixia Ding, Lili Song, Yan Miao, Xiang Wang, Yani Ma, Chengjuan Luo, Jingyan Tang, Longjun Gu, Jing Chen, Jun Lu, Yanjing Tang, Benshang Li

“…Furthermore, there was no difference in the recovery of B cells and the expansion of CAR-T cell copies.Conclusion and discussionIn conclusion, under the guidance of current CRS prevention and control measures, the rational use of corticosteroids does not affect the clinical efficacy and overall survival of CAR-T cell therapy in patients with B-ALL and also does not affect the persistence of CAR-T cells in vivo, but the dosage threshold needs further clinical or experimental verification.…”
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A compliant metastructure design with reconfigurability up to six degrees of freedom by Humphrey Yang, Dinesh K. Patel, Tate Johnson, Ke Zhong, Gina Olson, Carmel Majidi, Mohammad F. Islam, Teng Zhang, Lining Yao

“…These devices incorporate passive flexures and actively stiffness-changing rods to modify kinematic freedom. A rational design pipeline informs the flexures’ topological arrangements, geometric parameters, and control signals based on targeted mobilities, enabling the creation of unitary joints with up to six degrees of freedom. …”
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Sulfur Fixation by Chemically Modified Red Mud Samples Containing Inorganic Additives: A Parametric Study by Yang Liu, Yang Li, Feng-shan Zhou, Ying-mo Hu, Yi-he Zhang

“…Bayer red mud modified by fusel salt and waste mother liquor of sodium ferrocyanide as the main sulfur fixation agent and the calcium based natural mineral materials as servicing additives; the experimental results showed the following: (1) Through 10 wt% waste mother liquor of sodium ferrocyanide modifying Bayer red mud, sulfur fixation rate can increase by 13 wt%. (2) Magnesium oxide can obviously improve the sulfur fixation performance of Bayer red mud and up to a maximum sulfur fixation rate of 47 wt% at adding 1 wt% magnesium oxide. (3) Dolomite enhanced the sulfur fixation performances with the sulfur fixation rate of 68 wt% in optimized condition. (4) Vermiculite dust reduced sulfur dioxide during the fixed-sulfur process of modified Bayer red mud, and the desulphurization ration could reach up to a maximum 76 wt% at 950°C. (5) An advanced three-component sulfur fixation agent was investigated, in which the optimized mass ratio of modified Bayer red mud, dolomite, and vermiculite dust was 70 : 28 : 2 in order, and its sulfur fixation efficiency has reached to a maximum 87 wt% under its 20 wt% dosage in the coal.…”
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A Novel Method for Predicting Urban Residential Quality Distribution Based on Multi-Interest Consideration by Jiawen Ren, Xin Zhou, Jingjing An, Xing Shi, Xing Jin, Tianzhen Hong, Da Yan

“…Given limited resources, understanding how to improve urban residential quality and rationally plan the distribution of different quality levels warrants further study. …”
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A dendritic hexamer acceptor enables 19.4% efficiency with exceptional stability in organic solar cells by Tao Jia, Tao Lin, Yang Yang, Lunbi Wu, Huimin Cai, Zesheng Zhang, Kangfeng Lin, Yulong Hai, Yongmin Luo, Ruijie Ma, Yao Li, Top Archie Dela Peña, Sha Liu, Jie Zhang, Chunchen Liu, Junwu Chen, Jiaying Wu, Shengjian Liu, Fei Huang

“…Abstract To achieve the commercialization of organic solar cells (OSCs), it is crucial not only to enhance power conversion efficiency (PCE) but also to improve device stability through rational molecular design. Recently emerging giant molecular acceptor (GMA) materials offer various advantages, such as precise chemical structure, high molecular weight (beneficial to film stability under several external stress), and impressive device efficiency, making them a promising candidate. …”
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