Predictive value of enhanced CT and pathological indicators in lymph node metastasis in patients with gastric cancer based on GEE model by Ling Yang, Yingying Ding, Dafu Zhang, Guangjun Yang, Xingxiang Dong, Zhiping Zhang, Caixia Zhang, Wenjie Zhang, Youguo Dai, Zhenhui Li

“…Methods Sixty-six consecutive patients (235 regional lymph nodes) with pathologically confirmed gastric cancer who underwent surgery at our hospital between December 2020 and November 2021 were retrospectively reviewed. They were randomly allocated to training (n = 38, number of lymph nodes = 119) and validation (n = 28, number of lymph nodes = 116) datasets. …”
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Multi-institutional evaluation comparing guidance from International Ki67 Working Group vs National Health Commission of China on immunohistochemistry-based Ki67 assessment alongsi... by Yin Wang, Jiarui Zou, Qinghua Cao, Guihong Dai, Panhong Fan, Xue Gong, Jinyan Jiang, Yanqing Kong, Chao Liu, Chunhui Liu, Chenjia Lu, Meiren Li, Zhiqiang Lang, Yang Lin, Yan Peng, Haiyan Shi, Yuhuan Wang, Jiu Wang, Bichen Xie, Bing Yang, Guohua Yu, Cuiping Zhang, Hengming Zhang, Luting Zhou, Zilan Zhang, Zhenli Zhu, Junmei Hao

“…They were evaluated in this multi-institutional study alongside the results from the Quantitative Dot Blot (QDB) method.MethodsThree alternative adjacent sections from 40 primary ER+ breast cancer resection blocks were randomly assigned a number from 1 to 120 for Ki67 staining and reviewed by 21 pathologists, while the other three alternative sections were sent for QDB analysis of Ki67 protein levels. …”
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The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

“…Methods: The ESTO1 trial randomized 158 statin-naïve PCa patients to receive high-dose atorvastatin (80 mg daily) or placebo before prostatectomy. …”
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ADMET evaluation in drug discovery: 21. Application and industrial validation of machine learning algorithms for Caco-2 permeability prediction by Dong Wang, Jieyu Jin, Guqin Shi, Jingxiao Bao, Zheng Wang, Shimeng Li, Peichen Pan, Dan Li, Yu Kang, Tingjun Hou

“…Our findings, based on the Shanghai Qilu’s in-house dataset, showed that the boosting models retained a degree of predictive efficacy when applied to industry data. Furthermore, Y-randomization test and applicability domain analysis were employed to assess the robustness and generalizability of these models. …”
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Toxic Assessment of Heavily Traffic-related Fine Particulate Matter Using an in-vivo Wild-type Caenorhabditis elegans Model by Meng-Ching Chung, Kuo-Lin Huang, Japheth L. Avelino, Lemmuel L. Tayo, Chih-Chung Lin, Ming-Hsien Tsai, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang

“…Of these 23 day samples, three samples (Days A, B, and C) were randomly selected. The results showed that no immediate lethality was observed after acute (24 h) exposure of the nematodes. …”
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Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study by Seda Kahraman, Mutlu Hizal, Burcin Cakan Demirel, Deniz Can Guven, Ozge Gumusay, Basak Oyan Uluc, Ertugrul Bayram, Burcu Gulbagci, Alper Yasar, Sena Ece Davarci, Eda Eylemer Mocan, Omer Acar, Deniz Isik, Esra Aydin, Yusuf Karakas, Melike Ozcelik, Murat Keser, Sadi Kerem Okutur, Onder Eren, Serkan Menekse, Dincer Aydin, Funda Yilmaz, Ozlem Dogan, Gulhan Ozkanli, Hakan Yucel, Veli Sunar, Musa Baris Aykan, Ozlem Ozdemir, Berna Bozkurt Duman, Merve Keskinkilic, Teoman Sakalar, Ali Inal, Muge Karaoglanoglu, Asude Aksoy, Muhammed Muhiddin Er, Nazim Serdar Turhal, Nurhan Onal Kalkan, Mehmet Ali Nahit Sendur

“…Nevertheless, elderly and very old patients with HR+/HER2-MBC treated with CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented in randomized controlled trials. To contribute to the literature, we investigated the real-world efficacy, factors associated with survival and the rates of adverse events (AEs) of the treatment with palbociclib or ribociclib plus ET in the HR+/HER2- MBC patient cohort over the age of 65 for age subgroups. …”
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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…We calculated the prevalence of SMI by UK country, English region and deprivation quintile, antipsychotic and antidepressant medication prescription rates for people with SMI, and prevalence rates of common comorbidities in people with SMI compared with people without SMI.Design Retrospective cohort study from 2000 to 2012.Setting 627 general practices contributing to the Clinical Practice Research Datalink, a UK primary care database.Participants Each identified case (346 551) was matched for age, sex and general practice with 5 randomly selected control cases (1 732 755) with no diagnosis of SMI in each yearly time point.Outcome measures Prevalence rates were calculated for 16 conditions.Results SMI rates were highest in Scotland and in more deprived areas. …”
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Decreased prefrontal activation during verbal fluency task after repetitive transcranial magnetic stimulation treatment for depression in Alzheimer’s disease: a functional near-inf... by Yuanzhi Zhao, Yuanzhi Zhao, Conglong Qiu, Conglong Qiu, Ping Lin, Ping Lin, Mei Yang, Mei Yang, Ling Huang, Ling Huang, Zheng Zhao, Zheng Zhao, Xiangping Wu, Dongsheng Zhou, Dongsheng Zhou

“…This study investigated the influence of rTMS on cortical activation in patients with AD and depressive symptoms, measured using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task.MethodsIn this randomized, double-blind study, patients with AD and depression received either active rTMS (n = 17) or sham-rTMS (n = 16). …”
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Impact of same-day ART initiation on medical care and medication discontinuation among patients with incident HIV infection or AIDS in Taiwan: A population-based cohort study by Chen-Han Chueh, Hsiao-Jou Yu, Yu-Wen Wen, Ming-Neng Shiu, Yi-Ying Chen, Shao-Chin Chiang, Yi-Wen Tsai

“…Discrepancies exist between real-world evidence and randomized trials regarding early antiretroviral therapy (ART) initiation and care retention. …”
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Evaluation of the protective efficacy of OlysetPlus ceiling nets for reduction of malaria incidence in children in Homa Bay County, Kenya: a cluster-randomised controlled study pro... by Daisuke Yoneoka, Jesse Gitaka, James Kongere, Wataru Kagaya, Akira Kaneko, Yura K Ko, Chim W Chan, Mariko Kanamori, Bernard N Kanoi, Gordon Odhiambo Okomo, Protus Omondi, Kelvin B Musyoka, Takatsugu Okai, Victor Opiyo, Jared Oginga, Samuel Mungai, Kibor K Keitany, Elijah Songok, Noboru Minakawa

“…A total of 44 clusters will be randomly assigned in a 1:1 ratio to the intervention group (pyrethroid-PBO ceiling nets) and the control group. …”
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Evaluation of phosphate sources using ruminal fiber transit kinetics methodology by Claudiney de Jesus Couto, Bruna Cardoso Braga, Raphael dos Santos Gomes, Wagner Pessanha Tamy, Severino Delmar Junqueira Villela, Fernando de Paula Leonel, Fernando de Paula Leonel

“…Five crossbred heifers with an average initial weight of 150 ± 8.2 kg were used, randomly distributed in a 5x5 Latin square. The treatments were: negative control (NC) without supplementary phosphorus; dicalcium phosphate from igneous rock with sulfuric acidulation, neutralization with limestone, and the show physical form of microgranules (ISLG); Dicalcium phosphate from igneous rock with sulfuric acidulation, neutralization with hydrated lime, and the physical form of powder (ISLhP); Dicalcium phosphate from sedimentary rock with hydrochloric acidulation, neutralization with limestone, and the micro-granulated show physical form (SeCLG); Dicalcium phosphate from the monocalcium phosphate and hydrated lime reaction adjusted with phosphoric acid, and the powder physical form (MLhPaP). …”
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Testing a multi-behavioral intervention to improve oral health behaviors in the pediatric dental surgery population: protocol for the PROTECT trial by Joanna Buscemi, Teresa G. Borowski, David Avenetti, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Molly Martin, Molly Martin, Marc S. Atkins, Teresa Marshall, Michael Berbaum, Helen H. Lee, Helen H. Lee

“…This study aims to test the efficacy of the PROTECT intervention compared to Usual Care (UC), to improve behavioral oral health outcomes. We will conduct a randomized clinical trial to test the efficacy of PROTECT (n = 210) compared to UC (n = 210) in the pediatric DGA (dental surgery under general anesthesia) population. …”
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Effects of transcranial magnetic stimulation combined with extracorporeal shockwave therapy for poststroke spasticity: study protocol for a randomised controlled trial by Man Yang, Lu Liu, Peng-Yu Wang, Yang Zhu, Ling-Yi Liao, Qiu-Yi Peng, Yong Tao, Jin-Jing Liu, Xiang-Qin Fang, Shi-Hao Gao, Chang-Yue Gao

“…In this trial, 136 patients with PSS will be randomly divided into 4 groups: experimental group 1 (TMS), experimental group 2 (ESWT), experimental group 3 (ESWT+TMS) and control group, 34 patients in each group; all patients received routine rehabilitation. …”
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Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis by Vitor Engracia Valenti, André dos Santos Chagas, Peter Chedraui, Ingrid Soares de Souza, Andrey Alves Porto, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Júnior, Juliana Zangirolami-Raimundo, David M. Garner, Rodrigo Daminello Raimundo

“…This study included non-blinded, single or double-blinded randomized control trials and postmenopausal women diagnosed with T2DM. …”
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The efficacy of Artichoke leaf extract conjugated with organic zinc nanoparticles on growth, carcass traits and blood biochemical parameters of broilers by Elwy A. Ashour, Ahmed K. Aldhalmi, Mahmoud Kamal, Salem S. Salem, Samir A. Mahgoub, Abdulmohsen H. Alqhtani, Mahmoud Madkour, Ahmed A. Elolimy, Mohamed E. Abd El-Hack, Ayman A. Swelum

“…ABSTRACT: This study aimed to discover how using nano artichoke leaf extract Stabilized with zinc Nanoparticles (ZnO-Nano-ALPE) as an alternative to antibiotics and an antioxidant in broiler feed affected their growth, meat quality, and blood. In a completely randomized design experiment, 210 1-day-old chicks (Arbor Acres) were assigned to three trial groups. …”
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Comparison between sevoflurane and propofol induction in I-gel insertion in pediatric patients undergoing inguinal herniotomy by Harshita Singh, Harpreet Kaur, Shirin Parveen, Narendra Singh Bafila, Kirtika Yadav, Anam Rizwan, Dhruvraj Singh

“…Materials and Methods: The prospective observational study included 66 children aged 6 months–8 years with American society of anesthesiologists physical status I and II, scheduled for elective herniotomy. Participants were randomly divided into two groups. Group 1 was induced with Sevoflurane (4–6%), while Group 2 received intravenous Propofol (2.5 mg/kg). …”
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Development and validation of a predictive model and tool for functional recovery in patients after postero-lateral interbody fusion by Shuai Zhou, Zhenbang Yang, Wei Zhang, Shihang Liu, Qian Xiao, Guangzhao Hou, Rui Chen, Nuoman Han, Jiao Guo, Miao Liang, Qi Zhang, Yingze Zhang, Hongzhi Lv

“…The training and validation cohorts were randomly assigned in a 7:3 ratio. To pool data variables LASSO regression was used. …”
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Urban and rural residence: their influence on food group consumption in Iran by Susan Darroudi, Sara Saffar Soflaei, Farzam Kamrani, Zahra Khorasanchi, Zahra Abdollahi, Nasrin Talkhi, Maryam Allahyari, Seyyed Reza Sobhani, Maryam Mohammadi-Bajgiran, Amirmohammad Naderkhmseh, Maliheh Aghasizadeh, Habibollah Esmaily, Gordon Ferns, Majid Ghayour-Mobarhan

“…A total of 1697 participants were randomly recruited from different rural (N = 568), urban (N = 568), and suburban (N = 561) regions across Iran. …”
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Insights from social media into public perspectives on investigative genetic genealogy by Sara Huston, Sara Huston, Diana Madden, Andrea Villanes, Nathan Reed, Nathan Reed, Whitney Bash Brooks, Christopher Healey, Christi Guerrini

“…Third, drawing on the contextual framework of key IGG events, we selected three of the top ten events to code for sentiment along with a randomly sampled subset of tweets across the timeframe. …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…A total of 180 1-d female, yellow-feathered chickens were randomly allocated into 3 treatment groups, the controls (Ctr), the Salmonella-challenged treatment (Sal) and the protocatechuic acid treatment (PA). …”
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