Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes by Xiaoling Yao, Xin Cai, Shaoqin Zhang, Yuzheng Yang, Xiangyan Yang, Wukai Ma, Zong Jiang

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Evaluating the effectiveness of a mental health literacy module - A randomized controlled trial among school teachers by Vidya Prabhu, Lena Ashok, Veena Ganesh Kamath, Amitha Puranik, Sebastian Padickaparambil, Nikitha Sibil Rebello, Praveen Arhanthabailu, Varalakshmi Chandrasekaran

“…Methods: A parallel stratified cluster randomized controlled trial was conducted among high school teachers between November 2019 to September 2021. …”
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Causal Relationships Between Blood Lipid Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis by Huang P, Zhao Y, Wei H, Wu W, Guo Z, Ma S, Xu M, Wang Q, Jia C, Xiang T, Li H

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Efficacy and safety of immunotherapy for head and neck squamous cell carcinoma: a meta-analysis of randomized clinical trials by Cailing Jiang, Shuqin Wang, Lijun Zhu

“…This meta-analysis tries to provide a more precise assessment of the efficacy and safety of this integrated approach in HNSCC.MethodsWe conducted a systematic review and meta-analysis of randomized clinical trials according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines. …”
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Effect of Transcranial Direct Current Stimulation (TDCS) on Depression in Older Adults: A Pilot Randomized Controlled Trial by M. Zareie, S. Balal Habashi, P. Farokhnezhad Afshar

“…This study is an unblinded randomized controlled trial. We selected 60 patients with depression based on the Geriatric Depression Scale (GDS) and randomly divided them into two groups. …”
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Auricular acupressure for minimizing adverse reactions to colonoscopic bowel preparation in hospitalized patients: A randomized controlled trial by Jiahui Zhang, Chang Liu, Guodong Ruan, Haiyan Zhang, Beiping Zhang, Xuejun Hu, Cailing Zhong

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Bovine Antibody-Based Oral Immunotherapy for Reduction of Intragastric Helicobacter pylori Colonization: A Randomized Clinical Trial by CM den Hoed, AC de Vries, PBF Mensink, CM Dierikx, H Suzuki, L Capelle, H van Dekken, R Ouwendijk, EJ Kuipers

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Inhaled corticosteroids' effect on COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials by Yasra Badi, Mohamed Hammad, Abdelrahman G. Tawfik, Mona Muhe Eldeen Eshag, Mahmoud M. Elhady, Khaled Mohamed Ragab, Anas Zakarya Nourelden, Mohamed Hesham Gamal, Ahmed Hashem Fathallah

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Continuous Intra-Incisional Bupivacaine for Postoperative Analgesia after Hip Nailing Surgery: A Randomized Clinical Trial by Arash Farbood, Sanaz Abbasi, Naeimehossadat Asmarian, Mahsa Banifatemi, Vida Naderi-boldaji, Zeinabsadat Fattahi Saravi

“…This study investigates the effect of CWI of local anesthetic on postoperative pain control in intertrochanteric fracture patients undergoing hip nailing surgery. Methods. In this randomized clinical trial, 48 patients who were scheduled for hip nailing surgery were randomly assigned to receive (n = 24) or not receive (n = 24) bupivacaine infusion through a catheter inside the surgical wound, postoperatively. …”
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Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial by Bancha Satirapoj, Wisit Kaewput, Ouppatham Supasyndh, Prajej Ruangkanchanasetr

“…Twenty patients were randomly assigned to the placebo group and another 20 patients were randomly assigned to receive sulodexide 100 mg/day for 14 weeks. …”
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Exploring potential therapeutic targets for small cell lung cancer based on transcriptomics combined with Mendelian randomization analysis by Zhicheng Liao, Pengcheng Jia, Yifan Li, Zhihui Zheng, Jizhou Zhang

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Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…Thereafter, a simplified classifier (Euclidean distances) was used to assign the identified CS subphenotypes in three completed randomized controlled trials (RCTs) (OptimaCC, N = 57 [2011–2016, NCT01367743]; DOREMI, N = 192 [2017–2020, NCT03207165]; and CULPRIT-SHOCK, N = 434 [2013–2017, NCT01927549]) and explore heterogeneity of treatment effect with respect to 28-day mortality (primary outcome). …”
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Association between gastroesophageal reflux disease and metabolic syndrome: a bidirectional two-sample Mendelian randomization analysis by Tao He, Xiaoling Geng, Xue Lin, Yufei Li, Zhijun Duan

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The Effect of Low-Level Laser Therapy on Accelerating Tooth Movement in Orthodontic Patients: A Randomized Controlled Trial by Mohammad K. Alam, Mohammad Y. Hajeer, Dalia A. Alanazi, Shahad A. Alanazi, Haya O. Alruwaili

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A Prospective, Double-Blind, Randomized, Controlled Clinical Trial in the Gingivitis Prevention with an Oligomeric Proanthocyanidin Nutritional Supplement by R. M. Díaz Sánchez, G. Castillo-Dalí, A. Fernández-Olavarría, R. Mosquera-Pérez, J. M. Delgado-Muñoz, J. L. Gutiérrez-Pérez, D. Torres-Lagares

“…A prospective, double-blind, randomized, controlled clinical trial was carried out on 20 patients; it is divided into an experimental group and a control group after fulfilling the selection criteria. …”
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Comment on “Extended Versus Standard Complete Mesocolon Excision in Sigmoid Cancer. A Multicenter Randomized Controlled Trial” by Jean-Luc Faucheron, MD, PhD, Elisa Bobba, MD, Léa Guttierez, MD

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“Effect of oral systemic administration of vitamin D on the rate of maxillary canine retraction: A randomized controlled trial” by Davender Kumar, Revathi Mn, Rekha Sharma, Ashuma Sachdeva, Nameksh Raj Bhupali, Ravinder Solanki

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The Addition of Salmeterol 50 µg Bid to Anticholinergenic Treatment in Patients with COPD: A Randomized Placebo Controlled Trial by Kenneth R Chapman, Peter Arvidsson, AG Chuchalin, DP Dhillon, Peter Faurschou, Roger S Goldstein, AF Kuipers

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Evaluation of direct pulp capping in carious primary molars: a 12-month randomized controlled clinical trial by Nayera T. El Saied, Salwa M. Awad, Ashraf Y. Alhosainy

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Role of metabolic characteristics in the co-occurrence of insomnia, Alzheimer’s disease, and Parkinson’s disease: a Mendelian randomization study by Chengyong Liu, Chi Wang, Jing Jiang, Yuyang Bo, Lixiu Nan, Ying Zhang, Kongxi Zhu, Xiaoqiu Wang, Xinxin Feng, Xiaoyang Lian, Shan Qin

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