99mTc(CO)3-Labeled 1-(3-Nitropyridin-2-yl) Piperazine as Potential Radioligand for 5-HT7 Receptors by Sajjad Molavipordanjani

“…This study aims to develop an effective radiotracer for imaging 5-HT7R overexpression in GBM by utilizing a radiolabeled aryl piperazine derivative (99mTc(CO)3-[5]). …”
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HSP70-Inducible hNIS-IRES-eGFP Reporter Imaging: Response to Heat Shock by Jiantu Che, Mikhail Doubrovin, Inna Serganova, Lyudmila Ageyeva, Tatiana Beresten, Ronald Finn, Ronald Blasberg

“…Increases in eGFP fluorescence and radiotracer uptake were first noted at 6 hours, reached a maximum at 24 hours, and fell toward baseline at 72 hours. …”
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Development of [F]FPy-WL12 as a PD-L1 Specific PET Imaging Peptide by Wojciech G. Lesniak PhD, Ronnie C. Mease PhD, Samit Chatterjee PhD, Dhiraj Kumar PhD, Ala Lisok MA, Bryan Wharram MS, Venkateswara Rao Kalagadda PhD, Leisha A. Emens MD, PhD, Martin G. Pomper MD, PhD, Sridhar Nimmagadda PhD

“…The uptake of the radiotracer reflected the PD-L1 expression assessed by flow cytometry. …”
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Tc-Labeled Cyclic RGD Peptides for Noninvasive Monitoring of Tumor Integrin αβ Expression by Yang Zhou, Young-Seung Kim, Sudipta Chakraborty, Jiyun Shi, Haijuan Gao, Shuang Liu

“…It was found that the radiotracer tumor uptake followed the trend U87MG > MDA-MB-435 ≈ HT29 ≈ A549 > PC-3. …”
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Evaluation of Intraperitoneal [18F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity by Els F. Halff, Sridhar Natesan, David R. Bonsall, Mattia Veronese, Anna Garcia-Hidalgo, Michelle Kokkinou, Sac-Pham Tang, Laura J. Riggall, Roger N. Gunn, Elaine E. Irvine, Dominic J. Withers, Lisa A. Wells, Oliver D. Howes

“…Positron emission tomography (PET) using the radiotracer [18F]-FDOPA provides a tool for studying brain dopamine synthesis capacity in animals and humans. …”
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Evaluation of Glucose Uptake in Normal and Cancer Cell Lines by Positron Emission Tomography by Francesca Maddalena, Giacomo Lettini, Rosj Gallicchio, Lorenza Sisinni, Vittorio Simeon, Anna Nardelli, Angela Assunta Venetucci, Giovanni Storto, Matteo Landriscina

“…Indeed, [ 18 F]FDG incorporation on PET was comparable to [ 18 F]FDG uptake by autoradiography and 2-DG incorporation by colorimetric assay, although radiotracer-based methods exhibited more pronounced differences between individual cell lines. …”
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Evaluation of 2′-Deoxy-2′-Flouro-5-Methyl-1-β--Arabinofuranosyluracil as a Potential Gene Imaging Agent for Expression In Vivo by Mian M. Alauddin, Atranik Shahinian, Erlinda M. Gordon, Peter S. Conti

“…2′-Deoxy-2′-flouro-5-methyl-1-β- d -arabinofuranosyluracil (FMAU) has been evaluated in HT-29 cells as a potential positron emission tomography (PET) radiotracer for imaging HSV-tk gene expression in vivo. …”
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In Vivo Functional Assessment of Sodium-Glucose Cotransporters (SGLTs) Using [18F]Me4FDG PET in Rats by Yohji Matsusaka, Xinyu Chen, Paula Arias-Loza, Rudolf A. Werner, Naoko Nose, Takanori Sasaki, Steven P. Rowe, Martin G. Pomper, Constantin Lapa, Takahiro Higuchi

“…Thus, we aimed to assess the potential of the SGLT-targeting PET radiotracer alpha-methyl-4-deoxy-4-[18F]fluoro-D-glucopyranoside ([18F]Me4FDG) as a noninvasive intestinal and renal biomarker of SGLT-mediated glucose transport. …”
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In Vivo Imaging of Peripheral Benzodiazepine Receptors in Mouse Lungs: A Biomarker of Inflammation by Matthew J. Hardwick, Ming-Kai Chen, Kwamena Baidoo, Martin G. Pomper, Tomás R. Guilarte

“…The specificity of the PBR response was determined using a blocking dose of nonradioactive PK11195 given 30 min prior to radiotracer injection. Static planar images of the thorax of nonradioactive PK11195 pretreated animals showed a significantly lower level of radiotracer accumulation in control and in LPS-treated animals ( p < .05). …”
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Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism by Giorgio Fabiani, Carlos Henrique Ferreira Camargo, Raul Martins Filho, Gabriel Sampaio Froehner, Hélio Afonso Ghizoni Teive

“…In the group of drug-induced Parkinsonism, younger people were the ones who showed the most significant reductions in radiotracer uptake. In this group, nonmotor signs resulted in examinations with more significant reductions in radiotracer uptake. …”
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Dual Reporter Gene Imaging by Jiantu Che, Mikhail Doubrovin, Inna Serganova, Ludmila Ageyeva, Pat Zanzonico, Ronald Blasberg

“…A significant correlation between radiotracer accumulation and eGFP fluorescence intensity was demonstrated. …”
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Single-Photon Emission Computed Tomographic Imaging of the Early Time Course of Therapy-Induced Cell Death Using Technetium 99m Tricarbonyl His-Annexin A5 in a Colorectal Cancer Xe... by Christel Vangestel, Christophe Van de Wiele, Gilles Mees, Koen Mertens, Steven Staelens, Chris Reutelingsperger, Patrick Pauwels, Nancy Van Damme, Marc Peeters

“…Bevacizumab-treated mice showed no increased uptake of the radiotracer, and a peak of 99m Tc-(CO) 3 His-ann A5 uptake in panitumumab-treated mice was observed 24 hours posttreatment, as confirmed by caspase-3 immunostaining. …”
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Imaging Hepatocellular Carcinoma With Ga-Citrate PET: First Clinical Experience by Carina Mari Aparici MD, Spencer C. Behr MD, Youngho Seo PhD, R. Kate Kelley MD, Carlos Corvera MD, Kenneth T. Gao, Rahul Aggarwal MD, Michael J. Evans PhD

“…Further studies are required in a larger patient cohort to verify the molecular basis of radiotracer uptake and the clinical utility of this tool.…”
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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…Here, we used carbon-11-labeled CEP-32496 ([ 11 C]CEP-32496) as a positron emission tomography (PET) radiotracer to evaluate its pharmacokinetic properties and explore its potential for in vivo imaging. …”
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PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats by Laure Balasse, Julia Maerk, Frédéric Pain, Aurelie Genoux, Sylvain Fieux, Françoise Lefebvre, Christian Morel, Pascale Gisquet-Verrier, Philippe Lanièce, Luc Zimmer

“…The binding of [ 11 C]raclopride to D 2 dopamine receptors was measured in anesthetized and awake rats following injection of the radiotracer. Competitive binding was assessed with a cold raclopride injection 20 minutes later. …”
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PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to S. aureus Infection by Hao Jiang, Jiwei Gu, Haiyang Zhao, Sumit Joshi, Joel S. Perlmutter, Robert J. Gropler, Robyn S. Klein, Tammie L. S. Benzinger, Zhude Tu

“…PET with S1PR1-specific radiotracer [18F]TZ4877 could provide a noninvasive tool for detecting the early S1PR1 immune response to infectious diseases.…”
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Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma by Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D. Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M. Ametamey, Daniel Eberli

“…After muscle harvesting, inflammation levels were in parallel to radiotracer uptake amount, with significantly lower uptake in hPGC-1α overexpressing samples. …”
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Positron Emission Tomographic Imaging of the Cannabinoid Type 1 Receptor System with [C]OMAR ([C]JHU75528): Improvements in Image Quantification Using Wild-Type and Knockout Mice by Raúl Herance, Santiago Rojas, Sergio Abad, Xavier Jiménez, Juan Domingo Gispert, Olga Millán, Elena Martín-García, Aurelijus Burokas, Miquel Àngel Serra, Rafael Maldonado, Deborah Pareto

“…The results of this study support the feasibility of using PET with the radiotracer [ 11 C]JHU75528 to image the brain CB1 receptor system in mice. …”
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Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications by Hamideh Zarrinmayeh PhD, Paul R. Territo PhD

“…We have also reviewed receptors lacking radiotracer, laying the foundation for future discoveries of novel PET radioligands to reveal these receptors roles in CNS disorders.…”
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Imaging Multidrug Resistance P-glycoprotein Transport Function Using MicroPET with Technetium-94m-Sestamibi by Heather M. Bigott, Julie L. Prior, David R. Piwnica-Worms, Michael J. Welch

“…The positron-emitting radiotracer hexakis (2-methoxyisobutylisonitrile)- 94m Tc ( 94m Tc-MIBI) was synthesized and validated in cell transport studies as a substrate for MDR1 Pgp. …”
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