Clinicopathologic characteristics, therapeutic modalities and survival outcomes of plasmablastic lymphoma: A real-world study by Yan-Hua Zheng, Kun Xie, Hong-Yuan Shen, Zhuo Wan, Shan Gao, Wen-Rui Sun, Guang-Xun Gao, Li Liu, Juan Feng

“…Chemotherapy alone or chemotherapy combined with radiotherapy could significantly reduce the risk of death and extend the patients’ survival, yielding a HR of 0.209 (95% CI: 0.152–0.288) and 0.187 (95% CI: 0.089–0.394), respectively. …”
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Risk factors for brain metastasis in lung cancer: an umbrella review of systematic reviews and meta-analyses by Sumei Wang, Xinliang Wan, Handan Mo, Jixin Chen, Qichun Zhou, Shenghong Qiu, Yongchun Zou, Wanyin Wu, Qing Tang

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Polo-like Kinase 1 Expression as a Biomarker in Colorectal Cancer: A Retrospective Two-Center Study by Lana Jajac Brucic, Vesna Bisof, Majana Soce, Marko Skelin, Ivan Krecak, Andjela Nadinic, Branka Vrbicic, Zivana Puljiz, Suzana Hancic, Slavko Gasparov

“…Elevated expression of polo-like kinase 1 (PLK-1) has been linked to advanced disease stages and poorer treatment outcomes, including resistance to both chemotherapy and radiotherapy. However, data on PLK-1 expression in EOCRC compared to LOCRC remain limited. …”
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A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats by Lorea Iturri, Emmanuel Jouglar, Cristèle Gilbert, Julie Espenon, Marjorie Juchaux, Yolanda Prezado

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Salvage Magnetic Resonance Imaging–guided Transurethral Ultrasound Ablation for Localized Radiorecurrent Prostate Cancer by Mikael Anttinen, Pietari Mäkelä, Pertti Nurminen, Heikki Pärssinen, Simona Malaspina, Teija Sainio, Mikael Högerman, Pekka Taimen, Roberto Blanco Sequeiros, Peter J. Boström

“…Methods: Men with biochemically relapsed, biopsy-proven PCa following definitive radiotherapy underwent whole- or partial-gland sTULSA (NCT03350529). …”
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Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation by Chang Dong Yeo, Dong Won Park, Seong Hoon Yoon, Eun Young Kim, Jeong Eun Lee, Shin Yup Lee, Chang‐Min Choi, In‐Jae Oh, Do Jin Kim, Jeong Seon Ryu, Jae Cheol Lee, Young‐Chul Kim, Tae Won Jang, Kye Young Lee, Seung Hun Jang, Seung Joon Kim, for the Korean EGFR Registry Investigators

“…The primary endpoint is disease‐free survival in patients who have undergone radical therapy (surgery and radiotherapy) or progression‐free survival in those receiving targeted therapy (first, second, and subsequent lines), chemotherapy (first and subsequent lines), combination therapy, and palliative/maintenance therapy according to stages of EGFR‐mutated NSCLC. …”
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Deep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma by Laurens S. Ter Maat, Rob A. J. De Mooij, Isabella A. J. Van Duin, Joost J. C. Verhoeff, Sjoerd G. Elias, Tim Leiner, Wouter A. C. van Amsterdam, Max F. Troenokarso, Eran R. A. N. Arntz, Franchette W. P. J. Van den Berkmortel, Marye J. Boers-Sonderen, Martijn F. Boomsma, Fons J. M. Van den Eertwegh, Jan Willem de Groot, Geke A. P. Hospers, Djura Piersma, Art Vreugdenhil, Hans M. Westgeest, Ellen Kapiteijn, Ardine A. De Wit, Willeke A. M. Blokx, Paul J. Van Diest, Pim A. De Jong, Josien P. W. Pluim, Karijn P. M. Suijkerbuijk, Mitko Veta

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CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis by Ying Zhang, Ruiwei Yao, Mingyi Li, Chongkai Fang, Kunliang Feng, Xiuru Chen, Jinan Wang, Rui Luo, Hanqian Shi, Xinqiu Chen, Xilin Zhao, Hanlin Huang, Shuwei Liu, Bing Yin, Chong Zhong

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Radiological images of an advanced invasive carcinoma with mucinous aspects: A case report by Chiara Adriana Pistolese, MD, PhD, Francesca Di Giuliano, MD, PhD, Martina Cerocchi, MD, Maria Volpe, MD, Martina Cerasi Dellanea, MD, Flavia Briganti, MD, Paola Elda Gigliotti, MD, Carolina Goffredo, MD, Lucia Giudice, MD, Diletta Caccia, MD, Francesca Servadei, MD, Adriano De Majo, MD, PhD, Marco Materazzo, MD, Giorgio Pistilli, MD, Gianluca Vanni, MD, PhD, Valeria Liberto, MD

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PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands by Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko

“…Treatment of ACC is limited to surgery and/or adjuvant radiotherapy, which often fails to prevent disease recurrence, and no FDA-approved targeted therapies are currently available. …”
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Breast cancers with neuroendocrine differentiation: Retrospective case studies series from a single institution based on the 2019 WHO classification by Youngkyung Jeon, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Kyuehee Choi, Sun Young Jeong, Yeji Jung, Jaeyeon Jang, Dae-Ho Choi, Joohyun Hong, Hyo Jung Kim, Soo Youn Cho, Yeon Hee Park

“…All patients were treated with curative intent surgery; five patients received neoadjuvant chemotherapy, twelve patients received radiotherapy, six patients received adjuvant chemotherapy, and eight patients received hormone therapy. …”
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Predicting Urinary Function Outcomes Following Low-dose-rate Brachytherapy for Prostate Cancer by Gianni Rüedi, Manolis Pratsinis, Hans-Peter Schmid, Sabine Güsewell, Paul M. Putora, Ludwig Plasswilm, Christoph Schwab, Orlando Burkhardt, Armin Thoeni, Werner Hochreiter, Ladislav Prikler, Stefan Suter, Patrick Stucki, Michael Müntener, Nadja Blick, Hans Schiefer, Gautier Müllhaupt, Daniel S. Engeler

“…Patient summary: We created a tool to predict the likelihood of urinary problems after a type of radiotherapy called brachytherapy for prostate cancer. …”
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Evaluating the radiosensitivity of the oral microbiome to predict radiation-induced mucositis in head and neck cancer patients: A prospective trial by Andreas R. Thomsen, Elsa Beatriz Monroy Ordonez, Michael Henke, Benedikt Luka, Jörg Sahlmann, Henning Schäfer, Vivek Verma, Nadine Schlueter, Anca-Ligia Grosu, Tanja Sprave

“…Background: Predicting the occurrence and/or severity of oral mucositis (OM) before commencing radiotherapy (RT) remains very difficult. The aim of this prospective trial was to investigate whether the ex-vivo radiation sensitivity of oral keratinocytes from head and neck (H&N) cancer patients correlates with severe OM. …”
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An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene by Zita Reisz, Rita Pereira, Smitha Nevis, Alan Mackay, Leena Bhaw, Yura Grabovska, Ross Laxton, Valeria Molinari, Anna Burford, Barnaby Clark, Cristina Bleil, Bassel Zebian, Erika Pace, Annette Weiser, Fernando Carceller, Lynley Marshall, Andrew King, Istvan Bodi, Safa Al-Sarraj, Chris Jones, Matthew Clarke

“…The patient was treated with adjuvant radiotherapy, but progressed and passed away 13 months post-diagnosis. …”
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Effectiveness of a nurse-led coaching in self-care intervention for elderly undergoing total laryngectomy: a randomised controlled trial by Yan Liu, Lai Wei, Xue Li, Jian Chen, Huifen Wang, Liyuan Zheng, Shu'e Liu, Danxia Peng, Sanxia Ye, Yuchen Lu, Zhidan Mei, Chun Xu

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The spatially informed mFISHseq assay resolves biomarker discordance and predicts treatment response in breast cancer by Evan D. Paul, Barbora Huraiová, Natália Valková, Natalia Matyasovska, Daniela Gábrišová, Soňa Gubová, Helena Ignačáková, Tomáš Ondris, Michal Gala, Liliane Barroso, Silvia Bendíková, Jarmila Bíla, Katarína Buranovská, Diana Drobná, Zuzana Krchňáková, Maryna Kryvokhyzha, Daniel Lovíšek, Viktoriia Mamoilyk, Veronika Mancikova, Nina Vojtaššáková, Michaela Ristová, Iñaki Comino-Méndez, Igor Andrašina, Pavel Morozov, Thomas Tuschl, Fresia Pareja, Jakob N. Kather, Pavol Čekan

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Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population... by Xavier Castells, Beatriz Poblador-Plou, Alexandra Prados-Torres, Maria Sala, Javier Gorricho, Anna Jansana, Isabel Del Cura, Teresa Sanz Cuesta, A Gimeno Miguel, Manuela Lanzuela, Berta Ibañez, Ibai Tamayo, Conchi Moreno-Iribas, María Padilla-Ruiz, Maximino Redondo, Mercè Comas, Laia Domingo, Antonio Díaz-Holgado, Francisco Javier Salamanca, Mercè Abizanda, Talita Duarte, Javier Louro, María del Carmen Martínez, Cristóbal Molina, Guillermo Pérez, Ana María Muñoz, Óscar Toldos, Javier Baquedano, Rossana Burgui

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Suppression of MCP-1, IFN-γ and IL-6 production of HNSCC ex vivo by pembrolizumab added to docetaxel and cisplatin (TP) exceeding those of TP alone is linked to improved survival by Jana Wellhausen, Louisa Röhl, Michael Berszin, Irene Krücken, Irene Krücken, Veit Zebralla, Veit Zebralla, Markus Pirlich, Markus Pirlich, Matthaeus Stoehr, Matthaeus Stoehr, Susanne Wiegand, Susanne Wiegand, Susanne Wiegand, Andreas Dietz, Andreas Dietz, Theresa Wald, Theresa Wald, Gunnar Wichmann, Gunnar Wichmann

“…BackgroundAdding pembrolizumab, an anti-PD-1 antibody approved for treatment of head and neck squamous cell carcinoma (HNSCC) to neoadjuvant (induction-) chemotherapy utilizing docetaxel and cisplatin (TP) followed by radiotherapy may improve outcome in larynx organ-preservation (LOP) that is investigated in the European Larynx-Organ preservation Study (ELOS). …”
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Real-world experience with TTFields in glioma patients with emphasis on therapy usage by Claudius Jelgersma, Joan Alsolivany, Gülsüm Akkas, David Wasilewski, David Wasilewski, Bastian Gastl, Martin Misch, David Capper, David Capper, David Kaul, David Kaul, Lars Bullinger, Lars Bullinger, Peter Vajkoczy, Julia Onken, Julia Onken, Julia Onken

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Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in pat... by Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman

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