Orthoplastic surgery research: Three decades of growth and future directions by Alexander F. Dagi, Michael B. Amrami, Nikhil A. Gangoli, Dylan K. Kim, Jarrod T. Bogue

“…While meta-analyses support the clinical benefits of orthoplastic management for complex fractures, showing reduced surgical interventions and infection rates, the evidence base relies predominantly on retrospective studies, with no randomized controlled trials identified. Key opportunities to strengthen the field include conducting prospective studies, expanding research beyond lower extremity trauma to areas such as upper extremity reconstruction, oncologic applications, and paediatric care, addressing healthcare access disparities, evaluating cost-effectiveness across different healthcare systems, and developing standardized guidelines beyond the UK.…”
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Comparative safety profile of tyrosine kinase inhibitors in NSCLC: a network meta-analysis of hypertension and thrombotic risks by Mingming Tan, Chenwei Pu, Zhenzhen Wang, Chengwei Jin

“…BackgroundThis study examines the risks of hypertension and thrombotic events in NSCLC patients treated with Tyrosine Kinase Inhibitors (TKIs).ObjectiveTo compare the safety profiles of TKIs used in NSCLC treatment, focusing on hypertension and thrombotic risks.MethodsA comprehensive search identified randomized controlled trials evaluating the effects of TKIs in NSCLC patients. …”
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Pathological Role of Tonsillar B Cells in IgA Nephropathy by Yusuke Suzuki, Hitoshi Suzuki, Junichiro Nakata, Daisuke Sato, Tadahiro Kajiyama, Tomonari Watanabe, Yasuhiko Tomino

“…The therapeutic efficacy of tonsillectomy or tonsillectomy in combination with steroid pulse therapy for IgAN has been discussed. Although randomized control trials for these therapies are ongoing in Japan, the scientific rationale for these therapies remains obscure. …”
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A Meta-Analysis of Adalimumab for Fistula in Crohn’s Disease by Yin-mei Fu, Ming Chen, Ai-jun Liao

“…A computerized search of electronic databases, including PubMed, Web of Science, Embase, Google scholar, and the Cochrane Library from 2000 to October 2016, was performed. Randomized controlled trials (rcts) or nonrandomized controlled trials (n-rcts) were included in this article to evaluate the role of ADA in the management of fistula in CD. …”
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Physical Activity Targeted at Maximal Lipid Oxidation: A Meta-Analysis by A. J. Romain, M. Carayol, M. Desplan, C. Fedou, G. Ninot, J. Mercier, A. Avignon, J. F. Brun

“…Concerning weight loss, in the intervention versus control analysis, five studies with 185 participants were included with a significant effect size favors exercise (P=0.02) without significant heterogeneity (I2=0.0%, P=0.83). Further randomized controlled trials for comparing it with other exercise protocols and defining its dose effectiveness on large samples are needed.…”
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The intricate interplay between dietary habits and cognitive function: insights from the gut-brain axis by Ruyi Zhang, Ruyi Zhang, Meiya Zhang, Pengyu Wang

“…Future research must adopt a multidisciplinary approach, incorporating long-term, large-scale, multicenter randomized controlled trials to assess the enduring impacts of various dietary patterns on cognitive function, considering socioeconomic and cultural factors. …”
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Assessment of the Impact of Different Types and Intensities of Physical Exercise on the Quality of Life of Patients with Alzheimer’s Disease: A Literature Review by Katarzyna Barabasz, Paulina Więcławek, Piotr Juda, Patrycja Kłaptocz, Katarzyna Łukoś-Karcz, Dominik Bańkowski, Gabriela Pabian, Karol Musiał, Kamil Bielak

“…The review included 42 studies, including randomized controlled trials and meta-analyses.   Results Moderate-intensity aerobic and combined exercises improve memory and executive functions, while resistance training increases hippocampal volume, supporting spatial memory. …”
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Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome by Min Cheol Chang, Jin-Sung Park, Jong-moon Hwang, Donghwi Park

“…In the results, five articles (4 randomized controlled trials and 1 prospective observational study) were included in this review. …”
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Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable by Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer

“…Pragmatic and registry-based clinical trials offer viable alternatives to traditional randomized controlled trials, facilitating real-world applicability. …”
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The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review by Olga Theou, Liza Stathokostas, Kaitlyn P. Roland, Jennifer M. Jakobi, Christopher Patterson, Anthony A. Vandervoort, Gareth R. Jones

“…Eight electronic databases were searched for randomized controlled trials that identified their participants as “frail” either in the title, abstract, and/or text and included exercise as an independent component of the intervention. …”
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Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis by Tingting Bao, Liuting Zeng, Kailin Yang, Yuehua Li, Fengying Ren, Yulong Zhang, Ziren Gao

“…In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and postmenopausal women with osteopenia. …”
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Lipedema: Clinical Features, Diagnosis, and Management by Hatan Hisham Mortada, Abdulmalek W. Alhithlool, Nouf Z. AlBattal, Rashika K. Shetty, Ghaleb A. AL-Mekhlafi, Joon Pio Hong, Feras Alshomer

“…Further high-quality randomized controlled trials are urgently needed to continue advancing our understanding of this often neglected disease and exploring optimal medical and surgical treatment regimens tailored specifically for lipedema patients. …”
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Health Implications of Anabolic-Androgenic Steroids: Usage, Risks, and Treatment Approaches - The Literature Review by Krzysztof Jodłowski, Ewa Dubniewicz, Paula Majewska, Alicja Staszek, Wiktoria Łoskot, Jan Szwech, Mateusz Matczak, Karol Jasiński, Aleksandra Broda, Kacper Hoksa

“…Despite the growing concern over AAS misuse, current research is limited by methodological constraints, including a lack of randomized controlled trials and long-term studies. The review explores the health implications of AAS use, highlighting the importance of an interdisciplinary approach to managing AAS-related health issues, emphasizing harm reduction, pharmacological interventions, and fertility preservation techniques. …”
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Inspiratory Muscle Rehabilitation Training in Pediatrics: What Is the Evidence? by Dharini M. Bhammar, Harrison N. Jones, Jason E. Lang

“…There is a need to test and refine different IMRT protocols, conduct larger randomized controlled trials, and include patient-centered clinical outcomes to help improve the evidence base and support the use of IMRT in patient care.…”
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Viloxazine, a Non-stimulant Norepinephrine Reuptake Inhibitor, for the Treatment of Attention Deficit Hyperactivity Disorder: A 3 Year Update by Hannah W Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye, Alan D. Kaye

“…Phase 2 and 3 randomized control trials have demonstrated significant efficacy of viloxazine in improving ADHD symptoms versus placebo. …”
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Food science and COVID-19 by Klaus W. Lange

“…Rigorous research assessing the efficacy of food compounds in counteracting infections would require long-term randomized controlled trials in large samples. While no foods, single nutrients or dietary supplements are capable of preventing infection with COVID-19, a balanced diet containing sufficient amounts of macronutrients and diverse micronutrients is a prerequisite of an optimally functioning immune system. …”
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Bioartificial Liver Support by Vincent G Bain, Jose Luis Montero, Manuel de la Mata

“…Large multicentre, randomized, controlled trials are ongoing following several pilot studies. …”
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Review of Prevention and Management Strategies for Pressure Sores and Ulcers in Immobilized Orthopedic Patients by Ramya Mathew, Asha Cynthia D'sa, Nishitha Marina Machado, Chaithra Nayak

“…We reviewed seventeen research articles including case studies cohort studies randomized controlled trials and systematic reviews. The reviewed studies underscore several crucial elements in preventing and managing pressure ulcers in immobilized orthopedic patients including structured education and training care bundles evidence-based guidelines innovative interventions managing risk factors nursing care comprehensive skin care a positive attitude and a proactive approach. …”
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Tea in cardiovascular health and disease: a critical appraisal of the evidence by Klaus W. Lange

“…ABSTRACT: The findings of various epidemiological studies, interventions using randomized controlled trials and mechanistic experiments have suggested a protective role of tea and its bioactive components in cardiovascular health. …”
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Leadless Pacing: Current Status and Ongoing Developments by Richard G. Trohman

“…In order to clarify the role(s) of leadless pacing, this narrative review was undertaken by searching MEDLINE to identify peer-reviewed clinical trials, randomized controlled trials, meta-analyses, and review articles, as well as other clinically relevant reports and studies. …”
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