iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…The hemolytic effects were tested using rabbit red blood cells. In a C57BL/6 J mouse model of cryptococcal infection, treatment groups (AmB, iPSC-Exo/AmB, and iPSC-Exo) were administered corresponding drugs, with blood and brain samples collected for analysis. …”
Get full text

High hemolytic activity in Staphylococcus aureus t1081/ST45 due to increased hla protein production and potential RNAIII-independent regulation by Yu-Tzu Lin, Ngoc-Niem Bui, Yu-Syuan Cheng, Cheng-Wen Lin, Chun-Li Lee, Tai-Fen Lee, Po-Ren Hsueh

“…Materials and methods: The hemolytic activity of 67 CC45 isolates (44 t1081 and 23 non-t1081) from clinical blood cultures was assessed using rabbit red blood cells. The sequences of hla and its upstream regulatory regions and RNAIII were compared between the two groups. …”
Get full text

From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes by Lorena Gallego, Kimberly Harvey, Marta Pevida, Luis García-Consuegra, Olivia García-Suárez, Álvaro Meana, María Alvarez-Viejo, Luis Junquera

“…The membrane’s efficacy was tested by creating a critical bicortical and bilateral osteoperiosteal defect in rabbit mandibles. The right-side defects were covered with the collagen membrane, while the left-side defects were left untreated as a control. …”
Get full text

A Lipiodol Pickering Emulsion Stabilized by Iron‐Doped Carbon Nanozymes for Liver Transarterial Chemoembolization by Xiancheng Xia, Yang Li, Rongkang Huang, Yuanbin Wang, Wenxuan Xiong, Hui Zhou, Min Li, Xidong Lin, Youchen Tang, Bo Zhang

“…By integrating chemotherapy and chemodynamic therapy, ICN‐LPE demonstrates a synergistic antitumor effect and effectively inhibits tumor growth in a rabbit liver tumor model. Therefore, our ICN‐LPE shows an appealing clinical application prospect for TACE.…”
Get full text

Chromosome-level reference genome assembly for the mountain hare (Lepus timidus) by Fekete, Zsófia, Absolon, Dominic E., Michell, Craig, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

“…Compared to the previous pseudo-reference genome assembly of  L. timidus ssp. hibernicus Bell, assembled using the rabbit genome, this new reference genome represents the nominate subspecies and the species-specific chromosomal conformation. …”
Get full text

Robotic Assistance in Percutaneous Liver Ablation Therapies: A Systematic Review and Meta-Analysis by Ana K. Uribe Rivera, MD, Barbara Seeliger, MD, PhD, Laurent Goffin, MSc, Alain García-Vázquez, MD, Didier Mutter, MD, PhD, Mariano E. Giménez, MD, PhD

“…Several databases (PubMed/MEDLINE, ProQuest, Science Direct, Research Rabbit, and IEEE Xplore) were systematically searched for robotic preclinical and clinical percutaneous liver ablation studies, and relevant original manuscripts were included according to the Preferred Reporting items for Systematic Reviews and Meta-Analyses guidelines. …”
Get full text

Vector Field Heterogeneity for the Assessment of Locally Disorganised Cardiac Electrical Propagation Wavefronts From High-Density Multielectrodes by Lucia Pancorbo, Samuel Ruiperez-Campillo, Alvaro Tormos, Antonio Guill, Raquel Cervigon, Antonio Alberola, Francisco Javier Chorro, Jose Millet, Francisco Castells

“…Furthermore, it has been tested on animal experimental models of isolated Langendorff-perfused rabbit hearts. The proposed parameter exhibited superior capturing ability of heterogeneous propagation wavefronts compared to the classical Spatial Inhomogeneity Index, and simulations proved that the metric effectively captures gradual increments in disorganisation in propagation patterns. …”
Get full text

Establishing a Surgical Procedure for Rhesus Epiretinal Scaffold Implantation with HiPSC-Derived Retinal Progenitors by Ziming Luo, Kang Li, Kaijing Li, Bikun Xian, Ying Liu, Sijing Yang, Chaochao Xu, Zhigang Fan, Shoutao Lu, Haijun Zhang, Jian Ge

“…First, the cellular scaffolds were delivered by 18G catheter or retinal forceps into rabbit epiretinal space (n=50). Then, the cell survival rate was evaluated by Cell Counting Kit-8 (CCK-8). …”
Get full text

Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, E. E. Uldanova, E. А. Chuyko, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

“…In all cases Goat anti-rabbit IgG was used as the secondary antibody. The density of neurons in the CA1 region of the hippocampus was lower in Clstn2-KO mice of both sexes as compared with controls. …”
Get full text

Coproantigen detection and molecular identification of Cryptosporidium species among newborn and adult farm animals by Dina Aboelsoued, Nagwa I. Toaleb, Kadria N. Abdel Megeed

“…Then, C. parvum oocysts were used for preparation of antigens and rabbit immunization. Anti-C. parvum IgG PAbs were purified and characterized by SDS-PAGE and then labeled with horseradish peroxidase (HRP). …”
Get full text

Polydeoxynucleotide-Loaded Visible Light Photo-Crosslinked Gelatin Methacrylate Hydrogel: Approach to Accelerating Cartilage Regeneration by Sunjae Park, Youngjun Son, Jonggyu Park, Soyoon Lee, Na-Hyeon Kim, Se-Na Jang, Tae-Woong Kang, Jeong-Eun Song, Gilson Khang

“…Histological assessments in a rabbit cartilage defect model demonstrated superior regenerative effects of gelMA-PDRN hydrogels. …”
Get full text

A Surgical Cryoprobe for Targeted Transcorneal Freezing and Endothelial Cell Removal by Alina Akhbanbetova, Shinichiro Nakano, Stacy L. Littlechild, Robert D. Young, Madara Zvirgzdina, Nigel J. Fullwood, Ian Weston, Philip Weston, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J. Quantock

“…In vitro studies were conducted on 426 porcine corneas, followed by preliminary in vivo investigations on three rabbit corneas. Results. The corneal epithelium was destroyed by transcorneal freezing, as expected; however, the epithelial basement membrane remained intact. …”
Get full text

Growth Factor Comparison in Cortical Demineralized Bone Matrix that Demineralized Using Chloric and Acetic Acid by Mouli Edward, Ferdiansyah Mahyudin, Mohammad Hardian Basuki, Heri Suroto, Ferdiansyah Danang Perwira

“…We characterized the Insulin-like growth factor-1 (IGF-1), Bone morphogenetic protein-2 (BMP-2), and Transforming growth factor-β (TGF-β) content of 1 gram of New Zealand White Rabbit cortical bone immersed in 0.6 M hydrochloric acid and 0.5 M acetic acid for 3, 6, and 9 days. …”
Get full text

Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence by Priyanka, Priyanka, Mohini Sharma, Bhavna Vaid, Bhavna Vaid, Ram Bharti, Ram Bharti, Sachin Raut, Sachin Raut, R. S. Jolly, Neeraj Khatri, Neeraj Khatri

“…The murine thigh infection model was also used to investigate the in vivo efficacy.ResultsAll derivatives exhibited favorable physicochemical profiles and ADMET properties and are predicted to be safe based on their drug-like properties. in vitro studies demonstrated that derivatives are non-toxic to 3T3 L1, and in vivo studies confirmed their safety in mice at a dose of 300 mg/kg and their non-hemolytic nature against rabbit red blood cells. All compounds showed potent antibacterial activity against the tested bacteria, including the resistant MRSA strain 831. …”
Get full text

In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii by Wangxiao Zhou, Qianqian Chen, Changrui Qian, Kai Shen, Xinyi Zhu, Danying Zhou, Wei Lu, Zhewei Sun, Hongmao Liu, Kewei Li, Teng Xu, Qiyu Bao, Junwan Lu

“…In this study, we investigated the antimicrobial susceptibility and molecular characteristics of florfenicol resistance genes among Citrobacter isolates from animal and relevant environmental samples and conducted a comparative analysis of a multidrug-resistant Citrobacter freundii strain isolated from a rabbit. Among 20 Citrobacter strains isolated from animal samples, resistance was most commonly observed to ampicillin (100%), tetracycline (75%), streptomycin (65%), florfenicol (60%), chloramphenicol (60%), and aztreonam (50%), while all the strains found in environmental samples were resistant to few antibiotics. …”
Get full text

The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem D... by Fawzia Bardag-Gorce, Richard H. Hoft, Andrew Wood, Joan Oliva, Hope Niihara, Andrew Makalinao, Jacquelyn Thropay, Derek Pan, Imara Meepe, Kumar Tiger, Julio Garcia, Amanda Laporte, Samuel W. French, Yutaka Niihara

“…CAOMECS were cultured on a temperature-responsive surface and grafted onto rabbit corneas with Limbal Stem Cell Deficiency (LSCD). …”
Get full text

Evaluation of twin-arginine translocation substrate proteins as potential antigen candidates for serodiagnosis of brucellosis by Yao Wu, Yao Wu, Xin Yan, Mingjun Sun, Xiaohan Guo, Jiaqi Li, Xiangxiang Sun, Xiangxiang Sun, Mengda Liu, Mengda Liu, Haobo Zhang, Haobo Zhang, Wenlong Nan, Weixing Shao, Fangkun Wang, Xiaoxu Fan, Xiaoxu Fan, Shufang Sun

“…Both the combined protein group and YxeI displayed no cross-reactivity with rabbit serum immunized against Yersinia enterocolitica O9, Escherichia coli O157:H7, Mycobacterium tuberculosis, Vibrio cholerae, Legionella, and Salmonella, indicating relatively good specificity.ConclusionThe findings of this study suggest that Tat substrate proteins serve as promising candidate antigens with significant potential value for the clinical diagnosis of brucellosis.…”
Get full text

Correlation between Hyperalgesia and Upregulation of TNF-α and IL-1β in Aqueous Humor and Blood in Second Eye Phacoemulsification: Clinical and Experimental Investigation by Ruibo Yang, Chang Liu, Di Yu, Lechong Ma, Yan Zhang, Shaozhen Zhao

“…The aim of this study was to explore the correlation between intraoperative hyperalgesia of the second eye and the dynamic changes of tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels in aqueous humor (AH) of the second eye and whole blood after the first eye cataract surgery. A rabbit model of monocular phacoemulsification was established by administration of 0.3% levofloxacin. …”
Get full text

Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…The trial will compare the novel GvHD prophylaxis regimens post-transplant cyclophosphamide (PTCy) in combination with a CNI or sirolimus (PTCy-CNI or PTCy-sirolimus, respectively) to a current standard-of-care GvHD prophylaxis involving the use of Thymoglobulin (a specific brand of ATG containing rabbit polyclonal antibodies). The primary outcome measure is GvHD-free, relapse-free survival at 1 year. …”
Get full text

Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch by Francisco J. Chorro, Francisco J. Chorro, Francisco J. Chorro, Luis Such-Miquel, Luis Such-Miquel, Samuel Cuñat, Oscar Arias-Mutis, Oscar Arias-Mutis, Patricia Genovés, Patricia Genovés, Manuel Zarzoso, Manuel Zarzoso, Antonio Alberola, Antonio Alberola, Luis Such-Belenguer, Luis Such-Belenguer, Irene Del Canto, Irene Del Canto

“…The aim of this study was to investigate the electrophysiological modifications induced by eleclazine basally and during acute ventricular stretch.MethodsLeft ventricular stretch was induced at baseline and during perfusion with eleclazine in 26 Langendorff rabbit heart preparations. Programmed stimulation and high-resolution mapping techniques were applied using multiple epicardial electrodes.ResultsAt baseline, both the ventricular refractory period measured at a fixed cycle length (250 m) and its surrogate obtained during ventricular fibrillation (VF) decreased significantly during stretch (baseline 128 ± 15 vs. stretch 110 ± 14 m; n = 15; p < 0.001, and baseline 52 ± 13 vs. stretch 44 ± 9 m; n = 11; p < 0.05), while the VF dominant frequency (DF) increased significantly (DF baseline 13 ± 3 vs. stretch 17 ± 5Hz; n = 11; p < 0.01). …”
Get full text