Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial by Yang M, Zhou L, Long G, Liu X, Ouyang W, Xie C, He X

“…However, its impact on postoperative delirium and insulin sensitivity biomarkers remains unknown.Aim: This randomized, double-blind, placebo-controlled trial was to evaluate whether intranasal insulin reduces the incidence and severity of postoperative delirium (POD) in older patients undergoing joint replacement, and its effect on insulin sensitivity-related biomarkers.Methods: 212 older patients (≥ 65 years) were randomly assigned to receive either 40 IU of intranasal insulin (n=106) or a placebo (n=106) for 8 days. …”
Get full text

Immunogenicity and safety of a live attenuated varicella vaccine in children aged 1 to 12 years: A double-blind, randomized, parallel-controlled phase III clinical trial in China by Shiyuan Wang, Yang Zhang, Guifan Li, Jinhui Shi, Xianyun Chang, Hao Zhang, Fengcai Zhu, Jingxin Li, Kai Chu, Jinfang Sun

“…In this phase III, single-center, randomized, double-blind, active-controlled trial,1,200 healthy participants randomly assigned in a 1:1 ratio to receive one dose of either the test vaccine or the active control vaccine. …”
Get full text

Clinical and radiographic evaluation of silver diamine fluoride versus mineral trioxide aggregate as indirect pulp capping agents in deeply carious first permanent molars a randomized clinical trial by Marwa Ahmed Ahmed Zaghloul, Manal Ahmed El Sayed, Randa Youssef Abd Al-Gawad, Ahmed Mohamed Abd El- Samad

“…Methodology This study was conducted on (30) first permanent molars indicated for indirect pulp capping (IPC) randomly allocated to either SDF or MTA groups (n = 15). …”
Get full text

Ultrasound-guided deep versus superficial continuous serratus anterior plane block for pain management in patients with multiple rib fractures: A prospective randomized double-blind clinical trial by Mohamed F. Mostafa, Mohamed Abdel-Moniem Bakr, Mohamed Ismail Seddik, Mohammed Mamdouh Mohammed Mahmoud, Gamal M.A. Ibrahim, Ahmed Talaat Ahmed

“…Methods: Sixty-two adult patients having unilateral MRFs, were randomized into two groups to receive continuous superficial SAPB (group S, n = 31) or continuous deep SAPB (group D, n = 31). …”
Get full text

The impact of a 5G-based smart nursing information system and associated mobile hardware on clinical nurses’ work stress: a randomized controlled study in a Chinese hospital by Xuejiao Ruan, Yuying Lou, Xinhua Zhang, Zhulin Wu, Hongzhi Yuan

Subjects: Get full text

mHealth-based exercise vs. traditional exercise on pain, functional disability, and quality of life in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials by Liang Tang, Meng-Ming Wang, He-Xia Wang, Xiao-Ya He, Yue-Shuai Jiang

“…ObjectiveThis study aims to compare the efficacy of mHealth-based exercise interventions with traditional exercise in improving pain intensity, functional disability, and quality of life in patients suffering from knee osteoarthritis (OA).MethodRandomized controlled trials (RCTs) published from their inception to 23 August 2024 were searched in Cochrane, Embase, Medline, Web of Science. …”
Get full text

Retracted: Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study by Applied Bionics and Biomechanics

Get full text

Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study by Rafael Scaf de Molon, Rogier M. Thurlings, Birgitte Walgreen, Monique M. Helsen, Peter M. van der Kraan, Joni Augusto Cirelli, Marije I. Koenders

Get full text

Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized controlled trial by Dunbing Huang, Huan Tian, Wei Song, Jiaqi Wang, Zizhe Yao, Lize Xiong, Cai Jiang, Anren Zhang, Xiaohua Ke

Subjects: Get full text

Assessment of rainfed wheat productivity in a changing climate in Irbid, Jordan using statistical downscaling and Random Forest Regression prediction under RCP4.5 & 8.5 pathways by Tasnim Dheif Allah Althalaj, Fayha Muhammed Al-Shibli, Amani Abdullah Alassaf

“…Future wheat yields were predicted using the Random Forest Regression model. The results revealed a non-significant increase in total annual precipitation of 1.8% and 13.8% and a rise in annual mean temperature of 5.4% and 2.7% for Irbid and Baqura stations, respectively during the baseline timeframe on which wheat yield increased by 21.3%. …”
Get full text

Estimation of 1 km Dawn–Dusk All-Sky Land Surface Temperature Using a Random Forest-Based Reanalysis and Thermal Infrared Remote Sensing Data Merging (RFRTM) Method by Yaohai Dong, Xiaodong Zhang, Xiuqing Hu, Jian Shang, Feng Zhao

“…Under this background, this study merged the observations of the Medium Resolution Spectrum Imager (MERSI-LL) on board the dusk–dawn-orbit Fengyun (FY)-3E satellite and Global Land Data Assimilation System (GLDAS) data to estimate dawn–dusk 1 km all-sky LST using a random forest-based method (RFRTM). The results showed that the model had good robustness, with an STD of 0.62–0.86 K of the RFRTM LST, compared with the original MERSI-LL LST. …”
Get full text

A Double-Blind, Randomized, Controlled Trial of Topical Polysporin Triple Compound Versus Topical Mupirocin for the Eradication of Colonization with Methicillin-Resistant Staphylococcus aureus in a Complex Continuing Care Population by S O’Grady, Z Hirji, B Pejcic-Karapetrovic, S Fung, H Dedier, J Takata-Shewchuk, K Zhang, J Conly

Get full text

Long-Term Outcomes of a Health Information System-Based Feedback Intervention Study of Antimicrobial Prescriptions in Primary Care Institutions: Follow-Up of a Randomized Cross-Over Controlled Trial by Yan Y, Yang J, Lu Y, Cui Z, Chang Y

Get full text

A park-based group mobility program for older adults with difficulty walking outdoors: a qualitative process evaluation of the Getting Older Adults Outdoors (GO-OUT) randomized controlled trial by Kristina M. Kokorelias, Jacquie Ripat, Ruth Barclay, C. Allyson Jones, Nancy E. Mayo, Theresa Grant, Stephanie Scodras, Kyla Alsbury-Nealy, Charlotte Ryder-Burbidge, Nancy M. Salbach

Subjects: Get full text

A Comparison Between the Effects of Peribulbar and Sub-tenon Blocks Combined with General Anesthesia on the Incidence of Oculocardiac Reflex during Pediatric Strabismus Surgery: A Double-Blinded Randomized Control Study by Shymaa Fathy, Maha Gamil Hanna, Nasr Mahmoud Abdallah, Sarah Maher El Waraky, Essam El-Din Zaki Bassyouni, Hany Mohammed El-Hadi Shoukat

“…Materials and Methods: A randomized, double-blinded trial was conducted with 120 children (ASA I/II) scheduled for strabismus surgery. …”
Get full text

Efficacy of wearable transcutaneous electrical acupoint stimulation bracelet on moderate-to-severe postoperative nausea and vomiting in patients after general anesthesia: a study protocol for a multicenter randomized controlled trial by Peng Ding, Dong-yu Zheng, Hong-wei Zhu, Ming Gong, Yong-qiang Wang, Ling-yan Jin, Guang-li Ren, Hui-jing Shi, Yong-hua Li

“…Participants will be randomly allocated into the TEAS group or the control group in a 1:1 ratio. …”
Get full text

A Randomized Study to Compare the Effects of Once-Weekly Dulaglutide Injection and Once-Daily Glimepiride on Glucose Fluctuation of Type 2 Diabetes Mellitus Patients: A 26-Week Follow-Up by Huiqin Li, Xiaohua Xu, Jie Wang, Xiaocen Kong, Maoyuan Chen, Ting Jing, Zhiying Zhang, Guoping Yin, Xiaomei Liu, Yun Hu, Lei Ye, Xiaofei Su, Jianhua Ma

“…A total of 23 patients with T2DM were randomly assigned into two groups for 26 weeks: the dulaglutide group (n=13) and the glimepiride group (n=10). 72-hour CGMS was applied to all patients: before and after the treatment. …”
Get full text

Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Randomized Clinical Trial Pilot Study by Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

“…MethodsParticipants aged 18-70 years from internet research monitors were categorized into SD, SI, and SP groups based on screening assessment. They were randomly assigned to intervention or control groups within each subthreshold symptom. …”
Get full text

The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial by Katie B Biello, Kenneth H Mayer, Hyman Scott, Pablo K Valente, Jonathan Hill-Rorie, Susan Buchbinder, Lucinda Ackah-Toffey, Patrick S Sullivan, Lisa Hightow-Weidman, Albert Y Liu

“…Randomization was 1:1:1 and was stratified by site and participant age; there was no masking. …”
Get full text

Radiotherapy(R) Integration(I) Strategy for Small(S)-Cell Lung Cancer in Extensive(E) Stage (RISE) with up to 10 metastases- a study protocol of a randomized phase II trial by Łukasz Kuncman, Jacek Fijuth, Damian Tworek, Ewa Sierko, Paweł Cisek, Michał Masłowski, Maja Lisik-Habib, Magdalena Orzechowska, Katarzyna Galwas-Kliber, Adam Antczak, Izabela Chmielewska, Barbara Ziółkowska, Marta Kurczewska-Michalak, Wojciech Kuźnicki, Nina Jędrzejczak, Kinga Ranoszek, Mateusz Bilski

Get full text