Effectiveness of a harmonica-integrated, tele-supervised home-based pulmonary rehabilitation program on lung function and comprehensive health outcomes in patients with chronic obstructive pulmonary disease: a randomized controlled trial protocol by Qiuxuan Zeng, Xiaohong Lin, Wenli Chen, Daniel Yee Tak Fong, Junxin Li, Jiaying Li, Jiaying Li

“…This protocol outlines a randomized controlled trial (RCT) to evaluate the effectiveness of integrating harmonica playing into pulmonary rehabilitation (PR) programs.Methods and analysisThis single-center, two-arm RCT will be conducted at a tertiary hospital in Guangzhou, China. …”
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Corrigendum to ‘Raising awareness of alcohol as a modifiable risk factor for breast cancer: A randomized controlled trial comparing the efficacy of accessing an interactive website with a non-interactive website’ [The Breast (2025) 103868] by Claudia Sardu, Fabrizio Angius, Paolo Contu, Sofia Cosentino, Monica Deiana, Matteo Fraschini, Clelia Madeddu, Elena Massa, Alessandra Mereu, Luigi Minerba, Carola Politi, Silvia Puxeddu, Francesco Salis, Julia M.A. Sinclair, Roberta Agabio

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Assessment of a novel unidirectional mid-term absorbable barbed suture versus a competitor barbed suture for vaginal cuff closure after gynaecology surgery, study protocol of a randomized controlled trial - BARHYSTER by Petra Baumann, Lourdes Hinojosa Sánchez, Núria Grané Garcia, Larisa Sologiuc, Amadeus Hornemann

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Impact of non-invasive oxygen reserve index versus standard SpO2 monitoring on peripheral oxygen saturation during endotracheal intubation in the intensive care unit: Protocol for the randomized controlled trial NESOI2. by Hugo Hille, Aurélie Le Thuaut, Pierre Asfar, Quentin Quelven, Emmanuelle Mercier, Anthony Le Meur, Jean-Pierre Quenot, Virginie Lemiale, Grégoire Muller, Martin Cour, Alexis Ferré, Asael Berge, Anaïs Curtiaud, Maxime Touron, Gaetan Plantefeve, Jean-Charles Chakarian, Jean-Damien Ricard, Gwenhael Colin, Arthur Orieux, Patrick Girardie, Mathieu Jozwiak, Manon Rouaud, Camille Juhel, Jean Reignier, Jean-Baptiste Lascarrou, CRICS-TRIGGERSEP Network

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Efficacy of Plantago major Homoeopathic Mother Tincture as Mouth Wash in Comparison with Chlorhexidine Gluconate (0.2%) Mouthwash in Management of Oral Hygiene among Students: A Double-Blind, Parallel-group, Randomized Control Trial by Kunal Deshmukh, Sahana Hegde Shetiya, Parth Aphale, Anindita Dutta, Dharmendra B. Sharma, Garvit Singh

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Left Ventricular End-Diastolic Pressure and B-Type Natriuretic Peptide Levels Guidance of Low-Dose Furosemide Treatment to Prevent Contrast-Induced Nephropathy in Patients with Percutaneous Coronary Intervention: A Randomized Controlled Trial by Guoqiang Gu, Demin Liu, Rui Lu, Wei Cui

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A pilot randomized controlled study of integrated kidney palliative care and chronic kidney disease care implemented in a safety-net hospital: Protocol for a pilot study of feasibility of a randomized controlled trial by Jennifer S. Scherer, Wenbo Wu, Chen Lyu, Keith S. Goldfeld, Abraham A. Brody, Joshua Chodosh, David Charytan

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The effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, and health-related quality of life in adults with malignant lymphoma undergoing chemotherapy: a systematic review of randomized controlled trials by Charlotte Groenset, Magnus N. Bech, Mary Jarden, Nina Høgdal, Martin Hutchings, Charlotte Suetta, Jan Christensen

“…Peer-reviewed randomized controlled trials (RCTs) comparing exercise intervention with controls/usual care in adults (≥18 years) diagnosed with Hodgkin’s lymphoma and non-Hodgkin’s lymphoma undergoing chemotherapy were considered for inclusion. …”
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Assessing the effectiveness and the feasibility of a group-based treatment for self-stigma in people with mental disorders in routine mental health services in North-East Italy: study protocol for a pragmatic multisite randomized controlled trial by Antonio Lasalvia, Luca Bodini, Doriana Cristofalo, Veronica Fin, Philip T. Yanos, Chiara Bonetto

“…Narrative Enhancement and Cognitive Therapy (NECT) was developed in the United States to counteract self-stigma and has been supported by multiple randomized controlled trials. However, NECT has not yet been implemented in Italy or within a public mental health system grounded in community psychiatry. …”
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Qualitative methods: the missing link in orthopaedic research by Samantha Jones, Sarah Tyson

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Barriers and Facilitators in Implementing a Telemonitoring Application for Patients With Chronic Kidney Disease and Health Professionals: Ancillary Implementation Study of the NeLLY (New Health e-Link in the Lyon Region) Stepped-Wedge Randomized Controlled Trial by Marion Delvallée, Abdallah Guerraoui, Lucas Tchetgnia, Jean-Pierre Grangier, Nassira Amamra, Anne-Laure Camarroque, Julie Haesebaert, Agnès Caillette-Beaudoin

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Describing randomization in trials included in systematic reviews in orthopaedic surgery by Matthew Tang, Kimberley K. Lun, Adriane M. Lewin, Ian A. Harris

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Transradial versus Transfemoral Access and the Risk of Acute Kidney Injury following Primary Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Propensity-Score-Matched Studies by Gaspar Del Rio-Pertuz, Michel Juarez, Poemlarp Mekraksakit, Kanak Parmar, Mohammad M. Ansari

“…Studies included were randomized controlled trials (RCTs) and propensity-score-matched (PSM) studies evaluating the association of TRA versus TFA access with AKI in patients undergoing primary PCI for STEMI. …”
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Comment on “Graft Inflow Modulation by Splenic Artery Ligation for Portal Hyper Perfusion Does Not Decrease Rates of Early Allograft Dysfunction in Adult Live Donor Liver Transplantation: A Randomized Control Trial”: Can We Really Write Off Graft Inflow Modulation by Niteen Kumar, MBBS, MS, MCh, Abhideep Chaudhary, MBBS, MS, FACS, FAIS, FRCS (Glasgow)

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Osteochondral lesions of talus by Jitendra Mangwani, Claire Brockett, Elise Pegg

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Development of a family-centred core outcome set for infants with developmental dysplasia of the hip treated with a brace by Joanna Craven, Olivia O’Malley, Daniel C. Perry

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The Importance of Risk and Subgroup Analysis of Nonparticipants in a Geriatric Intervention Study by Elizabeth Rosted, Ingrid Poulsen, Carsten Hendriksen, Lis Wagner

“…Comparative study based on a randomized controlled trial. Setting. University hospital in the Capital Region of Denmark. …”
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Can Jurors Disregard Inadmissible Evidence? Using the Multiphase Optimization Strategy to Test Interventions Derived from Cognitive and Social Psychological Theories by Pamela N. Sandberg, Tess M. S. Neal, Karey L. O’Hara

“…Study 1 used a 2⁴ full factorial randomized controlled trial to evaluate the four candidate intervention strategies. …”
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Prenatal Intervention for Lower Urinary Tract Obstruction by David M. Kitchens, C. D. Anthony Herndon

“…Presently, the first randomized controlled trial to address whether prenatal vesicoamniotic shunting improves survival and renal function is underway, and should address the value of prenatal intervention.…”
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Role of Terlipressin in Cirrhotic Patients with Ascites and without Hepatorenal Syndrome: A Systematic Review of Current Evidence by Zhaohui Bai, Yang An, Xiaozhong Guo, Rolf Teschke, Nahum Méndez-Sánchez, Hongyu Li, Xingshun Qi

“…In 3 studies (1 randomized controlled trial and 2 single-arm studies without controls) involving 32 patients who received terlipressin for nonrefractory ascites, terlipressin improved hemodynamics by decreasing the heart rate and cardiac output and increasing the mean arterial pressure and systemic vascular resistance. …”
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