Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within... by Deborah D Stocken, Charles H Knowles, Jared Torkington, David Jayne, Julie Hepburn, Laura Knight, Neil Corrigan, Julie Cornish, Katie Gordon, Ashley Douglas, Kate Wilson, Megan Dale, Julie Croft, Christina Lloydwin, Alexandra Harriet Coxon-Meggy, Judith White, Alun Meggy, Aaron Quyn, Emily Farrow, Kheng-Seong Ng, Hannah Mather, Huey Yi Chong, Betty Tan, Ralph Powell, Andrea Warwick

“…Six-hundred participants from the UK and 200 participants from Australia, with major LARS symptoms, defined as a LARS score of ≥30, will be recruited to the randomised controlled trial (RCT) element. Participants entering the RCT will be randomised between OCM, TAI or SNM, all with equal allocation ratios.Cohort and RCT participants will be followed up for a 24-month period, completing a series of questionnaires measuring LARS symptoms and QoL, as well as clinical review for those in the RCT. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Future work Economic modelling, a feasibility trial and powered randomised controlled trial are needed to evaluate the Primary care Management of lower Urinary tract Symptoms tool in practice. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Thirty-six studies met the inclusion criteria: 1 ongoing randomised controlled trial, 13 completed cohort studies, 17 completed case-control studies and 5 ongoing cohort or case-control studies. …”
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Effectiveness of case management interventions for frequent users of healthcare services: a scoping review by Catherine Hudon, Maud-Christine Chouinard, Isabelle Dufour, Mireille Lambert, Cynthia Krieg

“…Eligible designs included randomised and non-randomised controlled trials and controlled and non-controlled before–after studies. …”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…We identified 39 randomised controlled trials and included 16 in the meta-analysis. …”
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COVID-19, Influenza and Economic Activity — An Impact Analysis Perspective by Adalbert Winkler

“…Impact analysis applying features of randomised control trials would provide clear evidence. However, this is currently unavailable due to a lack of an appropriate control group of countries without measures. …”
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Parent skills training for parents of children or adults with developmental disorders: systematic review and meta-analysis protocol by Corrado Barbui, Chiara Servili, Brian Reichow, Cary Kogan, Isaac Smith, M Taghi Yasamy

“…The purpose of this review protocol is to extend previous findings by systematically analysing randomised controlled trials of parent skills training programmes for parents of children with developmental disorders including intellectual disabilities and autism spectrum disorders and use meta-analytic techniques to identify programme components reliably associated with successful outcomes of parent skills training programmes.Methods and analysis We will include all studies conducted using randomised control trials designs that compare a group of parents receiving a parent skills training programme to a group of parents in a no-treatment control, waitlist control or treatment as usual comparison group. …”
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A systematic review of the effect of personal health records on patient activation by Irina Osovskaya, Ann Blandford, Henry WW Potts

“…Methods A literature search was conducted for randomised controlled trials and quasi-experimental studies published up to January 2024 across EMBASE, PsycINFO, CINAHL and PubMed. …”
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Training and education provided to local change champions within implementation trials: a rapid systematic review by Laura Jolliffe, Natasha A. Lannin, Stacy Larcombe, Brendan Major, Tammy Hoffmann, Elizabeth Lynch

“…We included randomised and cluster randomised controlled trials that reported on implementation interventions in healthcare settings involving a local change champion. …”
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A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…Objective To evaluate the safety profile of nicergoline compared with placebo and other active agents from published randomised controlled trials.Design Systematic review and meta-analysis of nicergoline compared with placebo and other active agents across various indications.Data sources MEDLINE, Medline-in-process, Cochrane, EMBASE, EMBASE alerts, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR) and Cochrane Methodology Register (CMR) for all the randomised controlled trials, open-label or blinded, in adults treated with nicergoline. …”
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Is differential cleaning needed for SARS-CoV-2 beyond standard procedures? A systematic review by Uduak Okomo, Ememobong N. Aquaisua, Osamagbe Asemota, Deborah Ndukwu, Josephine E. Egbung, Ekpereonne B. Esu, Olabisi A. Oduwole, John E. Ehiri

“…Contribution: Randomised controlled trials are crucial for evaluating cleaning effectiveness. …”
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Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus by Umile Giuseppe Longo, Stefano Campi, Giovanni Romeo, Filippo Spiezia, Nicola Maffulli, Vincenzo Denaro

“…More prospective randomised controlled trials are needed to compare the different techniques for clinical results, applicability, and cost-effectiveness.…”
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Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis proto... by Amalia Karahalios, Allan G Kermode, Yvonne C Learmonth, Julia Lyons, Stephanie Campese, Alexandra Metse, Claudia H Marck

“…Search terms will stem from three concepts: MS, depression and randomised controlled trials. Included studies will be randomised controlled trials, where participants are people with MS randomised to receive one of the aforementioned intervention types, and depression or depressive symptoms is the primary outcome, only outcome or secondary outcome with an a priori power calculation. …”
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Exploring the efficacy of psychotherapies for depression: a multiverse meta-analysis by Eirini Karyotaki, Pim Cuijpers, Constantin Yves Plessen, Clara Miguel, Marketa Ciharova

“…Background Hundreds of randomised controlled trials and dozens of meta-analyses have examined psychotherapies for depression—yet not all points in the same direction. …”
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Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight man... by Hiba Jebeile, Natalie B Lister, Sol Libesman, Kylie E Hunter, Caitlin M McMaster, Brittany J Johnson, Louise A Baur, Susan J Paxton, Sarah P Garnett, Amy L Ahern, Denise E Wilfley, Sarah Maguire, Amanda Sainsbury, Katharine Steinbeck, Lisa Askie, Caroline Braet, Andrew J Hill, Dasha Nicholls, Rebecca A Jones, Genevieve Dammery, Alicia M Grunseit, Kelly Cooper, Theodore K Kyle, Faith A Heeren, Fiona Quigley, Rachel D Barnes, Melanie K Bean, Kristine Beaulieu, Maxine Bonham, Kerri N Boutelle, Braulio Henrique Magnani Branco, Simona Calugi, Michelle I Cardel, Kelly Carpenter, Hoi Lun Cheng, Riccardo Dalle Grave, Yngvild S Danielsen, Marcelo Demarzo, Aimee Dordevic, Dawn M Eichen, Andrea B Goldschmidt, Anja Hilbert, Katrijn Houben, Mara Lofrano do Prado, Corby K Martin, Anne McTiernan, Janell L Mensinger, Carly Pacanowski, Wagner Luiz do Prado, Sofia M Ramalho, Hollie A Raynor, Elizabeth Rieger, Eric Robinson, Vera Salvo, Nancy E Sherwood, Sharon A Simpson, Hanna F Skjakodegard, Evelyn Smith, Stephanie Partridge, Marian Tanofsky-Kraff, Rachael W Taylor, Annelies Van Eyck, Krista A Varady, Alaina P Vidmar, Victoria Whitelock, Jack Yanovski, Anna L Seidler, Eating Disorders In weight-related Therapy (EDIT) Collaboration

“…The Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that contribute to eating disorder risk. …”
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Microbiota modifications in prehabilitation – the next step towards comprehensive preparation for surgery. The scoping review by Igor Łoniewski, Tomasz Banasiewicz, Jerzy Sieńko, Karolina Skonieczna-Zydecka, Ewa Stachowska

“…Evidence from systematic reviews, meta-analyses, and randomised controlled trials suggests that microbiota-targeted interventions can reduce SSIs, enhance immune responses, and promote quicker recovery. …”
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Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban by Azhar Farooqui, Tin Lwin, Daniel Costa, Simon Hetherington, Raj Mattu

“…Prospective randomised control trials should be conducted in patients with left ventricular thrombus to compare anticoagulants, assess the efficacy and safety of DOACs, and evaluate uninterrupted DOAC versus transient withdrawal for cardiac device procedures.…”
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Vaginal natural orifice transluminal endoscopic surgery (vNOTES): a new chapter in vaginal surgical innovation by Sarah Wylie, Eric Mutema, Wai Yoong

“…Clinicians wishing to implement vNOTES need to undergo appropriate training and appreciate judicious governance. Further randomised controlled trials will allow us to better understand if this newer technique will offer well-evidenced preferable outcomes and become the preferred surgical approach.…”
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Anxiety in Children Undergoing VCUG: Sedation or No Sedation? by David W. Herd

“…Seven comparative studies including two randomised controlled trials were reviewed. Midazolam given orally (0.5-0.6 mg/kg) or intranasally (0.2 mg/kg) is effective with no apparent effect on voiding dynamics. …”
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Endoscopic Vein Harvesting for Coronary Bypass Grafting: A Blessing or a Trojan Horse? by Ryan Accord, Jos Maessen

“…Most recent publications could not confirm these findings, however larger randomised controlled trials focusing on graft quality are being awaited.…”
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