Evaluating the Efficacy of a Serious Game to Deliver Health Education About Invasive Meningococcal Disease: Clustered Randomized Controlled Equivalence Trial by Lauren Bloomfield, Julie Boston, Martin Masek, Lesley Andrew, Donna Barwood, Amanda Devine

“…MethodsThis clustered, randomized controlled equivalence trial involved students (Years 7-10) from 6 secondary schools across metropolitan Western Australia who completed pre- and postintervention questionnaires with a follow-up at 3 months postintervention to measure the primary outcome of IMD knowledge acquisition following this self-guided intervention. …”
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Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study by Raham Hasan Mostafa, Ahmed Mohamed Khamis, Ashraf Nabil Saleh, Yehia Mamdouh Hassan Mekki, Mohamed Mohamed Kamal, Ismail Mohammed Ibrahim, Mohamed Abdulmohsen Abdulnaiem Ismaiel

“…Methods. A prospective, randomized, double-blind, parallel-group, placebo-controlled trial. …”
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The Effect of Free Weight Resistance Training on Cognitive Function Explored Through Eye Tracking: A Randomized Double-Blind Clinical Trial by Cristián Mateluna-Núñez, Romualdo Ibáñez-Orellana, César Campos-Rojas, Andrea Santana-Covarrubias, Rodrigo Fuentes Figueroa, Ricardo Martínez-Flores

“…In this study, we investigated the impact of a 10-week free weight resistance training (RT) program on cognitive function in healthy young adults. In this randomized controlled trial, 18 participants were assigned to either an experimental or control group. …”
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Comparison of high-flow nasal oxygenation and standard low-flow nasal oxygenation during rigid bronchoscopy: a randomized controlled trial by Hye Jin Kim, Chang Young Lee, Kyuho Lee, Namo Kim, Seungyeon Lee, Young Jun Oh

“…Methods All patients were administered general anesthesia with full muscle relaxation and were randomly assigned to receive either HFNO (HFNO group) or standard low-flow oxygenation (Standard group). …”
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Comparison of the Efficacy and Safety of Temporary Spinal Cord Stimulation versus Pulsed Radiofrequency for Postherpetic Neuralgia: A Prospective Randomized Controlled Trial by Xiaohong Li, Pan Chen, Jian He, Xiang Huang, Dacheng Tang, Lumiao Chen, Xiaoping Wang

“…From September 1, 2019, to May 30, 2020, 44 PHN patients admitted to the Pain Department of the Foshan First People’s Hospital, China were enrolled in this study. The patients were randomly assigned to SCS and PRF groups in a ratio of 1 : 1 and were given respective therapy for 8 days. …”
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Simulator training in focus assessed transthoracic echocardiography (FATE) for undergraduate medical students: results from the FateSim randomized controlled trial by Johannes Matthias Weimer, Franziska Marietta Sprengart, Thomas Vieth, Sebastian Göbel, Anna Dionysopoulou, Rebecca Krüger, Jan Beer, Andreas Michael Weimer, Holger Buggenhagen, Roman Kloeckner, Lukas Pillong, Johanna Helfrich, Elias Waezsada, Philipp Wand, Julia Weinmann-Menke

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Hemostatic effect of oxidized regenerated cellulose vs. topical tranexamic acid in total knee arthroplasty—a prospective randomized controlled trial by Bowei Li, Wenjie Pan, Jianbing Ma, Yuanchi Huang

“…AimsThis study compared the hemostatic effects and complications of oxidized regenerated cellulose (ORC) and topical TXA in total knee arthroplasty (TKA), thus providing a reference for the use of ORC as an alternative hemostatic agent to TXA in TKA.MethodsA total of 105 patients were included in this study and randomized into blank control, ORC, and TXA groups. …”
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Procedure Time and Students’ Perception Comparing Full Arch Digital Scans with Conventional Impressions: A Cross-Over Randomized Experimental Trial by Hayam A. Alfallaj, Mohammed A. Alsaloum, Sahr H. Altuwaijri, Omar S. Aldibasi, Lubna T. Alkadi

“…Ninety-six dental students each prepared tooth #36 for an all-ceramic crown on typodont models and were then randomly assigned into either group A: performed digital scan first, or Group B: performed conventional impression first. …”
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Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis by Yutong Li, Xingyu Song, Yuyang Huang, Sifan Zhou, Linkun Zhong

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Spirituality-based palliative care education on quality of life, death anxiety, and resilience of heart failure patients: Randomized controlled clinical trial by Roghayeh Balaghi Inaloo, Mostafa Bijani, Leila Nikrouz, Azizallah Dehghan, Abdulhakim Alkamel, Ali Taghinezhad, Zahra Khiyali

“…Methods: This investigation employed a randomized controlled clinical trial design without blinding, incorporating both experimental and control groups. 80 patients who were randomly assigned to intervention and control groups (40 patients per group). …”
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Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial by Aleksandra Gąsecka, Rafał Kaczorowski, Katarzyna Pomykała, Tomasz Kucharski, Magdalena Gajewska, Dominika Siwik, Katarzyna Karoń, Maciej Małyszko, Jaromir Hunia, Jakub Michal Zimodro, Paweł Kowalczyk, Oliwia Zagrocka-Stendel, Małgorzata Dutkiewicz, Katarzyna Koziak, Ceren Eyileten, Marek Postuła, Mateusz Wondołkowski, Marcin Grabowski, Mariusz Kuśmierczyk, Radosław Wilimski

“…Thirty-six consecutive patients undergoing elective off-pump CABG, pre-treated with ASA 1 × 75 mg for ≥7 days, were randomized to continue the prior treatment regimen, switch to ASA 1 × 150 mg, or ASA 2 × 75 mg. …”
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Effect of power training on physical functional performance of patients with Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials. by Samuel Brito de Almeida, Emmanuelle Silva Tavares Sobreira, Charles Phillipe de Lucena Alves, Danielle Pessoa Lima, Janine de Carvalho Bonfadini, Manoel Alves Sobreira-Neto, Thiago Holanda Freitas, Simony Lira do Nascimento, Pedro Braga-Neto

“…Inclusion criteria were randomized controlled trials comparing PT to a control group or another PA intervention in PD patients. …”
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Erratum: A randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis by Frontiers Production Office

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The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials by Mitra Hariri, Masoudreza Sohrabi, Ali Gholami

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Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials by Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Safeena Khan, Ammara Tahir, Muhammad Haris Khan, Touba Azeem, Abdul Moeez, Arysha Monis, Aban Masaud Mian, Fazia Khattak, Moosa Ali, Jibran Ikram

“…Results The meta-analysis of four randomized controlled trials including 3665 patients found that laquinimod significantly reduced the annualized relapse rate compared with placebo (mean difference = −0.08, 95% confidence interval [CI] = −0.12, −0.04, I 2  = 0%). …”
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Effect of Ranirestat on Sensory and Motor Nerve Function in Japanese Patients with Diabetic Polyneuropathy: A Randomized Double-Blind Placebo-Controlled Study by Jo Satoh, Nobuo Kohara, Kenji Sekiguchi, Yasuyuki Yamaguchi

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A randomized, double‐blind, placebo‐controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease by Darren Bentley, Marie Mannino, Marianne Manchester, Priscila Camillo Teixeira, Bernhard Reis, Malcolm Boyce, Sandra Nagel

“…The only available management option is lifelong adherence to a gluten‐free diet. This randomized, double‐blind, placebo‐controlled, parallel‐group, single‐center study tested the effects of the cathepsin S inhibitor RO5459072 on the immune response to a 13‐day gluten challenge in 19 participants with celiac disease (ClinicalTrials.gov: NCT02679014). …”
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Endotracheal Intubation by Paramedics Using Neodymium Magnet and Modified Stylet in Simulated Difficult Airway: A Prospective, Randomized, Crossover Manikin Study by Sedat Bilge, Onur Tezel, Yahya Ayhan Acar, Guclu Aydin, Attila Aydin, Gokhan Ozkan

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Effectiveness of a novel amine + zinc + fluoride toothpaste in reducing plaque and gingivitis: results of a six-month randomized controlled trial by Dutmanee Seriwatanachai, Terdphong Triratana, Petcharat Kraivaphan, Norbert Huber, Tilo Poth, Luis R. Mateo, Melissa Stellitano, Yun-Po Zhang

“…Materials and methods In a randomized, double-blind, two-cell, parallel-group design on healthy adults from the Bangkok, Thailand area presenting with initial gingivitis (Löe-Silness gingival index ≥ 1) and visible plaque (Turesky Modification-Quigley-Hein index ≥ 1.5) were assigned test and negative control toothpastes and instructed to brush twice daily for two minutes. …”
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Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials by Flávio Taira Kashiwagi, Regina El Dib, Huda Gomaa, Nermeen Gawish, Erica Aranha Suzumura, Taís Regina da Silva, Fernanda Cristina Winckler, Juli Thomaz de Souza, Adriana Bastos Conforto, Gustavo José Luvizutto, Rodrigo Bazan

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