Unconventional Nuclides for Radiopharmaceuticals by Jason P. Holland, Matthew J. Williamson, Jason S. Lewis

“…Rapid and widespread growth in the use of nuclear medicine for both diagnosis and therapy of disease has been the driving force behind burgeoning research interests in the design of novel radiopharmaceuticals. Until recently, the majority of clinical and basic science research has focused on the development of 11 C-, 13 N-, 15 O-, and 18 F-radiopharmaceuticals for use with positron emission tomography (PET) and 99m Tc-labeled agents for use with single-photon emission computed tomography (SPECT). …”
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[18F]Tetrafluoroborate, a new NIS PET/CT radiopharmaceutical: an overview focused on differentiated thyroid cancer by Arnoldo Piccardo, Francesco Fiz, Sergio Righi, Stefano Raffa, Mattia Riondato, Gianluca Bottoni, Matteo Bauckneht, Michela Massollo, Alessio Rizzo, Mehrdad Shoushtari Zadeh Naseri, Pierpaolo Trimboli, Giorgio Treglia

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Personalized metronomic radiopharmaceutical therapy through injection profile optimization via physiologically based pharmacokinetic (PBPK) modeling by Aryan Golzaryan, M. Soltani, Farshad Moradi Kashkooli, Babak Saboury, Arman Rahmim

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Tryptophan Kynurenine Pathway-Based Imaging Agents for Brain Disorders and Oncology—From Bench to Bedside by Erik Stauff, Wenqi Xu, Heidi H. Kecskemethy, Sigrid A. Langhans, Vinay V. R. Kandula, Lauren W. Averill, Xuyi Yue

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Radiopharmacokinetic modelling and radiation dose assessment of 223Ra used for treatment of metastatic castration-resistant prostate cancer by Vera Höllriegl, Nina Petoussi-Henss, Kerstin Hürkamp, Juan Camilo Ocampo Ramos, Wei Bo Li

Subjects: “…Radiopharmaceutical…”
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Currents status of radiotracers for breast cancer imaging in PET by Chloé Jean, Stéphane Roux, Abdelilah Aziz, Maxence Mocquery-corre, Rana Bazzi, Yacine Merrouche, Stéphane Dedieu, Nicolas Etique, Dimitri Papathanassiou, Jérôme Devy

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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [99mTc]Tc-labeled counterparts be used to estimate dosimetry? by Panagiotis Kanellopoulos, Quanyi Yu, Abouzayed Abouzayed, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova

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INTERNATIONAL ISOTOPES MARKETS by S. Z. Zhiznin, V. M. Timohov

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RevCAR-mediated T-cell response against PD-L1-expressing cells turns suppression into activation by Eugenia Crespo, Liliana R. Loureiro, Antonia Stammberger, Lydia Hoffmann, Nicole Berndt, Anja Hoffmann, Claudia Dagostino, Karla E. G. Soto, Luise Rupp, Claudia Arndt, Martin Schneider, Claudia R. Ball, Michael Bachmann, Marc Schmitz, Anja Feldmann

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Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging by Hugo Helbert, Winnie Deuther-Conrad, Michel de Haan, Barbara Wenzel, Gert Luurtsema, Wiktor Szymanski, Peter Brust, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga

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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

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Development of an automated method for in-house production of sodium 18F-fluoride for injection: process validation as a step toward routine clinical application by Marija Atanasova Lazareva, Maja Chochevska, Katerina Kolevska, Maja Velickovska, Filip Jolevski, Paulina Apostolova, Ana Ugrinska, Emilija Janevik-Ivanovska

“…Process validation was carried according to GMP guidelines to ensure consistency of [18F]NaF quality with international standards. The final radiopharmaceutical met all quality criteria specified by Ph. …”
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Radioimmunotherapy: A Specific Treatment Protocol for Cancer by Cytotoxic Radioisotopes Conjugated to Antibodies by Hidekazu Kawashima

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New Therapeutics to Treat Castrate-Resistant Prostate Cancer by Ömer Acar, Tarık Esen, Nathan A. Lack

“…In this review, we will examine mechanistic and clinical data of several newly approved therapeutics including the chemotherapeutic cabazitaxel, antiandrogen enzalutamide, endocrine disruptor abiraterone acetate, immunotherapy sipuleucel-T, and bone-targeting radiopharmaceutical alpharadin. In addition, we will examine other promising therapeutics that are currently in Phase III trials.…”
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Imaging in Periprosthetic Joint Infection Diagnosis: A Comprehensive Review by Armin Hoveidaei, Yasaman Tavakoli, Mohammad Reza Ramezanpour, Mahyaar Omouri-kharashtomi, Seyed Pouya Taghavi, Amir Human Hoveidaei, Janet D. Conway

“…Each imaging technique and radiopharmaceutical has been extensively studied, with unique diagnostic accuracy, limitations, and benefits for PJI diagnosis. …”
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Bone-Targeted Therapies in Metastatic Castration-Resistant Prostate Cancer: Evolving Paradigms by Joelle El-Amm, Ashley Freeman, Nihar Patel, Jeanny B. Aragon-Ching

“…While several radiopharmaceuticals were approved for pain palliation in mCRPC including strontium and samarium, alpharadin is the first radiopharmaceutical to show significant overall survival benefit. …”
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Folate Receptor–Targeted Single-Photon Emission Computed Tomography/Computed Tomography to Detect Activated Macrophages in Atherosclerosis: Can It Distinguish Vulnerable from Stabl... by Leah C.J. Winkel, Harald C. Groen, Bibi S. van Thiel, Cristina Müller, Antonius F.W. van der Steen, Jolanda J. Wentzel, Marion de Jong, Kim Van der Heiden

“…We investigated the feasibility of a folate-based radiopharmaceutical ( 111 In-EC0800) with high-resolution animal single-photon emission computed tomography/computed tomography (SPECT/CT) to differentiate between stable and vulnerable atherosclerotic plaques in apolipoprotein E 7 mice in which we can induce plaques with the characteristics of stable and vulnerable plaques by placing a flow-modifying cast around the common carotid artery. …”
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Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo by Desheng CHEN, Qinggang HUANG, Shiwei CAO, Zhi QIN

“…99mTc derived from 99Mo，stands as the preeminent radiopharmaceutical employed extensively in medical diagnostics worldwide. …”
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Quality of computed tomography image versus dose in hybrid studies: preliminary results in phantom by Adlin López Díaz, Armando del Pozo Almaguer, Adalberto Machado Tejeda, Karla Batista Ramó, Carlos F Calderón Marín, Leonel Torres Aroche

“…<p><strong>Background:</strong> hybrid studies produce a total radiation dose that is the result of the dose imparted by the radiopharmaceutical and that emitted by the computed tomography, therefore optimization is essential.…”
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Emerging Role of PET in the Diagnosis and Staging of Lung Cancer by Geoffery Coates, Stephen J Skehan

“…Malignant tumours demonstrate increased uptake of FDG, a positron-emitting radiopharmaceutical. This increased FDG uptake in tumours can be seen using PET. …”
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