Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…RNA-targeted therapy can precisely modulate the function of target RNA with minimal off-target effects and can be rationally designed based on sequence data. ASOs and siRNA-based drugs have unique capabilities for using in target groups of patients or can be tailored as patient-customized N-of-1 therapeutic approach. …”
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Assessment of the Efficiency of Thermal Waste Regeneration in the Blown Impassable Channels of Heating Mains by V. A. Sednin, T. V. Bubyr

“…To solve the problem of increasing the energy efficiency of thermal networks with heat pipelines located in impassable channels, a schematic and structural solution for the rational utilization of thermal waste generated during the transport of thermal energy has been developed. …”
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Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial by Marziyeh Heydari, Hossein Kazemi Zadeh, Soha Namazi, Hamid Emadi Koochak, Nasim Khajavi Rad, Mahnaz Khanavi, Arman Zargaran

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Study on Key Influencing Factors of Carbon Emissions from Farmland Resource Utilization in Northeast China Under the Background of Energy Conservation and Emission Reduction by Mulin Sun, Yuhao Fu, Mingyao Sun, Run Huang, Yun Teng

“…Under the background of energy conservation and emission reduction, how to rationally and scientifically utilize the non-renewable resources of northeastern farmland is particularly important. …”
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Antimicrobial Susceptibility Patterns of Shigella Species among Children under Five Years of Age with Diarrhea in Selected Health Centers, Addis Ababa, Ethiopia by Basha Ayele, Zeleke Mekonnen, Tesfaye Sisay Tessema, Etsehiwot Adamu, Estifanos Tsige, Getenet Beyene

“…Raising awareness about resistance and educating health professionals, policymakers, and the public can help improve the quality of patient care and rational antibiotic use.…”
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THE EFFECT OF USING ASPERGILLUS ORYZAE IN THE DIETS OF COMMON CARP FISH AND ITS IMPACT ON THE PRODUCTIVE TRAITS OF FISH. by A. S. Naser, E. A. A. Jaseem, S. H. ALwarshan

“…A total of 320 common carp fish were randomly distributed with an average weight of 90.5 (±25) g fish-¹ into sixteen plastic ponds with dimensions of 100 ˟ 100 ˟100 cm, for each tank capacity of 1000 litres, on eight experimental treatments and at a rate of two replicates for each one treatment and 20 fish for each replicate. Eight rations were made manually with a diameter of 4mm, and the experimental fish were fed with 3% of the body weight. …”
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Epidemiology and Mechanism of Drug Resistance of Multidrug-Resistant Klebsiella Pneumoniae Isolated from Patients with Urinary Tract Infection in Beijing Teaching Hospital, China by Xie Z, Jian J, Chen L

“…The experimental results can help control the use of quinolones and carbapenems, and we could provide rational drug use basis for clinicians to treat urinary tract infection. …”
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Viral conjunctivitis in children: the specific clinical features and treatment by N.V. Kazinskaya, V.Yu. Evgraphov, I.A. Il’inskaya

“…The article describes the most common types of child’s conjunctivitis and provides authors’ own findings for 195 patients, 0–18 years old, including the specific clinical features and the conside rations for treatment. In addition, a clinical case report is presented where an incorrect interpretation of symptoms of the anterior eye segment inflammation has led to the inappropriate medication administration and the development of such complications as keratitis and reduced visual acuity. …”
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EXPERIENCE OF IMPLEMENTING THE DISTANCE E-COURSE “STATISTICAL METHODS IN PHARMACY” IN THE MATHEMATICAL TRAINING OF FUTURE PHARMACEUTICAL SPECIALISTS by Iryna Zhovtonizhko, Maryna Nessonova, Mariana Barannyk, Nadiia Sheykina, Olga Marchenko

“…It is concluded, that the implementation of distance learning technology in the practice of Ukrainian higher pharmaceutical and medical education is necessary not only due to the current conditions that make it impossible to organize full-fledged offline education but also because of the efficiency of these technologies, primarily for organizing independent students’ work, that ensures the development of learners’ autonomy, contributes to the development of information culture, general digital competence, and a range of soft skills, including communication, interaction, collaboration in a digital environment, and the rational use of study time. …”
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Mechanical Properties and Control Rockburst Mechanism of Coal and Rock Mass with Bursting Liability in Deep Mining by Ming-tao Gao, Zhen-qi Song, Hui-qiang Duan, Heng-qi Xin, Jian-quan Tang

“…And their mechanical properties, energy evolution, and bursting properties are studied and analyzed. The rationality of the test results is also verified by the in-situ engineering practice. …”
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Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…This approach provides an additional layer of biosafety and thus has great potential for the application in the rational development of safer and more effective influenza viral vaccines.…”
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Investigation on inherent angle ventilation control of residential kitchen range hoods by Zhilin Guo, Huixing Li, Guohui Feng, Kailiang Huang, Tengfei Yu

“…Based on different airflow organization patterns, a supplementary ventilation system is designed. The rationality and effectiveness of the supplementary ventilation system are analyzed to establish an effective control scheme for reducing particulate matter in various kitchen environments. …”
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DIGITAL ECONOMY AND RECRUITMENT POTENTIAL: STRATEGICAL INTERCONNECTION AND PROSPECTS by G. Yu. Peshkova, А. Yu. Samarina

“…The authors have come to the conclusion that rational recruitment policy is an essential part of Russian economy’s digitalisation. …”
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EVALUATION OF ANTIBACTERIAL ACTIVITY OF TRICHILIA DREGEANA SOND (MELIACEAE) CRUDE EXTRACTS AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA by Tesfa Mossie, Temesgen Kasa, Bekesis Urge, Hilena Yifred

“…The findings are promising and encourage further investigation of the crude extracts’ phytochemical, toxicological, and pharmacological aspects to support their potential rational use in antimicrobial therapy. …”
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The use of the Prospector calculator reduces antibiotic therapy in exacerbations of chronic obstructive pulmonary disease by Marcin Paprocki, Szymon Żwirowski, Krzysztof Kuziemski

“…This study was designed to explore the hypothesis that utilization of a novel decision-making tool called Prospector would lead to lower consumption of antibiotics and provide a more rational approach to managing COPD exacerbations versus standard therapy in patients with COPD. …”
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The Impact of Multitasking on Transport Mode Choice in Autonomous Vehicle Age by Jamil Hamadneh, Domokos Esztergar-Kiss

“…The DCE considers the attributes and attributes levels of the alternatives where rationality is maintained in the design. A transport mode choice model, which includes several variables influencing the choice of a transport mode, is developed. …”
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Kebijakan Indonesia Menjadi Anggota Financial Action Task Force (FATF) Sebagai Kebijakan yang Rasional by Khilda Luqyana Arifin, Yanuar Rahmadan

“…This research analyzes Indonesia's interest in becoming a full member of the FATF which can be explained based on national interest theory and rational choice theory using literature-based data collection techniques. …”
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Effect of Various Foaming Agents on Ceramic Foam from Solid Waste by Chenglin Zhao, Chunmin Wang, Zichen Xia, Congcong Jiang, Yiran Dong, Zihao Lan

“…Due to the significant amount of solid waste generated annually in China, the rational use of these wastes has become increasingly important. …”
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Investigating the Construction Procedure and Safety Oversight of the Mechanical Shaft Technique: Insights Gained from the Guangzhou Intercity Railway Project by Jianwang Li, Wenrui Qi, Xinlong Li, Gaoyu Liu, Jian Chen, Huawei Tong

“…The achievements include a 22.22% reduction in construction time, a 20.27% decrease in investment, and lower worker risk. (2) Monitoring confirmed that all cutting edge and segment values remained safe, demonstrating the method’s feasibility and rationality. (3) Analyzing shaft monitoring data and field uncertainties, this study proposes recommendations for future work, including precise segment lowering control and introducing high-precision total stations and GPS technology to mitigate tunneling and assembly inaccuracies. …”
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Mapping the Discourse. Architecture Periodicals in/for the Teaching of Architecture History by Gaia Caramellino, Valeria Casali, Nicole De Togni

“…The analysis of the diverse agendas, rationalities, editorial strategies and networks between editors, owners, institutions, and the general audience allowed to question the very notion of milieu that the magazines contribute to create. …”
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