The Dose-Dependent Effects of Spironolactone on TGF-β1 Expression and the Vulnerability to Atrial Fibrillation in Spontaneously Hypertensive Rats by Mirong Tang, Yan Chen, Fuqing Sun, Liangliang Yan

“…Forty 20-week-old male SHRs were randomly divided into 4 groups (10 rats per group): 3 spironolactone groups were lower-dose group (10 mg·kg−1·d−1, dissolved in 2 ml saline solution, group SL), medium-dose group (40 mg·kg−1·d−1, dissolved in 2 ml saline solution, group SM), higher-dose group (80 mg·kg−1·d−1, dissolved in 2 ml saline solution, group SH) and one hypertension group (2 ml saline solution for stomach gavage, group H). …”
Get full text

Performance of perisel as shelter and periphyton substrate in the floating cage of Pacific white shrimp culture by Rifka Liling Palinggi, Tatag Budiardi, Daniel Djokosetiyanto

“…This research aimed to enhance the production performance of shrimp through the utilization of periphyton as a natural feed for shrimp. A completely randomized design with 3 treatments (in triplicates) were applied in this experiment, i.e floating cage without perishel (control), floating cage with PE perishel and PA perishel. …”
Get full text

The effect of prenatal balanced energy and protein supplementation on gestational weight gain: An individual participant data meta-analysis in low- and middle-income countries. by Dongqing Wang, Uttara Partap, Enju Liu, Janaína Calu Costa, Ilana R Cliffer, Molin Wang, Sudeer Kumar Nookala, Vishak Subramoney, Brittany Briggs, Imran Ahmed, Alemayehu Argaw, Shabina Ariff, Nita Bhandari, Ranadip Chowdhury, Daniel Erchick, Armando García-Guerra, Masoumah Ghaffarpour, Giles Hanley-Cook, Lieven Huybregts, Fyezah Jehan, Fatemeh Kaseb, Nancy F Krebs, Carl Lachat, Tsering Pema Lama, Dharma S Manandhar, Elizabeth M McClure, Sophie E Moore, Ameer Muhammad, Lynnette M Neufeld, Andrew M Prentice, Amado D Quezada-Sánchez, Dominique Roberfroid, Naomi M Saville, Yasir Shafiq, Bhim P Shrestha, Bakary Sonko, Sajid Soofi, Sunita Taneja, James M Tielsch, Laéticia Céline Toe, Naser Valaei, Wafaie W Fawzi

“…<h4>Methods and findings</h4>Individual participant data from 11 randomized controlled trials of prenatal BEP supplements (N = 12,549, with 5,693 in the BEP arm and 6,856 in the comparison arm) in low- and middle-income countries were used. …”
Get full text

Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.Design Randomised controlled trial with blinded assessment of primary outcome variable.Setting Outpatient primary healthcare population from 5 New Zealand sites.Participants 138 adults aged ≥16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.Interventions Participants were randomly allocated 1:1 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks.Main outcome measures The primary outcome measure was the proportion of participants who had a ≥2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. …”
Get full text

Interactive effects of triploidy induction and culture densities on growth performance and stress, immune, and metabolic responses in juvenile rainbow trout (Oncorhynchus mykiss) by Roghayeh Mahmoudi, Mahdi Naderi, Hakimeh Dopeikar, Seyed Ali Khorasaninasab, Seyed Hadi Seyedalhosseini

“…Juveniles (30.70 ± 1.04 g) were randomly stocked into 24 fiberglass tanks with a flow-through system. …”
Get full text

IDENTITAS ARSITEKTUR MANDAR PADA BANGUNAN TRADISIONAL DI KABUPATEN MAJENE by Nurmiati Zamad, Alfiah Alfiah

“…The method used in the research is a field survey by identifying 25 samples of traditional buildings from 403 populations in Banggae District Majene District. Sampling was done randomly from one kelurahan representing the research location. …”
Get full text

Effect of Auditory Integration Training on Children with Autism Spectrum Disorder and Auditory Attention Disorder by HUANG Qijun, ZHOU Kun, LIU Zhenhuan, YANG Jie

“…ObjectiveTo observe the effect of auditory integration training on language, social communication and behavior of Children with autism spectrum disorder (ASD) and auditory attention disorder.MethodsA total of 83 ASD children with auditory attention disorder treated in the children rehabilitation department of Changsha Maternal and Child Health Hospital from January 2020 to May 2021 were randomly divided into control group and observation group, with 41 cases and 42 cases respectively. …”
Get full text

The effect of repetitive transcranial magnetic stimulation on sleep quality in patients with more than mild depressive mood: a systematic review and meta-analysis by Yu’ang Liu, Silang Huang, Xinxin Zhang, Huangying Liao, Weiguo Liu, Zhi Zhang, Xianhui Qu, Ziwen Wang

“…BackgroundThe purpose of this study was to systematically evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) therapy on sleep quality in patients with more than mild depressive mood.MethodsRandomized controlled trials in PubMed, Cochrane Library, Web of Science, Embase, Scopus, and ScienceDirect on rTMS to improve sleep quality in patients with more than mild depressive mood up to September 2023 were searched. …”
Get full text

Early Effects of Bronchoscopic Cryotherapy in Metastatic Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Single-Center Prospective Study by Gediminas Vasiliauskas, Evelina Žemaitė, Erika Skrodenienė, Lina Poškienė, Gertrūda Maziliauskienė, Aurimas Mačionis, Skaidrius Miliauskas, Donatas Vajauskas, Marius Žemaitis

“…<b>Methods:</b> Fifty-five patients with metastatic non-small cell lung cancer who had received no prior treatment were randomized into two groups in a 1:1 ratio: the bronchoscopic cryotherapy group or the control group. …”
Get full text

Rehabilitation Impact of Vivifrail Exercise Program Type C on the Cognitive Function of Pre-Frail Elderly People in the Community by Sri Soenarti, Dwi Indriani Lestari, Muhammad Barlian Nugroho, Harien Lestari, Tita Hariyanti

“…This study was a quasi-experiment with a non-randomized control group pretest-posttest design. The sample was chosen by the quota sampling method. …”
Get full text

Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness by Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Yang-Jia Chen, Nan-Nan Zhang, Jian-Wen Xu, Jun Ni

“…A total of 64 patients were enrolled and randomly placed into the active and sham groups. Ultimately, 50 patients completed the study. …”
Get full text

Testing the Feasibility, Acceptability, and Potential Efficacy of an Innovative Digital Mental Health Care Delivery Model Designed to Increase Access to Care: Open Trial of the Dig... by Natalia Macrynikola, Kelly Chen, Erlend Lane, Nic Nguyen, Jennifer Pinto, Shirley Yen, John Torous

“…ConclusionsResults suggest that the Digital Clinic model is feasible, acceptable, and potentially efficacious, warranting a future randomized controlled trial to establish the efficacy of this innovative model of care.…”
Get full text

Phenology, growth, and seed tuber yield in potato (Solanum tuberosum L) varieties as influenced by plant density at adet, northwestern Ethiopia by Shege Getu Yayeh, Wassu Mohammed, Kebede Woldetsadk, Tewodros Bezu, Yigzaw Dessalegn, Semagn Asredie

“…The experiment was laid out in a randomized complete block design with three replications. …”
Get full text

Pair replacement on the spawning success of broodstock Seahorse (Hippocampus barbouri) by . Syafiuddin, M. Zairin Junior, Dedi Jusadi, Odang Carman, Ridwan Affandi

“…The experiment was designed to apply completely randomize design by using the following treatments: Treatment A, without replacement neither male nor female. …”
Get full text

Effects of Source on the Nitrogen Uptake, Allocation Patterns, and Performance of Strawberry (<i>Fragaria × ananassa</i> Duch.): A ¹⁵N-Tracer Study by Sirajo Salisu Jibia, Kanokwan Panjama, Chaiartid Inkham, Takashi Sato, Norikuni Ohtake, Soraya Ruamrungsri

“…Five treatments were applied: T1 (5.0 mM ¹⁵NO₃⁻), T2 (2.5 mM ¹⁵NO₃⁻ + 2.5 mM NH₄⁺), T3 (5.0 mM ¹⁵NH₄⁺), T4 (2.5 mM ¹⁵NH₄⁺ + 2.5 mM NO₃⁻), and T5 (N-free, control) in a completely randomized design. Significant (<i>p</i> < 0.05) differences were observed in N uptake and distribution and total N concentration among the treatments. …”
Get full text

Behavioral Study of Parkinson's Disease Rats Model with DigiGait^TM Imaging System by LIU Xinhao, MA Shujie, DING Daofang, LUO Kailiang, MA Xinran, JIANG Wenling, HU Jun

“…ObjectiveTo detect the feasibility of DigiGait^TM Imaging System in evaluating gait changes in rats model with Parkinson's disease (PD).MethodsA total of 24 clean male SD rats were randomly divided into normal group, sham operation group and model group, with eight rats in each group. …”
Get full text

Therapeutic Effect of Yijinjing Rehabilitation Training Combined with Interference Current Therapy on Patients with Knee Osteoarthritis by XU Ming, LI Ya, QIN Shuang, LU Xiaoye, AI Kun, ZHANG Hong

“…ObjectiveTo observe the effect of Yijinjing rehabilitation training combined with interference current therapy (ICT) on motor function and balance function of patients with knee osteoarthritis (KOA).MethodsA total of 68 patients with KOA in the Rehabilitation Medicine Department of Changsha Central Hospital from April 2022 to January 2023 were randomly divided into control group and observation group, with 34 cases in each group. …”
Get full text

A predictive risk‐scoring model for survival prognosis of multiple myeloma based on gain/amplification of 1q21: Experience in a tertiary hospital in South‐Western China by Yanqiu Xiong, Shanshan Liang, Wenjiao Tang, Li Zhang, Yuhuan Zheng, Ling Pan, Ting Niu

“…The patient cohort was randomly divided into a training set (66.5%, n = 244) and a validation set (33.5%, n = 133). …”
Get full text

Effect of high-quality nursing model on rehabilitation of patients with cerebral hemorrhage caused by cerebral vascular malformations (优质护理模式在脑血管畸形出血患者康复中的应用效果)... by LI Yunmeng (李云梦)

“…Methods Totally 120 patients with cerebral hemorrhage caused by cerebral vascular malformations admitted to hospital from January 2021 to December 2022 were randomly divided into two groups. The control group was given routine nursing, and the observation group was given high-quality nursing mode. …”
Get full text

Application of MRI image segmentation algorithm for brain tumors based on improved YOLO by Tao Yang, Xueqi Lu, Lanlan Yang, Miyang Yang, Jinghui Chen, Hongjia Zhao

“…Dataset 1 contains a total of 3,223 images, and Dataset 2 contains 216 images. From Dataset 1, we randomly selected 3,000 images and used the Labelimg tool to annotate the cancerous regions within the images. …”
Get full text