Cardioprotective effect of crocin in patients with breast cancer receiving anthracycline-based chemotherapy: A randomized, double-blind, placebo-controlled study by Xinye Li, Xin Su, Wanping Liang, Li Wang, Chao Yuan, Juping Xu, Yijun Zhang, Yan Liu, Ning Ma, Fan Yang, Yiyuan Yang, Liyuan Tao, Shipeng Sun, Hongcai Shang, Yanwei Xing

“…Eligible patients were randomly assigned to receive either treatment with crocin tablets or placebo for 6 months. …”
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Comparison between paracervical block and intrauterine lidocaine for pain management in surgical termination of first-trimester miscarriage: a randomized clinical trial by Doaa M. Effat, Mona A. Elkafrawy, Amira A.E. Shaban

“…Patients and methods One hundred fifty pregnant women suffering from first-trimester miscarriage and requiring pregnancy termination were randomly assigned into three equal groups. Group I (n=50), receiving paracervical block (10 ml of 2% of lidocaine 100 mg). …”
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How Abdominal Irrigation During Cesarean Delivery Affects Gastrointestinal Functions and Short-term Maternal Morbidities: A Randomized Controlled Study by Canan SATIR OZEL, Zelal Rojda GUNGORDU, Nisan Helin DONMEZ, Ergul DEMIRCIVI, Oguz Devrim YARDIMCI, Abdulkadir Turgut

“…The participants were randomized into two groups: abdominal irrigation (n=30) and control group (n=30). …”
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Mobile Phone App to Promote Lifestyle Change in People at Risk of Type 2 Diabetes: Feasibility 3-Arm Randomized Controlled Trial by Gyri Skoglund, Gunvor Hilde, Pernille Lunde, Venessa Vera Cruz Naceno, Cecilie Fromholt Olsen, Birgitta Blakstad Nilsson

“…The secondary aim was to assess recruitment rate, resource requirements, and change in potential outcomes for a full scale randomized controlled trial (RCT) study . …”
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Rapid Adaptation to Prevent Drug Use (RAPD): protocol of a pilot randomized trial to enhance the impact of an evidence-based intervention for youth by Andria B. Eisman, Christine Koffkey, Robert T. Partridge, Suzanne Brown, Bo Kim

“…We will pilot test RAPD in ten middle schools serving diverse student populations using a two-group, mixed method, cluster randomized controlled trial design. Aim 3: assess the costs and benefits of RAPD from multiple partner perspectives using a mixed methods approach. …”
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A multidisciplinary pain management program for patients with chronic low back pain: a randomized, single-blind, controlled, feasibility study by Anna Dalmau-Roig, Christian Dürsteler, Mirari Ochandorena-Acha, Francisco Vilchez-Oya, Inés Martin-Villalba, Amadeu Obach, Marc Terradas-Monllor

“…First, the feasibility outcomes (recruitment, completion, and drop-out rates) of a 5-month non-random prospective cohort (n = 227) were recorded. …”
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Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized controlled trial by Chenxu Dai, Chenxu Dai, Xuemei Zhao, Xuemei Zhao, Aoxue Li, Xuedong Zhang, Penglei Wang, Ye Zhang, Yun Wu

“…This study aimed to evaluate the effects of intranasal versus intravenous dexmedetomidine on emergence recovery and hemodynamics in children undergoing adenotonsillectomy.MethodsA total of 139 children, aged 3–10 years, who were scheduled for elective adenotonsillectomy were randomly assigned to receive intravenous dexmedetomidine (IV DEX group) or intranasal dexmedetomidine (IN DEX group), or saline (control group) after anesthesia induction. …”
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Effects of Pioglitazone on Asymmetric Dimethylarginine and Components of the Metabolic Syndrome in Nondiabetic Patients (EPICAMP Study): A Double-Blind, Randomized Clinical Trial by Pedram Shokouh, Adel Joharimoghadam, Hamidreza Roohafza, Masoumeh Sadeghi, Allahyar Golabchi, Maryam Boshtam, Nizal Sarrafzadegan

“…The present trial aimed to investigate the effects of pioglitazone on the serum level of asymmetric dimethylarginine (ADMA), a marker of endothelial function, and some indices of inflammation and glucose and lipid metabolism in nondiabetic metabolic syndrome patients. 104 eligible participants (57% female; age between 20 and 70) were enrolled in a double-blind placebo-controlled trial and were randomized to receive either pioglitazone (uptitrated to 30 mg/day) or matching placebo for 24 weeks. …”
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The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis by Peiye Zhu, Yunrui Jin, Jiya Sun, Xia Zhou

“…Review Manager 5.3 conducted meta-analysis of the data included in the literature.ResultsThis meta-analysis was conducted in six randomized controlled trials involving 533 participants. …”
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Comparative study between high and low dose methylene blue infusion in septic cancer patients: a randomized, blinded, controlled study by Ehab Hanafy Shaker, Ahmed Mohamed Soliman, Ahmed Abd Elmohsen Bedewy, Mai Mohamed Elrawas

“…Methods This double-blind, randomized, controlled trial comprised 90 patients divided into 3 groups: Group A received a 100 ml 0.9% NaCl placebo over 20 min; Group B received an MB bolus of 1 mg/kg in 100 ml 0.9% NaCl, and Group C received MB bolus of 4 mg/kg in 100 ml 0.9% NaCl during the same period. …”
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Effects of Trigger Point Dry Needling on Strength Measurements and Activation Levels of the Gluteus Medius: A Quasi-Experimental Randomized Control Study by Eric Schneider, Elizabeth S. Moore, Rob Stanborough, Emily Slaven

“… # Design Quasi experimental, single group, pretest-posttest, randomized control study # Methods A control and an intervention side were randomly assigned for each participant (_N_ = 39). …”
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Efficacy of 2‐Mercaptoethane Sulfonate Sodium (MESNA) in the Prevention of Pancreatitis After Endoscopic Retrograde Cholangiopancreatography: A Randomized Open Label Trial by Amir Sadeghi, Hesamoddin Samar, Mohammad Abbasinazari, Parvaneh Mohammadi, Ali Abazarikia, Shadi Ziaie

“…Eligible patients received 100 mg indomethacin suppository 30 min before undergoing ERCP. Randomly, the participants received 400 mg intravenous mesna or nothing 30 min before doing the procedure. …”
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Effectiveness and safety of human placenta hydrolysate injection into subacromial space in patients with shoulder impingement syndrome: a single-blind, randomized trial by Du Hwan Kim, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Don-Kyu Kim, Chul-Hyun Cho, Ye-Ji Kim

“…Methods This single-blind, randomized controlled study enrolled 50 patients with shoulder impingement syndrome who were randomly assigned to either the hPH or placebo groups. …”
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Effect of Ondansetron on Postoperative Pain and Vomiting after Acute Appendicitis Surgery: A Placebo-Controlled Double-Blinded Randomized Clinical Trial by Moein Khoori, Peyman Mirghaderi, Alireza Azarboo, Forough Jamil, Nasim Eshraghi, Alireza Abdollahzadeh Baghaei

“…Patients were randomly divided into two equal groups: group A received 4 mg of ondansetron IV (2 ml) and group B received 2 ml of normal slain IV (placebo). …”
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Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor by Xin Xu, Hui Yu, Mingyi Yang, Jiale Xie, Ke Xu, Erliang Li, Xianjie Wan, Jiachen Wang, Guoqiang Wang, Ying Pan, Peng Xu, Junfei Guo

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Decentralized clinical trials are better for the participants and for the planet: the case study of a double-blind randomized controlled trial in Singapore (PROMOTE study) by Lisa R. Fries, Nadia Khaled, Ivan Viveros Santos, Elvira Suniega-Tolentino, Motshewa Sesing, Melissa P. S. Toh, Chui Yuen Yang, Shiao Yng Chan, Shiao Yng Chan, Sara Colombo Mottaz

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Microneedling in Combination with Topical Pimecrolimus 1% versus Topical Pimecrolimus 1% for the Treatment of Refractory Stable Vitiligo: A Randomized Clinical Trial by Fariba Iraji, Ali Asilian, Zahra Talebzadeh, Mina Saber, Fatemeh Mokhtari, Amirhossein Siadat, Seyed Mohsen Hosseini

“…The left or right side of the patient’s lesion was randomly assigned to receive microneedling plus topical pimecrolimus for three months, while the other side received only topical pimecrolimus 1%. …”
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Does Preoperative Radio(chemo)therapy Increase Anastomotic Leakage in Rectal Cancer Surgery? A Meta-Analysis of Randomized Controlled Trials by Changjiang Qin, Xuequn Ren, Kaiwu Xu, Zhihui Chen, Yulong He, Xinming Song

“…PubMed, Embase, and the Cochrane Library were searched from January 1980 to January 2014. Randomized controlled trials included all original articles reporting anastomotic leak in patients with rectal cancer, among whom some received preoperative radiotherapy or chemoradiotherapy while others did not. …”
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Incorporating health literacy principles into the adaptation of a methods motivational interviewing approach for enrolling black adults in a pilot randomized trial by Olayinka O. Shiyanbola, Meng-Jung Wen, Martha A. Maurer

“…The content used health literacy principles including plain language, infographics, and a pictorial roadmap to guide participants about the purpose of a trial, the randomization process, the study objectives, and timeline. …”
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Analysis of Hepatic Artery Infusion (HAI) Chemotherapy Using Randomized Trials of Floxuridine (FUDR) for Colon Cancer Patients with Multiple Liver Metastases by Yuanming Li

“…Although HAI has only been performed in a few locations previously, this study used randomized trials of floxuridine (FUDR) to characterize patient selection and first perioperative results during the deployment of a new HAI program. …”
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