Tumor Size Is a Critical Factor in Adjuvant Chemotherapy for T3-4aN0M0 Gastric Cancer Patients after D2 Gastrectomy by Shi Chen, Li-Ying Ou-Yang, Run-Cong Nie, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, Ying-Bo Chen, Jun-Sheng Peng

“…Our results imply that tumor size should be a critical factor in the decision to utilize adjuvant chemotherapy for T3-4aN0M0 gastric cancer patients after D2 gastrectomy. Additional randomized controlled trials are required before this conclusion can be considered definitive.…”
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Voluntary Forelimbs Exercise Reduces Immobilization-Induced Mechanical Hyperalgesia in the Rat Hind Paw by Kumiko Ishikawa, Satoshi Oga, Kyo Goto, Junya Sakamoto, Ryo Sasaki, Yuichiro Honda, Hideki Kataoka, Minoru Okita

“…We examined the effect of voluntary forelimb exercise on immobilized-induced hyperalgesia in hind paws of rats. Wistar rats were randomly divided into the (1) both hind limbs immobilized group (IM group), (2) immobilization and exercise with nonimmobilized fore limbs group (EX group), and (3) control group. …”
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Drug risk Factors Associated with a Sustained Outbreak of Clostridium difficile Diarrhea in a Teaching Hospital by Swapan K Nath, Suzette Salama, Devia Persaud, James H Thornley, Ian Smith, Gary Foster, Coleman Rotstein

“…Eighty controls were selected from a group of 290 controls randomly chosen from the outbreak period. The controls were matched to cases according to age, admitting diagnosis and unit of admission. …”
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Incidence of hyperkalemia RAASi and SGLT-2i treatment in individuals with diabetic kidney disease: a systematic review and network meta-analysis by Yahui Yuan, Yahui Yuan, Yahui Yuan, Chun Chen, Yuping Lin, Yehao Luo, Yehao Luo, Yehao Luo, Zhaojun Yang, Zhaojun Yang, Zhaojun Yang, Jingyi Guo, Jingyi Guo, Jingyi Guo, Qiaoyun Liu, Qiaoyun Liu, Qiaoyun Liu, Lu Sun, Guanjie Fan, Guanjie Fan, Guanjie Fan

“…BackgroundThis study aims to evaluate the incidence of hyperkalemia and serum potassium levels associated with the use of sodium-glucose cotransporter-2 inhibitors (SGLT-2i), renin‐angiotensin‐aldosterone system inhibitors (RAASi) and concurrent use of these medications in individuals with diabetic kidney disease (DKD).MethodsA comprehensive systematic search was performed in EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Scopus, and PubMed database, covering studies up to March 2024. Relevant randomized controlled trials (RCT) included adults with DKD who were treated with SGLT-2i and RAASi or their combination, with a minimum follow-up duration of 12 weeks. …”
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Predictive nomograms of repeat intrahepatic recurrence and overall survival after radiofrequency ablation of recurrent colorectal liver metastases by Ji-Chen Wang, Bin-Bin Jiang, Zhong-Yi Zhang, Yu-Hui Liu, Li-Jin Shao, Song Wang, Wei Yang, Wei Wu, Kun Yan

“…Objectives This study was conducted to develop nomograms for predicting repeat intrahepatic recurrence (rIHR) and overall survival (OS), after radiofrequency ablation (RFA), treatment in patients with recurrent colorectal liver metastases (CLMs) after hepatectomy based on clinicopathologic features.Methods A total of 160 consecutive patients with recurrent CLMs after hepatectomy who were treated with ultrasound-guided percutaneous RFA from 2012 to 2022 were retrospectively included. Patients were randomly divided into a training cohort and a validation cohort, with a ratio of 8:2. …”
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Wenxin Granules Influence the TGFβ-P38/JNK MAPK Signaling Pathway and Attenuate the Collagen Deposition in the Left Ventricle of Myocardial Infarction Rats by Ya Huang, Aiming Wu, Lixia Lou, Dongmei Zhang, Bo Nie, Yizhou Zhao, Keke Liu, Mingjing Zhao, Hongcai Shang

“…The proximal left anterior descending coronary artery in rats was ligated to induce acute MI. Then, animals were randomly assigned to the model group, the Carvedilol group, and the Wenxin Granules group. …”
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Safety and Effectiveness of BPaL-Based Regimens to Treat Multidrug-Resistant TB: First Experience of an Italian Tuberculosis Referral Hospital by Gina Gualano, Maria Musso, Paola Mencarini, Silvia Mosti, Carlotta Cerva, Pietro Vittozzi, Antonio Mazzarelli, Angela Cannas, Assunta Navarra, Stefania Ianniello, Paolo Faccendini, Fabrizio Palmieri

“…Based on the evidence generated by the TB-PRACTECAL and ZeNix randomized controlled trials, BPaL/BPaLM regimens are recommended over the currently recommended longer regimens in patients with MDR-TB or monoresistance to rifampin (RR). …”
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Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project by Hugo Hornero-Ramirez, Arianne Morissette, Bruno Marcotte, Armelle Penhoat, Béryle Lecomte, Baptiste Panthu, Jacob Lessard Lord, Florence Thirion, Laurie Van-Den-Berghe, Emilie Blond, Chantal Simon, Cyrielle Caussy, Nathalie Feugier, Joël Doré, Philippe Sanoner, Alexandra Meynier, Yves Desjardins, Geneviève Pilon, André Marette, Patrice D. Cani, Martine Laville, Sophie Vinoy, Marie-Caroline Michalski, Julie-Anne Nazare

“…The SINFONI project investigates a multifunctional (MF) nutritional strategy’s impact combining different bioactive compounds on inflammation, GM modulation and CM profile. In this randomized crossover-controlled study, 30 subjects at CM-risk consumed MF cereal-products, enriched with polyphenols, fibers, slowly-digestible starch, omega-3 fatty acids or Control cereal-products (without bioactive compounds) for 2 months. …”
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The effect of blended learning on tacking technique improvement in preteen sailing by Mohamed Abdelkader Souissi, Linda Toumi, Omar Trabelsi, Ismail Dergaa, Ahmed Ghorbel, Adnene Gharbi, Katja Weiss, Thomas Rosemann, Nizar Souissi, Beat Knechtle

“…Thirty-one children aged 11–13 years old were randomly divided into three groups with different learning strategies: BLIV, BLI, and a control group (CONT). …”
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A Spray Foliar Containing <i>Methylobacterium symbioticum</i> Did Not Increase Nitrogen Concentration in Leaves or Olive Yield Across Three Rainfed Olive Orchards by Manuel Ângelo Rodrigues, João Ilídio Lopes, Sandra Martins, Cátia Brito, Carlos Manuel Correia, Margarida Arrobas

“…The third trial, managed according to EU organic farming rules, was organized in a completely randomized design with three treatments: with (yes) and without (no) inoculant and with a treatment involving a seaweed extract, also for foliar application. …”
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Effect of Vernonia amygdalina leaf meal on growth performance, intestinal mucosa activity, digestive enzymes, absorption capacity, and immunity in broiler chickens by B.M. Tokofai, B.M. Orounladji, K. Idoh, O.E. Oke, A. Agbonon

“…Two hundred and forty, one-day-old male Cobb 500 broiler chicks were randomly divided into four groups: an unsupplemented control and VA-1, VA-3 and VA-5 receiving VALM incorporation at concentrations of 1, 3 and 5 g/kg, respectively. …”
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Safety and Efficacy of Topical Lotilaner Ophthalmic Solution 0.25% for the Treatment of Demodex Blepharitis: A Pilot Study by Roberto Gonzalez-Salinas, Elizabeth Yeu, Mark Holdbrook, Stephanie N. Baba, Juan Carlos Ceballos, Martha Massaro-Corredor, Claudia Corredor-Ortega, Nallely Ramos-Betancourt, Hugo Quiroz-Mercado

“…This novel treatment appears to be safe and well tolerated. Randomized controlled studies are needed to confirm the results.…”
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Efficacy of biocompost from pineapple waste coupled with indigenous fungi strains Trichoderma spp. on soil fertility, nutrients uptake, growth, and yield of Ananas comosus (L.) M... by Nguyen Quoc Khuong, Truong Thi Kim Chung, Le Thi My Thu, Tran Chi Nhan, Lieu Mong Ca, Le Thanh Quang, Ly Ngoc Thanh Xuan, Ngo Thanh Phong

“…Method: The experiment with two factors followed a completely randomized block design, including 20 treatments (4 replications). …”
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The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository: rationale and blueprint by Hakim Baazaoui, Stefan T. Engelter, Stefan T. Engelter, Stefan T. Engelter, Henrik Gensicke, Henrik Gensicke, Henrik Gensicke, Lukas S. Enz, Lukas S. Enz, Marios Psychogios, Marios Psychogios, Matthias Mutke, Matthias Mutke, Patrik Michel, Davide Strambo, Alexander Salerno, Henk A. Marquering, Paul J. Nederkoorn, Nabila Wali, Stephanie Tanadini-Lang, Björn Menze, Ezequiel de la Rosa, Kaiyuan Yang, Gian Marco De Marchis, Gian Marco De Marchis, Tolga D. Dittrich, Tolga D. Dittrich, Francesco Valletta, Francesco Valletta, Manon Germann, Carlo W. Cereda, João Pedro Marto, Lisa Herzog, Patrick Hirschi, Zsolt Kulcsar, Susanne Wegener, Susanne Wegener

“…This dataset reflects the current state of practice in stroke patient evaluation and management and will enable researchers to retrospectively study clinically relevant questions outside the scope of randomized controlled clinical trials. New centres are invited to join MAGIC if they meet the requirements outlined here. …”
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Clinical efficacy of a virtual reality tool for the treatment of obesity: study protocol of a randomised controlled trial by Dimitra Anastasiadou, Jose Antonio Ramos-Quiroga, Mel Slater, Bernhard Spanlang, Desiderio Cano Porras, Marta Comas, Andreea Ciudin, Gemma Parramon Puig, Julia Vázquez-De Sebastián, Pilar Lusilla-Palacios

“…Participants will be recruited from the external consultations of the Vall d'Hebron University Hospital and be randomly assigned to three groups. The experimental group 1 will engage in a virtual self-conversation using the ConVRself platform, the experimental group 2 will participate in a ‘pre-established discourse’ provided by the virtual counsellor, who will give psychoeducation advice, and the control group will continue with treatment as usual. …”
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Effects of biophilic virtual reality on cognitive function of patients undergoing laparoscopic surgery: study protocol for a sham randomised controlled trial by Bin Gao, Yanling Zhou, Jianhua Wang, Binbin Zhu, Qiuyan Weng, Wenjun Luo, Xiuchao He, Lufei Jin, Qinwen Wang, Ahmad Khaled Ahmad Harb

“…Participants will be randomly assigned to receive biophilic VR or sham VR (1:1 ratio), all patients have 20 min of exposure per day during the hospital stay. …”
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Microencapsulated Escape Lysine with Tannin as an Adjuvant in Sheep Diets by Roberto Matheus Oliveira, José Morais Pereira Filho, Claudiney Inô, Évyla Andrade, Kevily Henrique Lucena, Juliana Paula Oliveira, Elzania Pereira, Ronaldo Oliveira, Ricardo Edvan, Leilson Bezerra

“…Forty intact male Santa Ines × Dorper sheep (~4 months old, BW 23 ± 1.2 kg) were allocated, in a randomized block design, to four treatments: control group (no lysine addition), supplementation with free lysine, escape lysine, and escape lysine + tannin extract. …”
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Manifestation of agronomically valuable traits in the progeny of a sorghum mutant carrying the genetic construct for RNA silencing of the γ-kafirin gene by L. A. Elkonin, N. V. Borisenko, T. E. Pylaev, O. A. Kenzhegulov, S. Kh. Sarsenova, N. Yu. Selivanov, V. M. Panin

“…The mutant lines were grown in experimental plots in three randomized blocks. The studied lines were characterized by improved digestibility of kafirins, a modified type of endosperm, completely or partially devoid of the vitreous layer, an increased percentage of lysine (by 75 %), reduced plant height, peduncle length, 1000-grains weight, and grain yield from the panicle. …”
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Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study by Noraidatulakma Abdullah, Ying‐Xian Goh, Aisyatul Najihah Khuzaimi, Azwa Shawani Kamalul Arifin, Nurul Ain Mhd Yusuf, Nazihah Abd Jalal, Norliza Ismail, Nurul Faeizah Husin, Mohd Arman Kamaruddin, Rahman Jamal

“…Of these, 750 who developed diabetes were selected as cases, while 3750 controls were chosen randomly from healthy participants. This nested case–control study included 4500 eligible participants from The Malaysian Cohort, with a 1:5 case‐to‐control ratio. …”
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Interindividual Variability Response to Resistance and High-Intensity Interval Training on Blood Pressure Reduction in Hypertensive Older Adults by Johnattan Cano-Montoya, Nicolas Hurtado, Carolina Núñez Vergara, Sebastián Báez Vargas, Marcela Rojas-Vargas, Sergio Martínez-Huenchullán, Cristian Alvarez, Mikel Izquierdo

“…Methods: Thirty-nine participants were randomized into RT-G (<i>n</i> = 13), HIIT-G (<i>n</i> = 13), or control (CG, <i>n</i> = 13) groups. …”
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