A comprehensive review of urinary tract fistulas: the evolution of etiologies, surgical techniques, and contemporary outcomes by Noah Nigro, Gary Shahinyan, Shujian Lin, Rohan G. Bhalla, Brian J. Flynn

“…The study concludes with advocacy for more widespread access to the RAL platform as well as more research, including randomized controlled trials, to further refine the body of evidence and promote patient outcomes.…”
Get full text

Treatment of Generalized Anxiety Disorder with Gabapentin by Matej Markota, Robert J. Morgan

“…However, there are no randomized controlled trials on the effectiveness of this medication in generalized anxiety disorder (GAD), and there are only a few case reports. …”
Get full text

Renal Replacement Therapy in the Critical Care Setting by Adeel Rafi Ahmed, Ayanfeoluwa Obilana, David Lappin

“…Recently published randomized control trials (RCTs) have further questioned our understanding of RRT in critical care. …”
Get full text

Failure of Recombinant Activated Factor VII in Treatment of Diffuse Alveolar Hemorrhage due to Cryoglobulinemic Vasculitis by Dania Khoulani, Bharat Rao, Ammar Khanshour, Philip Kuriakose, Lenar Yessayan

“…It is increasingly being used in life-threatening hemorrhage in a variety of other settings in which conventional therapy is unsuccessful. Randomized controlled trials of rFVIIa in DAH are lacking. However, several case reports have described a complete or sustained control of DAH using rFVIIa after patients failed to respond to medical treatment. …”
Get full text

Exploring cerebellar transcranial magnetic stimulation in post-stroke limb dysfunction rehabilitation: a narrative review by Zhan Wang, Likai Wang, Likai Wang, Fei Gao, Yongli Dai, Chunqiao Liu, Jingyi Wu, Mengchun Wang, Qinjie Yan, Yaning Chen, Chengbin Wang, Litong Wang

“…It synthesizes findings from randomized controlled trials and case studies, examining the efficacy, safety, and underlying mechanisms of cerebellar TMS. …”
Get full text

Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19 by Aliede E. in ‘t Veld, Manon A. A. Jansen, Luuk C. A. Ciere, Matthijs Moerland

“…This is supported by the initial outcomes of the well-designed randomized controlled trials: so far, evidence for a beneficial effect of HCQ treatment for COVID-19 is weak and conflicting.…”
Get full text

Glutamine Supplementation in Sick Children: Is It Beneficial? by Elise Mok, Régis Hankard

“…Further mechanistic data is needed along with large randomized controlled trials in select populations of sick children, who may eventually benefit from supplemental Gln.…”
Get full text

Eclecticism in child welfare by Terje Halvorsen

“…Several researchers then advocated a clean-up campaign where one through randomized controlled trials should decide which theories are true and which methods work. …”
Get full text

Repair of Posterior Vaginal Wall Defect Using Biologic Graft for Stage III-POP-Q Pelvic Organ Prolapse in a Patient with History of a J-Pouch by Ali Azadi, Stephanie Casey, Paravasthu Ramanujam, Darya Tehranchi, Donald Ostergard

“…In traditional posterior colporrhaphy, randomized controlled trials have not shown any benefit of graft augmentation (Maher, 2016). …”
Get full text

Combining transcranial direct current stimulation and robotic-assisted training to address upper extremity deficits in acute disseminated encephalomyelitis: a case report by Maureen Ahiatsi, Matthieu Vincenot, Christian Bocti, Guillaume Léonard, Marie-Hélène Milot

“…Further large-scale randomized controlled trials are needed to confirm these findings and rigorously assess the efficacy of this approach in acute disseminated encephalomyelitis individuals. …”
Get full text

An Overview of the Impact of Statin Therapy on Cardiac Incident Risk by Urszula Świrk, Aleksandra Paprocka, Karolina Kalinowska, Paulina Fijałek, Jan Karczmarz, Marika Gutowska, Agnieszka Kosińska, Wiktoria Belcarz, Joanna Orzechowska, Michał Orzechowski

“…Evidence from large-scale randomized controlled trials and meta-analyses consistently demonstrates that statins significantly reduce the incidence of major cardiovascular events by lowering low-density lipoprotein (LDL) cholesterol levels and exerting pleiotropic effects like improving endothelial function and stabilizing atherosclerotic plaques. …”
Get full text

Application of oral nutritional supplements to control body weight loss in postoperative patients suffering from solid tumors: a systematic review and meta-analysis by Ying Liu, Zhen Wu, Tingting Shao, Wanzhen Zheng, Jing Huang

“…Data from eligible studies were extracted, and pooled mean differences (MD) along with their 95% confidence intervals (CIs) for BWL were computed.ResultsA total of 12 randomized controlled trials (RCTs) with 2,268 participants were finally included. …”
Get full text

Is Exploration of Alternate Immune Pathways Needed in Hidradenitis Suppurativa? A Case of Atopic Dermatitis and Concurrent Hidradenitis Suppurativa Responding to Dupilumab by Sean McCormack, Noor Tazudeen, Benjamin C. Garden

“…HS has been effectively treated with biologic medications; however, many such biologics lack large randomized controlled trials. Only one such biologic, adalimumab, has been approved by the US Food and Drug Administration (FDA) for the treatment of HS. …”
Get full text

Effects Of Hormonal Supplements In Women with Poor Ovarian Response Undergoing Assisted Reproductive Technology by Silan Melis Bozan, Gurkan Bozdag

“…However, there is a need to support the available data with further randomized controlled trials seeking for live birth rate as the primary outcome. …”
Get full text

Motion – Cyclo-oxygenase-2 Selective Nonsteroidal Anti-Inflammatory Drugs are as Safe as Placebo for the Stomach: Arguments Against the Motion by Andreas Maetzel

“…Selective COX-2 inhibitors are less likely to damage the upper gastrointestinal tract, as has been shown by large, randomized, controlled trials. Specifically, the newer agents are superior to ibuprofen and naproxen in this regard, but celecoxib and diclofenac were not significantly different in patients who were not also taking low-dose acetylsalicylic acid. …”
Get full text

Selective Decontamination of the Digestive Tract Reduces Pneumonia and Mortality by Lenneke E. M. Haas, Marcus J. Schultz

“…Selective decontamination of the digestive tract (SDD) has been subject of numerous randomized controlled trials in critically ill patients. Almost all clinical trials showed SDD to prevent pneumonia. …”
Get full text

Sports and Bone Health: The Impact of Physical Activity on Bone Mineral Density by Larysa Bielecka

“…Materials and Methods A review of randomized controlled trials (RCTs) published between 2022 and 2024 was conducted to evaluate the effects of physical activity on bone mineral density. …”
Get full text

The Pharmacotherapy of Chronic Pain: A Review by Mary E Lynch, C Peter N Watson

“…The search strategy included randomized, controlled trials, and where available, systematic reviews and meta-analyses. …”
Get full text

The Role of Acromioplasty for Management of Rotator Cuff Problems: Where Is the Evidence? by Lewis L. Shi, T. Bradley Edwards

“…Recently, however, numerous high-quality prospective randomized controlled trials have been published examining the role of acromioplasty. …”
Get full text

Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease by Gerson Suarez-Cedeno, Jessika Suescun, Mya C. Schiess

“…Deep Brain Stimulation (DBS) was approved by the FDA in 2002 as neuromodulation therapy for advanced Parkinson’s disease, prompting several randomized controlled trials that confirmed its safety and effectiveness. …”
Get full text