Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol by Andre Pascal Kengne, Eugene Sobngwi, Jean Jacques N Noubiap, Jobert Richie N Nansseu, Joël Fokom-Domgue, Eric V Balti

“…We aim to search for and summarise available evidence on the accuracy of fructosamine measurements to diagnose and monitor DM.Methods and analysis This systematic review will include randomised control trials, controlled before-and-after studies, time series designs, cohort studies, case–control studies and cross-sectional surveys reporting the diagnosis and/or monitoring of DM (type 1 DM, type 2 DM and gestational DM) with fructosamine compared with other measures of glycaemia (fasting glucose, oral glucose tolerance test, random glucose, HbA1c), without any language restriction. …”
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Addressing palliative care and end-of-life issues in patients with advanced cancer: a systematic review of communication interventions for physicians not specialised in palliative... by Corinna Bergelt, Karin Oechsle, Nele Harnischfeger, Hilke M Rath

“…Results were narratively synthesised.Results 24 publications reporting 22 interventions were included. 13 publications reported randomised controlled trials. A majority of the interventions addressed one specific PC/EoL issue, most often breaking bad news. …”
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Equality, Diversity and Inclusion characteristics measured or reported in randomised trials of intrapartum interventions: A Scoping Review [version 1; peer review: 2 approved] by Aoife Smith, John Gilmore, Susan Hannon, Valerie Smith

“…As a preliminary exploration for future discussion and development, we undertook a scoping review to identify the types, frequency, and extent of EDI characteristics that were measured and reported in randomised controlled trials (RCTs) of intrapartum interventions specifically. …”
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Comparison of Hydrus and iStent microinvasive glaucoma surgery implants in combination with phacoemulsification for treatment of open-angle glaucoma: systematic review and network... by Xiaoyu Wang, Rongrong Hu, Dongyu Guo, Nan Hong, Xiuyuan Xuan

“…Objectives To compare the efficacy and safety of two Schlemm’s canal-based microinvasive glaucoma surgery (MIGS) devices, the Hydrus Microstent and the iStent Trabecular Bypass combined with phacoemulsification for treatment of open-angle glaucoma.Design Systematic review and network meta-analysis.Methods Literature searches were conducted on PubMed, Web of Science, Cochrane Library and ClinicalTrials.gov to identify randomised controlled trials (RCTs) assessing the Hydrus or the iStent implantation combined with phacoemulsification for treatment of open-angle glaucoma until September 2020. …”
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High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis by Jing Wang, Ling Wu, Yu-Ling Yan, Bo Qiu, Song-Bai Deng, Xiao-Dong Jing, Jian-Lin Du, Ya-Jie Liu, Qiang She

“…Objective To evaluate the efficacy and safety of high-intensity statin therapy in patients with chronic kidney disease (CKD).Design A systematic review and meta-analysis.Data sources Randomised controlled trials (RCTs) comparing high-intensity statin therapy (atorvastatin 80 mg or rosuvastatin 20/40 mg) with moderate/mild statin treatment or placebo were derived from the databases (PubMed, Embase, Ovid, the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, and ISI Web of Knowledge).Outcome measure Primary end points: clinical events (all-cause mortality, stroke, myocardial infarction and heart failure); secondary end points: serum lipid, renal function changes and adverse events.Results A total of six RCTs with 10 993 adult patients with CKD were included. …”
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Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis by Paul Roderick, Peter Clive Hayes, Julie Parkes, Ryan Buchanan, Oliver John Kennedy, Jonathan Andrew Fallowfield

“…However, due to a lack of randomised controlled trials, potential publication bias and there being no accepted definition of coffee, the quality of evidence under the GRADE criteria was ‘very low’.Conclusions Increased consumption of caffeinated coffee and, to a lesser extent, decaffeinated coffee are associated with reduced risk of HCC, including in pre-existing liver disease. …”
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Need to clamp indwelling urinary catheters before removal after different durations: a systematic review and meta-analysis by Xiaoyan Fan, Sumin Ma, Jiayi Gu

“…Objective This meta-analysis aimed to evaluate the effect of bladder training by clamping on bladder urethral function in patients with indwelling urinary catheters used for different durations.Design Systematic review and meta-analysis.Data sources The UpToDate, Cochrane Library, OVID, PubMed, China National Knowledge Infrastructure, CINAHL and Embase were screened from 1 January 2000 to 28 February 2022.Eligibility criteria for selecting studies Randomised controlled trials (RCTs) or quasi-experimental designs comparing the efficacy of bladder training in patients with an indwelling urinary catheter by clamping or free drainage before urinary catheter removal were published in English or Chinese.Data extraction and synthesis Two reviewers independently extracted the data and assessed the quality of studies. …”
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Effect of home-based interventions on basic activities of daily living for patients who had a stroke: a systematic review with meta-analysis by Ping Qin, Canxin Cai, Xuan Chen, Xijun Wei

“…Objectives To investigate the effectiveness of home-based interventions in improving the ability to do basic activities of daily living in patients who had a stroke.Methods Randomised controlled trials were searched through MEDLINE, Embase and CINAHL from their inception to 31 December 2021. …”
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Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis by Francisco Rodríguez, Daniel Samacá-Samacá, Claudia Hernández-Castillo, Laura Prieto-Pinto, Carolina Sardi, Hugo Ocampo, Joshua Kock, Fabián Hernández

“…The Cochrane Collaboration guidelines and the Confidence in Network Meta-Analysis framework were used for the SR and the certainty of evidence, respectively.Results From 4128 identified records through electronic databases and complementary searches, 63 randomised controlled trials (RCTs) met the eligibility criteria, with 42 included in the NMA. …”
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In situ simulation for cardiopulmonary resuscitation training: A systematic review by Andrea Cortegiani, Mariachiara Ippolito, Cristian Abelairas-Gómez, Sabine Nabecker, Alexander Olaussen, Kasper G. Lauridsen, Yiqun Lin, Taylor Sawyer, Joyce Yeung, Andrew S. Lockey, Adam Cheng, Robert Greif, Aaron Donoghue, Barbara Farquharson, Chih-Wei Yang, Heike Geduld, Kathryn Eastwood, Kevin Nation, Sebastian Sch naubelt, Tasuku Matsuyama, Ying-Chih Ko, Katherine S. Allen, Tracy Kidd, Jan Breckwoldt, Ming-Ju Hsieh

“…Objectives: To evaluate the effectiveness of in situ simulation for cardiopulmonary resuscitation (CPR) training on clinical and educational outcomes. Methods: Randomised controlled trials (RCT) and non-randomised studies evaluating in situ simulation for cardiopulmonary resuscitation CPR training of healthcare workers in any setting compared to traditional training and reporting data on patients’ survival, patients’ outcomes, clinical performance and teamwork in actual or simulated resuscitation and resources needed were included. …”
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A model based cost-utility analysis of Embedding referral to structured self-management education into standard practice (Embedding) compared to usual care for people with type 2 d... by Melanie J Davies, Alan Brennan, Danielle H Bodicoat, Daniel John Pollard, Anju Keetharuth, Michelle Hadjiconstantinou, Agnieszka Glab, Joesph P Mensa, Alison Northern

“…With costs and effectiveness parameters coming from analyses of data from a cluster randomised control trial.Setting English National Health Service.Participants People with T2DM from 64 GP practices in England.Interventions Embedding SSME implementation package Usual care.Primary and secondary outcome measures The primary outcome measure was the incremental cost-effectiveness ratio. …”
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Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

“…We aim to provide an overview of the characteristics of studies evaluating COVID-19 treatment.Design Rapid scoping reviewData sources Medline, Embase and biorxiv/medrxiv from inception to 15 May 2021.Setting Hospital and community care.Participants COVID-19 patients of all ages.Interventions COVID-19 treatment.Results The literature search identified 616 relevant primary studies of which 188 were randomised controlled trials and 299 relevant evidence syntheses. …”
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Relationship between Tai Chi and clinical outcomes in elderly patients with COVID-19: a protocol for systematic review and dose–response meta-analysis by Yang Wang, Na Li, Xiao Peng, Chun Wang, Sheng He, Jinfeng Yang, Yuanpeng Liao

“…All eligible randomised controlled trials or controlled clinical trials related to Tai Chi for elderly patients with COVID-19 will be included. …”
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Modified sutureless and glue-free method versus conventional sutures for conjunctival autograft fixation in primary pterygium surgery: a systematic review and meta-analysis by Faisal Aljahdali, Waleed Khayyat, Abdulelah T BinYamin, Sultan A Al-Qahtani, Mohammed D Alghamdi, Ali Saleh Alsudais, Husain A Alalgum, Halah Bin Helayel, Mohammed AlMutlak

“…This systematic review and meta-analysis compared the modified sutureless glue-free (MSGF) method with conventional sutures (CS) for conjunctival autograft fixation in primary pterygium surgery.Methods A comprehensive search was conducted in MEDLINE, Embase, CENTRAL, Google Scholar and ClinicalTrials.gov for randomised controlled trials (RCTs) comparing MSGF and CS conjunctival autografts. …”
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Protocol for an adaptive platform trial of intended service user-derived interventions to equitably reduce non-attendance in eye screening programmes in Botswana, India, Kenya and... by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, James R Carpenter, Sailesh Mishra, Shalinder Sabherwal, Luke Allen, Sarah Karanja, Ari Ho-Foster, Nigel Bolster, Malebogo Tlhajoane, Bakgaki Ratshaa

“…This platform trial aims to test multiple, iterative, low-risk public health interventions and simple service modifications with a series of individual randomised controlled trials (RCT) conducted in each country, with the aim of increasing the proportion of people attending.Methods and analysis We will set up a platform trial in each country to govern the running of a series of pragmatic, adaptive, embedded, parallel, multiarm, superiority RCTs to test a series of service modifications suggested by intended service users. …”
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Effectiveness of multicomponent interventions in primary healthcare settings to promote continuous smoking cessation in adults: a systematic review by Carlos Martín Cantera, Elisa Puigdomènech, Jose Luis Ballvé, Olga Lucía Arias, Lourdes Clemente, Ramon Casas, Lydia Roig, Santiago Pérez-Tortosa, Laura Díaz-Gete, Sílvia Granollers

“…Objective The objective of the present review is to evaluate multicomponent/complex primary care (PC) interventions for their effectiveness in continuous smoking abstinence by adult smokers.Design A systematic review of randomised and non-randomised controlled trials was undertaken.Eligibility criteria for included studies Selected studies met the following criteria: evaluated effects of a multicomponent/complex intervention (with 2 or more intervention components) in achieving at least 6-month abstinence in adult smokers who visited a PC, biochemical confirmation of abstinence, intention-to-treat analysis and results published in English/Spanish.Methods We followed PRISMA statement to report the review. …”
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Shorter versus longer durations of antibiotic treatment for patients with community-acquired pneumonia: a protocol for a systematic review and meta-analysis by Gordon Guyatt, Arnav Agarwal, Mark Loeb, John Basmaji, Ya Gao, Maryam Ghadimi, Layla Bakaa, Luis Enrique Colunga Lozano, Saad Asif, Aninditee Das

“…We have therefore planned a systematic review and meta-analysis evaluating the impact of shorter versus longer durations of antibiotic therapy for patients with CAP.Methods and analysis We searched Ovid MEDLINE, Embase, CINAHL and Cochrane Central Register of Controlled Trials from inception to September 2021 for randomised controlled trials evaluating shorter versus longer duration of antibiotics. …”
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Effective dietary interventions during pregnancy: a systematic review and meta-analysis of behavior change techniques to promote healthy eating by Hannah O’Connor, Nina Meloncelli, Shelley A. Wilkinson, Anna Mae Scott, Lisa Vincze, Alita Rushton, Samantha Dawson, Jenna Hollis, Bree Whiteoak, Sarah Gauci, Susan de Jersey

“…Six databases were searched to identify randomised control trials (RCTs) reporting on dietary intake in pregnant women over the age of sixteen, with an active intervention group compared to a control group receiving usual care or less intensive interventions. …”
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Blinding assessment in randomised sham-controlled trials of acupuncture:protocol for a systematic survey by Ling Li, Xin Sun, Jiali Liu, Minghong Yao, Yong Fu, Jiahui Yang, Xiaochao Luo

“…Introduction Although various sham acupuncture techniques have been employed to ensure blinding in randomised controlled trials (RCTs) of acupuncture, the effectiveness of blinding in these trials and its influence on trial effect size estimates remain unclear. …”
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Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…It will also provide recommendations for integrating these interventions into community-based chronic disease management.Methods and analysis To identify potentially relevant randomised controlled trials, a reverse search strategy will be employed to ascertain all non-pharmacological interventions for PH. …”
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