Analgesic Characteristics of Bupivacaine Alone and in Combination with Dexmedetomidine or Meperidine in Spinal Anesthesia during Cesarean Section: A Double-Blind Randomized Clinical Trial Study by Simin Azemati, Amir Zarghami, Reza Jouybar, Vida Naderi-boldaji

“…In this double-blind randomized clinical trial study, ninety pregnant women were divided into groups to receive 10 mg bupivacaine (group B), 10 mg bupivacaine with 5 μg dexmedetomidine (group BD), or 10 mg bupivacaine with 10 mg meperidine (group BM) intrathecal. …”
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Immunogenicity and safety of a COVID-19 DNA vaccine in healthy adults and elderly: A randomized, observer-blind, placebo-controlled phase 2 trial by Siyue Jia, Chengwei Shao, Xin Cheng, Hongxing Pan, Zhijian Wang, Yu Xia, Jianfang Xu, Xuefen Huai, Danjing Leng, Jiarong Wang, Gan Zhao, Bin Wang, Jingxin Li, Fengcai Zhu

“…Eligible participants from each age group were enrolled and randomly assigned in a 3:3:2 ratio to receive two doses of INO-4800 (1.0 mg or 2.0 mg) or placebo, followed by electroporation on day 0 and day 28. …”
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Effects of a Serratus Anterior Plane Block After Video-Assisted Lung Wedge Resection: A Single-Center, Prospective, and Randomized Controlled Trial by Seokjin Lee, Tae-Yun Sung, Choon-Kyu Cho, Gyuwon Lee, Woojin Kwon

“…<i>Materials and Methods</i>: In total, 22 patients undergoing VATS lung wedge resections were randomized into two groups (SAPB and control): both received intravenous patient-controlled analgesia (PCA), and one group received additional SAPB. …”
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Effects of photobiomodulation combined with rehabilitation exercise on pain, physical function, and radiographic changes in mild to moderate knee osteoarthritis: A randomized controlled trial protocol. by Yan Ling Tay, Mohd Azzuan Ahmad, Nor Hamdan Mohamad Yahaya, Devinder Kaur Ajit Singh

“…<h4>Methods</h4>This protocol outlines a parallel-group, randomized, double-blind, placebo-controlled trial. …”
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Do Nonsuicidal Severely Depressed Individuals with Diabetes Profit from Internet-Based Guided Self-Help? Secondary Analyses of a Pragmatic Randomized Trial by Sandra Schlicker, Kiona K. Weisel, Claudia Buntrock, Matthias Berking, Stephanie Nobis, Dirk Lehr, Harald Baumeister, Frank J. Snoek, Heleen Riper, David D. Ebert

“…The aim of the study was to test whether disease-specific severity indicators moderate the treatment outcome in a 6-week minimally guided web-based self-help intervention on depression and diabetes (GET.ON Mood Enhancer Diabetes (GET.ON M.E.D.)) and to determine its effectiveness in a nonsuicidal severely depressed subgroup. Methods. Randomized controlled trial- (RCT-) based data (N=253) comparing GET.ON M.E.D. to an online psychoeducation control group was used to test disease-specific severity indicators as predictors/moderators of a treatment outcome. …”
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A randomized controlled trial comparing immersive virtual reality games versus nitrous oxide for pain reduction in common outpatient procedures in pediatric surgery by Cordula Scherer, Ladina A. Lanz, Thoralf R. Liebs, Nadine Kaiser, Mirjam Zindel, Steffen M. Berger

“…Methods The study employs a randomized controlled trial design, utilizing VR technology and nitrous oxide in separate groups in 100 children at the age from 6 to 15 undergoing minor surgical procedures. …”
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A Pilot Randomized Crossover Trial of Wet Suction and Conventional Techniques of Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Upper Gastrointestinal Subepithelial Lesions by Mika Takasumi, Takuto Hikichi, Minami Hashimoto, Jun Nakamura, Tsunetaka Kato, Hitomi Kikuchi, Yuichi Waragai, Ko Watanabe, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Manabu Hayashi, Yuki Sato, Hiroki Irie, Ryoichiro Kobashi, Yoshinori Okubo, Masao Kobayakawa, Hiromasa Ohira

“…We conducted a pilot randomized crossover trial to explore whether the wet technique could be useful with regard to tissue adequacy of upper GI-SELs (UGI-SELs) compared to the conventional EUS-FNA technique (“dry” technique). …”
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Gabapentin versus Transdermal Fentanyl Matrix for the Alleviation of Chronic Neuropathic Pain of Radicular Origin: A Randomized Blind Multicentered Parallel-Group Noninferiority Trial by Chang Ju Hwang, Jae Hyup Lee, Jung-Hoon Kim, Sang Hyuk Min, Kun-Woo Park, Hyoung-Yeon Seo, Kwang-Sup Song

“…The study was designed as a randomized blind multicentered parallel-group noninferiority trial. …”
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Protocol paper: randomized controlled trial of the smart online-to-offline model development for chronic diseases management through digital health in real world setting by Jae Eun Shin, Juho Choi, Heejung Lee, Suk-Won Lee, Juhwan Oh

Subjects: “…Randomized controlled trial…”
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Evaluation of Clinical Effectiveness and Subjective Satisfaction of a New Toothbrush for Postsurgical Hygiene Care: A Randomized Split-Mouth Double-Blind Clinical Trial by Marco Montevecchi, Annalisa Moreschi, Maria Rosaria Gatto, Luigi Checchi, Vittorio Checchi

“…Following the first periodontal surgery, a test (TB1) or control (TB2) toothbrush was randomly assigned. After the second surgery, the remaining toothbrush was given. …”
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Effectiveness of the Chronic Care Model in Type 2 Diabetes Management in a Community Health Service Center in China: A Group Randomized Experimental Study by Jing-Xia Kong, Lin Zhu, Hong-Mei Wang, Ying Li, An-Ying Guo, Chao Gao, Yan-Yao Miao, Ting Wang, Xiao-Yang Lu, Hong-Hong Zhu, Donald L. Patrick

“…This study was aimed at evaluating the effectiveness of the Chronic Care Model in type 2 diabetes management. Methods. A group randomized experimental study was conducted. Twelve communities of the Zhaohui Community Health Service Center in Hangzhou, China, were randomly assigned into an intervention group (n=6) receiving the Chronic Care Model-based intervention and a control group (n=6) receiving conventional care. …”
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Safety, Tolerability, and Pharmacokinetics of NIM‐1324 an Oral LANCL2 Agonist in a Randomized, Double‐Blind, Placebo‐Controlled Phase I Clinical Trial by Andrew Leber, Raquel Hontecillas, Nuria Tubau‐Juni, Josep Bassaganya‐Riera

“…Oral NIM‐1324 was assessed for safety, tolerability and PK in normal healthy volunteers in a randomized, double‐blind, placebo‐controlled trial. …”
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The Effect of an Educational Application on The Quality of Life and Treatment Adherence in Mothers of Children with Congenital Heart Disease Undergoing Cardiac Surgery: A Randomized Clinical Trial by Mohammad Rajabi, Jamalodin Begjani, Reza Negarandeh

“…Mothers were randomly assigned to intervention (n=36) and control (n=36) groups. …”
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Effects of Functional Electrical Stimulation Based on Walking Pattern with Different Treatment Time on Lower Limb Function in Stroke Patients：A Randomized Controlled Study by XUE Jingjing, KONG Huimin, LIAO Meixin, XUE Yunlian, XIAO Lingjun

“…ObjectiveFocusing on the intelligent and multi-channel functional electrical stimulation (FES) based on normal walking patterns, we explored the correlation between therapeutic effect and stimulating time for improving lower extremity motor function of stroke patients, to provide evidence for further clinical applications of FES based on walking patterns.MethodsThe Minimize software was used to divided 18 stroke patients randomly into a group treated with 60 min FES in walking pattern (9 patients, 60 min-stimulation group), and the rest were treated with 30 min FES in walking pattern (9 patients, 30 min-stimulation group). …”
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Ultrasound-Guided Rhomboid Block versus Paravertebral Block in Postoperative Analgesia for Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Clinical Trial by Yan Wang, Xiaoping Gu, Simin Huang, Minke Shi, Xiaofeng He, Zhengliang Ma

“…It was a prospective, randomized, double-blinded clinical trial involving 132 patients with video-assisted thoracic surgery divided into three groups: the general anesthesia (GA) group, RIB group, and PVB group on T5 vertebra, using 0.4% ropivacaine at 3 mg/kg, registered in the Chinese Clinical Trial Registry (ChiCTR2100054057, “https://www.chictr.org.cn”). …”
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Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial by Mahshad Shafiee, Amir Sadeghi, Fateme Ghafouri-Taleghani, Maryam Nilghaz, Maryam Ghods, Behnaz Narimani, Azita Hekmatdoost, Atoosa saidpour

“…Forty-six participants were randomly assigned to either the intervention group (TRF with LOV diet) or the control group, with 21 participants completing the 12-week study in each group. …”
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Remote Lifestyle Intervention to Reduce Postpartum Weight Retention: Protocol for a Community-Engaged Hybrid Type I Effectiveness-Implementation Randomized Controlled Trial by Lindsay M Martin, Christine D McKinney, Lia Escobar Acosta, Janelle W Coughlin, Noelene K Jeffers, Alexandra Solano-Umaña, Kathryn A Carson, Nae-Yuh Wang, Wendy L Bennett, Kelly M Bower

“…Participants will be 360 pregnant individuals with overweight or obesity enrolled between 20 and 33 weeks of gestation and randomized 1:1 to Healthy for Two–Home Visiting or usual home visiting services. …”
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A Triple-Masked, Randomized Controlled Trial Comparing Ultrasound-Guided Brachial Plexus and Distal Peripheral Nerve Block Anesthesia for Outpatient Hand Surgery by Nicholas C. K. Lam, Matthew Charles, Deana Mercer, Codruta Soneru, Jennifer Dillow, Francisco Jaime, Timothy R. Petersen, Edward R. Mariano

“…Adult subjects who were scheduled for elective ambulatory hand surgery under regional anesthesia and sedation were recruited and randomly assigned to receive ultrasound-guided supraclavicular brachial plexus block or distal block of the ulnar and median nerves. …”
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Adipose-Derived Stromal Cells for Treatment of Patients with Chronic Ischemic Heart Disease (MyStromalCell Trial): A Randomized Placebo-Controlled Study by Abbas Ali Qayyum, Anders Bruun Mathiasen, Naja Dam Mygind, Jørgen Tobias Kühl, Erik Jørgensen, Steffen Helqvist, Jens Jørgen Elberg, Klaus Fuglsang Kofoed, Niels Groove Vejlstrup, Anne Fischer-Nielsen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup

“…MyStromalCell trial is a randomized double-blind placebo-controlled study including sixty patients with CCS/NYHA class II-III, left ventricular ejection fraction > 40%, and at least one significant coronary artery stenosis. …”
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Comparative Evaluation Of Postoperative Sensitivity Using Total-Etch Versus Self-Etch Bonding Techniques In Resin Composite Restorations: A Randomized Clinical Trial by Shahid Ahmad Marwat, Hassan Maqbool, Umair ul Haq, Zarnab Rizwan, Khadija Sajid, Shakeel Ur Rehman Khattak

“… Objective: To assess and compare postoperative sensitivity in resin composite restorations using the self-etch versus total-etch technique. Methods: A randomized clinical trial conducted at the Department of Operative Dentistry &Endodontics, from April 1st, 2022, to September 30th, 2022. …”
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