Examining power dynamics in global health governance using topic modeling and network analysis of Twitter data by Jennifer J Prah, Gian Franco Bermudez

“…We empirically tested whether global health governance (GHG) operates under the rational actor model (RAM) and characterised GHG power dynamics.Design We collected approximately 75 000 tweets of 20 key global health actors, between 2016 and 2020, using Twitter API. …”
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Self-Medication Practices Among Population in the Sulaimani City, Kurdistan Region, Iraq by Soran Hamalaw

“…Even though, the study suggests that while self-medicated individuals are unlikely to experience adverse effects from their drugs, promoting rational drug use is recommended to mitigate its negative consequences.…”
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Assessing the Impact of Covid19-Pandemic on the Household Income in Kamuganguzi Sub-County Kabale District. by Arinda, Redeemer Present

“…Additionally, 33.3% of respondents reported that reduced food rations, leading to famine, were a major effect of COVID-19 on families. …”
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Role of Financial Institution on the Success of Small-Scale Enterprises in Uganda: A Case Study of Lyamujungu SACCO in Kabale District. by Kyarimpa, Glorius

“…The study findings showed role of unsecured loans on the performance of Small and Medium Enterprises in Lyamujungu Sacco and these are ease of Access to Finance, supporting Cash Flow and Working Capital Needs, encouraging Entrepreneurship and Innovation, fostering Business Growth and Expansion, enhancing Financial Flexibility, reducing Financial Constraints Beck, mitigating the Impact of Credit Rationing, encouraging entrepreneurship and innovation. …”
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Temporal and Spatial Analysis of Coastal Landscape Patterns Using the GEE Cloud Platform and Landsat Time Series by Chao Chen, Jintao Liang, Taohua Ren, Yi Wang, Zhisong Liu

“…This study is anticipated to provide robust evidence for the rational planning of future development directions and the deployment of landscape ecological spatial services.…”
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SMYD3 drives cell cycle and epithelial-mesenchymal transition pathways through dual gene transcriptional repression and activation in HPV-negative head and neck cancer by Madhavi Murali, Abbas Saeed, Sohyoung Kim, Kyunghee Burkitt, Hui Cheng, Arfa Moshiri, Jawad Akhtar, Daniel Tsai, Marie Luff, Baktiar Karim, Vassiliki Saloura

“…This study provides insights into the epigenetic role of SMYD3 as an oncogene in HPV-negative HNSCC and supports SMYD3 as a rational therapeutic target in HPV-negative HNSCC.…”
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IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch by Maria Abreu, Marta Miranda, Mafalda Castro, Iolanda Fernandes, Renata Cabral, Ana Helena Santos, Sónia Fonseca, João Rodrigues, Magdalena Leander, Catarina Lau, Inês Freitas, Susana Coimbra, Alice Santos-Silva, Margarida Lima

“…Our study suggests a role for IL-31 in CTCL-associated itch, especially in advanced disease and SS, offering a rational target for new therapeutic approaches. Increased serum IL-8 observed in some patients may be related to concomitant infections, and its role in exacerbating itch by recruiting neutrophils and promoting the release of neutrophil proteases deserves further investigation.…”
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Combining Serum DNA Methylation Biomarkers and Protein Tumor Markers Improved Clinical Sensitivity for Early Detection of Colorectal Cancer by Guoying Zhang, Fang He, Guodong Zhao, Zihui Huang, Xiang Li, Xia Xia, Yidi Guo, Weiping Xu, Shangmin Xiong, Yong Ma, Minxue Zheng, Wanli Liu

“…These results suggested a rational path towards developing a CRC screening method that takes advantage of leftover blood chemistry test samples. …”
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Automatic Segmentation of Abdominal Aortic Aneurysm From Computed Tomography Angiography Using a Patch-Based Dilated UNet Model by Merjulah Roby, Juan C. Restrepo, Haehwan Park, Satish C. Muluk, Mark K. Eskandari, Seungik Baek, Ender A. Finol

“…Building upon this work, we included the application of Non-Uniform Rational B-Splines (NURBS) to enhance the segmentation process. …”
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Decoding Urinary Tract Infection Trends: A 5-Year Snapshot from Central Portugal by Francisco Rodrigues, Patrícia Coelho, Sónia Mateus, Armando Caseiro, Hatem Eideh, Teresa Gonçalves, Miguel Castelo Branco

“…Conclusion: The findings highlight the importance of strict infection control, targeted prevention measures, and rational antibiotic use to combat resistance. Ongoing surveillance and personalized treatment approaches are essential to improve UTI management and outcomes.…”
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Investigation of the suspended solids removal from mine water by the rock accumulation effect in the underground reservoir of coal mines by Binbin JIANG, Jingfeng LI, Liqiang MA, Min WU, Chen SU, Jihui LI

“…The opening of an underground coal mine reservoir provides an effective technical approach to ensure the rational utilization of water resources during mining operations. …”
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Equivalent method for DFIG wind farms based on modified LightGBM considering voltage deep drop faults by Xuecheng Liu, Peixiao Fan, Jun Yang, Song Ke, Binyu Ma, Yangzhou Pei, Jian Xu

“…Simulation results demonstrate that the proposed DFIG wind farms equivalent model, compared to traditional methods, not only can adapt to a broader range of operating scenarios but also achieves superior identification of wind turbine operating states, making the equivalent method rational and effective.…”
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Enhancing smart home environments: a novel pattern recognition approach to ambient acoustic event detection and localization by Ahsan Shabbir, Abdul Haleem Butt, Taha Khan, Lorenzo Chiari, Ahmad Almadhor, Vincent Karovic

“…Random forest and linear discriminant analysis classifiers were employed for event detection, while the estimation signal parameters through rational-in-variance techniques (ESPRIT) algorithm was used for sound source localization.ResultsThe study achieved high detection accuracy, with random forest and linear discriminant analysis classifiers attaining 95% and 87%, respectively, for event detection. …”
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Solar‐Driven Hydrogen Peroxide Production via BiVO4‐Based Photocatalysts by Hui Ling Tan, Casandra Hui Teng Chai, Jerry Zhi Xiong Heng, Quyen Vu Thi, Xuelian Wu, Yun Hau Ng, Enyi Ye

“…The challenges and future prospects in this field are also discussed to facilitate the rational design of high‐performing BiVO4‐based photocatalysts and photoelectrodes for H2O2 generation under visible light.…”
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Study on the Instability Characteristics and Bolt Support in Deep Mining Roadways Based on the Surrounding Rock Stability Index: Example of Pansan Coal Mine by Jucai Chang, Kai He, Zhiqiang Yin, Wanfeng Li, Shihui Li, Dongdong Pang

“…This indicates that the control effect of the full-length anchoring bolt support is better and verifies the rationality of the surrounding rock stability index to describe the instability characteristics. …”
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<i>Clostridium difficile</i>-associated disease by V. T. Ivashkin, O. S. Shifrin, A. S. Tertycnhy, Ye. A. Poluektova, T. L. Lapina, O. S. Lyashenko, K. V. Ivashkin

“…Metronidazole, vancomycin, dioctaedric smectite and probiotics are used for treatment of C. difficile infection. Rational use of antibiotics, shortening of hospital stay terms whenever possible, especially for patients of 65 years of age and older is recommended to reduce the risk of clostridial infection development. …”
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In situ detection of piRNA‐651 in exosomes and cells for cancer diagnosis by a new gold nanoparticle nucleic acid probe by Qin‐Xin Gao, Qian‐Qian Wu, Zhi‐Ying Dong, Xiao‐Yuan Qin, Lin‐Yan Zhai, Bao‐Ping Xie, Wen‐Jun Duan

“…To avoid low sensitivity and kinetics in detecting large‐sized PIWI‐interacting RNA complexes, we rationally designed the structure and detection scheme of piR‐651 probe, which was synthesized by modifying 13‐nm gold particles with high‐density Anchor‐Report DNA duplexes through the butanol dehydration method. …”
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An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode by Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu

“…Overall, HNC-1664 achieves broad-spectrum characteristics by favoring an alternative base pairing strategy to non-catalytically block RNA synthesis, providing a novel concept for the rational development of NA drugs.…”
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A Review of Agricultural Film Mapping: Current Status, Challenges, and Future Directions by Mengmeng Zhang, Jinwei Dong, Quansheng Ge, Hasituya, Pengyu Hao

“…The accurate and timely agricultural film maps are expected to support effective land management, rationalize human land use behavior, and inform policy formulation for environmental sustainability.…”
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…To fully utilize the potential of bpAbs for anti-HER2 drug development, it is crucial to consider formats that offer stability and high-yield production, along with a functional balance between the two epitopes. In this study, we rationally designed a bpAb, KJ015, that shares a common light chain with two Fab arms and exhibits functionally balanced high affinity for two HER2 non-overlapping epitopes. …”
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