Comprehensive Cellular Senescence Evaluation to Aid Targeted Therapies by Xiaolan Zhou, Xiaofeng Zhu, Weixu Wang, Jing Wang, Haimei Wen, Yuqi Zhao, Jiayu Zhang, Qiushi Xu, Zhaozhao Zhao, Ting Ni

“…Drug resistance to a single agent is common in cancer-targeted therapies, and rational drug combinations are a promising approach to overcome this challenge. …”
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A Bayesian active learning platform for scalable combination drug screens by Christopher Tosh, Mauricio Tec, Jessica B. White, Jeffrey F. Quinn, Glorymar Ibanez Sanchez, Paul Calder, Andrew L. Kung, Filemon S. Dela Cruz, Wesley Tansey

“…Further, the model identifies a panel of top combinations for Ewing sarcomas, which follow-up validation experiments confirm to be effective, including the rational and translatable top hit of PARP plus topoisomerase I inhibition. …”
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Promoting in-situ stability of hydroxide exchange membranes by thermally conductive network for durable water electrolysis by Wei Wang, Ruixiang Guo, Aodi Zheng, Xiaorui Jin, Xiongjie Jia, Zhiwei Ren, Yangkai Han, Lifeng Zhang, Yeming Zhai, Xiaofen Liu, Haoran Jiang, Yun Zhao, Kai-Ge Zhou, Meiling Wu, Zhongyi Jiang

“…This study manifests the significance of thermal conductivity of HEM on the durability of water electrolysis, which provides guidelines on the rational design of highly durable HEMs in practical operation conditions for water electrolysis, fuel cells, and beyond.…”
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Scale-free topology optimization for software-defined wireless sensor networks: A cyber-physical system by Ru Huang, Xiaoli Chu, Jie Zhang, Yu Hen Hu

“…The multiple-factor-driven virtual force field and network division–oriented particle swarm algorithm are introduced into the deployment strategy of super-node for the implementation in wireless sensor networks topology initialization, which help to rationally allocate heterogeneous network resources and balance the energy consumption in wireless sensor networks. …”
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Design of Negative Pressure Spiral Feeding Device for Tangential and Longitudinal Axial Intersection of Combine Harvester by Zhong Tang, Xiyao Li, Xinda Chen, Yang Chen

“…The airflow velocity distribution of the spiral feed head semicircular cross section and power consumption of the longitudinal axial spiral feeding head were used to verify the effectiveness and rationality of the negative pressure spiral feeding device. …”
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Research on Function Family of Large Bending Model Based on Mechanics for Cannula Flexible Needle by Yan-Jiang Zhao, Yan-Yi Pei, He Zhang, Yin Chen, Ji-Long Lu

“…The results showed that the mean errors were 0.98 mm and 1.02 mm, the maximum errors were 1.43 mm and 1.53 mm, and the root mean square errors were 0.45mm and 0.51mm, respectively for two cases of the stylet extension lengths, fulfilling the required accuracy for the ordinary clinical surgery, which proves the rationality and accuracy of the proposed method.…”
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Essential characteristics of law as a phenomenon of social reality by Lutskyi R., Coughlan V., Tabachyn V.

“…For the first time, the author systematizes and generalizes the levels of political and legal understanding of the concept of «rights as a phenomenon of social reality» through the prism of a rational correlation between the will of the State and its citizens, taking into account the realities of today. …”
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Effect of plasma beta on the nonlinear evolution of m/n = 2/1 double tearing mode in high Lundquist number regime by Dingzong Zhang, Zhaoqing Wu, Jun Ma, Wenfeng Guo, Yanqing Huang, Hongbo Liu

“…The results demonstrate that the impact of plasma beta on plasmoid dynamics varies significantly with the separation distance between rational surfaces. In the small separation regime ( $\Delta r = 0.1$ ), no plasmoids are observed, regardless of plasma beta and resistivity. …”
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Intelligent Screening of Prostate Cancer Individuals Using an Enzyme‐Assisted Multicolor Visualization Platform by Ruomei Teng, Ming Li, Zikang Chen, Jianli Lin, Yuhan Zhang, Hang Li, Zejun Yan, Dingyuan Zhang, Caiping Ding, Youju Huang

“…The concept of enzyme‐assisted multicolor sensing can be further expanded by modifying the type of immobilized enzymes, providing a valuable guideline for the rational design of multiple probes to measure specific biomarkers in biological samples.…”
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A multi-objective, multi-interpretable machine learning demonstration verified by domain knowledge for ductile thermoelectric materials by Xiangdong Wang, Yan Cao, Jialin Ji, Ye Sheng, Jiong Yang, Xuezhi Ke

“…Furthermore, domain knowledge helps to rationalize the two favorable features. The compounds with large EN(ab)A/B tend to have high band degeneracies, resulting in high zT. …”
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Ginsenoside Rg1 Improves Differentiation by Inhibiting Senescence of Human Bone Marrow Mesenchymal Stem Cell via GSK-3β and β-Catenin by Ziling Wang, Rong Jiang, Lu Wang, Xiongbin Chen, Yue Xiang, Linbo Chen, Minghe Xiao, Li Ling, Yaping Wang

“…To demonstrate the effect of Ginsenoside Rg1 on the differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Subsequently, a rational mechanism for the detection of Rg1 which affects mesenchymal stem cell differentiation was explored. …”
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An Investigation of the Enolization and Isomeric Products Distribution in the Water Promoted Aldol Reaction of Tropinone and Granatanone by Ryszard Lazny, Artur Ratkiewicz, Krzysztof Brzezinski, Aneta Nodzewska, Katarzyna Sidorowicz

“…The dependence of the anti/syn-diastereoselectivity on the amount of water used may be rationalized on the basis of change in the polarity of the reaction medium. …”
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Periodic solutions for a class of perturbed sixth-order autonomous differential equations by Chems Eddine Berrehail, Amar Makhlouf

“…,x(5)), where p and q are rational numbers different from 1, 0, −1 and p ≠ q, ε is a small enough parameter and F ∈ C2 is a nonlinear autonomous function. …”
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Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats by Chunling Zhou, Xiaoxin Li, Aiping He, Tianzhu Liu, Jinmiao Tian, Meihua Jiang, Lina Fang

“…VS-5584 is a small-molecular compound that showed equivalent activity against mTOR and all class I PI3K isoforms and demonstrated preclinical activity in diverse cancer cell lines and xenograft tumor model, and rational combination of VS-5584 and other target therapies achieved promising outcomes in oncology. …”
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Electron‐Lattice Synergistic Coordination for Boosting the Electro‐Optic Response of the Crystal by Jinfeng Han, Yuzhou Wang, Fei Liang, Kui Wu, Dazhi Lu, Deliang Cui, Haohai Yu, Huaijin Zhang

“…Here, an electron‐lattice synergistic coordination strategy is proposed for boosting the E‐O response, and with the langasite as the subject, a novel crystal La3Zr0.5Ga5Si0.5O14 (LZGS) is designed. By the rational introduction of the Zr4+ ion in the octahedral site, it is found that the E‐O response can be obviously improved attributed to the active 4d orbitals of the Zr4+ ion and the optical phonons of the flexible (ZrO6) unit. …”
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Performance of the Cold-Bending Channel-Angle Buckling-Restrained Brace under Cyclic Loading by Kun Wang, Junwu Xia, Xiaomiao Chen, Bo Xu, Xiangzhou Liang, Jian Wang

“…Finally, all the tested CCA-BRBs exhibited a stable energy absorption performance and verified the specimens’ construction was rational.…”
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Designing the trajectories of variant teaching of the basics of artificial intelligence in the school course of computer science taking into account the possibilities of project-re... by Sergey D. Karakozov, Nadezhda N. Samylkina

“…On the basis of the proposed components of the methodology of teaching artificial intelligence basics and data analysis, the possibilities of designing different learning trajectories in accordance with personal requests of participants of educational relations, as well as for the rational use of resources of the information educational environment of the organization in the implementation of basic educational programs of general education are shown. …”
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Hierarchical Clustering of Residential Appliances Considering the Characteristics of the Appliances by Shima Simsar, Mahmood Alborzi, Ali Rajabzadeh Ghatari, Ali Yazdian

“…Based on the results, it was found that the proposed clustering method can rationally classify different types of home appliances by selecting the appropriate characteristics since the appliances in a cluster are very similar to each other and can help users understand the operating conditions of the appliances.…”
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Tailoring IPM plans to fight a cloaked pest: helping smallholder farmers combat the sweetpotato weevil in sub-Saharan Africa by Chad A. Keyser, Frederick S. Walters, Haley Turner, Elka Armstrong, Jeff Davis, Brooke Bissinger, Brant Johnson, Agnes Alajo, Paul Musana, Joseph Odongo, Benard Yada, Milton A. Otema

“…In this paper we, (1) outline factors that contribute to SPW infestation; (2) review available strategies and ongoing research for control of SPW, including chemical pesticides, biological control (macro-organismal as well as microbial control), cultural practices, selective breeding, and biotechnology; and (3) discuss the potential for implementing an integrated pest management (IPM) approach that leverages a combination of techniques. We rationalize that a multifaceted strategy for SPW control will improve both the quantity and quality of sweetpotato production in Africa.…”
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Advancing the utilization of 2D materials for electrocatalytic seawater splitting by Shemsu Ligani Fereja, Andleeb Mehmood, Qianqian Ji, Waseem Raza, Ahmed Hussen, Jie Hu, Shuo Zhai, Xingke Cai

“…This review provides valuable insights for the rational design and development of cutting‐edge 2D material electrocatalysts for seawater‐electrolysis applications.…”
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