Strategies to Identify Recognition Signals and Targets of SUMOylation by Elisa Da Silva-Ferrada, Fernando Lopitz-Otsoa, Valérie Lang, Manuel S. Rodríguez, Rune Matthiesen

“…The strategies and analysis presented here should contribute to the understanding of SUMO-controlled functions and provide rational approach to identify biomarkers or choose possible targets for intervention in processes where SUMOylation plays a critical role.…”
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Emerging Spatiotemporal Dynamics in Multiterminal Neuromorphic Nanowire Networks Through Conductance Matrices and Voltage Maps by Davide Pilati, Fabio Michieletti, Alessandro Cultrera, Carlo Ricciardi, Gianluca Milano

“…This work allows a better understanding of the local nonlinear dynamics in NW networks and their impact on the information processing capabilities, providing new insights for a rational design of self‐organizing neuromorphic systems.…”
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A Cumulative Expansion Force-Finding Method for Suspension-Cable Truss Composite Structure by Lifan Huang, Bin Luo, Mingmin Ding, Chunshui Zhang, Yangjie Ruan

“…The results show that CEFM could find out the optimal cable force distribution of the suspension-cable truss composite structure, with a geometry shape of whole structure and a rational stress level of all the components.…”
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The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways by Chunxing Pan, Xiaoying Liu, Yating Zheng, Zejun Zhang, Yongliang Li, Biao Che, Guangrong Liu, Lanyue Zhang, Changzhi Dong, Haji Akber Aisa, Zhiyun Du, Zhengqiang Yuan

“…These data further look insights into the molecular mechanisms of melanogenesis suppression by glabridin, rationalizing the application of the natural compound for skin healthcare.…”
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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes by Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

“…By deciphering the molecular fingerprint of cells treated with therapies targeting translation we identify a rational approach to select broad-spectrum antivirals with potential to counteract future pandemic viruses.…”
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Shear Behaviors of the Intersurface between Rice Straw Rope and Dredger Fill Silt: Experimental and Mechanism Studies by Guizhong Xu, Ji Chen, Shenjie Shi, Angran Tian, Qiang Tang

“…The further development of land reclamation, port waterway, and wharf construction brings about proper treatments of dredger fill silt, while huge amounts of rice straw set aside in China argument rational disposal every year. Therefore, rice straw is bundled up as ropes, which represent as drainage body and reinforcement, to make eco-friendly treatment for dredger fill silt. …”
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Dynamic Analysis, Circuit Design, and Synchronization of a Novel 6D Memristive Four-Wing Hyperchaotic System with Multiple Coexisting Attractors by Fei Yu, Li Liu, Hui Shen, Zinan Zhang, Yuanyuan Huang, Changqiong Shi, Shuo Cai, Xianming Wu, Sichun Du, Qiuzhen Wan

“…The Routh–Hurwitz criterion is used to prove the rationality of the controller, and the feasibility and effectiveness of the proposed synchronization method are proved by numerical simulations.…”
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Graphitic Carbon Nitride for Photocatalytic Hydrogen Production from Water Splitting: Nano-Morphological Control and Electronic Band Tailoring by Yongbo Fan, Xinye Chang, Weijia Wang, Huiqing Fan

“…This review starts with the basic principle of photocatalysis and the development history, synthetic strategy, and structural properties of g-C₃N₄ materials, followed by the rational design and engineering of g-C₃N₄ from the perspectives of nano-morphological control and electronic band tailoring. …”
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Research on Fatigue Model of Semi-Rigid Base Asphalt Pavement before and after Polymer Grouting by Bei Zhang, Xu Zhang, Yanhui Zhong, Xiaolong Li, Meimei Hao, Xianwei Sang, Xiaoliang Wang, Jianyang Liu

“…With the increase in the number of fatigue test loads, the cumulative evolution trend of the fatigue damage is basically consistent with the results of the numerical simulation, which verifies the rationality of the numerical model. This research is relevant for providing a reference for extending the service life of expressways and improving the technical level of expressway maintenance.…”
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Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide by Sarah L. Newstead, Amanda J. Gates, M. Gillian Hartley, Caroline A. Rowland, E. Diane Williamson, Roman A. Lukaszewski

“…Understanding how F. tularensis interacts with host macrophages will help in the rational design of new and effective therapies.…”
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Optimization Model and Algorithm of Empty Pallets Dispatching under the Time-Space Network of Express Shipment by Kang Zhou, Shiwei He, Rui Song, Xiaole Guo, Kaiming Li

“…Finally, the validity and rationality of the optimization model are verified by a case study. …”
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Inclusion of levels of cotton expeller in the feeding of confined sheep: productive behavior, carcass characteristics and meat quality by Jorge Daniel Caballero Mascheroni, Guido Arnaldo Portillo, Javier Feliciano González Cabañas, Luis Alberto Alonzo Griffith, Tania Fariña Díaz, Nicolas Daniel Prieto Quevedo

“…The diets consisted of totally mixed rations, with a forage-concentrate ratio of 30:70 (dry matter basis). …”
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Structural optimization design of novel Senegal vertical axis wind turbine by Zheng LI, Long ZHAO, Jie ZHANG, Qilong XIE, Hexu SUN

“…Firstly, the curvature of the rotor blades was optimized using the Bessel curve function and modeled using the SOLIDWORKS software, resulting in four different curvature curves for the blades; Secondly, the parameters such as wind energy utilization, moment coefficient, and their pressure distribution and velocity distribution plots at different tip speed ratios were compared and analyzed using computational fluid dynamics (CFD) model, and their wake characteristics were also compared; Finally, an experimental platform was built to verify the rationality of the simulation. The results show that the optimized blade type effectively improves the wind energy utilization of the modified Senegal drag type vertical axis wind turbine, and the A4 type blade has a high wind energy utilization of 26.31%, which is about 36% higher than that of the A1 type wind turbine.The designed novel wind turbine structure has superior power generation performance, which provides some reference for program design in the field of vertical axis wind turbines.…”
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Developing novel Lin28 inhibitors by computer aided drug design by Victor M. Matias-Barrios, Mariia Radaeva, Graciella Rosellinny, Qiongqiong Jia, Ning Xie, Monica Villanueva, Hanadi Ibrahim, Jason Smith, Martin Gleave, Nada Lallous, Suzana K. Straus, Artem Cherkasov, Xuesen Dong

“…Results from nuclear magnetic resonance spectroscopy confirmed that Ln268 perturbs the conformation of the zinc knuckle domain of Lin28, validating the rational drug design by CADD. The inhibitory effects of Ln268 are dependent on Lin28 protein expression in cancer cells, highlighting limited off-target effects of Ln268. …”
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Site Saturation Mutagenesis Applications on Candida methylica Formate Dehydrogenase by Gülşah P. Özgün, Emel B. Ordu, H. Esra Tütüncü, Emrah Yelboğa, Richard B. Sessions, Nevin Gül Karagüler

“…In this work, site saturation mutagenesis (SSM) which is a combination of both rational design and directed evolution approaches is applied to alter the coenzyme specificity of NAD+-dependent cmFDH from NAD+ to NADP+ and increase its thermostability. …”
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Study on the Impact of Land Use and Climate Change on the Spatiotemporal Evolution of Vegetation Cover in Chongqing, China by Shuai Liang, Dandan Xu, Danni Luo, Anjing Xiao, Xinyue Yuan

“…The results of this study can provide a scientific basis for urban planning and ecological conservation, especially in formulating effective urban management and land management strategies to protect the ecological environment and rationally utilise land resources.…”
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PRELIMINARY RESULTS OF GEO-ARCHAEOLOGICAL RESEARCH OBTAINED DURING THE 3rd INTERNATIONAL EXPEDITION OF THE R/V “MARE NIGRUM” (01.06.2024 – 15.06.2024) by M.M. Ievlev, O.V. Chubenko, V.O. Iemelianov, N.O. Fedoronchuk

“…DOORS will raise public awareness and promote the rational use of the Black Sea environment, contribute to closer coordination between the next cycle of implementation of the MSFD (EU Marine Strategy Framework Directive) and the Bucharest Convention, and deepen public understanding of the value of ecosystem services in the Black Sea. …”
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Carbon emission effects of land use change in Nanchang, West of Central China Region by Shuai Fu, Bingxian Xu, Yuxin Peng, Ciyi Huangxiong, Xiuxiang Li

“…The adjustment and optimization of energy consumption structure and the improvement of human-land policies in Nanchang from the perspectives of optimizing land use layout and structure, rationally controlling population size, and advocating low-carbon lifestyle are conducive to the construction of ecological civilization and sustainable development of Nanchang.…”
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Seismic performance of bridge pier integrated by multiple steel pipes with directly-connected piles using soil-water coupled three-dimensional elasto-plastic finite element analysi... by Muhammad Mahmood Ul Hassan, Koichi Isobe, Yasumasa Soga, Yasuo Sawamura, Hiroki Sugiyama, Masatsugu Shinohara

“…A bridge pier integrated by multiple steel pipes with directly-connected piles was proposed as a way to design a rational foundation for bridge pier structures, and its feasibility was examined by comparing its seismic behaviour with that of a bridge pier with a conventional footing. …”
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Tuning electronic structure and carrier transport properties through crystal orientation control in two-dimensional Dion-Jacobson phase perovskites by Byunggeol Kim, Jeehong Park, Donghee Kang, Na Eun Jung, Kitae Kim, Hongsun Ryu, Joon Ik Jang, Soohyung Park, Yeonjin Yi

“…This work presents a rational strategy to control parallel and perpendicular crystal growth in C6N2H16PbI4 (4AMPPbI4)-based DJ phase perovskite thin films. …”
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