Personalized treatment strategies for breast adenoid cystic carcinoma: A machine learning approach by Sakhr Alshwayyat, Mahmoud Bashar Abu Al Hawa, Mustafa Alshwayyat, Tala Abdulsalam Alshwayyat, Siya sawan, Ghaith Heilat, Hanan M. Hammouri, Sara Mheid, Batool Al Shweiat, Hamdah Hanifa

“…The 5-year overall survival (OS) rates were highest for surgery + radiotherapy (RT) (94.9 %) and lowest for surgery + chemotherapy (CTX) + RT (80.1 %). …”
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Intricacies of human–AI interaction in dynamic decision-making for precision oncology by Dipesh Niraula, Kyle C. Cuneo, Ivo D. Dinov, Brian D. Gonzalez, Jamalina B. Jamaluddin, Jionghua Judy Jin, Yi Luo, Martha M. Matuszak, Randall K. Ten Haken, Alex K. Bryant, Thomas J. Dilling, Michael P. Dykstra, Jessica M. Frakes, Casey L. Liveringhouse, Sean R. Miller, Matthew N. Mills, Russell F. Palm, Samuel N. Regan, Anupam Rishi, Javier F. Torres-Roca, Hsiang-Hsuan Michael Yu, Issam El Naqa

“…To investigate such collaborative decision-making process, we conducted a Human–AI interaction study on response-adaptive radiotherapy for non-small cell lung cancer and hepatocellular carcinoma. …”
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Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices by Asmaa M. Zahran, Helal F. Hetta, Zeinab Albadry M. Zahran, Alaa Rashad, Amal Rayan, Dalia O. Mohamed, Zeinab Ahmed Abd Elhameed, Salah M. Khallaf, Gaber El-Saber Batiha, Yasir Waheed, Khalid Muhammad, Hanaa Nafady-Hego

“…We recruited 40 cases of advanced NSCLC, stages III and IV, aged>18–<70 years old, and eligible to receive chemotherapy with or without radiotherapy, along with 20 healthy controls of comparable age and sex; after diagnosis and staging of patients, blood samples were collected for flow cytometric detection of Mo-MDSCs. …”
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Global research trends on gastrointestinal cancer and mental health (2004–2024): a bibliographic study by Wenjin Han, Tianmeng Wang, Zhiqiang He, Caihua Wang, Zhaozhao Hui, Shuangyan Lei, Nan Hao, Ning Li, Xiaoqin Wang, Xiaoqin Wang

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Outcomes of oncologic arthroplasty in children and adolescents with malignant limb tumors: a systematic review by Vyacheslav I. Zorin, Sergei V. Vissarionov, Alexandr Y. Makarov, Timofey S. Rybinskikh, Kristina N. Rodionova

“…However, the development and refinement of chemotherapy and radiotherapy protocols, along with advances in surgical techniques and implants, have significantly altered the treatment landscape for these patients. …”
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Computational insights into Sitahe (Leuconotis eugenifolia) bioactive compounds: A promising approach for radioprotection through p53 inhibition by Dian Pribadi Perkasa, Iin Kurnia, Taufik Muhammad Fakih, Teja Kisnanto, Dwi Ramadhani, Harry Nugroho Eko Surniyantoro, Boky Jeanne Tuasikal, Alfian Mahardika Forentin, Mukh Syaifudin

“…The radioprotective potential of Sitahe (Leuconotis eugenifolia) phytochemicals in cancer radiotherapy remains largely unexplored. In this study, in silico docking simulations were conducted to systematically assess the ability of key phytochemicals from Sitahe to modulate p53 activity, a critical gene in DNA repair and cancer therapy. …”
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DNA vaccines as promising immuno-therapeutics against cancer: a new insight by Alireza Shariati, Arya Khezrpour, Fatemeh Shariati, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Aref Yarahmadi, Sajad Alavimanesh, Sajad Alavimanesh, Sina Kamrani, Mohammad Hossein Modarressi, Pouria Khani

“…Several approaches including structural modification, combination therapy with conventional and novel cancer treatments (such as chemotherapy, radiotherapy, and immune checkpoint blockade (ICB)), and the incorporation of adjuvants into the plasmid structure have been studied to enhance the vaccine’s immunogenicity and improve the clinical outcome of cancer patients. …”
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Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Due to impaired DNA damage repair, conventional cytotoxic therapies or radiotherapy should be avoided whenever feasible to mitigate the high incidence of treatment-related secondary malignancies in these patients. …”
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CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors in non-small cell lung cancer by Carlos M Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot Blatt, Ganesh V. Raj, Yi Yin

“…Preclinical studies indicate that CDK4/6i may collaborate by influencing DNA damage repair pathways during radiotherapy. Since PARP1 expression was also significantly upregulated in NSCLC, we analyzed the efficacy of combining PARP1 and CDK4/6 inhibition in NSCLC models. …”
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MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair by Jiandong Zhang, Lei Ma, Limin He, Quanxiao Xu, Yan Ding, Lidong Wang

“…Background: While radiation-induced lung injury decreases quality of life and suppresses efficacy of radiotherapy, to date, the relationship between radiation-induced lung injury and repair remains unclear. …”
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The role of PCBP1 in carbon ion-induced ferroptosis and inhibition of lung adenocarcinoma proliferation by Zhenchao Kang, Zihan Fu, Xuejiao Tian, Yichao Geng, Qiuning Zhang, Yanli Liu, Xinhua Wang, Hongtao Luo, Zhen Yang, Zhen Yang

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Overweight and obesity among adolescents: health-conscious behaviours, acceptance, and the health behaviours of their parents by Anna Lewandowska, Grzegorz Rudzki, Tomasz Lewandowski, Anna Bartosiewicz, Michał Próchnicki, Aleksandra Stryjkowska-Góra, Barbara Laskowska, Małgorzata Sierpińska, Sławomir Rudzki, Sergii Pavlov

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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…This knowledge may help to optimize the combination of the selected IMQ dose with e.g. chemotherapy or radiotherapy to elicit synergistic effect in cancer treatment. …”
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Comprehensive analysis of peripheral dose in electron beam therapy with a Varian TrueBeam Linac by Kapil Dev Maharaj, Mahsheed Sabet, Joshua Dass, Mounir Ibrahim, Talat Mahmood, Pejman Rowshanfarzad

“…Conclusions: This study highlights the importance of considering peripheral doses in electron radiotherapy. It is important to note the impact on healthy tissues beyond the treatment area to ensure patient safety and prevent the long-term side effects of treatment. …”
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The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer by Mustafa Kandaz, Atalay Balsak, Hatice Bengü Çobanoğlu

“…Methods: Ninety-seven patients with NPC who received adjuvant radiotherapy between 1998 and 2022 were analyzed retrospectively. …”
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Modeling dose uncertainty in cone-beam computed tomography: Predictive approach for deep learning-based synthetic computed tomography generation by Cédric Hémon, Lucía Cubero, Valentin Boussot, Romane-Alize Martin, Blanche Texier, Joël Castelli, Renaud de Crevoisier, Anaïs Barateau, Caroline Lafond, Jean-Claude Nunes

“…Background and purpose:: Cone-beam computed tomography (CBCT) is essential in image-guided radiotherapy (RT) for patient positioning and daily dose calculation. …”
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Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells by Yajun Wu, Pengyuan Liu, Wendy Chen, Shiting Bai, Sisi Chen, Jianglin Chen, Xiaogang Xu, Jindan Xia, Yufei Wu, Jianjun Lai, Chuan Sun, Zhenghong Lao, Xiaoqing Wan, Zhibing Wu

“…Purpose Radiotherapy (RT) is the primary treatment for prostate cancer (PCa); however, the emergence of castration-resistant prostate cancer (CRPC) often leads to treatment failure and cancer-related deaths. …”
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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma by Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

“…Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common malignant urological tumor, and regrettably, and is insensitive to chemotherapy and radiotherapy, resulting in poor patient outcomes. DBF4 plays a critical role in DNA replication and participates in various biological functions, making it an attractive target for cancer treatment. …”
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Clinical Characteristics of Neuropathic Pain and Its Relationship with Cancer in Different Corporal Areas—A Systematic Review by Fernanda Danés-López, Cristóbal Diaz-Palominos, Anggie Ortiz Domínguez, Alanna Silva Rodriguez, Constanza Astorga, Daniela Martínez-Hernández, Juan Jose Valenzuela-Fuenzalida, Juan Sanchis-Gimeno, Pablo Nova-Baeza, Alejandra Suazo-Santibáñez, Gustavo Oyanedel-Amaro, Mathias Orellana-Donoso, Héctor Gutiérrez Espinoza

“…<b>Background:</b> Neuropathic pain (NP) and cancer are caused by nerve damage due to cancer or treatments such as chemotherapy, radiotherapy, and surgery, with a prevalence that can reach up to 40%. …”
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Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Zaid Ahmed Shamsi, Vlad Paraoan, Chang Kim, Sarah Raihanah Saifuddin, Thomas D A Cosker, Duncan Whitwell, Christopher L M H Gibbons, Dionisios Stavroulias, Francesco DiChiara

“…Standard practice currently comprises wide surgical excision, often accompanied by adjuvant chemotherapy and/or radiotherapy. This approach necessitates a multidisciplinary team, ideally in specialised cancer centres. …”
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