The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence by Goran B. Klintmalm, Björn Nashan

“…The mammalian target of rapamycin (mTOR) inhibitors with a mechanism of action that is different from other immunosuppressive agents has the potential to address some of these issues. …”
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Fructose-Induced Carbonyl/Oxidative Stress in S. cerevisiae: Involvement of TOR by Bohdana V. Valishkevych, Ruslana A. Vasylkovska, Liudmyla M. Lozinska, Halyna M. Semchyshyn

“…The TOR (target of rapamycin) signaling pathway first described in the budding yeast Saccharomyces cerevisiae is highly conserved in eukaryotes effector of cell growth, longevity, and stress response. …”
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Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases by Carmen Rodriguez-Cerdeira, Elena Sanchez-Blanco, Alberto Molares-Vila

“…We also reviewed new macrolides, like rapamycin, everolimus, and temsirolimus. In addition to the literature review, we report a novel class of nonantibiotic 14-member macrocycle with anti-inflammatory and immunomodulatory effects. …”
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mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression by Hao Wang, Jianwei Chen, Guangxu Bai, Wen Han, Ran Guo, Na Cui

“…The mammalian target of rapamycin (mTOR) is essential for regulating lymphocyte apoptosis; we hypothesized that it mediates CD4+ T cell apoptosis during ROS-related ERS. …”
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A Case of Uterine Lymphangioleiomyomatosis Complicated by Tuberous Sclerosis Complex by Kaori Yamada, Yukio Yamanishi, Junichi Aratake, Nanayo Sasagasako, Yoshihide Inayama, Rei Gou, Atsuko Kawamura, Megumi Yamanishi, Kenzo Kosaka

“…Here, we report an uncommon case of uterine LAM treated with everolimus, which is a mechanistic target of rapamycin (mTOR) inhibitor. A 42-year-old female patient (gravida 0) with a history of TSC presented with abdominal pain. …”
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Bevacizumab Demonstrates Prolonged Disease Stabilization in Patients with Heavily Pretreated Metastatic Renal Cell Carcinoma: A Case Series and Review of the Literature by Nicole M. Agostino, Rebecca Gingrich, Joseph J. Drabick

“…These include the immunotherapeutics, alfa-interferon, and interleukin-2, and agents that target the vascular endothelial growth factor receptor (VEGFR) via its tyrosine kinase, such as sorafenib, sunitinib, and pazopanib, or the mammalian target of rapamycin (mTOR), such as temsirolimus and everolimus. …”
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Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
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AMPK Activation Mediated by Hinokitiol Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells through Autophagy Flux by Ju-Hee Lee, Jae-Kyo Jeong, Sang-Youel Park

“…The treatment of hinokitiol-treated MSCs with the autophagy activator, rapamycin, restored the hinokitiol-induced decrease in the adipocyte differentiation of MSCs. …”
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A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress by Maja Bencun, Laura Spreyer, Etienne Boileau, Jessica Eschenbach, Norbert Frey, Christoph Dieterich, Mirko Völkers

“…As a critical regulator of cell growth, protein synthesis and autophagy mechanistic target of rapamycin complex 1 (mTORC1) is an important mediator of pathological cardiac remodeling. …”
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Exogenous dopamine application ameliorates chilling injury and preserves quality of kiwifruit during cold storage by Morteza Soleimani Aghdam, Zeinab Asle-Mohammadi, Amin Ebrahimi, Farhang Razavi

“…By 150 µM dopamine application, higher SUMO E3 ligase (SIZ1) and target of rapamycin (TOR) genes expression accompanied by lower poly(ADP-Ribose) polymerase 1 (PARP1) and sucrose non-fermenting 1-related kinase 1 (SnRK1) genes expression was associated with higher salicylic acid, ATP, NADPH and proline accumulation in kiwifruits during storage at 1 °C for 120 days. …”
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Clinicopathological features of two ultra-rare cases of malignant perivascular epithelioid cell tumors (PEComas) involving the uterus with recent updates by Bharat Rekhi, Santosh Menon

“…In view of multiple tumor deposits, the second patient was induced with a mammalian target of rapamycin (m-TOR) inhibitor (everolimus) but unfortunately died of the disease. …”
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The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation by Jia-lu Zhang, Xue-fei Wang, Jia-lin Li, Cong Duan, Jiu-feng Wang

“…Moreover, 25HC inhibited TFEB (transcription factor-EB) expression, blocked its translocation into the nucleus and reversed Mechanistic Target of Rapamycin Complex 1 (mTORC1) activity, which in turn hindered lipophagy and PDCoV replication. …”
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Cytomegalovirus Infection in Patient with Clear Cell Renal Cell Carcinoma by Ikhwan Rinaldi, Abdul Muthalib, Januar Widodo Sutandar, Hendro Adi Kuncoro, Bambang Irawan Harsono, Nelly Susanto, Tjondro Setiawan, Kevin Winston, Idham Rafly Dewantara, Ihya Fakhrurizal Amin, Yuli Maulidiya Shufiyani

“…In this case report, we present the case of a 61-year-old man with clear cell renal cell carcinoma who underwent targeted therapy with the receptor tyrosine kinase (RTK) inhibitor lenvatinib and the mammalian target of rapamycin (mTOR) inhibitor everolimus. The patient was hospitalized for 26 days and admitted to the intensive care unit (ICU) due to shortness of breath, decreased oxygen saturation, and irregular breathing. …”
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Porphyra haitanensis polysaccharide (PH) attenuates cell hyperplasia via remodeling the cross-talk between Hippo/YAP and mTOR pathways by Chong Wang, Wanglei Lin, Zhihua Sun, Yiming Sun, Yanbo Wang, Linglin Fu

“…Moreover, both the inhibition of Hippo by YAP1 knock-down and the suppression of mTOR by rapamycin impaired PH function. These results indicated that PH attenuated hyperplasia activity by remodeling the cross-talk between Hippo/YAP and mTOR pathways, which revealed potential targets and approaches for treating hyperplasia-related diseases and provided novel ways to utilize P. haitanensis as well as other related functional foods.…”
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The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets by Peng Wang, Qian Zhang, Liang Tan, Yanan Xu, Xubiao Xie, Yong Zhao

“…The mechanistic target of rapamycin (mTOR) is a conserved intracellular serine/threonine kinase which belongs to the phosphoinositide 3-kinase- (PI3K-) related kinase family. …”
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Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…Sestrin2 leads to AMP-activated protein kinase- (AMPK-) and GTPase-activating protein activity toward Rags (GATOR) 1-mediated inhibition of mammalian target of rapamycin complex 1 (mTORC1), thereby enhancing autophagy. …”
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Nitroxyl protects H9C2 cells from H/R-induced damage and inhibits autophagy via PI3K/Akt/mTOR pathway. by Li Li, Zhixin Wang, Yaxuan Lyu, Yanqing Guo

“…Further experiments demonstrated that the effects of HNO were mediated through upregulation of PI3K/Akt/mTOR pathway. Rapamycin reversed the inhibition of HNO on H/R-induced autophagy in H9C2 cells, which abrogated the protective effect of HNO.…”
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The molecular view of mechanical stress of brain cells, local translation, and neurodegenerative diseases by T. M. Khlebodarova

“…The roles of the mTOR (mammalian target of rapamycin) signaling pathway; the RNA-binding FMRP protein; the CYFIP1 protein, interacting with FMRP; the family of small GTPases; and the WAVE regulatory complex in the regulation of translation initiation and actin cytoskeleton rearrangements in dendritic spines of the activated synapse are discussed. …”
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Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis by Min Wei, Qiaoji Jiang, Shuang Bian, Pengzhao Chang, Bangbang Li, Changzhou Shi, Yangang Zhu, Yanchen Wang, Pingfu Hou, Jingjing Li

“…Thus, in this study, a H2O2-NIR dual-mode nanomotor, Gd-doped mesoporous carbon nanoparticles/Pt with rapamycin (RAPA) loading and AntiCD36 modification (Gd-MCNs/Pt-RAPA-AC) was constructed. …”
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Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria by Jinyun Chen, Qian Wang, Xuebing Feng, Zhuoya Zhang, Linyu Geng, Ting Xu, Dandan Wang, Lingyun Sun

“…Moreover, activation of autophagy with rapamycin increased T cell apoptosis, whereas inhibition of autophagy with 3-MA decreased T cell apoptosis. …”
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