Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…Nevertheless, the possible synergy in combining these two therapeutic strategies primarily rely on the rational design of medical protocols (e.g., sequence and timing of agent administration; drug selectivity; compatibility of combined therapies i.e., adoptive T cell or agents, i.e., MEK inhibitor trametinib, PD-1 and PDL-1 blockers). …”
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Evaluation Method of Floor Heave Damage Degree and a Case Study in Zaoquan Coal Mine, China by Ai Chen, Qing Ma, Xuesheng Liu

“…The damage degree of floor heave can be divided into five types: light type, obvious type, severe type, destructive type, and extremely severe type. Finally, the rationality and accuracy of the method are verified by the measured value and evaluation value of No. 130203 roadway in the Zaoquan coal mine. …”
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Self-directed flourishing: a conceptual meta-framework for dealing with the challenges of 21st-century learning and education by Eri Mountbatten-O’Malley, Thomas Howard Morris

“…The authors achieve this through a conceptual and theoretical exploration of the social nature of human beings and learning in the context of readings of human nature, and moral and rational powers. Findings – It is proposed that education should be designed to empower learners to meet the demands of rapidly changing conditions. …”
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Current state and development of police law as a subsystem of administrative law by O. A. Zhydovtseva

“…In order for legal norms to have an effective impact on police-citizen relations, legislation must meet the criteria of rationality and reasonableness. They should not create any gaps or conflicts in the legislation, which additionally indicate the need to further develop police law, which should be a solid foundation for the activities of each police department.…”
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Application of Coupling Model of Xin'anjiang River Runoff and TANK Confluence in Southern Humid Area by QIU Wenyi, ZHU Yongjun, ZHAN Zhongyu

“…After comparison and analysis with the 12-year runoff results measured by the Tongshanyuan Hydrological Station, the inter-annual changes of runoff depth are consistent, and the error of runoff results is not more than 2%, so it is believed that the calculation results of the combined runoff analysis method are reasonable, which can not only meet the rationality of the results, but also repair the short board for the lack of hydrological data in the area. …”
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Covoiturage au Grand-Nokoué et plateformes numériques de mobilité partagée en Afrique de l'Ouest by Raynald Ballo

“…Data from an immersion in the field reveals three major factors: a more flexible relationship to time without a culture of rigorous planning, out of step with the rational logic of platforms; a deeply rooted community conception of travel based on social proximity, contrary to sharing with strangers; a sense of insecurity towards outsiders and a primacy of individual comfort, contrary to the spirit of carpooling. …”
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Cabezas, Mar. Ética y emoción. El papel de las emociones en la justificación de nuestros juicios morales. 2014. Plaza y Valdés. 396pp. by Nino Rosanía Maza

“… En 2001 apareció un artículo, del psicólogo Jonathan Haidt, de curioso título llamado: The emotional dog and its rational tail: A social intuitionist approach to moral judgment, donde se evidenciaba que, en algunas circunstancias, no nos llegamos a creer que algo es moralmente incorrecto razonando al respecto; más bien, tenemos una emoción y esta nos lleva a juzgar que es un error. …”
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Design and Motion Simulation of the Drive Mechanism of Oil-immersed Transformer Spherical Detection Robots by Zhou Jiajun, Wu Binghui, Ji Dongmei, Deng Yangtai

“…Then, the dynamic model of the drive mechanism is constructed, and the rationality of the eccentric moment drive mechanism of the single pendulum is analyzed and verified. …”
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Predicting Shear Capacity of FRP-Reinforced Concrete Beams without Stirrups by Artificial Neural Networks, Gene Expression Programming, and Regression Analysis by Ghazi Bahroz Jumaa, Ali Ramadhan Yousif

“…The ANNs model, and to a lower level the GEP model, showed the superiority in accuracy and efficiency, while the NLR model showed that it is simple, rational, and yet accurate. Additionally, the parametric study indicated that the ANNs model defines accurately the interaction of all parameters on shear capacity prediction and have a great ability to predict the actual response of each parameter in spite of its complexity and fluctuation nature.…”
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Enhancing Financial Decision-Making: Real Options Complementing the Net Present Value Technique in the Financial Services Sector by Ferina Marimuthu, Kyle Fitzgerald

“…The results suggest that when faced with hypothetical projects where initial NPV turns negative with the adoption of real options, decision-makers are more likely to make rational choices that optimize the outcome. Implications and Recommendations: Based on the findings, the adoption of a combined NPV and real options strategy for practitioners in the financial services sector is recommended in order to make more informed and flexible investment decisions, which would ultimately benefit their organizations and stakeholders. …”
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Legal and economic dilemmas of sustainable development in times of global crisis by Maciej Rudnicki

“…The starting point for the reflections were a range of issues bordering philosophy, morality, economy and law, regarding the rational management of natural resources and protection of the natural environment, as well as the regulation and forming of peoples’ attitudes and behaviours in relation to the natural environment, and the setting of legal boundaries for those behaviours and sanctions for crossing them. …”
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The Defects and Improvements of the Internal Control Audit in Chinese Universities with respect to the Probabilistic Hesitant Fuzzy Environment by Jingjuan Zhu, Ling Xu, Yunzhong Liu, Dawei Zhu, Liangliang Chen

“…The most critical factors influencing the quality of internal control audit in universities are, in order, the difficulty of rational use of the results of internal control audit by universities, the poor support of the leadership for internal control audit, and the insufficient professional knowledge and skills of internal auditors to conduct internal control audit. …”
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Potential of water sediments in construction materials: Current approaches and critical consideration of future challenges by Jan Fořt, Ayodele Afolayan, Václav Kočí, Lenka Scheinherrová, Jiří Jan, Jakub Borovec, Robert Černý

“…The provided summary of benefits, disadvantages, challenges, and future potential of freshwater dredged sediments (FDS) use can stimulate the rationalization of material flows, reduce the dependence on primary raw materials in the construction industry, and at the same time contribute to maintaining the functionality of water reservoirs.…”
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Structure-function analysis of carrier protein-dependent 2-sulfamoylacetyl transferase in the biosynthesis of altemicidin by Yuhao Zhu, Takahiro Mori, Masayuki Karasawa, Kohei Shirai, Wenjiao Cheng, Tohru Terada, Takayoshi Awakawa, Ikuro Abe

“…These findings facilitated rational engineering of the enzyme to expand the substrate range and to generate azaindane dinucleotide derivatives.…”
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Forecasting the Number of the Wounded after an Earthquake Disaster Based on the Continuous Interval Grey Discrete Verhulst Model by Jun Zhang, Tongyuan Wang, Jianpeng Chang, Yan Gou

“…At the same time, the rationality and validity of the model are verified by examples. …”
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Preserflo MicroShunt Implantation: A Narrative Review of Its Standalone Benefits vs. Combined Use with Phacoemulsification in Managing Open-Angle Glaucoma by Małgorzata Chilmonczyk, Kinga Gołaszewska, Emil Saeed, Joanna Konopińska

“…A combined procedure with phacoemulsification is related to an increased risk of fibrosis of the filtering bleb; however, it is a rational approach for patients with high intraocular pressure and clinically significant lens opacification. …”
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Exploring Logical Intuition in Base-Rate Problems Using the Instructional Manipulation Paradigm by Debiao Zhu, Ping Lu, Zhujing Hu, Jianyong Yang, Dandan Nie

“…The study provides additional evidence for human rationality.…”
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Approaches to Developing New Complex Meat Products with Preset Qualitiy by Alexei S. Miroshnik, Ivan F. Gorlov, Marina I. Slozhenkina

“…A profitable meat-processing business relies on the rational use of its resources, which, in its turn, depends on the constant improvement of product formulations and development of new ones. …”
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The appropriate nutrient conditions for methicillin-resistant Staphylococcus aureus and Candida albicans dual-species biofilm formation in vitro by Pavlína Vávrová, Ondřej Janďourek, Adéla Diepoltová, Petr Nachtigal, Klára Konečná

“…Our results allow the rational employment of nutrition conditions within methicillin-resistant Staphylococcus aureus and Candida albicans dual-species biofilm formation in vitro for preclinical research. …”
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Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses by Liping Liu, Jiayu Zhao, Zichao Huang, Yudi Xu, Hongyu Chen, Ruirui Qiao, Wantong Song, Zhaohui Tang, Thomas P. Davis, Xuesi Chen

“…This study demonstrates that a rational design of vaccine carriers for solving spatial transmission issues could greatly improve cancer vaccine efficiencies.…”
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