Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial. by Dimuthu Muthukuda, Chamini Kanatiwela de Silva, Saumiyah Ajanthan, Namal Wijesinghe, Anuradha Dahanayaka, Arunasalam Pathmeswaran

“…<h4>Materials and methods</h4>This was a randomized, double-blinded, placebo-controlled clinical trial. …”
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Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial. by Yu-Hao Lin, Zhi-Jun Zhang, Jin-Qing Zhong, Zhi-Yi Wang, Yi-Ting Peng, Yan-Mei Lin, Huo-Ping Zhang, Jian-Qing Tian

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Comparing the safety and efficacy of remimazolam-based total intravenous anesthesia versus volatile agent-based anesthesia: a meta-analysis of randomized controlled trials by Ji-In Park, Hyo-Seok Na, Keum-O Lee, Jung-Hee Ryu, Hyun-Jung Shin

“…We estimated the relative risk (RR) and mean difference with 95% CIs using a random-effects model. Results A total of 969 patients from 12 randomized controlled trials were included. …”
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Efficacy of the ECHOMANTRA online intervention to support recovery from anorexia nervosa in adult patients: study protocol of a randomized controlled multi-center trial by Yolanda Quiles, Álvaro Ruiz, Eva León-Zarceño, Javier Manchón, Marie-Carmen Neipp, Sofía Payá-López, Katina Kovacheva, Valentina Cardi

“…Methods In a multi − center pilot randomized controlled trial (RCT), 148 adult AN patients, and their carers, will be randomized to receive treatment as usual (TAU) or TAU plus ECHOMANTRA. …”
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Efficacy and Safety of Sacubitril/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open‐Label, Noninferiority Study (PARASOL Study) by Koichi Yamamoto, Daisuke Yarimizu, Ayano Shimanishi, Shunsuke Eguchi, Kazuma Iekushi, Yoichi Takami, Yoichi Nozato, Kazuomi Kario, Hiromi Rakugi

“…A total of 359 Japanese patients with essential hypertension (office systolic blood pressure [SBP] ≥ 150 to < 180 mmHg), aged 18–79, were randomly assigned to receive either once‐daily sacubitril/valsartan 200 mg or once‐daily amlodipine 5 mg in a 1:1 allocation ratio. …”
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Accelerated symptom improvement in Parkinson’s disease via remote internet-based optimization of deep brain stimulation therapy: a randomized controlled multicenter trial by Alireza Gharabaghi, Sergiu Groppa, Marta Navas-Garcia, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S. Feldman, Michael J. Soileau, Lan Luo, S. Elizabeth Zauber, Benjamin L. Walter, Chengyuan Wu, Hong Lei, Damian M. Herz, Ming-Hua Chung, Yagna Pathak, Bram Blomme, Binith Cheeran, Corneliu Luca, Daniel Weiss

“…Ninety-six patients were randomly assigned in a 1:1 ratio using automated allocation, blocked into groups of 4, allocation concealed, and no stratification. …”
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Response to Letter to Editor on “Tuina versus physiotherapy or a combination of both for the management of chronic nonspecific low back pain: A randomized controlled trial” by Qinqyu Ma, Jiaxu Chen

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Day before late regimen vs standard split dose of low-volume PEG-CS for early morning colonoscopy: Multicenter randomized controlled trial by Luigi Pasquale, Giuseppe Grande, Rocco Maurizio Zagari, Paolo Biancheri, Antonio Pisani, Paola Da Massa Carrara, Bastianello Germanà, Enrico Ciliberto, Gianpaolo Cengia, Antonietta Lamazza, Patrizia Lorenzini, Mariavittoria V Carati, Liboria Laterza, Flavia Pigò, Desiree Picascia, Carmelo Stillitano, Matteo Pollastro, Elisabetta Dal Pont, Stefania Maraggi, Rita Conigliaro, Giuseppe Galloro

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Effects of Meaningful Action Observation Therapy on Occupational Performance, Upper Limb Function, and Corticospinal Excitability Poststroke: A Double-Blind Randomized Control Trial by Aryan Shamili, Afsoon Hassani Mehraban, Akram Azad, Gholam Reza Raissi, Mohsen Shati

“…The main goal of this study was to investigate the effectiveness of AOT of occupations and tasks that are meaningful for chronic stroke patients on occupational performance, upper-extremity function, and corticospinal changes. Method. A randomized control trial was designed to compare between experimental (n=13) and control groups (n=14). …”
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Impacts of a puberty and period education intervention among 9- to 12-year-old girls in the New York metropolitan area: a randomized trial by Angela-Maithy N. Nguyen, Micaela Camozzi, Marni Sommer

“…Methods We conducted a randomized educational intervention between February–May 2023 among girls ages 9–12 years in after-school programs in the New York metropolitan area (n = 123). …”
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Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study by Juan Antonio Carrillo-Norte, Guillermo Gervasini-Rodríguez, María Ángeles Santiago-Triviño, Virginio García-López, Rafael Guerrero-Bonmatty

“…Adults aged 30–81 years (50 % female) with grade II or III OA and a minimum pain score of 40 on the 0 to 100 visual analogue scale (VAS) were enrolled. Participants were randomly assigned to receive either 10 g of the test product (verum group) or placebo and were assessed at baseline (T0, pre-treatment) and after a six-month follow-up period (T6). …”
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Metformin Treatment in Type 2 Diabetes in Pregnancy: An Active Controlled, Parallel-Group, Randomized, Open Label Study in Patients with Type 2 Diabetes in Pregnancy by Jahan Ara Ainuddin, Nasim Karim, Sidra Zaheer, Syed Sanwer Ali, Anjum Ara Hasan

“…To assess the effect of metformin and to compare it with insulin treatment in patients with type 2 diabetes in pregnancy in terms of perinatal outcome, maternal complications, additional insulin requirement, and treatment acceptability. Methods. In this randomized, open label study, 206 patients with type 2 diabetes in pregnancy who met the eligibility criteria were selected from the antenatal clinics. …”
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Effectiveness of couple-based violence prevention education in reducing intimate partner violence during pregnancy in rural Ethiopia: A cluster randomized controlled trial. by Zeleke Dutamo Agde, Jeanette H Magnus, Nega Assefa, Muluemebet Abera Wordofa

“…The 16 clusters were randomly allocated into 8 intervention groups and 8 control groups. …”
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Risk of Candida Infection and Serious Infections in Patients with Moderate-to-Severe Psoriasis Receiving Biologics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yue Feng, Baosen Zhou, Zhen Wang, Guijuan Xu, Lili Wang, Tingting Zhang, Yanping Zhang

“…PubMed, EMBASE, and Cochrane Library were searched for eligible randomized controlled trials (RCTs) from their inception to December 2021. …”
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Effect of blindfolding the lead resuscitator on frequency of closed-loop communication during veterinary cardio-pulmonary resuscitation training: a randomized, controlled pilot study by Olivia X. Walesby, Giacomo Stanzani, Lindsay Kellett-Gregory, Mayank Seth, Emily K. Thomas

“…Additionally, two associated online questionnaires were completed by participants.SettingPrivate veterinary referral hospital in the United Kingdom.InterventionForty volunteers were randomly allocated into ten groups of four. Each group was randomized as either control (CG) or blindfolded (BG) with the lead resuscitator always a veterinarian. …”
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Comparison of the Effect of Adding Dexmedetomidine as an Adjuvant to Bupivacaine for Postoperative Pain Management in Patients Undergoing Shoulder Rotator Cuff Repair – A Randomized Clinical Trial by Shahryar Sane, Alireza Mahoori, Ali Tabrizi, Hamed Koohsoltani

“…Materials and Methods: This double-blind, randomized clinical trial was performed on 80 patients aged 20 to 60 with ASA I and II who were candidates for elective shoulder rotator cuff repair. …”
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Associated adverse outcomes with tumor treating fields when combined to temozolomide versus temozolomide alone for the treatment of glioblastoma: a meta-analysis of randomized trials by Yuanyuan Chen, Yan Chen, Hong Zhen, Danhua Lou

“…All the studies were randomized trials. The majority of the participants were males (68.0–75.0%) with a mean age of the varying from 54.0 to 69.0 years. …”
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Development and feasibility of an mHealth intervention for psychoeducational support of Nigerian women diagnosed with breast cancer undergoing chemotherapy: A pilot randomized controlled trial. by Oluwadamilare Akingbade, Ka Yi Hong, Oluwabukola Sharon Ayo, Adetutu Sefinat Alade, Moshood Akinwumi Lawal, Ibironke Elizabeth Somoye, Victoria Adediran, Olamide Sado, Ka Ming Chow

“…Thirty women newly diagnosed with BC and undergoing chemotherapy were randomly assigned to an intervention or a control group. …”
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A randomized controlled trial on the effect of smartphone-based mental health application among outpatients with depressive and anxiety symptoms: A pilot study in Malaysia by Sharon Tan, Mohammad Ayob Bin Ismail, Tuti Iryani Mohd Daud, Rozita Hod, Norfazilah Ahmad

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Comparison of a ready-to-use intranasal dexmedetomidine spray with traditional intranasal dexmedetomidine drops for sedation in preschool children: a prospective, randomized, controlled study by Qi-Qi Jin, Wei-Cha Cai, Ying-Feng Zhou, Yan-Tong Zhang, Gang Chen, Meng-Ting Xu, Jun Li, Kai-Ming Yuan

“…PurposeThis study compared the efficacy and acceptability of a ready-to-use intranasal dexmedetomidine spray (DS) versus traditional drops administered by syringe (DD) in pediatric patients undergoing elective surgery.Patients and MethodsEighty-six preschool children were enrolled in a prospective, randomized, controlled study. Children were randomly assigned to receive either DS or DD. …”
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