Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides by Heqian Zhang, Yihan Wang, Yanran Zhu, Pengtao Huang, Qiandi Gao, Xiaojie Li, Zhaoying Chen, Yu Liu, Jiakun Jiang, Yuan Gao, Jiaquan Huang, Zhiwei Qin

“…Conclusions: The findings of this study pave the way for the rational drug design of activity-enhanced peptide antibiotics.…”
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Different Metabolites in the Roots, Seeds, and Leaves of Acanthopanax senticosus and Their Role in Alleviating Oxidative Stress by Jie Su, Qi Wang, Zhifeng Li, Yan Feng, Yan Li, Shinlin Yang, Yulin Feng

“…The results of this study reveal the distribution characteristics and the antioxidant activity of different metabolites of A. senticosus and provide a reference for the rational development of its medicinal parts.…”
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Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MS/MS after Oral Administration of Drynariae rhizoma Extract by Zhan-Ling Xu, Ming-Yue Xu, Hai-Tao Wang, Qing-Xuan Xu, Ming-Yang Liu, Chun-Peng Jia, Fang Geng, Ning Zhang

“…In order to make good and rational use of Drynariae rhizoma in future, a rapid, sensitive, and selective ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS) method was developed to investigate the pharmacokinetics of eight main flavonoids in rat plasma after oral administration of the Drynariae rhizoma extract, including neoeriocitrin, luteolin-7-O-β-D-glucoside, astragalin, naringin, eriodictyol, luteolin, naringenin, and kaempferol. …”
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Bearing Behavior of H-Shaped Honeycombed Steel Web Composite Columns with Rectangular Concrete-Filled Steel Tube Flanges under Eccentrical Compression Load by Jing Ji, Chenyu Yu, Liangqin Jiang, Jiedong Zhan, Hongguo Ren, Sixue Hao, Shaojie Fan, Li Jiang, Yubo Lin, Lingjie He

“…By comparison with the existing test results, the rationality of the constitutive model of materials and FE modeling was verified. …”
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Resistance of barley cultivars approved for use in Russia to harmful organisms and toxic aluminum ions by R. A. Abdullaev, B. A. Batasheva, N. V. Alpatieva, M. A. Chumakov, E. E. Radchenko, O. N. Kovaleva, O. V. Yakovleva

“…Background. The most rational way to reduce barley crop losses from diseases, pests and adverse edaphic factors is cultivation of resistant varieties. …”
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Ultrasonication-assisted lipase-catalyzed esterification of chlorogenic acid: A comparative study using fatty alcohol and acids in solvent and solvent-free conditions by Chia-Hung Kuo, Parushi Nargotra, Tsung-Han Lin, Chwen-Jen Shieh, Yung-Chuan Liu

“…Catalytic factors such as reaction time (12 h ∼ 36 h), enzyme dosage (10 ∼ 50 mg), and ultrasonication power (90 ∼ 150 W) were optimized using Box-Behnken design (BBD) while temperature (60 ℃) and molar ration (chlorogenic acid/octanol, 1:500) were kept constant. …”
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Reforming public service of Republic of Kazakhstan as necessary condition for effective development of national economy by S. S. Dontsov, A. S. Kadyrova, S. A. Rakhimova, A. A. Nurgaliyeva, A. A. Titkov

“…The article emphasizes the importance of rational reforms of the public service in Kazakhstan for the successful implementation of all major strategic plans and effective development of the national economy as a whole. …”
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Fall risk-increasing drugs and associated health outcomes among community-dwelling older patients: A cross-sectional study in Croatian cohort of the EuroAgeism H2020 project by Paar Elizabeta, De Lai Eleonora, Držaić Margita, Kummer Ingrid, Bužančić Iva, Hadžiabdić Maja Ortner, Brkic Jovana, Fialová Daniela

“…Our study highlights the need for rationalization of FRID use. To reduce the unnecessary exposure to FRIDs in older adults, health-care professionals must consider high individualization of medication schemes regarding selection, dosing, and combinations of only necessary FRIDs.…”
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Chinese Medicine Huzhen Tongfeng Formula Effectively Attenuates Gouty Arthritis by Inhibiting Arachidonic Acid Metabolism and Inflammatory Mediators by Jianping Deng, Zicong Wu, Chen Chen, Zhenling Zhao, Yifei Li, Zhengquan Su, Yiguang Lin, Yifei Wang, Zhiping Wang

“…These findings extend our understanding of the pharmacological action of HZTF, rationalizing the application HZTF as an effective herbal therapy for GA.…”
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Genotyping Genebank Collections: Strategic Approaches and Considerations for Optimal Collection Management by Noelle L. Anglin, Peter Wenzl, Vania Azevedo, Charlotte Lusty, David Ellis, Dongying Gao

“…Data from genotyping can help define genetic diversity within a collection, identify genetic gaps, reveal genetic redundancies and verify uniqueness, enable the comparison of collections of the same crop across genebanks (rationalization), and determine errors or mix-ups in genetic identity that may have occurred in a germplasm collection. …”
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Opposite outcomes of triglyceride-glucose index and associated cardiovascular mortality risk in type 2 diabetes mellitus participants by different obesity criteria by Hui Huang, Jing Tian, Jiahui Xu, Qingguang Chen, Mengjie Cai, Hao Lu, Fan Gong

“…Among non-obese T2DM participants (BMI-defined), the hazard ration for CVD mortality was 1.73 in the fourth quartile group of TyG index compared with the first quartile group. …”
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Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…Besides highlighting new potential drug targets, PAL can provide valuable information on efficacy and liabilities of small molecules at the molecular level, which could be exploited to greatly facilitate the rational optimization of compounds in terms of potency and safety. …”
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An Enhanced End-to-End Object Detector for Drone Aerial Imagery by Quan Yu, Qiang Tong, Lin Miao, Lin Qi, Xiulei Liu

“…Look Forward Stage introduces a more rational gradient structure which eliminates inter-layer information bias between decoders. …”
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The Scale Effect of Coarse-Grained Materials by Triaxial Test Simulation by Xiaotao Ai, Guangjin Wang, Xiangyun Kong, Bo Cui, Bin Hu, Hongling Ma

“…The results showed that under the same confining pressure, the peak stress and initial deformation modulus Ei increased with the increase of the maximum particle size dmax, while the degree of shear shrinkage and Poisson’s ration υ decreased. As the confining pressure increased, the scale effect of coarse-grained materials would be magnified. …”
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The evolution and development of railway passenger transportation clearing method in China by Yin Zhou, Wei Fang, Yan Xu, Huaixiang Wang, Lu Liu

“…Purpose – As an important part of the management of railway passenger transport, the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency and service quality of railway passenger transport enterprises. …”
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A Master–Slave Game-Based Strategy for Trading and Allocation of Virtual Power Plants in the Electricity Spot Market by Na Yang, Liuzhu Zhu, Bao Wang, Rong Fu, Ling Qi, Xin Jiang, Chengyang Sun

“…This method ensures the rational allocation of electricity consumption among distributed energy resources within the VPP and derives the optimized bidding prices and quantities for both the VPP and its internal members. …”
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Rigid‐Flexible Coupling Realized by Synergistic Engineering of the Graphitic‐Amorphous Architecture for Durable and Fast Potassium Storage by Mingchi Jiang, Ning Sun, Bin Cao, Xuyang Jian, Razium Ali Soomro, Bin Xu

“…This work elucidates the impact of carbon configurations on K‐storage performance and proposes a structural model for efficient K‐ion storage, which is instrumental in the rational design and advancement of carbon anodes in PIBs.…”
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Genetic Diversity and Structure of a Critically Endangered Ornamental Species, <i>Rhododendron farinosum</i>, with Extremely Small Populations by Fengjuan Li, Linyuan Fan, Jingli Zhang, Wen Liu, Wei Li, Yongpeng Ma, Hong Ma

“…To unravel the reasons behind the endangerment of this species and provide guidance for the rational conservation of this species, this study obtained a large number of SNP loci by using double-digest restriction-site-associated DNA sequencing (ddRAD-seq) to evaluate the genetic diversity and genetic structure of <i>R. farinosum</i>, as well as to infer the population history of this species. …”
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The Modified Gil-Vernet Antireflux Surgery: A Successful Technique for High-Grade Vesicoureteral Reflux Correction in Children—Long-Term Follow-Up by Mahmoudreza Moradi, Abolhassan Seyedzadeh, Saeed Gharakhloo, Aref Teymourinezhad, Kaveh Kaseb, Haress Rezaee

“…This simple and safe technique can correct bilateral VURs simultaneously; thus, it is rational to be considered for high-grade VUR correction. …”
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Study on Damage Model and Damage Evolution Characteristics of Backfill with Prefabricated Fracture under Seepage-Stress Coupling by Jifeng Hou, Zhongping Guo, Weizhen Liu, Hengze Yang, WenWu Xie

“…The mechanical properties of backfill with prefabricated fracture under different seepage water pressures and confining pressures were tested and the rationality of the model was verified. The research shows that the mechanical properties of backfill with prefabricated fracture under the seepage-stress coupling are determined by the seepage water pressure, the load, the initial fracture, and the coupling effect. …”
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