NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder by Bin Gong, Chenxu Xiao, Yu Feng, Yu Feng, Jing Shen

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Psychosocial Interventions for Elderly People with Bipolar Disorder: Systematic Review with Meta-Analysis by Carolina Raquel Sales Vieira, Eduarda Rezende Freitas

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A Hybrid Random Forest and Least Squares Support Vector Machine Model Based on Particle Swarm Optimization Algorithm for Slope Stability Prediction: A Case Study in Sichuan–Tibet Highway, China by Tao Shu, Wei Tao, Haotian Lu, Hao Li, Jingxuan Cao

“…These indicators were analyzed and visualized to examine their reliabilities after preprocessing. Combined with random forest (RF), particle swarm optimization (PSO), and least squares support vector machine (LSSVM) algorithms, a hybrid prediction model that the RF–PSO–LSSVM model is proposed for identifying slope stability, and its reliability is verified by other prediction models that SVM, logistic regression, decision trees, k-nearest neighbor, naive Bayes, and linear discriminant analysis. …”
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Poly-ADP ribose polymerase (PARP) inhibitor regimens for platinum-sensitive ovarian cancer in randomized, double-blind, phase III controlled trials: protocol for a systematic review and network meta-analysis by Xiaolian Peng, Jie Liu

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A single-site randomized controlled trial of partner navigation to HCV treatment for people who inject drugs: a study protocol for the You’re Empowered for Treatment Initiation (YETI) partner trial by Meghan D. Morris, Judy Y. Tan, Claire C. McDonell, Maia Scarpetta, Tiffany N. Nguyen, Jennifer C. Price, Torsten B. Neilands

“…We aim to recruit 250 PWID and their primary injecting partners in San Francisco, California, randomizing them 1:1 to either a control or intervention group. …”
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Comparison between 18F-DCFPyL PET/MRI-guided ultrasound fusion targeted biopsy and systematic biopsy for tumor detection and grading in selected patients: A prospective randomized controlled trial by Shaoxi Niu, Yachao Liu, Liyan Ao, Xiaohui Ding, Xiao Chang, Jinhang Li, Jiajin Liu, Kan Liu, Nanxing Zou, Baixuan Xu, Yong Xu, Baojun Wang, Xu Zhang

“…Methods: Eighty-seven selected biopsy-naive patients were randomized into two groups: TB (n=41) and systematic biopsy (control; n=46). …”
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Effect of PCSK9 inhibitor on early neurological deterioration in acute ischemic stroke patients with a history of coronary heart disease: a study protocol for a randomized controlled trial in Dalian, China by Xing Gong, Xinting Yu, Lanlan Pu, Yang Jiao, Lin Liu, Hua Cao, Xiaofei Ji

“…Methods This is a prospective, randomized, parallel-group, blinded-endpoint, single-center clinical study. …”
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The Effect of Propolis Irrigation as an Adjunctive to Scaling and Root Surface Debridement on Periodontal Health Status, Glycemic Control and Biochemical Markers in Subjects with Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical by Hozan Wrya Azeez

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Correction: Active versus sham transcranial direct current stimulation (tDCS) as an adjunct to varenicline treatment for smoking cessation: Study protocol for a double-blind single dummy randomized controlled trial. by Laurie Zawertailo, Helena Zhang, Noreen Rahmani, Tarek K Rajji, Peter Selby

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Is It Possible to Achieve Favorable Accelerated Dental Changes with No Periodontal Complications When Retracting Upper Anterior Teeth Assisted by Flapless Corticotomy Compared to Traditional Corticotomy? A Two-Arm Randomized Controlled Trial by Hanin Nizar Khlef, Mohammad Younis Hajeer

“…The sample was divided randomly and equally into two groups. Randomization was carried out by random numbers generated by the computer with a 1 : 1 allocation ratio. …”
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A Comparative Study between Conventional Diaphragmatic Breathing Exercise and Virtual Reality-based Diaphragmatic Breathing Exercise on Quality of Life in Chronic Obstructive Pulmonary Disease Patients: A Randomized Control Trial by Sridhar Shirodkar, Medha Deo

“…Materials and Methods: In a randomized controlled study involving 72 COPD patients divided into two groups of 36 in each, the control and experimental groups performed a short 5 min breathing exercise for 6 consecutive days. …”
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Comparison of the Efficacy between Bilateral Ultrasound Guided Erector Spinae Block versus Incision Site Infiltration for Duration of Analgesia in Lumbar Spinal Surgery Using Levobupivacaine: A Prospective, Randomized Comparative Study by Karthik G Sheshadri, Sudheer Ramegowda, Mahesh Chandra, Prajyot Bhurli, Ashwani Kristipati, Renjan R I

“…Methods: A prospective randomized single blinded study was carried out in 50 patients of ASA grade I and II, aged 20 to 60 years scheduled for elective lumbar spine surgeries. …”
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Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Cell Lung Cancer by Koichi Takayama, Shunichi Sugawara, Yasuo Saijo, Makoto Maemondo, Atsushi Sato, Shinzo Takamori, Taishi Harada, Tetsuro Sasada, Tatsuyuki Kakuma, Junji Kishimoto, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Yoichi Nakanishi

“…Previously treated PS0-1 patients with IIIB/IV EGFR (epidermal growth factor receptor) wild genotype NSCLC were randomly assigned to docetaxel (60 mg/m2 on Day 1) plus PPV based on preexisting host immunity or docetaxel plus placebo. …”
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Efficacy and Safety of Ergoferon in Children from 6 Months to 6 Years Old with Acute Respiratory Viral Infections in Contemporary Outpatient Practice: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial by N. A. Geppe, B. M. Blokhin, O. V. Shamsheva, S. T. Abdrakhmanova, K. A. Alikhanova, G. T. Myrzabekova

“…To evaluate the efficacy and safety of Ergoferon in combination with symptomatic therapy in children from 6 months to 6 years old with acute respiratory infections (ARI) in contemporary outpatient practice, an international, multicenter, double-blind, placebo-controlled, randomized, parallel-group clinical trial was performed. …”
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Efficacy of Single-Pill Combination of Telmisartan 80 mg and Hydrochlorothiazide 25 mg in Patients with Cardiovascular Disease Risk Factors: A Prospective Subgroup Analysis of a Randomized, Double-Blind, and Controlled Trial by Harold Bays, Pingjin Gao, Birgit Völker, Michaela Mattheus, Luis M. Ruilope, Dingliang Zhu

“…Hypertensive patients were randomized (2 : 1) to receive T80/H25 or T80 for 6 weeks, following a 1-week, low-dose, and run-in period. …”
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Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized controlled trial by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…Design This study is a multicenter, non-inferiority, randomized (1:1), open-label, controlled trial. Methods & analysis The patients assigned to the control group will undergo curative surgery within two weeks after successful SEMS placement. …”
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The Antimicrobial Effect of Pomegranate Peel Extract versus Chlorhexidine in High Caries Risk Individuals Using Quantitative Real-Time Polymerase Chain Reaction: A Randomized Triple-Blind Controlled Clinical Trial by Benoy Jacob, Nivedhitha Malli Sureshbabu, Manish Ranjan, Aishwarya Ranganath, Riluwan Siddique

“…The aim of the present study was to compare the antibacterial effectiveness of chlorhexidine and PPE oral rinse on S. mutans, Lactobacilli, and Veillonella, in clinical salivary samples of patients with advanced stages of dental caries at baseline and two and four weeks with PCR technique. This triple-blind randomized clinical trial involved 60 high caries risk adult patients, 19–59 years of age, randomly allocated into two groups of 30 subjects each. …”
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Effectiveness of a Web-Based Self-Guided Intervention (MINDxYOU) for Reducing Stress and Promoting Mental Health Among Health Professionals: Results From a Stepped-Wedge Cluster Randomized Trial by Yolanda López-del-Hoyo, Selene Fernández-Martínez, Adrian Perez-Aranda, Alicia Monreal-Bartolomé, Alberto Barceló-Soler, Loreto Camarero-Grados, Carilene Armas-Landaeta, José Guzmán-Parra, Vera Carbonell, Daniel Campos, Xinyuan Chen, Javier García-Campayo

“…MethodsIn a stepped-wedge cluster randomized design, 357 health professionals from health centers in Aragon and Málaga, Spain, were recruited. …”
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Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial by Hui-Min Hu, Hui-Min Hu, Wen-Hui Liu, Wen-Hui Liu, Chen Li, Chen Li, Qing Shi, Qing Shi, Chun-Hua Liu, Chun-Hua Liu, An-Xiang Liu, An-Xiang Liu, Yi-Fan Li, Yi Zhang, Peng Mao, Bi-Fa Fan

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Immunogenicity and safety of a live attenuated varicella vaccine in healthy subjects aged between 13 to 55 years: a double-blind, randomized, active-controlled phase iii clinical trial in China by Yang Zhang, Shiyuan Wang, Guifan Li, Jinhui Shi, Xianyun Chang, Hao Zhang, Fengcai Zhu, Jingxin Li, Hongxing Pan, Jinfang Sun

“…Vaccination with the varicella vaccine (VarV) effectively prevents chickenpox.Research design and methods In this phase III, single-center, randomized, double-blind, active-controlled trial, 1,200 healthy participants randomly assigned in a 1:1 ratio to receive two doses of either the test vaccine or the active control vaccine. …”
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