Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…These findings provide new insights into the complex mechanisms underlying RPE-EMT and PVR pathogenesis, with implications for rational strategies for potential therapeutic applications in PVR by targeting RPE-EMT.…”
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A Review of Integrated Optimization Method of Batch Planning and Scheduling for Steelmaking-Continuous Casting-Hot Rolling Production Under Uncertain Environment Based on Lagrangia... by Liangliang Sun, Xirang Hao, Yunpeng Li, Jinghan Xue, Natalia M. Matsveichuk, Yuri N. Sotskov, Qichun Zhang

“…The synergy of the two aims to optimize production profitability, energy consumption, efficiency, etc., through rational decisions, ensuring the efficiency and flexibility of the steel production process. …”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Current recommendations of the Russian Gastroenterological Association are developed to acquaint medical practitioners with modern diagnostics, treatment and trends in rational drug therapy for gastroesophageal reflux disease (GERD).General provisions. …”
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Predicting Multi-Scenario Land Use Changes and Soil Erosion in the Huaihe River Basin Based on Coupled PLUS-CSLE Model by GUO Weiling, XU Liuyang, JIA Jiang, GAO Chang, XIA Xiaolin, WANG Bangwen, ZHANG Jingyu, CHEN Lei, CHEN Yingjian

“…[Objective] Understanding the future temporal and spatial evolution of land use and soil erosion in the Huaihe River Basin is of significant importance for rational and coordinated use of land resources, formulating future soil and water conservation strategies, and promoting sustainable development strategies. …”
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Microbial Surface Confined Growth Strategy for the Synthesis of Highly Loaded NiCoP Nanoparticles with Hollow Derived Carbon Shells for Sodium Ion Capture by Jianhua Yuan, Tianxiao Sun, Jinfeng Chen, Runhong Zhou, Jianglin Cao, Fei Yu, Liqing Li, Xiumin Zhong, Jie Ma

“…In response to these limitations, Finite element simulations are used to help in the rational design of the NiCoP structure. A novel microbial surface confined growth strategy is employed to synthesize highly loaded NiCoP nanoparticles (NiCoP NPs) supported on hollow derived carbon shells (NPC), constructing a stable composite structure known as NiCoP@NPC. …”
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Integrative analysis of metabolite and transcriptome reveals the biosynthetic pathway and candidate genes for iridoid glycoside biosynthesis in Neopicrorhiza scrophulariiflora (Pen... by Ke Rao, Ke Rao, Siyu Liu, Siyu Liu, Xiaohui Tang, Guofu Jia, Shaohua Yang, Chaoxiang Ren, Chaoxiang Ren, Jin Pei, Jin Pei

“…Due to overharvesting, N. scrophulariiflora resources are facing the risk of depletion, urgently requiring resource protection and rational utilization. However, the biosynthetic pathways and related genes of active compounds in N. scrophulariiflora have not been fully investigated. …”
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Epidemiologic characteristics of infectious disease-related public health emergencies in Guangdong province, 2014 – 2023: a surveillance data analysis by Weiyi CHEN, Runing GUO, Yun HUANG, Jianhua HUANG, Meiling YANG, Jiya DAI, Fengxiang SHI, Wenjia LIANG

“…ObjectiveTo analyze the epidemiological characteristics of infectious disease-related public health emergencies in Guangdong Province from 2014 to 2023, for the development of effective infectious disease prevention and control strategies and rational allocation of health resources. MethodsData on infectious disease public health emergencies reported in Guangdong province from 2014 to 2023 were obtained from the Public Health Emergency Management Information System of the Chinese Center for Disease Control and Prevention. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair by Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo

“…Taken together, we rationally explained a novel and important mechanism of the miR-124-mediated high sensitivity to TMZ-induced cell death in GBM and provided evidence to support that miR-124-RAD51 regulatory axis could be a promising candidate in the comprehensive treatment with TMZ in GBM.…”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…These effects were directly linked to their inhibition of PKM2 enzymatic activity, validating the proposed mechanism of action in their rational design. ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Isolation, purification, structural characteristic and antioxidative property of polysaccharides from A. cepa L. var. agrogatum Don by Hongcheng Liu, Hongxiu Fan, Jing Zhang, Shanshan Zhang, Wenting Zhao, Tingting Liu, Dawei Wang

“…These results provide a reference for further research and rational development of ALAP polysaccharides. Keywords: Polysaccharides, Allium cepa L. var. agrogatum Don, Structural characterization, Antioxidative property…”
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Dynamically Cyclic Fe2+/Fe3+ Active Sites as Electron and Proton-Feeding Centers Boosting CO2 Photoreduction Powered by Benzyl Alcohol Oxidation by Ben Lei, Gaofeng Zhou, Zhongyou Gong, Chao Liu, Ying Zhou, Vitaliy P. Guro, Yanjuan Sun, Jianping Sheng, Fan Dong

“…Solar-driven CO2 photoreduction holds promise for sustainable fuel and chemical productions, but the complex proton-coupled multi-electron transfer processes and sluggish oxidation half-reaction kinetics substantially hinder its efficiency. Here, we devised a rational catalyst design to address these challenges by fabricating ferrocene carboxylic acid-functionalized Cs3Sb2Br9 nanocrystals (CSB-Fc NCs), which facilitate simultaneous benzyl alcohol oxidation and CO2 reduction reactions under visible-light irradiation. …”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…Conclusions: TG can treat hypertension by affecting differential strains and differential metabolites, providing a scientific basis for guiding the rational use of TG.…”
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Evaluating the Accessibility of Urban Public Open Spaces Based on an Improved 2SFCA Model: A Case Study Within Chengdu’s Second Ring Road by Ling Jian, Xiaojiang Xia, Yinbing Zhao, Yang Zhang, Yuanqiao Wang, Yi Tang, Jie Chang, Changliu Wang

“…The rational allocation of urban public open spaces (UPOS) is critical for creating a livable urban environment. …”
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Integrating biodiversity assessments into local conservation planning: the importance of assessing suitable data sources by Ferraille, Thibaut, Kerbiriou, Christian, Bigard, Charlotte, Claireau, Fabien, Thompson, John D.

“…Finally, we propose a workflow to guide SEA stakeholders through the process of data rationalization and use in conservation planning. …”
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Understanding spatiotemporal changes and influencing factors in the habitat quality of coastal waters: A case study of Jiangsu Province, China (2006–2020) by Zhou Chen, Yanjing Chen, Haifeng Zhang, Hong Zhang, Min Xu

“…However, there were few effective and rational explorations of spatiotemporal changes and influencing factors in coastal waters habitat quality. …”
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As-cast microstructure characteristics of K439B nickel-based superalloy thin- walled castings of different thickness by ZHOU Depeng, SUI Dashan, MA Jinyuan, GUI Daxing, DONG Anping, SUN Baode

“…These results of the experimental and simulation analysis could provide a reference to rationally design the casting process for the K439B nickel-based superalloy thin-walled casting crafts.…”
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Diagnostics and treatment of exocrine pancreatic insufficiency: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…Patient should intake at least normal daily amount of fat and divide daily ration to at least six meals. Patients should be motivated to restrain from alcohol consumption and smoking as they can lead to further progression of pancreatic exocrine insufficiency and symptoms of pancreatitis.…”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…Patient should be consulted by nutritionist, no significant limitation of fat intake is recommended. Daily ration should be divided into six or more meals. Patients should be motivated to stop both alcohol intake and smoking as they can cause progression of PEI alone and/or persistence of symptoms, like pancreatic pain.…”
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The global energy challenge: second-generation feedstocks on marginal lands for a sustainable biofuel production by Claudio Russo, Valerio Cirillo, Nausicaa Pollaro, Fabio Terribile, Andrea Chiodini, Albino Maggio

“…To fully exploit this option, it will be critical to calibrate plant growth models to estimate the potential biofuel production on marginal land from second-generation feedstock and to create tools for a more rational management of this land. Graphical abstract…”
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