Non-professional phagocytosis of senescent cancer cells revealed in a 3D-bioprinted model of an irradiated lung tumour by Parul Yadav, Pritiranjan Mondal, Sibani Jani, Deepak K. Saini, Kaushik Chatterjee

“…This study explores the application of extrusion-based 3D bioprinting technology to create complex scaffolds mimicking the microenvironment of senescent cancer cells induced by radiotherapy. Using a viscoelastic hydrogel bioink composed of a blend of alginate and gelatin, we fabricated scaffolds with porosity and mechanical properties appropriate for culturing lung cells. …”
Get full text

An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance by Hang Zou, Pingping Wang, Zhihao Bai, Liping Liu, Jingtong Wang, Yanfang Cheng, Bairong He, Zujin Zhao, Lei Zheng

“…This ultimately causes severe cell damage and restores the sensitivity of tumor cells to radiotherapy and chemotherapy. Thus, QM-DMAC serves as a highly efficient lysosome-targeting photosensitizer and an excellent therapeutic sensitizer. …”
Get full text

PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

Get full text

From skin to heart: The rare journey of pleomorphic dermal sarcoma metastasis by Maria Gabriela Matta, MD MSc, Dipesh Raniga, MD, Vinicius Carraro do Nascimento, MD, Gayle Therese Hill, BSc, Mohamed Nasser Essack, MD, Ian Agahari, MD

“…Despite clear surgical margins and adjuvant radiotherapy, he later exhibited metastatic disease affecting the lungs and heart. …”
Get full text

Primary pulmonary meningioma: a case report and literature review by Jun Cheng, Chunfen Guo

“…A small proportion of malignant cases may require lobectomy and adjuvant radiotherapy and chemotherapy due to tumor invasiveness.…”
Get full text

Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case by Naushad A. B. Ahamed, Khalid Sait, Nisreen Anfnan, Khader Farwan, S. H. M. Nizamuddin, Saleh S. Baeesa

“…Based on her modified WHO risk factors scoring she was started on chemotherapy and whole brain radiotherapy, which resulted in a complete response. …”
Get full text

Supraclavicular Artery Island Flap in Head-and-neck Reconstruction: Our Experience by Abhinav Thaduri, Bhinyaram Jat, Amit Kumar, Amit Kumar Tyagi, Abhijeet Singh, Vikramjit Singh Kailey, Dileep Dungala Maharaj, Shahab Usmani, Kartikesh Gupta

“…Results: All patients underwent wide excision of the tumor following oncological principles, and four out of seven patients received postoperative adjuvant radiotherapy. Two patients with parotid tumors underwent facial skin excision along with total parotidectomy. …”
Get full text

Advances in Illuminating Prostate Cancer with Emerging Phototherapies by Ali Usman

“…Despite advancements in diagnostics and treatment options, conventional therapies for prostate cancer, including surgery, radiotherapy, chemotherapy and androgen deprivation therapy, face limitations such as treatment resistance, limited precision and off-target side-effects. …”
Get full text

MCNP-X Monte Carlo Code Application for Mass Attenuation Coefficients of Concrete at Different Energies by Modeling 3 × 3 Inch NaI(Tl) Detector and Comparison with XCOM and Monte C... by Huseyin Ozan Tekin

Get full text

Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab by Shingo Nakayama, Mamoru Sasaki, Shojiroh Morinaga, Naoto Minematsu

“…The patient received stereotactic radiotherapy for the brain metastases, followed by administration of pembrolizumab. …”
Get full text

Evaluating the Predictive Value of the Dose-volume Parameters and Vascular Endothelial Growth Factor Expression on Rectal Toxicity in Prostate Cancer Patients by Marziyeh Mirzaeiyan, Hossein Khanahmad, Simin Hemati, Mahnaz Etehadtavakol, Zahra Sharifonnasabi, Parvaneh Shokrani

“…Despite recent advances to conform the dose distribution to the tumor volume, it is still impossible to perform radiotherapy based on the biological characteristics of each individual. …”
Get full text

Cerebral Metastasis from a Previously Undiagnosed Appendiceal Adenocarcinoma by Antonio Biroli, Paolo Cipriano Cecchi, Susanne Pragal, Esther Hanspeter, Andreas Schwarz

“…A right hemicolectomy was performed, and the specimen showed a moderately differentiated mucinous appendiceal adenocarcinoma. Whole brain radiotherapy was administrated. A subsequent thorax-abdomen CT scan revealed multiple lung and hepatic metastasis. …”
Get full text

Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural–Mesenchymal Transition by Andrey V. Markov, Arseny D. Moralev, Kirill V. Odarenko

“…Glioblastoma is one of the most aggressive brain cancers, characterized by active infiltrative growth and high resistance to radiotherapy and chemotherapy. Sesquiterpene triterpenoids (STLs) and their semi-synthetic analogs are considered as a promising source of novel anti-tumor agents due to their low systemic toxicity and multi-target pharmacological effects on key processes associated with tumor progression. …”
Get full text

Influential Factors and Synergies for Radiation-Gene Therapy on Cancer by Mei Lin, Junxing Huang, Yujuan Shi, Yanhong Xiao, Ting Guo

“…Radiation-gene therapy, a dual anticancer strategy of radiation therapy and gene therapy through connecting radiation-inducible regulatory sequence to therapeutic gene, leading to the gene being induced to express by radiation while radiotherapy is performed and finally resulting in a double synergistic antitumor effect of radiation and gene, has become one of hotspots in the field of cancer treatment in recent years. …”
Get full text

A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma by Liviu Feller, Razia A. G. Khammissa, Johan Lemmer

“…Despite radical surgery, radiotherapy, or chemotherapy, local recurrence and distant metastasis are frequent. …”
Get full text

Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study by Sanjay Kumar Rai, Tej Pratap Gupta, Bhavya Sirohi, Surbhi Rajauria, Nitish Khandelwal

“…This risk of developing DVT is increased much fold in the presence of metastasis, chemotherapy, radiotherapy, fracture fixation, and arthroplasty.…”
Get full text

PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis by A. Stravodimou, A. Cairoli, T. Rausch, R. Du Pasquier, P. Michel

“…With careful reduction of the immunosuppression after the first manifestation and with the use of chemotherapy combined with radiotherapy after the second manifestation, our patient showed complete disappearance of neurologic symptoms and she is clinically well with good kidney function. …”
Get full text

Acromegaly: Role of Surgery in the Therapeutic Armamentarium by Gerardo Guinto, Miguel Abdo, Erick Zepeda, Norma Aréchiga, Moisés Mercado

“…Radiation therapy can be also indicated in two main forms for residual tumor with medically refractory patients: radiosurgery for small tumors or fractionated stereotactic radiotherapy for larger ones.…”
Get full text

Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature by Umesh Jayarajah, D. M. Hilary Fernando, Kasun Bandara Herath, M. V. Chandu de Silva, S. A. S. Goonewardena

“…Primary signet-ring cell carcinoma is a variant of adenocarcinoma which is extremely rare, associated with poor prognosis and generally found to be resistant to chemotherapy and radiotherapy. We report a case of primary signet-ring cell carcinoma of the bladder which was successfully treated with partial cystectomy. …”
Get full text

Failure of Colorectal Anastomosis: Risk Factors, Prevention, Diagnosis, Therapeutic Tactics by M. F. Cherkasov, A. V. Dmitriev, V. S. Groshilin, S. V. Pereskokov, M. A. Kozyrevskiy, A. A. Urupina

“…In almost all studies, the height of the tumour and the anastomosis from the anus, preoperative radiotherapy and male sex are independent risk factors for the development of colorectal anastomotic leakage. …”
Get full text