Engineering active sites in ternary CeO2-CuO-Mn3O4 heterointerface embedded in reduced graphene oxide for boosting water splitting activity by Sahar Jafari, Zohreh Shaghaghi

“…Abstract The rational design of highly efficient and stable bifunctional catalysts for overall water splitting is vitally important. …”
Get full text

Analysis of Gas Pipeline Failure Factors Based on the Novel Bayesian Network by Machine Learning Optimization by Shuangqing Chen, Shun Zhou, Zhe Xu, Yongbin Liu, Bing Guan, Xiaoyu Jiang, Wencheng Li

“…By comparing with the results of traditional methods, the rationality of the results obtained by the model is verified. …”
Get full text

Expert decision-making in clinicians: An auto-analytic ethnographic study of operational decision-making in urgent care. by Nicola Irvine, Robert Van Der Meer, Itamar Megiddo

“…<h4>Conclusion</h4>Expert clinicians employ intuitive decision-making supported by rational analysis in early urgent care decision-making. …”
Get full text

Bilevel Optimization of Regular Bus-Subway-Shared Bicycle Cooperative Operation considering Dual Uncertainties by Yunqiang Xue, Tong He, Tao Li, Hongzhi Guan, Yang Qiu

“…The comprehensive optimization results have effectively fulfilled the objectives of the bilevel optimization model, thereby confirming the rationality and practicality of the optimization approach. …”
Get full text

Effect of High-Fat Diet on Spatial Learning and Memory and Regulatory Role of N-Methyl-D-Aspartate Receptors in the Dentate Gyrus by LIU Huaying, DONG Wei, ZHANG Zihan, LI Yingshun, JIN Qinghua

“…This study provides a theoretical basis for rational diet and understanding the mechanism of HFD-induced impairments in learning and memory.…”
Get full text

ORGANICITY OF THE PHENOMENON OF CULTURE AS AN EXPLICATION OF VITALITY by D. B. Svyrydenko, O. D. Yatsenko, O. V. Prudnikova

“…The chaotic state of voluntarily acts is transformed into cultural codes and stereotypes by rationalization. The modern global nature of crisis phenomena, both in the worldview, in the social, and in the ecological dimension, requires reformatting the understanding of culture as a continuation of nature, and not its antipode.…”
Get full text

Drug Use Evaluation of Beta-Blockers in Medical Wards of Nedjo General Hospital, Western Ethiopia by Ginenus Fekadu, Firomsa Bekele, Kumera Bekele, Sagni Hanbisa, Gemechis Belay, Mudasir Maqbool

“…Additionally, drug information centers have proved useful and effective in promoting rational drug use. Hence, it should be recommended for general use.…”
Get full text

Effects of Covid-19 Pandemic on School Dropout in Selected Primry Schools in Nyarusiza Sub-County Kisoro District. by Sibo, Dusabe Chris Jackson

“…The findings of the study revealed that male respondents were highly represented in the study by 56.7%; married respondents were also highly represented by 64%; and 33.3% showed that Reduced pupil ration in Countries which forced to adopt quarantine measures was the major effect of Covid-19 on school enrollment., The recommendations of the study included the following: The government should increase spending for immediate health-related expenditures such as supplies including masks, gloves, and other personally productive equipment, in addition to ICU beds (as Uganda currently has only 55 functional ICU beds, resulting in approximately 1.3 ICU beds per million Ugandans) and ventilators. …”
Get full text

Molecular profiling of bladder cancer xenografts defines relevant molecular subtypes and provides a resource for biomarker discovery. by Sharada Mokkapati, Ganiraju Manyam, Alexis R. Steinmetz, Côme Tholomier, Alberto Martini, Woonyoung Choi, Bogdon Czerniak, Byron H Lee, Colin P Dinney, David J McConkey

“…These findings will allow for the rational use of appropriate models to develop targeted therapies to overcome or manipulate mechanisms of treatment resistance in BLCA.…”
Get full text

Develop Reusable Carbon Sub‐Micrometer Composites with Record‐High Cd(II) Removal Capacity by Mengke Cui, Huiting Jiao, Shijie Yuan, Bin Dong, Zuxin Xu

“…The findings reported pioneered a new avenue for the rational design of high‐performance environmental remediation materials, aiming to overcome the limitations of traditional mine drainage treatment.…”
Get full text

Long-term results of antiviral therapy in patients with chronic hepatitis C with sustained virologic response by T. M. Ignatova, T. N. Lopatkina, V. P. Chulanov, Ye. V. Gaydasheva, S. N. Batskikh, G. V. Mikhaylovskaya, D. T. Abdurakhmanov, S. Yu. Karpov, Ye. N. Nikulkina, O. A. Chernova

“…Highly sensitive PCR methods are rational for assessment of SVO.…”
Get full text

Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…These findings provide new insights into the complex mechanisms underlying RPE-EMT and PVR pathogenesis, with implications for rational strategies for potential therapeutic applications in PVR by targeting RPE-EMT.…”
Get full text

Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Current recommendations of the Russian Gastroenterological Association are developed to acquaint medical practitioners with modern diagnostics, treatment and trends in rational drug therapy for gastroesophageal reflux disease (GERD).General provisions. …”
Get full text

Predicting Multi-Scenario Land Use Changes and Soil Erosion in the Huaihe River Basin Based on Coupled PLUS-CSLE Model by GUO Weiling, XU Liuyang, JIA Jiang, GAO Chang, XIA Xiaolin, WANG Bangwen, ZHANG Jingyu, CHEN Lei, CHEN Yingjian

“…[Objective] Understanding the future temporal and spatial evolution of land use and soil erosion in the Huaihe River Basin is of significant importance for rational and coordinated use of land resources, formulating future soil and water conservation strategies, and promoting sustainable development strategies. …”
Get full text

Integrative analysis of metabolite and transcriptome reveals the biosynthetic pathway and candidate genes for iridoid glycoside biosynthesis in Neopicrorhiza scrophulariiflora (Pen... by Ke Rao, Ke Rao, Siyu Liu, Siyu Liu, Xiaohui Tang, Guofu Jia, Shaohua Yang, Chaoxiang Ren, Chaoxiang Ren, Jin Pei, Jin Pei

“…Due to overharvesting, N. scrophulariiflora resources are facing the risk of depletion, urgently requiring resource protection and rational utilization. However, the biosynthetic pathways and related genes of active compounds in N. scrophulariiflora have not been fully investigated. …”
Get full text

Epidemiologic characteristics of infectious disease-related public health emergencies in Guangdong province, 2014 – 2023: a surveillance data analysis by Weiyi CHEN, Runing GUO, Yun HUANG, Jianhua HUANG, Meiling YANG, Jiya DAI, Fengxiang SHI, Wenjia LIANG

“…ObjectiveTo analyze the epidemiological characteristics of infectious disease-related public health emergencies in Guangdong Province from 2014 to 2023, for the development of effective infectious disease prevention and control strategies and rational allocation of health resources. MethodsData on infectious disease public health emergencies reported in Guangdong province from 2014 to 2023 were obtained from the Public Health Emergency Management Information System of the Chinese Center for Disease Control and Prevention. …”
Get full text

Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
Get full text

Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair by Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo

“…Taken together, we rationally explained a novel and important mechanism of the miR-124-mediated high sensitivity to TMZ-induced cell death in GBM and provided evidence to support that miR-124-RAD51 regulatory axis could be a promising candidate in the comprehensive treatment with TMZ in GBM.…”
Get full text

CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…These effects were directly linked to their inhibition of PKM2 enzymatic activity, validating the proposed mechanism of action in their rational design. ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
Get full text

Isolation, purification, structural characteristic and antioxidative property of polysaccharides from A. cepa L. var. agrogatum Don by Hongcheng Liu, Hongxiu Fan, Jing Zhang, Shanshan Zhang, Wenting Zhao, Tingting Liu, Dawei Wang

“…These results provide a reference for further research and rational development of ALAP polysaccharides. Keywords: Polysaccharides, Allium cepa L. var. agrogatum Don, Structural characterization, Antioxidative property…”
Get full text