Effect of mechanical debridement with and without adjunct antimicrobial photodynamic therapy for the treatment of peri-implant disease in obese patients: A systematic review and meta-analysis of randomized controlled trials by Sultan Albeshri, Raed AlRowis

“…The risk of bias (RoB) within studies was assessed and GRADE analysis was performed. Results: Three randomized controlled trials (RCTs) were included. The number of participants ranged between 49 and 80 individuals. …”
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Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized controlled trial by Ni-Na Hou, Meng-Yun Zhang, Yu-Wei Zhang, Hong-Jing Wu, Hong Luo, Heng Yang

“…Methods In total, 90 elderly patients were randomized into three groups: the esketamine HS group (0.2 mg/kg induction, 0.25 mg/(kg·h) infusion), the esketamine LS group (0.2 mg/kg induction, 0.125 mg/(kg·h) infusion), and the control group (group C receiving an equal volume of saline). …”
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Novel 2D strain-rate-dependent lamina-based and RVE/phase-based progressive fatigue damage criteria for randomly loaded multi-layer fiber-reinforced composites by M. Shariyat

“…Then, these criteria are implemented to a composite chassis frame of an SUV car under realistic random road inputs and the theoretical results are verified by the experimental results. …”
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One-day low-residue diet is equally effective as the multiple-day low-residue diet in achieving adequate bowel cleansing: a meta-analysis of randomized controlled trials by Raeni Dwi Putri, Fiki Amalia, Festy Aldina Utami, Yunisa Pamela, Mas Rizky A.A. Syamsunarno

“…We searched multiple databases for randomized controlled trials (RCTs) and analyzed the outcomes using a fixed-effects model. …”
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Raising awareness of alcohol as a modifiable risk factor for breast cancer: A randomized controlled trial comparing the efficacy of accessing an interactive website with a non-interactive website by Claudia Sardu, Fabrizio Angius, Paolo Contu, Sofia Cosentino, Monica Deiana, Matteo Fraschini, Clelia Madeddu, Elena Massa, Alessandra Mereu, Luigi Minerba, Carola Politi, Silvia Puxeddu, Francesco Salis, Julia M.A. Sinclair, Roberta Agabio

“…Methods: We conducted a randomized controlled trial among women waiting for mammography. …”
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Assessment of Clinical Analgesic Levels and Serum Biomarkers in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial Comparing the Efficacy of Diclofenac and Methotrexate Combined Therapy with Extracorporeal Shockwave Therapy by Mei Zhang, Zhongyuan Ma, Rinkiko Suguro, Menglin Zhu, Esther Xinyi Chen, Xin Dong, Meixiu Chen, Linling Cheng, Bolun Su, Yizhun Zhu

“…Extracorporeal shockwave therapy (ESWT) has been identified as a viable alternative therapeutic approach in light of the present protracted clinical course of pharmacological treatment, and changes in levels of marker proteins in the blood samples of RA patients can be utilized to assess treatment outcomes. Methods. A randomized controlled trial was conducted involving forty patients diagnosed with rheumatoid arthritis (RA) who were assigned randomly to two groups. …”
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Strategies to Increase Response Rate and Reduce Nonresponse Bias in Population Health Research: Analysis of a Series of Randomized Controlled Experiments during a Large COVID-19 Study by Christina J Atchison, Nicholas Gilby, Galini Pantelidou, Sam Clemens, Kevin Pickering, Marc Chadeau-Hyam, Deborah Ashby, Wendy S Barclay, Graham S Cooke, Ara Darzi, Steven Riley, Christl A Donnelly, Helen Ward, Paul Elliott

“…MethodsOver 19 rounds, a random sample of individuals aged 5 years and older from the general population in England were invited by mail to complete a web-based questionnaire and return a swab for SARS-CoV-2 testing. …”
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Supporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized trial by Kara M. Magane, Richard Saitz, Sarah Fielman, Marc R. LaRochelle, Christopher W. Shanahan, Christine A. Pace, Michael LaValley, Kaley Penington, Skylar Karzhevsky, Emily Hurstak

“…This four-arm factorial design randomized trial will assess whether population health management (PHM) and clinical care management (CCM) support for primary care providers (PCPs) are associated with improved AUD treatment engagement among their patients, beyond electronic health record (EHR) prompting and decision support alone. …”
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The role of histone lactylation genes in hepatocellular carcinoma prognostic models and their immune cell infiltration features: a comprehensive analysis of single-cell, spatial transcriptome, Mendelian randomization and experiment by Shanjie Luan

“…Furthermore, single-cell analysis was used to discover the cell–cell communication and Mendelian randomization was used to study the causal relationships between immune cell and HCC. …”
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An Intensive Perioperative Regimen of Pregabalin and Celecoxib Reduces Pain and Improves Physical Function Scores Six Weeks after Total Hip Arthroplasty: A Prospective Randomized Controlled Trial by Nicole ME Carmichael, Joel Katz, Hance Clarke, Deborah Kennedy, Hans J Kreder, Jeffrey Gollish, Colin JL McCartney

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Comparative- and Cost-Effectiveness Research Determining the Optimal Intervention for Advancing Transgender Women With HIV to Full Viral Suppression (Text Me, Alexis!): Protocol for a Randomized Controlled Trial by Cathy J Reback, Thomas Blue, Ali Jalali, Raphael Landovitz, Michael J Li, Raymond P Mata, Danielle Ryan, Philip J Jeng, Sean M Murphy

“…MethodsText Me, Alexis! is a 3-arm randomized controlled trial. Participants (N=195) will be randomized (1:1:1) into: PHN alone (n=65), SMS text messaging alone (n=65), or PHN+SMS text messaging (n=65). …”
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Risk of diabetic ketoacidosis caused by sodium glucose cotransporter-2 inhibitors in patients with type 1 diabetes: a systematic review and network meta-analysis of randomized controlled trials by Ying Liu, Shiwen Yang, Aidou Jiang, Dan Zou, Zhaoyang Chen, Na Su, Na Su

“…We conducted a network meta-analysis to evaluate the incidence of DKA at different doses in the treatment of T1DM.MethodsWe searched electronic databases and clinical trial registries, including PubMed, Embase (Ovid SP), the Cochrane Central Register of Controlled Trials (Ovid SP), and ClinicalTrials.gov, for randomized controlled trials (RCTs) concerning SGLT2 inhibitors in patients with T1DM from inception to December 2023. …”
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SleepNow – A combined cognitive behavioral therapy for insomnia and physical exercise intervention in men with metastatic prostate cancer: results from a feasibility randomized controlled trial by Beverley Lim Høeg, Katrine Bjerre Løppenthin, Josée Savard, Christoffer Johansen, Jesper Frank Christensen, Mads Nordahl Svendsen, Niels Holländer, Pernille Envold Bidstrup

“…Patients/material and methods: We conducted a feasibility randomized trial in patients under treatment for castration resistant mPCa with insomnia (Insomnia Severity Index [ISI] score ≥ 8). …”
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Moderate Hypofractionated Post-Prostatectomy Radiotherapy (MYSTERY) Versus Conventionally Fractionated Post-Prostatectomy Radiotherapy (COPORT) for the Patients With Localized Prostate Cancer: The Protocol of a Prospective, Randomized Trial by Yiyin Liang MD, Weiwei Zhang MD, Xianzhi Zhao MD, Huojun Zhang MD, PhD

“…Methods and analysis This study is a prospective, single-center, open-label, randomized controlled clinical trial. Patients with localized prostate cancer will be randomly allocated to receive COPORT (66-74 Gy at 2 Gy per fraction) or MYSTERY (57.5-65 Gy at 2.5 Gy per fraction). …”
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Is C-reactive protein sufficient to guide antimicrobial therapy for lower respiratory tract infections among children? Results from a stepped-wedge cluster randomized trial in Uganda. by Chris A Rees, Prashant Mahajan, Quique Bassat

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Effect of Nutrition Education Based on Health Belief Model on Nutritional Knowledge and Dietary Practice of Pregnant Women in Dessie Town, Northeast Ethiopia: A Cluster Randomized Control Trial by Tona Zema Diddana, Gezahegn Nigusse Kelkay, Amanuel Nana Dola, Abinet Arega Sadore

“…Community-based cluster randomized control trial was employed. A total of 138 pregnant women participated. …”
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Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study by Wentong Wang, Zhuli Liu, Yongxiong Wu

“…Here, we performed a randomized controlled study to investigate the effectiveness of acupuncture combined with drug therapy (TCM and Western) to treat cerebral infarction (phlegm-blood stasis syndrome) and CAP. …”
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Effectiveness of Contralaterally Controlled Functional Electrical Stimulation versus Neuromuscular Electrical Stimulation on Upper Limb Motor Functional Recovery in Subacute Stroke Patients: A Randomized Controlled Trial by Songhua Huang, Peile Liu, Yinglun Chen, Beiyao Gao, Yingying Li, Chan Chen, Yulong Bai

“…Fifty patients within six months poststroke were randomly assigned to the CCFES group (n=25) and the NMES group (n=25). …”
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The impact of neuroscience education therapy, behavioral economics, and digital navigators on patient migraine treatment adherence to a mobile health application: a prospective pilot randomized controlled trial by Mia T. Minen, Erin K. Waire, John Torous, Jessica Fishman, Richard B. Lipton, Scott W. Powers

“…We conducted a 6-month prospective pilot randomized controlled trial testing if a multi-component package of behavioral interventions increased treatment adherence among patients using one of two different mHealth migraine self-management programs (low-intensity program consisting only of a headache diary versus high-intensity program consisting of a headache diary and behavioral exercises). …”
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A Randomized Trial Comparing Seven-Day Ranitidine Bismuth Citrate and Clarithromycin Dual Therapy to Seven-Day Omeprazole, Clarithromycin and Amoxicillin Triple Therapy for the Eradication of Helicobacter pylori by Sander Veldhuyzen van Zanten, Naoki Chiba, Alan Barkun, Carlo Fallone, Alain Farley, Alan Cockeram, Chrystian Dallaire, Lorinda Simms, Barbara Nicholls

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