Positive end-expiratory pressure increases intracranial pressure but not pressure reactivity index in supine and prone positions: a porcine model study by Rønnaug Hammervold, Rønnaug Hammervold, Rønnaug Hammervold, Erta Beqiri, Peter Smielewski, Benjamin S. Storm, Benjamin S. Storm, Benjamin S. Storm, Benjamin S. Storm, Erik W. Nielsen, Erik W. Nielsen, Erik W. Nielsen, Erik W. Nielsen, Erik W. Nielsen, Claude Guérin, Shirin K. Frisvold, Shirin K. Frisvold

“…We also explored whether other baseline variables influenced potential variances in ICP and PRx.MethodologyTwelve anesthetized pigs were randomized to begin in either supine or prone position, across PEEP of 5, 10, 15, and 20 cmH2O. …”
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Protocol for a multicentre, prospective, open-label, randomised controlled trial to compare PROs and safety outcomes between preoperative and postmastectomy radiotherapy in locally... by Li Zhang, Jiong Wu, Guangyu Liu, Shuang Hao, Jianjing Hou, Changming Zhou, Yifeng Hou, Keda Yu, Zhen Hu, Genhong Di, Zhi Min Shao, Xiaoli Yu

“…Female patients aged >18 years with breast cancer who are treated with neoadjuvant systemic treatment, require both mastectomy and radiotherapy and are suitable for DIEP flap reconstruction will be included. Patients will be randomly assigned (1:1) to a preoperative radiotherapy group or a postoperative radiotherapy group. …”
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Dose effects of iron on growth, antioxidant potential, intestinal morphology, and intestinal barrier in yellow-feathered broilers by J. Chen, K.W. Lei, S.Y. Li, D.P. Li, Y.L. Wang, X. Wang, X. Bai, Y.L. Huang

“…A total of 720 1-day-old male yellow-feathered broilers were randomly divided into 9 treatments, with 8 cages per treatment and 10 birds per cage. …”
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The efficacy and safety of qiwei baizhu san in the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis by Quan Zhang, Hongyan Liu, Jiahong Zhang, Yujie Ouyang, Xiaoxu Fu, Xiaoxu Fu, Xiaoxu Fu, Chunguang Xie, Chunguang Xie, Chunguang Xie

“…As of August 2024, we searched eight databases to screen and include randomized controlled trials of QWBZS for T2DM. Heterogeneity sources were examined via subgroup analyses, the robustness of the results was determined by sensitivity analyses, publication bias was evaluated using funnel plots and Egger’s test, evidence quality was appraised with GRADEpro, and possible mechanisms of QWBZS for T2DM were categorized and summarized.ResultsThis analysis encompassed 14 qualifying trials with a total of 1,169 subjects. …”
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Effects of prolonged NaHCO3 exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carass... by Jia Liu, Faye Zhang, Zihao Yan, Zhengyao Guo, Yuqian Lu, Baolan Yao, Yuehong Li, Wenfa Lv

“…A total of 240 fish (31.19 ± 1.03 g) were randomly allocated to two groups and treated with 0 mmol/L (CK) and 50 mmol/L NaHCO3 (CA) respectively, to simulate the carbonate alkaline water environment. …”
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Multimodal Deep Learning for Differentiating Bacterial and Fungal Keratitis Using Prospective Representative Data by N.V. Prajna, MD, Jad Assaf, MD, Nisha R. Acharya, MD, MS, Jennifer Rose-Nussbaumer, MD, Thomas M. Lietman, MD, J. Peter Campbell, MD, MPH, Jeremy D. Keenan, MD, MPH, Xubo Song, PhD, Travis K. Redd, MD, MPH

“…We also compared the performance of the MADURAI-trained computer vision model against a model with identical architecture but trained on a preexisting dataset collated from multiple prior bacterial and fungal keratitis randomized clinical trials (RCTs) (the RCT-trained computer vision model). …”
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Changes in clinical and imaging variables during withdrawal of heart failure therapy in recovered dilated cardiomyopathy by Brian P. Halliday, Ruth Owen, John Gregson, Ali Vazir, Rebecca Wassall, Zohya Khalique, Amrit S. Lota, Upasana Tayal, Daniel J. Hammersley, Richard E. Jones, Dudley J. Pennell, Martin R. Cowie, John G.F. Cleland, Sanjay K. Prasad

“…Methods and results Clinical, biochemical, and imaging data from patients during phased withdrawal of therapy in the randomized or single‐arm cross‐over phases of TRED‐HF were profiled. …”
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Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention by Junyan Zhang, Zhongxiu Chen, Ran Liu, Yuxiao Li, Hongsen Zhao, Yanning Li, Minggang Zhou, Hua Wang, Chen Li, Li Rao, Yong He

“…Methods: We prospectively enrolled PCI-HBR patients from May 2022 to April 2024 at West China Hospital of Sichuan University. The cohort was randomly divided into training and internal validation sets in a ratio of 7:3. …”
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The prevalence and antimicrobial resistance of respiratory pathogens isolated from feedlot cattle in Canada by Porjai Rattanapanadda, Porjai Rattanapanadda, Dana Ramsay, Alyssa Butters, Calvin W. Booker, Sherry J. Hannon, Steve Hendrick, Joyce Van Donkersgoed, Brian N. Warr, Sheryl P. Gow, Paul S. Morley

“…ObjectivesThe purpose of this study was to characterize the prevalence of antimicrobial resistance in Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolated from healthy feedlot cattle over 2 years, and investigate factors potentially associated with recovery of resistant isolates.MethodsDeep-guarded nasopharyngeal (NP) swabs were used to sample feedlot cattle in multiple randomly selected feedlots (2019 n = 21, 2020 n = 26) at 2 timepoints. …”
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Effect of Traditional Chinese Medicine collapse stains combined with western medicine in treating acute herpes zoster (中药溻渍联合西医治疗急性期带状疱疹的疗效观察)... by YAO Meiyu (姚美玉), SUN Mingli (孙明丽), TANG Ling (唐玲), ZHOU Jie (周洁), CHEN Hong (陈宏)

“…Methods A total of 60 patients with acute herpes zoster were randomly divided into observation group and control group, with 30 cases in each group. …”
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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

“…This study aims to evaluate the effectiveness of three popular frameworks—Consolidated Framework for Implementation Research (CFIR), Theoretical Domains Framework (TDF) and Normalization Process Theory (NPT)—in improving implementation outcomes for the integrated TCM and Western medicine clinical practice guideline for stroke management.Methods and analysis This study employs a hybrid type III design with a factorial randomised controlled trial, where 45 TCM hospitals will be randomly assigned to one of eight experimental conditions based on the use or non-use of each framework (CFIR, TDF, NPT). …”
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Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol by Meghedi Vartanian, Konrad Jakob Endres, Yee Teng Lee, Silke Friedrich, Marie-Theres Meemken, Imke Schamarek, Kerstin Rohde-Zimmermann, Robin Schürfeld, Lina Eisenberg, Anja Hilbert, Frauke Beyer, Michael Stumvoll, Julia Sacher, Arno Villringer, Julia F. Christensen, A. Veronica Witte

“…We therefore aim to examine the effects of prebiotic and neurocognitive behavioral interventions on food decision-making and to assay the underlying mechanisms in a Randomized Controlled Trial (RCT). Method This study uses a parallel arm RCT design with a 26-week intervention period. …”
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Factors associated with attention-deficit/hyperactivity disorder among Tunisian children by Asma Guedria, Asma Guedria, Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Manel Ben Fredj, Randaline Ayoub, Randaline Ayoub, Randaline Ayoub, Hela Ben Abid, Hela Ben Abid, Hela Ben Abid, Ahmed Mhalla, Ahmed Mhalla, Ahmed Mhalla, Hela Slama, Hela Slama

“…The second group included 80 healthy control children. They were randomly selected and matched for age and gender. A literature-based questionnaire assessing the socio-demographic data, biological and environmental factors associated with ADHD was administered to the parents. …”
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Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats by Yongting Zhang, Yuwen Li, Wenting Li, Jie Cai, Ming Yue, Longfeng Jiang, Ruirui Xu, Lili Zhang, Jun Li, Chuanlong Zhu

“…We examined the therapeutic potential of passage five (P5) and ten (P10) human umbilical cord- (hUC-) MSCs via their transplantation into Sprague-Dawley (SD) rats with D-galactosamine (D-GalN) and LPS-induced acute liver failure (ALF). SD rats were randomly divided into three groups: control group, P5 hUC-MSCs group, and P10 hUC-MSCs group. …”
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Hantavirus antibody seroprevalence and risk factors among adults in West Kazakhstan, 2023 by Ulyana Gubareva, Ulyana Gubareva, Ulyana Gubareva, Roberta Horth, Roberta Horth, Dilyara Nabirova, Dilyara Nabirova, Nur Tukhanova, Nur Tukhanova, Elmira Utegenova, Elmira Utegenova, Zhanna Shapiyeva, Zangar Turliyev, Nazym Tleumbetova, Nurbek Maykanov, Manar Smagul, Alan L. Landay, Gavin Cloherty, Gavin Cloherty, Francisco Averhoff, Francisco Averhoff, Edmond F. Maes

“…Estimate antibody seroprevalence for hantaviruses and identify associated risk factors among high-risk adults in western Kazakhstan in 2023.MethodsIn this cross-sectional study, adults were randomly sampled from public clinic registries in 14 villages in West Kazakhstan during June–July 2023. …”
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Development and validation of a nomogram for predicting immune-mediated colitis in lung cancer patients treated with immune checkpoint inhibitors: a retrospective cohort study in C... by Qianjie Xu, Xiaosheng Li, Yuliang Yuan, Guangzhong Liang, Zuhai Hu, Wei Zhang, Ying Wang, Haike Lei

“…This study aimed to identify the clinical risk factors associated with IMC development in patients with lung cancer and to develop a risk prediction model to facilitate personalized treatment and care strategies.MethodsThe data collected included 21 variables, including sociodemographic characteristics, cancer-related factors, and routine blood markers. The dataset was randomly partitioned into a training set (70%) and a validation set (30%). …”
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Exploring the synergistic effect of rose distillation waste and biostimulant beside other organic amendments onRosa damascena seedlings’ growth by Soumia El Malahi, Lahcen Irahoui, Wafaa Mokhtari, Mounia Ennami, Houda Taimourya, Jamaa Zim, Abdallah Zayani, Bahija Zakeri, Khalid Dhassi, Mimoun Mokhtari, Lalla Mina Idrissi Hassani

“…Method: The data was collected experimentally in a controlled greenhouse condition.  A complete randomized block design with three replicates was applied to conduct the experimental units. …”
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Investigating a caregiver-assisted social skills group programme for primary and early high school-aged children with acquired brain injury or cerebral palsy: protocol for a pilot... by Koa Whittingham, Roslyn N Boyd, Rose Gilmore, Leanne Sakzewski, Nicola Hilton, Afroz Keramat, Bianca Thompson, Jacqui Barfoot, Christine T Moody

“…Thirty-two school-aged children (grades 3+; 8–13 years) with an ABI or CP and their caregiver(s) will be recruited and randomly assigned to either 12 week PEERS Plus or waitlist usual care. …”
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Knowledge towards health impacts of climate change among Amhara Sayint community, Northeastern Ethiopia by Genanew Mulugeta Kassaw, Asmamaw Malede, Adinew Gizeyatu, Metadel Adane, Asha Embrandiri, Awoke Keleb, Gete Berihun, Abebe Kassa Geto, Belachew Tekleyohannes Wogayehu, Gebremeskel Kibret Abebe, Tibebu Habtie Zewde, Sisay Abebe Debela, Solomon Seyoum, Amana Ogeto Luke, Gashaw Wondaya, Atitegeb Abera Kide, Mekonnen Moges, Denise Metoyer, Mesfin Gebrehiwot

“…Design/methodology/approach – A community-based cross-sectional study was conducted from 20 July to 5 September 2022, involving 605 randomly selected households in Amhara Sayint district, Northeastern Ethiopia. …”
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Efficacy and Safety of Pramipexole Sustained Release versus Immediate Release Formulation for Nocturnal Symptoms in Chinese Patients with Advanced Parkinson’s Disease: A Pilot Stud... by Haiyan Zhou, Shuhua Li, Hongmei Yu, Shenggang Sun, Xinhua Wan, Xiaodong Zhu, Chun-Feng Liu, Ling Chen, Wei Xiang, Yaqing Sun, Haibo Chen, Shengdi Chen

“…A total of 98 patients were randomly allocated (1 : 1) to either pramipexole SR (n = 49) or pramipexole IR (n = 49) groups. …”
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