High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients with Severe Bronchial Asthma Complicated with Respiratory Failure by Wanru Geng, Wuliji Batu, Shuhong You, Zhaohui Tong, Hangyong He

“…Its efficacy was analyzed comparatively to conventional oxygen therapy (COT). HFNC and COT were randomly performed based on conventional treatment. …”
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The correlation of the forkhead transcription factor foxo1 expression and histopathological pancreatic lesions in dogs by Firas M. Abed, Ahmed N. Abduljawaad, Omar A. Al-Mahmood, Karam H. Yehia, Hana Kh. Ismail

“…Additionally, cyst formations, metaplasia, and granulation tissue were determined. Dogs were randomly chosen, and all pancreatic samples were assessed through histopathological and immunohistochemical evaluation. …”
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The relationship between hypomagnesemia and ICU mortality in severe hemorrhagic stroke patients: an observational multicentre study on eICU database by Xinzhao Jiang, Faliang Gao, Zongjie Shi, Fang Liu, Wenyan Zhao, Guihong Gong

“…Conclusions Our findings suggested that hypomagnesemia is associated with increased risks of ICU mortality and mechanical ventilation use in severe hemorrhagic stroke patients. Future randomized, prospective studies are needed to elucidate the role of hypomagnesemia and explore potential interventions.…”
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Does candidate race influence simulated patient ratings in standardised assessments of clinical practice? A single-blinded randomised study in UK medical schools by Celia Brown, Amir H Sam, Rachel Westacott, Mark Gurnell, Sarah Khavandi, Malcolm Reed, Ann Sebastian, Kerry Badger

“…This study aimed to determine whether being a non-white candidate affected scoring by simulated patients, compared with a white candidate, at three different performance grades in the same history-taking station.Design Single-blinded, video-based, randomised study.Participants 163 simulated patients watched a randomly allocated set of six videos. Each set consisted of three white and three non-white (South Asian, black and Chinese) candidates performing at either fail, borderline or pass grades. …”
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Effect of integrated Traditional Chinese and western medicine in the treatment of diabetic foot gangrene (中西医结合治疗糖尿病足坏疽临床效果观察) by CUI Yangfang (崔杨芳), ZHANG Xuejian (张雪键), LIU Ai (刘爱), TANG Yue (唐月), WANG Yanke (王艳可), ZHAO Yue (赵月)

“…Methods Totally 60 patients with diabetic foot gangrene were randomly divided into the control group and observation group, with 30 cases in each group. …”
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Variability of the thousand-seed weight in bread wheat (Triticum aestivum L.) by Urošević Dušan, Knežević Desimir, Matković-Stojšin Mirela, Živić Jelica, Mićanović Danica, Kondić Danijela, Zečević Veselinka

“…Fifty wheat varieties in a field experiment designed as a randomized block system were used for this study in three replications on the field in Kraljevo, Serbia during two vegetation seasons (2015-2017). …”
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A qualitative mystery shopper study that de(codes) the experiences of English and Spanish-speaking patients who call to schedule a first-time primary care appointment in the Los An... by Esmeralda Melgoza, Ahmad Ismail, Lucía Félix-Beltrán, Rosario Majano, Arturo Vargas Bustamante

“…Primary care offices were randomly selected to participate in this qualitative mystery shopper study. …”
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Quality assessment of packaged water brands in a university teaching hospital in southern Nigeria by Ekanem AM, Benson SA, Ekpuk IN, Amafaye WD, Akpan IE, Udo AI, Edem SA, David E, Akpabio KO, Nneamaka AA

“…Methodology: This was a facility based descriptive cross-sectional study involving the physicochemical and biological analysis of 10 randomly selected packaged water (5sachet and 5 bottled water) brands. …”
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Growth, yield and nutrient uptake of two tomato varieties using some agricultural wastes as nutrient sources on an Alfisol of derived savanna by Christopher Aboyeji, Gbadamosi Abiodun, Temidayo Olofintoye, Adeniyi Helen, Afolayan John, Bambgose Oluwasola, Adebukola Adewumi

“…The bags were arranged in a completely randomized design.  Treatments were replicated four times.Results The application of charred poultry feather waste and plantain peel significantly increased vegetative growth and yield parameters of tomato when compared with the control. …”
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Pharmacokinetics of pradofloxacin, florfenicol, and tulathromycin and response to treatment of steers experimentally infected with Mannheimia hemolytica by Derek M. Foster, Jennifer L. Halleran, Megan E. Jacob, Stephanie Hempstead, Luke B. Borst, Tatiane T. Negrao Watanabe, Hiroko Enomoto, Mark G. Papich

“…Animals Twenty‐four Holstein and Holstein/Jersey cross steers ranging in age from 6 to 15 months. Methods A randomized, blinded clinical trial was performed. After transport stress, steers were inoculated with Mannheimia hemolytica to induce BRD. …”
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Mitigating salinity stress on tomato growth, water regime, gas exchange, and yield with the application of QuitoMax by Leandris Argentel-Martínez, Ofelda Peñuelas-Rubio, Carlos Ávila Amador, Fábio Steiner, Jorge González Aguilera, Jae-Ho Shin, Alan Mario Zuffo, Rafael Felippe Ratke, Paulo Eduardo Teodoro, Ugur Azizoglu

“…Three treatments were established in plastic pots, using a completely randomized design: T1, saline soil (ECse = 6.9 dS m−1 without QuitoMax application); T2, nonsaline soil (ECse = 0.95 dS m −1 with QuitoMax application); and T3, saline soil (ECse = 6.9 dS m−1) with QuitoMax application. …”
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Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects by Tomoyuki Hara, Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Hirotaka Watanabe, Taka-aki Sakaue, Yoshinari Obata, Hirofumi Nagao, Shiro Fukuda, Takashi Kanamoto, Mitsuyoshi Takahara, Naoto Katakami, Ken Nakata, Iichiro Shimomura

“…Blood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise. This pilot randomized crossover trial (UMIN000036520) aimed to investigate the changes in plasma HX after whole-body vibration exercise (WBVE) and their relationships with body composition and muscle-related parameters, enrolling eighteen healthy male volunteers. …”
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Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis by Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu, Fei Xu, Fei Xu

“…ObjectivesTo explore the mechanism underlying the effect of Fructus Akebiae (FAE) against hepatic fibrosis in mice through combined network pharmacology, liver metabolomics, and 16S rDNA analyses of the gut microbiota.MethodsIn this study, we randomly divided mice into the control, model, FAE high-dose, FAE medium-dose, and FAE low-dose groups to analyze the pathological changes in the hepatic fibrosis and levels of the α-SMA, collagen 1, Nuclear Factor Kappa B (NF-κ B), Toll Like Receptor 4 (TLR4). …”
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Medicinal plants with neuroprotective potential in East African countries: A systematic review by Ibe Michael Usman, Ekom Monday Etukudo, Elna Owembabazi, Wusa Makena, Augustine Oviosun, Makeri Danladi, Vivian Ojiakor, Patrick Maduabuchi Aja, Emeka Anyanwu, Yanurkis Duranones Rosales, Mario Edgar Fernandez Diaz, Josiah Ifie, Ismahil Adekunle Adeniyi, Ilemobayo Victor Fasogbon, Victor Bassey Archibong

“…Method: The present study is a systematic review that included randomized controlled trial studies using experimental animal models for various nervous system related conditions treated with medicine plants sourced from within any of the East African countries. …”
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Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants by Maélson Klever da Silva, Antonio Carlos Gonçalves de Carvalho, Even Herlany Pereira Alves, Felipe Rodolfo Pereira da Silva, Larissa dos Santos Pessoa, Daniel Fernando Pereira Vasconcelos

“…Three examiners extracted data from articles with a clear association between polymorphisms in the inflammatory mediator gene and the development of periodontitis through meta-analysis using the fixed or randomized statistical models to calculate the Odds Ratio with values of P<0.05 considered significant. …”
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Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis by Yinan Yao, Ming Yue, Jie Wang, Hongbo Chen, Mei Liu, Feng Zang, Jun Li, Yun Zhang, Peng Huang, Rongbin Yu

“…A comprehensive analysis was performed to evaluate the efficacy and safety of the grazoprevir combined with elbasvir, with or without ribavirin (RBV), in 777 treatment-naive and treatment-experienced patients with HCV genotype 1 infection from 3 randomized controlled trials (RCTs). Method. We collected data from the following trials: C-WORTHY (NCT01717326), C-SALVAGE (NCT02105454), and C-EDGE (NCT02105467). …”
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Activation of Opioid Receptors Attenuates Ischemia/Reperfusion Injury in Skeletal Muscle Induced by Tourniquet Placement by Yue-Xian Guo, Gui-Ying Wang, Wen-jie Cheng, Cai-Zhen Yan, Shuang Zhao, Zhao Li, Peng Liu, Xiu-Li Wang

“…The objective of this study is to determine if oxycodone (Oxy) reduces skeletal muscle I/R damage induced by tourniquet placement and explores the underlying mechanisms. Method. Mice were randomly assigned to the sham, I/R, Oxy, and I/R with Oxy groups. …”
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WhatsApp and atopic dermatitis: a clinical trial by Thaís Braga Cerqueira, Renata Robl Imoto, Mariana Muzzolon, Vânia Oliveira de Carvalho

“…Methods: Researcher-blinded randomized controlled clinical trial. The experimental group (EG) received messages about AD and the control group (CG) about general health. …”
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Glycerol Monolaurate Complex Improved Antioxidant, Anti-Inflammation, and Gut Microbiota Composition of Offspring in a Sow–Piglet Model by Dan Li, Min Yang, Zhao Ma, Lianqiang Che, Bin Feng, Zhengfeng Fang, Shengyu Xu, Yong Zhuo, Jian Li, JiHhua Wang, Zhengfan Zhang, Zehui Wu, Tao Lin, De Wu, Yan Lin

“…In total, 64 pregnant sows were randomly divided into control, antibiotic, 0.1% GML, and 0.2% GML groups. …”
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A Systematic Review and Meta-Analysis of Mapping Biopsy for Primary Extramammary Paget’s Disease in Reducing Recurrence Following Surgical Excision by Thirrisha Murugan, Louis Choon Kit Wong, MD, Xing-Yi Sarah Ong, MD, Sze Huey Tan, PhD, Joey Wee-Shan Tan, MSc, Ying Liu, PhD, Nicholas B. Shannon, PhD, MD, Jianbang Chiang, MBBS, MRCP, MMed, Eileen Poon, MBBS, MRCP, MMED, Jason Yongsheng Chan, MBBS, MRCP, MMed, FAMS, PhD, Valerie Shiwen Yang, MB BChir, PhD, MRCP, FAMS, Nagavalli Somasundaram, MBBS, MRCP, MMED, Mohamad Farid, MBBS, MRCP, MMed, Ru Xin Wong, MBBS, FRCR, Wen Long Nei, MBBS, FRCR, Jin Wei Kwek, MBBS, FRCR, FAMS, Choon Hua Thng, MBBS, FRCR, FAMS, Tiffany Hennedige, MBBS, FRCR, MMed, MCI, Po Yin Tang, BMEDSc, MBBS, FRCPath, FRCAPA, Sathiyamoorthy Selvarajan, MBBS, PGDCP, FRCPath, MCS, FAMS, Kae Jack Tay, MBBS, MRCS, MMed, MCI, FAMS, Mohamed Rezal Abdul, MB, BCh, BAO, LRCP&SI, MSurg, Jolene Si Min Wong, MBBS, MMed, FRCS, Chin Jin Seo, MB, BCh, BAO, MMed, FRCS, Khee Chee Soo, MBBS, MD, FRACS, FACS, Claramae Shulyn Chia, MBBS, MMed, FRCS, Chin-Ann Johnny Ong, MBBS, MMed, FRCS, PhD

“…Mapping biopsies are able to improve EMPD surgical excision outcomes but given the rarity of the disease and heterogeneity of mapping biopsy procedures, further confirmation with randomized controlled trials or a larger patient pool is necessary.…”
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