The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials by Yuqi Liu, Juan Li, Jinfang Ma, Nanwei Tong

“…We finally included DR-related studies involving intensive glucose control with large sample size and long follow-up time, including five large and high-quality randomized clinical trials (RCTs): DCCT, UKPDS, ACCORD, AdRem, and VADT. …”
Get full text

Evaluating the Impact of Pharmacotherapy in Augmenting Quit Rates Among Hispanic Adults in an App-Delivered Smoking Cessation Intervention: Secondary Analysis of a Randomized Controlled Trial by Margarita Santiago-Torres, Kristin E Mull, Brianna M Sullivan, Ana Paula Cupertino, Ramzi G Salloum, Matthew Triplette, Michael J Zvolensky, Jonathan B Bricker

“…Given the randomized design, we first tested the potential interaction of pharmacotherapy use and intervention arm on 12-month cigarette smoking abstinence. …”
Get full text

Evaluation of Pain Intensity Caused by Nickel-Titanium Archwires of Different Sizes in the First Stage of Fixed Orthodontic Treatment: A Double-Blind Randomized Clinical Trial by Aydin Sohrabi, Shabnam Tahamtan, Sana Seyed Shariatdoust, Ali Rafighi

“…The aim of the present study was to comparatively assess pain induced by different-sized nickel-titanium archwires during the first stage of fixed orthodontic therapy.Methods and Materials: This double-blind randomized clinical trial included a total of 81 patients who received fixed orthodontic therapy. …”
Get full text

Effectiveness of Repetitive Facilitative Exercise Combined with Electrical Stimulation Therapy to Improve Very Severe Paretic Upper Limbs in with Stroke Patients: A Randomized Controlled Trial by Hitoshi Ohnishi, Hiroyuki Miyasaka, Naoki Shindo, Kazuki Ito, Shiori Tsuji, Shigeru Sonoda

“…This study included 99 of the very severe paresis stroke patients with scores of zero or 1a in the Finger-Function test of the Stroke Impairment Assessment Set (SIAS). We randomly divided the patients into four groups, namely, NMES, RFE, RFE under NMES, and conventional training (CT) groups. …”
Get full text

Optimal dose of oxytocin to improve social impairments and repetitive behaviors in autism spectrum disorders: meta-analysis and dose–response meta-analysis of randomized controlled trials by Yingying Zhang, Xiaolu Zhang, Linghong Huang

“…However, there have been inconsistencies in the effects of OXT on social impairments and repetitive behaviors.MethodsA comprehensive search in PubMed, the Cochrane Library, Embase, and Web of Science was conducted to gather randomized controlled trials (RCTs) on the efficacy of OXT in patients diagnosed with ASD up to 11/06/2024. …”
Get full text

Effectiveness of the User-Centered “Healthcare CEO” App for Patients With Type 1 Diabetes Transitioning From Adolescence to Early Adulthood: Protocol for a Randomized Controlled Trial by Yueh-Tao Chiang, Hsing-Yi Yu, Pei-Kwei Tsay, Chi-Wen Chen, Chi-Wen Chang, Chien-Lung Hsu, Fu-Sung Lo, Philip Moons

“…Participants will be randomly assigned to either the experimental or control group through central randomization. …”
Get full text

A Mendelian randomization study of depression and risk of cervical cancer (抑郁和宫颈癌发病风险相关的孟德尔随机化分析) by LIU Yinxia (刘银侠), YU Ping (俞萍), XU Yang (徐阳)

Subjects: Get full text

Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a Core Outcome Set by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“…Objective: The aim of this project is to establish a core outcome set (COS) for patients with moderate-to-severe TBI in randomized control trials in neurocritical care research. …”
Get full text

Cardiopulmonary fitness in children/adolescents with chronic kidney disease and the impact of exercise training: a systematic review and meta-analysis of observational study and randomized controlled trials by Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong

Get full text

Transcatheter edge-to-edge mitral valve repair <i>versus</i> medical therapy for secondary mitral regurgitation: a meta-analysis of randomized controlled trials by Emídio Mata, Bárbara Lage Garcia, Mariana Tinoco, Margarida Castro, Luísa Pinheiro, João Português, Francisco Ferreira, Silvia Ribeiro, Bruno Melica, António Lourenço

“…A study-level random-effects meta-analysis was conducted using trial-reported point estimates. …”
Get full text

Effectiveness of home-based exercise for functional rehabilitation in older adults after hip fracture surgery: A systematic review and meta-analysis of randomized controlled trials. by Lijun Zhao, Xiaona Zhao, Bin Dong, Xiaobin Li

“…Comprehensive literature search was performed on PubMed, EMBASE, Web of Science, Cochrane library, and Clinicaltrails.gov to identify eligible randomized controlled trials (RCTs). Standard mean difference (SMD) and risk ratio (RR) with 95% confidence interval (CI) was calculated. …”
Get full text

Proton therapy versus conventional radiotherapy for the treatment of cavernous sinus benign meningioma, a randomized controlled phase III study protocol (COG-PROTON-01) by Paul Lesueur, Benedicte Clarisse, Justine Lequesne, Idlir Licaj, Loic Feuvret, Dinu Stefan, Damien Ricard, Georges Noel, Jacques Balosso, Marie Lange, Aurelie Capel, Isabelle Durand-Zaleski, Marie Castera, Berenice Legrand, Nicolas Goliot, Camille Hedou, Jean Michel Grellard, Samuel Valable

“…Methods COG-PROTON-01 is the first worldwide randomized phase III prospective study evaluating long-term toxicity of these two irradiation modalities (PRT and XRT)for the treatment of cavernous sinus meningioma. …”
Get full text

Effects of Exergaming on Morphological Variables, Biochemical Parameters, and Blood Pressure in Children and Adolescents with Overweight/Obesity: A Systematic Review with Meta-Analysis of Randomized Controlled Trials by Jordan Hernandez-Martinez, Joaquín Perez-Carcamo, Hassan Melki, Izham Cid-Calfucura, Edgar Vasquez-Carrasco, Pedro Delgado-Floody, Claudio Romero, Tomás Herrera-Valenzuela, Braulio Henrique Magnani Branco, Pablo Valdés-Badilla

“…Results: Out of 72 records, 6 randomized controlled trials with 191 children and adolescents with overweight/obesity were included. …”
Get full text

Evaluating the Impact of Simulated Patients on Knowledge, Skills and Attitudes of Laypeople Following a Basic First Aid Course: Protocol for a Cluster-Randomized Controlled Trial

“…Methods: This study will be a cluster-randomized controlled trial, that will take place from September 2018 to June 2020. …”
Get full text

Preliminary results of open comparative randomized study PHG-M3/P01-09 «ORION» on application of «Phosphogliv» in combined therapy of chronic hepatitis C by M. V. Mayevskaya

Get full text

Supplementation with Korean Red Ginseng Improves Current Perception Threshold in Korean Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Trial by Kahui Park, YuSik Kim, Junghye Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn, Ji Sun Nam

“…Methods. This study was a randomized, double-blind, placebo-controlled trial. …”
Get full text

Response to Comment on: “Prognostic Relevance of Primary Tumor Sidedness in Early-Stage Colorectal Cancer: An Integrated Analysis of 4 Randomized Controlled Trials (JCOG2003A)” by Akira Ouchi, MD, PhD, Shunsuke Tsukamoto, MD, PhD, Atsuo Takashima, MD, PhD, Yasuhiro Shimada, MD, Tetsuya Hamaguchi, MD, PhD, Masafumi Inomata, MD, PhD, Yasumasa Takii, MD, Ryo Sadachi, PhD, Yukihide Kanemitsu, MD

Get full text

Comparing Treatment with Nebulized 3% Hypertonic Saline Versus Nebulized 0.9% Saline In Patients With Acute Bronchiolitis: A Double-Blind Randomized Controlled Trial by Uzma Abid, Ayesha Afzal, Nahdia Zaman, Ammara Farooq, Sidrah Yousaf, Sonia Fazal

“… Objective: To establish the therapeutic role of nebulized hypertonic saline solution in the management of acute bronchiolitis in terms of primary and secondary outcomes. Methods: This randomized control trial was conducted in the Pediatric department of Holy Family Hospital, Rawalpindi for 8 months from September 2021 to April 2022 after ethical approval. …”
Get full text

The effect of an app-based dietary education on dietary intake and cardiometabolic risk markers in people with type 2 diabetes: results from a randomized controlled trial by Linnea Sjöblom, Essi Hantikainen, Anna Dahlgren, Ylva Trolle Lagerros, Stephanie E. Bonn

“…Methods In this two-armed randomized clinical trial, people with type 2 diabetes were recruited within a primary care setting and randomized 1:1 to a smartphone-delivered dietary education for 12 weeks or a control group receiving regular care only. …”
Get full text

A Correlation Study of Birthing Ball Technique and Sacral Massage on Maternal and Fetal Well-being Among Parturient Women: A Non-Randomized Clinical Trail by Sundaram Madavan, Bhuvaneswari Gopalakrishnan, Chandrika Anand, Thenmozhi

Get full text