Effects of irrigation and organic fertilizer on pumpkin yield, quality, and water-fertilizer use efficiency in arid northwest China by Meng Yin, Jinxia Zhang, Liangliang Du, Lin Ding, Tao Zhong, Pengliang Tian, Runheng Yang

“…The study included ten treatments with a completely randomized two-factor design, comprising three irrigation quotas, three organic fertilizer application rates and a control group (CK). …”
Get full text

Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation by Dong Q, Wu J, Zhang H, Chen X, Xu X, Chen J, Shi C, Luo L, Zhang D

“…This study explores the complex immunometabolic landscape of RA to identify potential therapeutic targets.Patients and Methods: We integrated genome-wide association study (GWAS) data involving 1,400 plasma metabolites, 731 immune cell traits, and RA outcomes from over 58,000 participants. Mendelian randomization (MR) and mediation analyses were applied to evaluate causal relationships among plasma metabolites, immune cells, and RA. …”
Get full text

Application of N-Acetyl-Glucosaminil-N-Acetyl-Muramyl Dipeptide during Triple Component Anti-Helicobacter Pylori Therapy in the Period of Coronavirus Infection COVID-19 by M. R. Konorev, E. N. Tyshevich, R. A. Pavlyukov

“…Aim: evaluation of the incidence of COVID-19 infection after three-component H. pylori eradication therapy while taking N-acetyl-glucosaminyl-N-acetyl-muramyl dipeptide (GMDP).Materials and methods. A prospective randomized comparative clinical study was carried out. …”
Get full text

The effect of temperature on the physiological condition and growth performance of freshwater eel elver Anguilla bicolor bicolor McClelland, 1844 by Latifa Fekri, Ridwan Affandi, Muhammad Fajar Rahardjo, Tatag Budiardi, Charles Parningotan Haratua Simanjuntak, Tezza Fauzan, Indrayani Indrayani

“…The study used a completely randomized design with five different levels of temperature (22°C, 24°C, 26°C, 28°C, and 30°C) as treatments with two replications. …”
Get full text

Establishment of a New Hyperglycemic Obesity Cardiac Dysfunction Mouse Model with Triacsin C by ZHAO Xiaona, WANG Peng, YE Maoqing, QU Xinkai

“…Objective This study aims to establish a novel hyperglycemic obesity mouse model by utilizing Triacsin C, an inhibitor of acyl-CoA synthetase long-chain family member 1 (ACSL1), combined with a high-fat diet, to simulate the changes in adipose tissue and cardiac function observed in patients with obesity-related type 2 diabetes.MethodsTwenty adult SPF-grade male C57BL/6J mice were randomly divided into two groups: the Control group (injected intraperitoneally with citric acid-sodium citrate buffer, Con group) and the TC group (injected intraperitoneally with Triacsin C, TC group). …”
Get full text

Exploring Health Educational Interventions for Children With Congenital Heart Disease: Scoping Review by Neda Barbazi, Ji Youn Shin, Gurumurthy Hiremath, Carlye Anne Lauff

“…ResultsThe review identified 11 studies: 9 randomized controlled trials and 2 observational studies. …”
Get full text

Determination of Seroprevalence and Risk Factors of Crimean–Congo Haemorrhagic Fever (CCHF) in the Endemic Region in Turkey: A Population-Based Cross-Sectional Study by Rıza Çıtıl, Mücahit Eğri, Yalçın Önder, Fazilet Duygu, Yunus Emre Bulut, Özkan Yaşayancan, Nagehan Yıldız Çeltek, Şafak Şahin

“…In this population-based cross-sectional study, a total of 85 Family Medicine Units (FMUs), from over 170 in Tokat, were randomly selected using 50% sampling. The sample size was determined among the subjects aged ≥20 who registered with the FMUs, due to gender, age group, and the urban/rural population size of Tokat using the stratified cluster sampling method. …”
Get full text

Prevalence, predictors, and economic burden of mental health disorders among asylum seekers, refugees and migrants from African countries: A scoping review. by Wael Osman, France Ncube, Kamil Shaaban, Alaa Dafallah

“…In accordance with our inclusion criteria, our review found only one study that examined the economic impact of MH disorders in these groups, leaving a significant knowledge gap. According to this randomized controlled trial, intervention to reduce psychological impairment can help young people stay in school, improve their quality-adjusted life year (QALY), and earn an incremental cost-effectiveness ratio (ICER) of $7260 for each QALY gained.…”
Get full text

How long does it take to start minimal enteral feeding in preterm Neonates admitted to NICUs in Southern Oromia, Ethiopia? by Anteneh Fikrie, Terefu Yambo, Alo Edin, Miesa Gelchu, Dejene Hailu, Mark Spigt

“…Method A facility-based retrospective follow up study was conducted among 434 randomly selected preterm neonates admitted to NICU of Bule Hora University Teaching Hospital and Yabello General Hospital from January 1, 2021 to December 30, 2022. …”
Get full text

The Use of Coffee Cherry Pulp Extract as an Alternative to an Antibiotic Growth Promoter in Broiler Diets by Wanaporn Tapingkae, Phatchari Srinual, Pimporn Khamtavee, Naret Pintalerd, Thanongsak Chaiyaso, Mongkol Yachai, Chanidapha Kanmanee, Chompunut Lumsangkul, Orranee Srinual

“…Five hundred 1-day-old Ross 308 chicks were randomly assigned to five groups: a basal diet control, a basal diet with antibiotic growth promoters at 0.25 g/kg, and groups supplemented with CCPE at 0.5, 1.0, and 2.0 g/kg diet over 35 days. …”
Get full text

The Metabolome Characteristics of Aerobic Endurance Development in Adolescent Male Rowers Using Polarized and Threshold Model: An Original Research by Fanming Kong, Miaomiao Zhu, Xinliang Pan, Li Zhao, Sanjun Yang, Jinyuan Zhuo, Cheng Peng, Dongkai Li, Jing Mi

“…Methods: Twenty-four male rowers aged 14–16 were randomly divided into a THR group and a POL group (12 participants each). …”
Get full text

Different lysine-to-methionine ratios in a low-protein diet affect the microbiome and metabolome, influencing the jejunal barrier function in Tibetan sheep by Fengshuo Zhang, Zhenling Wu, Yu Zhang, Quyangangmao Su, Kaina Zhu, Xuan Chen, Shengzhen Hou, Linsheng Gui

“…IntroductionThe objective of this study was to evaluate the effects of the dietary lysine (Lys)/ methionine (Met) ratio in a low-protein diet on short-chain fatty acid (SCFA) profiles, villus morphology, antioxidant capacity, and immune status of the jejunum in Tibetan sheep.MethodsA total of 90 weaned Tibetan sheep, each 2 months old with an initial weight of 15.37 ± 0.92 kg, were randomly divided into three treatment groups. These groups were supplemented with different Lys/Met ratios of 3 [low protein-high methionine (LP-H)], 2 [low protein-medium methionine (LP-M)], and 1 [low protein-low methionine (LP-L)] in the basal diet (10% crude protein). …”
Get full text

EFFECT OF GLOMUS MOSSEAE, AZOTOBACTER CHROOCOCCUM AND VERMICOMPOST TEA ON SOME RHIZOSPHERE CHARACTERS AND MYCORRHIZAL DEPENDENCY OF CUCUMBER PLANTS by Z. H. Al-Rawi, J. S. Alkobaisy

“…The experiment was designed with a randomized, completely-blocked design (RCBD) with three replications. …”
Get full text

Efficacy of MCU-based and 3D-FEA for Improving Cervical Spondylosis by Meigui KE, Ruixu XU, Ningying HUANG, Hai GUO, Xinghui YAN, Nanxi WU, Sidong DOU

“…Objective:Based on the Muli-Cervical Unit(MCU)and three-dimensional finite element analysis(3D-FEA),this study explored whether the"Tuo tian zhuang"exercise in the Southern Shaolin Yi Jin Jing can improve the efficacy of electroacupuncture in the treatment of cervical spondylosis.Methods:Patients who met the inclusion criteria for cervical spondylosis of cervical type were randomized assigned by age stratification into control group and experimental group. …”
Get full text

Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress by Yuequan Zhu, Yazeed Haddad, Ho Jun Yun, Xiaokun Geng, Yuchuan Ding

“…A total of forty 6-week-old male C57BL/6J mice were randomly divided into the CRS and control groups. In the CRS group (n=20), mice were placed in a well-ventilated Plexiglas tube for 6 hours per day for 28 consecutive days. …”
Get full text

Survival analysis of patients with hepatocellular carcinoma based on the ratio of platelet count to spleen diameter by Huiwen Yan, Dongdong Zhou, Dongdong Zhou, Xiaoli Liu, Peng Wang, Tingting Jiang, Zhiyun Yang

“…The aim of this study was to apply a new method to establish and validate a model for predicting the prognosis of patients based on PSL with HCC.MethodsA total of 1,104 patients with clinical diagnosed with HCC following non-surgical therapy randomly divided the patients into a primary cohort and a validation cohort in a ratio of 7:3, in which 772 HCC patients were in the primary cohort and a total of 332 HCC patients were in the validation cohort. …”
Get full text

Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…Variants R444* (rs377049098) and R444Q (rs72549376) were not found in the general population sample either (576 randomly selected West Siberia residents). All the detected mutations caused the development of the autosomal recessive form of primary congenital glaucoma. …”
Get full text

Efficacy and safety of NeoAdjuvant chemotherapy with or without tIslelizumab followed by debulking surgery for oVarian cancEr (NAIVE study) in China: study protocol of an open-labe... by Ying Zhu, Jianwei Zhou, Zhigang Zhang, Jiaojiao Zhang, Jing Fei, Xiaoqing Zhu

“…Enrolled patients will be randomly assigned in a 1:1 ratio to either the experimental arm, which will receive neoadjuvant platinum-based chemotherapy in combination with tislelizumab, or the control arm, which will receive neoadjuvant platinum-based chemotherapy. …”
Get full text

Investigation of antioxidant capacity in farmed beluga (Huso huso) fingerling fed with Echinacea purpurea and garlic (Allium sativum) powder extracts by Soheil Bazari Moghadam, Forouzan Bagherzadeh Lakani, Jalil Jalilpoor, Mehdi Masoumzadeh

“…Materials and methods: A total of 210 fish with an average weight of 27.74 ± 0.26 g were randomly placed in twenty one 500-L fiberglass tanks, and fed with basal diet supplemented with powder extracts in seven treatments (with three replications) including control (without adding garlic and E. purpurea), treatment 1 = 250 mg/kg garlic, treatment 2 = 500 mg/kg garlic, treatment 3 = 1000 mg/kg garlic, treatment 4 = 250 mg/kg E. purpurea, treatment 5 = 500 mg/kg E. purpurea, treatment 6 = 1000 mg/kg E. purpurea for 8 weeks. …”
Get full text

Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis–A preclinical systematic review and meta-analysis by Jinchen Chong, Zepeng Chen, Jiaze Ma, Linhai He, Yijia Zhu, Zhihua Lu, Zhengxi Qiu, Chen Chen, Yugen Chen, Feng Jiang

“…Methods A systematic search was conducted across databases including PubMed, EBSCO, Web of Science, and Science Direct, up to March 2024, identifying randomized controlled trials (RCTs) examining baicalin’s impact on UC in animal models. …”
Get full text