Molecular Mechanism of Germinated Foxtail Millet Bioactive Peptides in Attenuating Copper-induced Oxidative Damage in Caenorhabditis elegans by Huiqi ZHANG, Xiao CHEN, Xueling JIN, Jingjing LI, Juanli YUAN, Jinyan GAO, Hongbing CHEN, Yong WU

“…Objective: This study aimed to explore the mitigating effects of germinated foxtail millet bioactive peptides (GRBPs) on copper-induced oxidative damage in Caenorhabditis elegans (C. elegans) and its potential mechanisms. Methods: By randomly grouping, the wild-type N2 C. elegans were divided into a control group and GRBPs groups to examine the effects of GRBPs feeding on mobility and survival rate of C. elegans induced by copper. …”
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Growth Factor Comparison in Cortical Demineralized Bone Matrix that Demineralized Using Chloric and Acetic Acid by Mouli Edward, Ferdiansyah Mahyudin, Mohammad Hardian Basuki, Heri Suroto, Ferdiansyah Danang Perwira

“…Methods: This in vitro experimental laboratory study used a randomized controlled post-test-only group design. We characterized the Insulin-like growth factor-1 (IGF-1), Bone morphogenetic protein-2 (BMP-2), and Transforming growth factor-β (TGF-β) content of 1 gram of New Zealand White Rabbit cortical bone immersed in 0.6 M hydrochloric acid and 0.5 M acetic acid for 3, 6, and 9 days. …”
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Near vision assessment for adults using the NIH Toolbox by John-Christopher A. Finley, Jerry Slotkin, Cindy J. Nowinski, Cindy J. Nowinski, Katy Bedjeti, Nicholas Volpe, Sandra Weintraub, Sandra Weintraub, Richard Gershon

“…Additionally, two equivalent versions of the chart-based test were randomly assigned to participants.ResultsAnalyses revealed that test–retest reliability of the NIH Toolbox Near Visual Acuity Test was good (intraclass correlation = 0.87, p < 0.001). …”
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Use of Complementary and Alternative Medicine Practices in Patients Admitted to The Pediatric Neurology Outpatient Clinic by Deniz Yüksel, Ergin Atasoy, Ülkühan Öztoprak, Erhan Aksoy, Fatih Mehmet Akif Özdemir, Halil Celik, Nesrin Ceylan

“…For the study, 360 patients’ parents who came to the Pediatric Neurology clinic for treatment were randomly selected, and a face-to-face survey lasting 2 minutes was conducted with 300 patients’ parents who agreed to participate in the study. …”
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Intraoperative haemodynamic optimisation using the Hypotension Prediction Index and its impact on tissular perfusion: a protocol for a randomised controlled trial by Javier Ripollés-Melchor, Ane Abad-motos, Juan Victor Lorente, Ignacio Jimenez, Alejandra Becerra, Wilbert Wesselink, Francesca Reguant, Irene Mojarro, Maria de los Angeles Fuentes, Elizabeth Agudelo, Francisco Herrero-Machancoses, Paula Callejo, Joan Bosch, Manuel Ignacio Monge

“…All participants will be randomly assigned to a control or intervention group. …”
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Improving community-based first response to out of hospital cardiac arrest (FirstCPR): protocol for a cluster randomised controlled trial by Sandra Ware, Blake Angell, Julie Redfern, Clara Chow, Cate Ferry, Lee Taylor, Christopher Semsarian, Adrian Bauman, Janet E Bray, Simone Marschner, Michael Nelson, Saurabh Kumar, Matthew Vukasovic, Kevin Lai, Paul M Middleton, Pramesh Kovoor, Garry Jennings, Sonali Munot, Andrew Coggins, Alan Robert Denniss, Sarah Khanlari, Ian Opperman

“…Community groups (clusters) will be stratified by region, size and organisation type, and then randomly assigned to either immediately receive the intervention programme, comprising digital and in-person education and training opportunities about CPR and OHCA over 12 months, or a delayed programme implementation. …”
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Effectiveness of screening for colorectal cancer with a faecal occult-blood test, in Finland by J Pitkäniemi, K Seppä, M Hakama, O Malminiemi, T Palva, M-S Vuoristo, H Järvinen, H Paimela, P Pikkarainen, A Anttila, L Elovainio, T Hakulinen, S Karjalainen, L Pylkkänen, M Rautalahti, T Sarkeala, H Vertio, N Malila

“…We evaluate the effectiveness of screening as a public health policy in the largest population so far reported.Methods We randomly allocated (1:1) men and women aged 60–69 years to those invited for screening and those not invited (controls), between 2004 and 2012. …”
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The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model by Guochun Ou, Qin Liu, Chengxiu Yu, Xiaoju Chen, Wenbo Zhang, Yong Chen, Tao Wang, Yongqiang Luo, Guolu Jiang, Mingmei Zhu, Hongmei Li, Mei Zeng

“…Thirty BALB/c mice were randomly allocated to control, OVA, and MaR1 + OVA groups. …”
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Pentavalent Antimonials Combined with Other Therapeutic Alternatives for the Treatment of Cutaneous and Mucocutaneous Leishmaniasis: A Systematic Review by Taisa Rocha Navasconi Berbert, Tatiane França Perles de Mello, Priscila Wolf Nassif, Camila Alves Mota, Aline Verzignassi Silveira, Giovana Chiqueto Duarte, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verziganassi Silveira

“…The combination of other drugs or treatment modalities with pentavalent antimonials has proved to be effective for cutaneous and mucocutaneous leishmaniasis and for most seemed to be safe. However, new randomized, controlled, and multicentric clinical trials with more robust samples should be performed, especially the combination with immunomodulators.…”
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Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model by Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei

“…Subsequently, the MRI, pathomorphism, as well as Morriss water maze test were conducted to determine CSVD-related indicators. 8 weeks post-surgery, animals were randomly administered SAL, DAPT, ATN161 or saline.The aim was to explore the protective effects of SAL in CSVD as well as its possible mechanism. …”
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Optimized framework for evaluating F3 transgressive segregants in cayenne pepper by Ifayanti Ridwan, Muh Farid, Feranita Haring, Nuniek Widiayani, Ahmad Yani, Nirwansyah Amier, Muhammad Alfan Ikhlasul Amal, Jekvy Hendra, Nawab Ali, Mekhled Mohamed Alenazi, Mahmoud F. Seleiman, Willy Bayuardi Suwarno, Muhammad Fuad Anshori

“…This research was designed with a randomized completed block design with 16 transgressive segregant genotypes and three check varieties. …”
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Development and validation of a nomogram for predicting perioperative transfusion in children undergoing cardiac surgery with CPB by Wenting Wang, He Wang, Jia Liu, Yu Jin, Bingyang Ji, Jinping Liu

“…Methods From September 2014 to December 2021, 23,884 pediatric patients under the age of 14 were randomly divided into training and testing cohorts at a 7:3 ratio. …”
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Flavonoids, Isoquinoline Alkaloids, and Their Combinations Affect Growth Performance, Inflammatory Status, and Gut Microbiome of Broilers Under High Stocking Density and Heat Stres... by Kittisak Insawake, Thaweesak Songserm, Ornprapun Songserm, Yongyuth Theapparat, Kazeem D. Adeyemi, Konkawat Rassmidatta, Yuwares Ruangpanit

“…A total of 2100 one-day-old male Ross 308 broiler chicks were distributed into 70 replicates, randomly assigned to one of seven dietary treatments and raised during the summer for 37 days. …”
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Novel combination therapy for platinum-eligible patients with locally advanced or metastatic urothelial carcinoma: a systematic review and network meta-analysis by Takafumi Yanagisawa, Keiichiro Mori, Akihiro Matsukawa, Tatsushi Kawada, Satoshi Katayama, Ekaterina Laukhtina, Pawel Rajwa, Fahad Quhal, Benjamin Pradere, Wataru Fukuokaya, Kosuke Iwatani, Renate Pichler, Jeremy Yuen-Chun Teoh, Marco Moschini, Wojciech Krajewski, Jun Miki, Shahrokh F. Shariat, Takahiro Kimura, European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)

“…Abstract Recent phase 3 randomized controlled trials (RCTs) demonstrate the promising impact of immune checkpoint inhibitor (ICI)-based combination therapies on locally advanced or metastatic urothelial carcinoma (UC). …”
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Comparative study of Baduanjin and brisk walking on balance and stability in older adults by Ya-Guang Yu, Jun Zhang, Lin Wang, Dai-Feng Yu, Gong-Bing Shan, Xiao Fu

“…Sixty elderly individuals aged 65 to 79 were selected and randomly divided into the Baduanjin group, the brisk walking group, and the control group that did not engage in exercise. …”
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The Real-World Clinical Outcomes of Heavily Pretreated HER2+ and HER2-Low Metastatic Breast Cancer Patients Treated with Trastuzumab Deruxtecan at a Single Centre by Anna-Maria Lazaratos, Matthew Dankner, Aalya Hamouda, Soumaya Labidi, Victor Cohen, Lawrence Panasci, Jennifer E. Friedmann, François Patenaude, Cristiano Ferrario, Mark Basik, April A. N. Rose, Parvaneh Fallah

“…Background: Trastuzumab deruxtecan (TDXd) is an antibody–drug conjugate that has demonstrated impressive activity in randomized controlled clinical trials in the context of patients with HER2-amplified and HER2-low metastatic breast cancer. …”
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Nutritional parameters of sheep fed diets based on grass silage with brewery residue and a concentrate with rice bran by Anderson de Moura Zanine, Breno de Moura Gimenez, Daniele de Jesus Ferreira, Michelle de Oliveira Maia Parente, Henrique Nunes Parente, Edson Mauro Santos, Glayciane Costa Gois, Fleming Sena Campos, Luana Milena Pinheiro Rodrigues, Jessica Maria de Sousa Oliveira, Nelquides Braz Viana, Daimy Salas Aguilar, George de Sousa Lima Paiva, Dilier Olivera Viciedo

“…Sixteen sheep (30 ± 1.46 kg and 12 months old) were distributed in a randomized block experimental design. The treatments were: MGS containing 10% DBR + concentrate (100% corn); MGS containing 10% DBR + concentrate (50% corn and 50% rice bran); MGS containing 30% DBR + concentrate (100% corn); MGS containing 30% DBR + concentrate (50% corn and 50% rice bran), with 4 replicates per treatment. …”
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Dose-Dependent Hemodynamic, Biochemical, and Tissue Oxygen Effects of OC99 following Severe Oxygen Debt Produced by Hemorrhagic Shock in Dogs by William W. Muir, Carlos L. del Rio, Yukie Ueyama, Bradley L. Youngblood, Robert S. George, Carl W. Rausch, Billy S. H. Lau, Robert L. Hamlin

“…Subsequently twenty-four dogs were randomly assigned to one of four groups (n=6 per group) and administered: 0.0, 0.065, 0.325, or 0.65 g/kg of OC99 combined with 10 mL/kg lactated Ringers solution administered in conjunction with 20 mL/kg Hextend IV over 60 minutes. …”
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Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: predicting Which One is Right Here (WORTH) study protocol by Yannan Jiang, Tony R Merriman, Rui Qian Yeu, Rebecca Brandon, Dale Griffiths, Kate Smallman, Allan Moffitt, Glenn Doherty, Ryan Paul, Jennie Harré Hindmarsh, Kerry Macaskill-Smith, Brandon Orr-Walker, Rinki Murphy

“…Participants are assigned to complete 4 months of vildagliptin 50 mg per day or pioglitazone 30 mg per day, followed by 4 months of the other medications in randomly allocated sequences. Participant characteristics, including ethnicity, obesity, lipid profile and candidate genotypes are collected at baseline. …”
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Characterization of the Droplet Population Generated by Centrifugal Atomization Nozzles of UAV Sprayers by Fábio Henrique Rojo Baio, Job Teixeira de Oliveira, Marcos Eduardo Miranda Alves, Larissa Pereira Ribeiro Teodoro, Fernando França da Cunha, Paulo Eduardo Teodoro

“…The experimental design was implemented in a completely randomized scheme, containing variations in the nozzles (hydraulic nozzle and centrifugal atomization nozzle) and application rate (AR) (5, 10, and 15 L ha⁻¹ in the test with the hydraulic nozzle; and 9.2, 12.8, and 15.6 L ha⁻¹ in the test with the centrifugal nozzle), with five replicates per treatment. …”
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