Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol by Carolina Freitas Alves Amaral-Moreira, Daiane Sofia Morais Paulino, Belmiro G. Pereira, Patricia Moretti Rehder, Fernanda G. Surita

“…Methods We designed an open randomized controlled trial comparing two treatments for pregnant women with type II diabetes mellitus (DM) and gestational diabetes (DMG): the metformin group (intervention) and the insulin group (as a routine service). …”
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Metabolic and Hepatic Effects of Energy-Reduced Anti-Inflammatory Diet in Younger Adults with Obesity by Gordana Kenđel Jovanović, Ines Mrakovcic-Sutic, Sandra Pavičić Žeželj, Indira Benjak Horvat, Lucia Šuša, Dario Rahelić, Sanja Klobučar Majanović

“…Methods. A two-arm randomized controlled trial surveyed 81 participants’ (mean age, 43 years) anthropometric and body composition changes. …”
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The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial by Marloes P. van der Aa, Vera Hoving, Ewoudt M. W. van de Garde, Antonius de Boer, Catherijne A. J. Knibbe, Marja M. J. van der Vorst

“…In a recent randomized controlled trial (RCT) in obese adolescents, 18 month-treatment with metformin versus placebo was reported to lead to stabilisation of the BMI. …”
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Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis by Luping Sun, Zhidan Huang

“…A total of 14 randomized controlled trials and 1464 AKP patients were included in the study, with follow-up duration of 1-12 months. …”
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Boosting knowledge, attitudes, and practices: An experimental controlled study evaluating the effectiveness of m-health training on antimicrobial resistance for hemodialysis nurses by Hossam Alhawatmeh, Mohammed Aljarrah, Issa M Hweidi, Nezam Al-Nsair, Mohammad S Alyahya, Sawsan Abuhammad

“…Design: A parallel group randomized controlled trial. Methods: A convenience sample of 64 nurses was cluster-randomized into either an m-health group ( n = 32) or a control group ( n = 32). …”
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Rationale and design of a randomized clinical trial of integrated eHealth for PrEP and medications for opioid use disorders for women in the criminal legal system. The Athena study by Jaimie P. Meyer, Stacey Brunson, Carolina R. Price, Morgan Mulrain, Julie Nguyen, Frederick L. Altice, Tassos C. Kyriakides, Karen Cropsey, Ellen Eaton

“…In a two parallel-arm randomized controlled trial, we are assessing an innovative eHealth delivery model that integrates PrEP with MOUD and is tailored to meet the specific needs of women involved in the criminal legal system. …”
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Enhancing stone expulsion: The efficacy of combined medical therapy with tamsulosin and dexamethasone in renal colic patients by Reza Kazemi, Mohammad Shahrashoub, Amir Javid, Narjes Saberi, Pouria Ghasemi, Saina Paymannejad

“…Materials and Methods: This prospective, double-blind, randomized controlled trial with 1:1 balanced randomization was conducted from September 2022 to March 2023 at Al-Zahra Hospital, a tertiary care facility affiliated with Isfahan University of Medical Sciences. …”
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Effects of a synthetic analog of the bovine appeasing pheromone on the overall welfare of dairy calves from birth through weaning by J. Garcia-Alvarez, E. Teruel, A. Cozzi, E. Harris, S.M. Rutter, A. Beaver

“…The main objective of this study was to determine if the use of the bovine appeasing pheromone (BAP) would improve the welfare of dairy calves; therefore, in this randomized controlled trial, 72 Holstein Friesian dairy calves were housed in individual hutches after birth and were randomly allocated to receive BAP or a placebo once every 2 wk from birth through weaning. …”
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Can the Onset of Type 2 Diabetes Be Delayed by a Group-Based Lifestyle Intervention in Women with Prediabetes following Gestational Diabetes Mellitus (GDM)? Findings from a Randomi... by Angela O’Dea, Marie Tierney, Brian E. McGuire, John Newell, Liam G. Glynn, Irene Gibson, Eoin Noctor, Andrii Danyliv, Susan B. Connolly, Fidelma P. Dunne

“…A two-group, mixed methods randomized controlled trial in which 50 women with a history of GDM and abnormal glucose tolerance postpartum were randomly assigned to intervention (n=24) or wait control (n=26) and postintervention qualitative interviews with participants. …”
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Comparing simple and functional jejunal interposition with preserved duodenal passage after total gastrectomy by Xue-Lu Zhou, Yan-Qing Deng, Pei-Jie Zhang, Hai Huang, Huan-Bin Zhang, Hong-Shuai Li, You-Hua Wang, Jian-Hua Luo

“…Objective: This prospective randomized controlled trial aimed to compare the effectiveness of functional jejunal interposition (FJI) and simple jejunal interposition (SJI) as reconstruction methods following total gastrectomy for gastric cancer. …”
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Composite Primary Outcomes Reported in Studies of Critical Care: A Scoping Review by Prashanti Marella, MD, Sansuka De Silva, Antony G. Attokaran, Kevin B. Laupland, PhD, Lars Eriksson, BA, Mahesh Ramanan, MMed

“…All studies (both non-randomized controlled trial [RCT] and RCT) conducted in ICUs treating adult patients (18 yr old or older) that described CPOs and their definitions, were included for mapping, reporting, and analyzing CPOs without any restrictions. …”
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High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis by Fouad Aoun, Ksenija Limani, Alexandre Peltier, Quentin Marcelis, Marc Zanaty, Alexandre Chamoun, Marc Vanden Bossche, Thierry Roumeguère, Roland van Velthoven

“…Nonetheless, a randomized controlled trial is needed to confirm these results.…”
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Adapting self-measured blood pressure monitoring to reduce health disparities (ASPIRE): a pilot hybrid effectiveness‑implementation study protocol by Rasha Khatib, Nicole Glowacki, Iridian Guzman, Maureen Shields, Joseph Chase, Melanie Gordon

“…Methods This pilot hybrid effectiveness-implementation randomized controlled trial (RCT) will be conducted at a primary care clinic in South Side Chicago, serving a diverse patient population. …”
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Corneal Topographic Changes Due to Pediatric Epiblepharon Surgery by Shindo J, Matsumura N, Nakamura J, Asano M, Ohno T, Mizuki N

“…Jun Shindo,1,2 Nozomi Matsumura,1 Jutaro Nakamura,2 Mizuki Asano,1 Tomoko Ohno,1 Nobuhisa Mizuki2 1Department of Ophthalmology, Kanagawa Children’s Medical Center, Yokohama, Kanagawa, 232-8555, Japan; 2Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 236-0004, JapanCorrespondence: Jun Shindo, Department of Ophthalmology, Kanagawa Children’s Medical Center, Mutsukawa, Yokohama, Kanagawa, 232-8555, Japan, Tel +81 45 711 2351, Fax +81 45 721 3324, Email junjunon.nike.6228@gmail.comPurpose: This study aimed to investigate changes in corneal morphology following pediatric lower-lid epiblepharon surgery using a topographic modeling system 5 (TMS-5®).Patients and Methods: A randomized controlled trial compared two surgical interventions for pediatric epiblepharon: incisional (modified Hotz procedure with lid margin splitting) and nonincisional. …”
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Impact of Scleroderma‐Associated Autoantibodies on Clinical Outcome Assessments: Post Hoc Analysis From a Randomised, Double‐blind, Placebo‐controlled, Phase 3 Trial of Tocilizumab... by Basmah Al Dulaijan, Suiyuan Huang, Celia J. F. Lin, Christopher P. Denton, Dinesh Khanna

“…Our objective was to assess the influence of baseline SSc‐Abs on the trajectories of the clinical outcome assessments (COAs) in a phase III randomized controlled trial. Methods We used data on both the groups who received placebo (Pbo) and tocilizumab from the focuSSced trial. …”
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Knowledge, practice, and information sources regarding infectious diseases among Chinese children and adolescents: a National-Level cross-sectional study by Yuan Zeng, Feifei Li, Wei Liang, Yinyue Liu, Zhiyong Zou, Julien S. Baker, Yanhui Dong, Jun Ma, Jie Hu, Yide Yang, Bin Dong

“…Methods This study used data collected from the baseline survey of a China national multi-centered cluster-randomized controlled trial in 2013. A total of 30,287 children completed a questionnaire package that included measures for knowledge, preventive practice and information sources related to infectious diseases. …”
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Safety and efficacy of oral cancer vaccine B440 in patients with PD-1/PD-L1 inhibitor-resistant advanced urothelial cancer: a study protocol for a phase 1 multicenter, open-label,... by Junya Furukawa, Yasumasa Kakei, Sae Murakami, Hiroshi Kita, Hideto Ueki, Takuto Hara, Jun Teishima, Nobuyuki Hinata, Hideaki Miyake, Masato Fujisawa, Toshiro Shirakawa

“…Discussion If this trial shows B440 to be safe and effective, it may lead to a late phase randomized controlled trial in advanced urothelial cancer. Ultimately, we hope to provide a new treatment option for such patients. …”
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Effect of Weight-Loss Diet Combined with Taurine Supplementation on Fasting Levels of Fibroblast Growth Factors19, 21, and 𝛃-klothoCo-Receptor in Obese Women: A Randomized Clinical... by Maryam Asadi, Fatemeh Haidari, Hossein Bavi Behbahani, Maryam J Chitsazi, Javad Mohammadi-asl, Kambiz Ahmadi-Angali

“…This study is the first randomized controlled trial to assess the effectiveness of a Tau supplement in combination with a weight loss intervention on fibroblast growth factors (FGF) 19, 21, and β-Klotho co-receptor in obese women. …”
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Outcomes of a pilot randomized clinical trial testing brief interventions to increase HIV pre-exposure prophylaxis uptake among rural people who inject drugs attending syringe serv... by Hilary L. Surratt, Sarah Brown, Abby L. Burton, Will Cranford, Laura C. Fanucchi, Christie Green, Stephanie M. Mersch, Rebecca Rains, Philip M. Westgate

“…Design: Parallel group randomized controlled trial. Methods: Eighty participants were enrolled from two rural SSP locations in southeastern Kentucky. …”
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Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponso... by Jonathan E Elliott, Jessica S Brewer, Allison T Keil, Brittany R Ligman, Mohini D Bryant-Ekstrand, Alisha A McBride, Katherine Powers, Savanah J Sicard, Elizabeth W Twamley, Maya E O'Neil, Andrea D Hildebrand, Thuan Nguyen, Benjamin J Morasco, Jessica M Gill, Bradley A Dengler, Miranda M Lim

“…The present study, LION (light vs ion therapy) extends this preliminary work as a fully powered, sham-controlled, participant-masked randomized controlled trial (NCT03968874), implemented as fully remote within the VA (target n = 120 complete). …”
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