Acceptability and efficacy of the culturally adapted problem management plus intervention for people with disability in Pakistan: a pilot cluster randomized controlled trial by Basharat Hussain, Basharat Hussain, Muhammad Tahir Khalily, Muhammad Tahir Khalily, Ahmed Waqas, Atif Rahman, Ioannis Angelakis, Anum Nisar, Sabir Zaman, Tanveer Akhtar

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A systematic review and meta-analysis of randomized controlled trials for physical activity among colorectal cancer survivors: directions for future research by Jiayu Mao, Xiaoke Qiu, Yi Zhang, Can Wang, Xueli Yang, Qiuping Li

“…The Physiotherapy Evidence Database (PEDro) scale was used to assess the methodological quality of eligible studies, and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) method was used to evaluate the certainty of evidence. The random-effects model was used in meta-analysis, and data were analyzed using standardized mean differences and 95% confidence intervals. …”
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Improved early postoperative cognition in elderly gastrointestinal patients: a randomized controlled trial on the role of ultrasound-guided stellate ganglion block by Ruyue Xue, Yuexian Li, Mei Zhan, Lin Yang, Defeng Sun

“…BackgroundThis study evaluates the impact of ultrasound-guided stellate ganglion block (SGB) on early postoperative cognitive dysfunction (POCD) in elderly patients who underwent laparoscopic gastrointestinal (GI) surgery, as well as its potential effect on oxidative stress and inflammatory responses.MethodsIn this randomized controlled trial, 104 elderly patients scheduled for elective laparoscopic GI surgery were randomized to receive ultrasound-guided SGB before general anesthesia (SGB group) or general anesthesia alone (control group). …”
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Can home care work be organized to promote musculoskeletal health for workers? Results from the GoldiCare cluster randomized controlled trial by Fredrik Klæboe Lohne, Marius Steiro Fimland, Javier Palarea-Albaladejo, Svend Erik Mathiassen, Andreas Holtermann, Skender Redzovic

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ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial by Christian Burisch, Abhav Bellary, Frank Breuckmann, Jan Ehlers, Serge C Thal, Timur Sellmann, Daniel Gödde

“…MethodsWe designed a randomized controlled trial, in which adult high school students attempt to solve CME tests across six medical specialties in three study arms in total with 18 CME training courses per study arm under different interventional conditions with varying amounts of permitted use of ChatGPT-4. …”
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The effect of Camellia sinensis ointment on perineal pain and episiotomy wound healing in primiparous women: A triple-blind randomized clinical trial. by Masoumeh Sayahi, Azam Jahangirimehr, Zahra Hatami Manesh, Faraz Mojab, Maryam Nikbina

“…Participants were randomly assigned into two groups of intervention (Camellia sinensis extract ointment) and control (placebo) with a follow-up of 14 days. …”
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Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial by Francesca Colombo, Stefano Alfano, Massimo Milani

“…This study aimed to evaluate the efficacy of a novel “In & Out” strategy, combining topical and oral melatonin supplementation, in managing skin aging compared to topical treatment alone. A randomized, prospective study was conducted on 39 healthy females aged 55–69 years. …”
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Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection by Haoyu Ran, Changying Li, Syed M. Musa Rizvi, Ruiqin Zhou, Lingwen Kong, Sun Shuangling, Yue Shao, Kejia Wu, Changzhu Duan, Jun Luo, Haoming Shi, Qingchen Wu, Cheng Zhang

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Reducing children’s anxiety and pain in dental environment using an eye massage device combined with natural sounds—a randomized controlled trial by Dajma Abed, Jamila Bchara, Dani Abed, Jina Alfeel, Nada Bshara

“…A total of 105 children aged between 8 and 10 years whose dental treatment required inferior alveolar nerve block (IANB) injection participated in this randomized controlled clinical trial. The participants were randomly divided into three groups: Group A: eye massage with natural sounds; Group B: eye massage only; and Group C (control group): traditional behavior management techniques. …”
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Comparison of Nasopharyngeal Airway Device and Nasal Oxygen Tube in Obese Patients Undergoing Intravenous Anesthesia for Gastroscopy: A Prospective and Randomized Study by Qiansong Xiao, Yingying Yang, Yinbin Zhou, Yan Guo, Xing Ao, Ran Han, Jiali Hu, Dongfeng Chen, Chunhui Lan

“…This prospective and randomized study evaluated the efficacy and safety of the nasopharyngeal airway relative to the nasal oxygen tube in obese patients undergoing painless gastroscopy. …”
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N-Butyl-2-Cyanoacrylate Adhesive Versus Absorbable Tacks in Laparoscopic Groin Hernia Repair: A Multicenter Randomized Clinical Trial by Clayton C. Petro, MD, Benjamin K. Poulose, MD, Michael J. Rosen, MD, Alfredo M. Carbonell, II, DO, Adel G. El-Ghazzawy, MD, Jeremy A. Warren, MD, Emanuele Lo Menzo, MD, Ajita S. Prabhu, MD, David M. Krpata, MD, Samuel Szomstein, MD, Vimal Narula, MD, Crystal F. Totten, MD, Kelly R. Haisley, MD, Andrew C. Bernard, MD, Henrik O. Berdel, MD, Jessica K. Reynolds, MD, Zachary D. Warriner, MD, John S. Roth, MD

“…From 2019 to 2021, 284 patients were randomized to either NB2C adhesive or absorbable tacks (n = 142/142). …”
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Bimanual Microincision Cataract Surgery versus Coaxial Microincision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials and Cohort Studies by Chenxi Fu, Naipin Chu, Xiaoning Yu, Ke Yao

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A Randomized Case-Series Study Comparing the Stability of Implant with Two Different Surfaces Placed in Fresh Extraction Sockets and Immediately Loaded by Leonardo Vanden Bogaerde, Lars Sennerby

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A web-based pilot randomized controlled trial to test the efficacy of education and contact-based interventions in reducing public suicide stigma by Nathalie Oexle, Matthias Lühr, Daniele Valacchi, Nicolas Rüsch

“…Methods We conducted a web-based randomized controlled trial among N = 2,043 participants recruited from an established online research panel. …”
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Testing the Recruitment Frequency, Implementation Fidelity, and Feasibility of Outcomes of the Heart Failure Activity Coach Study (HEALTHY): Pilot Randomized Controlled Trial by Andreas Blomqvist, Maria Bäck, Leonie Klompstra, Anna Strömberg, Tiny Jaarsma

“…Participants were randomized to either have their mHealth tool updated with the Activity Coach app (intervention group) or a sham version (control group). …”
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Comparison of the Efficacy and Safety of Levocetirizine versus Bilastine for the Treatment of Chronic Spontaneous Urticaria in the Pediatric Population: An Observer-blinded Randomized Control Trial by Debashree Sahoo, Maitreyee Panda, Ajaya Kumar Jena, Anil Kumar Panda

“…Materials and Methods: This was a randomized, observer-blinded study where 65 patients (6–16 years) with a history of urticaria >6 weeks were divided into two groups with computer-generated randomization. …”
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Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial by Mohammad Jafar Eghbal, Ali Haeri, Arash Shahravan, Ali Kazemi, Fariborz Moazami, Mohammad Ali Mozayeni, Eshaghali Saberi, Mohammad Samiei, Mehdi Vatanpour, Alireza Akbarzade Baghban, Mahta Fazlyab, Ardavan Parhizkar, Mahboobe Ahmadi, Nazila Akbarian Rad, Shima Bijari, Delaram Bineshmarvasti, Paria Davoudi, Roya Dehghan, Mandana Dehghani, Habibollah Ebrahimi, Nafiseh Emami, Nafiseh Farajian, Rahim Fereidooni, Gelareh Ghobadi, Mostafa Ghodrati, Atefeh Gohari, Azadeh Hashemi, Mohammadreza Hosseini, Elham Karami, Nasir Kheirabadi, Sepideh Kozegari, Hadi Labaf Ghasemi, Alireza Majidi, Parastu Malekzadeh, Vahid Mehrabi, Mehrnush Mohammadi, Leila Moradi Eslami, Atefeh Noghani, Negin Omatali, Negar Pourhatami, Behnam Rahbani Nobar, Saeid Rahmani, Parviz Shafaq, Sara Soofiabadi, Somaye Teimoori, Farzaneh Vatandoost, Saeed Asgary

“…This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium-enriched mixture (PCEM) in permanent mature teeth. …”
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Elucidating the causal associations and mechanisms between circulating immune cells and idiopathic pulmonary fibrosis: new insights from Mendelian randomization and transcriptomics by Han Yang, Xuanyu Wu, Xiang Xiao, Jiajing Chen, Xiaomin Yu, Wen Zhao, Fei Wang

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Self-administered active versus sham acupressure for diarrhea predominant irritable bowel syndrome: a nurse-led randomized clinical trial by Maha Gamal Ramadan Asal, Ahmed Abdelwahab Ibrahim El-Sayed, Samira Ahmed Alsenany, Zahraa Hassan Ramzy, Rasha Fathy Ahmed Dawood

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Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial by Karen J. Bosma, Myriam Lafreniere-Roula, Arlene Jiang, Anna Heath, Yongdong Ouyang, Kaitlyn Wade, Pingzhao Hu, Karen E. A. Burns, Claudio M. Martin, Yoanna Skrobik, Sorcha Mulligan, Kevin E. Thorpe, Laurent Brochard, members of the Canadian Critical Care Trials Group and the REVA Network

“…Abstract Background We previously published the protocol and statistical analysis plan for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study in Trials ( https://doi.org/10.1186/s13063-023-07163-w ). …”
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